Composition Comprising Antibody That Binds To Domain Ii Of Her2 And Acidic Variants Thereof - EP3401335

The patent EP3401335 was granted to Genentech on Jun 30, 2021. The application was originally filed on Jan 28, 2009 under application number EP18157419A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3401335

GENENTECH
Application Number
EP18157419A
Filing Date
Jan 28, 2009
Status
Granted And Under Opposition
May 28, 2021
Grant Date
Jun 30, 2021
External Links
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Patent Family

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ABEL & IMRAYMar 30, 2022ABEL & IMRAYADMISSIBLE
EUROPEAN OPPOSITIONSMar 30, 2022KILBURN & STRODEADMISSIBLE
STRAWMANMar 28, 2022GILL JENNINGS & EVERYWITHDRAWN
POHLMANMar 22, 2022POHLMANADMISSIBLE
HEXALNov 8, 2021KONIG SZYNKA TILMANN VON RENESSE DUSSELDORFADMISSIBLE
HEXALNov 8, 2021KONIG SZYNKA TILMANN VON RENESSE PATENTANWALTE PARTNERSCHAFT MBB DUSSELDORFADMISSIBLE

Patent Citations (140) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONEP0003089
DESCRIPTIONEP0404097
DESCRIPTIONEP0599274
DESCRIPTIONEP0659439
DESCRIPTIONUS2002004587
DESCRIPTIONUS2003157108
DESCRIPTIONUS2004093621
DESCRIPTIONUS2005101617
DESCRIPTIONUS2006013819
DESCRIPTIONUS2006018899
DESCRIPTIONUS2006088523
DESCRIPTIONUS2007020261
DESCRIPTIONUS3773919
DESCRIPTIONUS4485045
DESCRIPTIONUS4544545
DESCRIPTIONUS4676980
DESCRIPTIONUS4816567
DESCRIPTIONUS4933294
DESCRIPTIONUS4943533
DESCRIPTIONUS4968603
DESCRIPTIONUS5013556
DESCRIPTIONUS5183884
DESCRIPTIONUS5208020
DESCRIPTIONUS5212290
DESCRIPTIONUS5229275
DESCRIPTIONUS5264586
DESCRIPTIONUS5401638
DESCRIPTIONUS5457105
DESCRIPTIONUS5475001
DESCRIPTIONUS5480968
DESCRIPTIONUS5500362
DESCRIPTIONUS5545807
DESCRIPTIONUS5565332
DESCRIPTIONUS5567610
DESCRIPTIONUS5571894
DESCRIPTIONUS5573905
DESCRIPTIONUS5587458
DESCRIPTIONUS5589369
DESCRIPTIONUS5591669
DESCRIPTIONUS5616582
DESCRIPTIONUS5641869
DESCRIPTIONUS5641870
DESCRIPTIONUS5654307
DESCRIPTIONUS5677171
DESCRIPTIONUS5679683
DESCRIPTIONUS5712374
DESCRIPTIONUS5714586
DESCRIPTIONUS5731168
DESCRIPTIONUS5739277
DESCRIPTIONUS5747498
DESCRIPTIONUS5760041
DESCRIPTIONUS5766863
DESCRIPTIONUS5770599
DESCRIPTIONUS5772997
DESCRIPTIONUS5773001
DESCRIPTIONUS5783186
DESCRIPTIONUS5804396
DESCRIPTIONUS5821337
DESCRIPTIONUS5824311
DESCRIPTIONUS5837234
DESCRIPTIONUS5866572
DESCRIPTIONUS5891996
DESCRIPTIONUS6002008
DESCRIPTIONUS6084095
DESCRIPTIONUS6140332
DESCRIPTIONUS6194551
DESCRIPTIONUS6235883
DESCRIPTIONUS6242195
DESCRIPTIONUS6265410
DESCRIPTIONUS6339142
DESCRIPTIONUS6344455
DESCRIPTIONUS6344459
DESCRIPTIONUS6391874
DESCRIPTIONUS6399602
DESCRIPTIONUS6455534
DESCRIPTIONUS6521620
DESCRIPTIONUS6528624
DESCRIPTIONUS6538124
DESCRIPTIONUS6596726
DESCRIPTIONUS6602684
DESCRIPTIONUS6602863
DESCRIPTIONUS6713484
DESCRIPTIONUS6949245
DESCRIPTIONWO0042072
DESCRIPTIONWO0100245
DESCRIPTIONWO03011878
DESCRIPTIONWO03086467
DESCRIPTIONWO9100360
DESCRIPTIONWO9105264
DESCRIPTIONWO9220373
DESCRIPTIONWO9308829
DESCRIPTIONWO9311161
DESCRIPTIONWO9316185
DESCRIPTIONWO9321232
DESCRIPTIONWO9321319
DESCRIPTIONWO9400136
DESCRIPTIONWO9404690
DESCRIPTIONWO9411026
DESCRIPTIONWO9422478
DESCRIPTIONWO9603397
DESCRIPTIONWO9616673
DESCRIPTIONWO9630347
DESCRIPTIONWO9633978
DESCRIPTIONWO9633980
DESCRIPTIONWO9640210
DESCRIPTIONWO9700271
DESCRIPTIONWO9704801
DESCRIPTIONWO9730087
DESCRIPTIONWO9738731
DESCRIPTIONWO9738983
DESCRIPTIONWO9802463
DESCRIPTIONWO9814451
DESCRIPTIONWO9817797
DESCRIPTIONWO9843960
DESCRIPTIONWO9845479
DESCRIPTIONWO9850038
DESCRIPTIONWO9850433
DESCRIPTIONWO9858964
DESCRIPTIONWO9906378
DESCRIPTIONWO9906396
DESCRIPTIONWO9909016
DESCRIPTIONWO9919488
DESCRIPTIONWO9922764
DESCRIPTIONWO9924037
DESCRIPTIONWO9951642
OPPOSITIONWO0100245
OPPOSITIONWO2004008099
OPPOSITIONWO2006033700
OPPOSITIONWO2006044908
OPPOSITIONWO2006063042
OPPOSITIONWO2006078307
OPPOSITIONWO2006091693
OPPOSITIONWO2006096861
OPPOSITIONWO2007013950
OPPOSITIONWO2007145862
OPPOSITIONWO2009099829
OPPOSITIONWO2014172371
OPPOSITIONWO9957134
SEARCHEP1308455
SEARCHWO2006033700

Non-Patent Literature (NPL) Citations (263) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- AASLAND et al., Br. J. Cancer, (19880000), vol. 57, pages 358 - 363-
DESCRIPTION- AGNEW, Chern Intl. Ed. Engl., (19940000), vol. 33, pages 183 - 186-
DESCRIPTION- AGUS et al., Cancer Cell, (20020000), vol. 2, pages 127 - 137-
DESCRIPTION- AGUS et al., Proc Am Soc Clin Oncol, (20030000), vol. 22, page 192-
DESCRIPTION- A. L. LEHNINGER, Biochemistry, Worth Publishers, (19750000), pages 73 - 75-
DESCRIPTION- ARTEAGA et al., Cancer Res., (19940000), vol. 54, pages 3758 - 3765-
DESCRIPTION- BACUS et al., Cancer Research, (19920000), vol. 52, pages 2580 - 2589-
DESCRIPTION- BACUS et al., Molecular Carcinogenesis, (19900000), vol. 3, pages 350 - 362-
DESCRIPTION- BASELGA et al., J. Clin. Oncol., (19960000), vol. 14, pages 737 - 744-
DESCRIPTION- BASELGA; MENDELSOHN, Pharmac. Ther., (19940000), vol. 64, pages 127 - 154-
DESCRIPTION- BORST et al., Gynecol. Oncol., (19900000), vol. 38, page 364-
DESCRIPTION- BRENNAN et al., Science, (19850000), vol. 229, page 81-
DESCRIPTION- BRODEUR et al., Monoclonal Antibody Production Techniques and Applications, Marcel Dekker, Inc., (19870000), pages 51 - 63-
DESCRIPTION- BRUGGERMANN et al., Year in Immuno., (19930000), vol. 7, page 33-
DESCRIPTION- CAPEL et al., Immunomethods, (19940000), vol. 4, pages 25 - 34-
DESCRIPTION- CARON et al., J. Exp Med., (19920000), vol. 176, pages 1191 - 1195-
DESCRIPTION- CARPENTER et al., Ann. Rev. Biochem., (19870000), vol. 56, pages 881 - 914-
DESCRIPTION- CARRAWAY; CANTLEY, Cell, (19940000), vol. 78, pages 5 - 8-
DESCRIPTION- CARRAWAY et al., Nature, (19970000), vol. 387, pages 512 - 516-
DESCRIPTION- CARTER et al., Bio/Technology, (19920000), vol. 10, pages 163 - 167-
DESCRIPTION- CARTER et al., Proc. Natl. Acad. Sci. USA, (19920000), vol. 89, page 4285-
DESCRIPTION- CHANG et al., Nature, (19970000), vol. 387, pages 509 - 512-
DESCRIPTION- CHARI et al., Cancer Research, (19920000), vol. 52, pages 127 - 131-
DESCRIPTION- CHO et al., Nature, (20030000), vol. 421, pages 756 - 760-
DESCRIPTION- CHOTHIA et al., J. Mol. Biol., (19870000), vol. 196, page 901-
DESCRIPTION- CHOTHIA; LESK, J. Mol. Biol., (19870000), vol. 196, pages 901 - 917-
DESCRIPTION- CLACKSON et al., Nature, (19910000), vol. 352, pages 624 - 628-
DESCRIPTION- CLYNES et al., PNAS (USA), (19980000), vol. 95, pages 652 - 656-
DESCRIPTION- COHEN et al., Oncogene, (19890000), vol. 4, pages 81 - 88-
DESCRIPTION- COOK et al., Mol. Cell. Biol., (19910000), vol. 11, pages 2547 - 2557-
DESCRIPTION- CUNNINGHAM; WELLS, Science, (19890000), vol. 244, pages 1081 - 1085-
DESCRIPTION- DAERON, Annu. Rev. Immunol., (19970000), vol. 15, pages 203 - 234-
DESCRIPTION- DE HAAS et al., J. Lab. Clin. Med., (19950000), vol. 126, pages 330 - 41-
DESCRIPTION- DREBIN et al., Cell, (19850000), vol. 41, pages 695 - 706-
DESCRIPTION- DREBIN et al., Oncogene, (19880000), vol. 2, pages 273 - 277-
DESCRIPTION- D'SOUZA et al., Proc. Natl. Acad. Sci., (19940000), vol. 91, pages 7202 - 7206-
DESCRIPTION- EARP et al., Breast Cancer Research and Treatment, (19950000), vol. 35, pages 115 - 132-
DESCRIPTION- EPSTEIN et al., Proc. Natl. Acad. Sci. USA, (19850000), vol. 82, page 3688-
DESCRIPTION- FALLS et al., Cell, (19930000), vol. 72, pages 801 - 815-
DESCRIPTION- FENDLY et al., Cancer Research, (19900000), vol. 50, pages 1550 - 1558-
DESCRIPTION- FRANKLIN et al., Cancer Cell, (20040000), vol. 5, pages 317 - 328-
DESCRIPTION- FUKUSHIGE et al., Mol Cell Biol., (19860000), vol. 6, pages 955 - 958-
DESCRIPTION- GABIZON et al., J. National Cancer Inst., (19890000), vol. 81, no. 19, page 1484-
DESCRIPTION- GARRETT et al., Mol. Cell, (20030000), vol. 11, pages 495 - 505-
DESCRIPTION- GAZZANO-SANTORO et al., J. Immunol. Methods, (19960000), vol. 202, page 163-
DESCRIPTION- "Genebank", Database accession no. X03363-
DESCRIPTION- GODING, Monoclonal Antibodies: Principles and Practice, Academic Press, (19860000), pages 59 - 103-
DESCRIPTION- GRIFFITH et al., EMBOJ., (19930000), vol. 12, pages 725 - 734-
DESCRIPTION- GROENEN et al., Growth Factors, (19940000), vol. 11, pages 235 - 257-
DESCRIPTION- GRUBER et al., J. Immunol., (19940000), vol. 152, page 5368-
DESCRIPTION- GUERIN et al., Oncogene Res., (19880000), vol. 3, pages 21 - 31-
DESCRIPTION- GU et al., Cancer Lett., (19960000), vol. 99, pages 185 - 9-
DESCRIPTION- GUYER et al., J. Immunol., (19760000), vol. 117, page 587-
DESCRIPTION- HANCOCK et al., Cancer Res., (19910000), vol. 51, pages 4575 - 4580-
DESCRIPTION- HARARI et al., Oncogene, (19990000), vol. 18, pages 2681 - 89-
DESCRIPTION- HARWERTH et al., J. Biol. Chem., (19920000), vol. 267, pages 15160 - 15167-
DESCRIPTION- HIGASHIYAMA et al., Science, (19910000), vol. 251, pages 936 - 939-
DESCRIPTION- HINMAN et al., Cancer Research, (19930000), vol. 53, pages 3336 - 3342-
DESCRIPTION- HO et al., J. Biol. Chem., (19950000), vol. 270, pages 14523 - 14532-
DESCRIPTION- HOLLINGER et al., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 6444 - 6448-
DESCRIPTION- HOLMES et al., Science, (19920000), vol. 256, pages 1205 - 1210-
DESCRIPTION- HUDZIAK et al., Mol. Cell. Biol., (19890000), vol. 9, no. 3, pages 1165 - 1172-
DESCRIPTION- HUMPHREY et al., PNAS (USA), (19900000), vol. 87, pages 4207 - 4211-
DESCRIPTION- HWANG et al., Proc. Natl Acad. Sci. USA, (19800000), vol. 77, page 4030-
DESCRIPTION- JAKOBOVITS et al., Nature, (19930000), vol. 362, pages 255 - 258-
DESCRIPTION- JAKOBOVITS et al., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, page 2551-
DESCRIPTION- JOHNS et al., J. Biol. Chem., (20040000), vol. 279, no. 29, pages 30375 - 30384-
DESCRIPTION- JOHNSON, KEVIN S.; CHISWELL, DAVID J., Current Opinion in Structural Biology, (19930000), vol. 3, pages 564 - 571-
DESCRIPTION- JONES et al., Nature, (19860000), vol. 321, pages 522 - 525-
DESCRIPTION- KANNAN et al., J. Biol. Chem., (19970000), vol. 272, no. 6, pages 3330 - 3335-
DESCRIPTION- KASPRZYK et al., Cancer Research, (19920000), vol. 52, pages 2771 - 2776-
DESCRIPTION- KERN et al., Cancer Res., (19900000), vol. 50, page 5184-
DESCRIPTION- KIM et al., J. Immunol., (19940000), vol. 24, page 249-
DESCRIPTION- KIMURA et al., Nature, (19900000), vol. 348, pages 257 - 260-
DESCRIPTION- KING et al., Science, (19850000), vol. 229, page 974-
DESCRIPTION- KLAPPER et al., Oncogene, (19970000), vol. 14, pages 2099 - 2109-
DESCRIPTION- KOHLER et al., Nature, (19750000), vol. 256, page 495-
DESCRIPTION- KOMURASAKI et al., Oncogene, (19970000), vol. 15, pages 2841 - 2848-
DESCRIPTION- KOSTELNY et al., J. Immunol., (19920000), vol. 148, no. 5, pages 1547 - 1553-
DESCRIPTION- KOTTS et al., In Vitro, (19900000), vol. 26, no. 3, page 59A-
DESCRIPTION- KOZBOR, J. Immunol., (19840000), vol. 133, page 3001-
DESCRIPTION- KRAUS et al., PNAS (USA), (19890000), vol. 86, pages 9193 - 9197-
DESCRIPTION- KUMAR et al., Mol. Cell. Biol., (19910000), vol. 11, no. 2, pages 979 - 986-
DESCRIPTION- LEE et al., Pharm. Rev., (19950000), vol. 47, pages 51 - 85-
DESCRIPTION- LEMKE, G., Molec. & Cell. Neurosci., (19960000), vol. 7, pages 247 - 262-
DESCRIPTION- LEVI et al., Journal of Neuroscience, (19950000), vol. 15, pages 1329 - 1340-
DESCRIPTION- LEWIS et al., Cancer Immunol. Immunother., (19930000), vol. 37, pages 255 - 263-
DESCRIPTION- LEWIS et al., Cancer Res., (19960000), vol. 56, pages 1457 - 1465-
DESCRIPTION- LEWIS et al., Cancer Research, (19960000), vol. 56, pages 1457 - 1465-
DESCRIPTION- LODE et al., Cancer Research, (19980000), vol. 58, pages 2925 - 2928-
DESCRIPTION- MAIER et al., Cancer Res., (19910000), vol. 51, pages 5361 - 5369-
DESCRIPTION- MARCHIONNI et al., Nature, (19930000), vol. 362, pages 312 - 318-
DESCRIPTION- MARKS et al., BiolTechnology, (19920000), vol. 10, pages 779 - 783-
DESCRIPTION- MARKS et al., J. Mol. Biol., (19910000), vol. 222, pages 581 - 597-
DESCRIPTION- MARQUARDT et al., Science, (19840000), vol. 223, pages 1079 - 1082-
DESCRIPTION- MARTIN et al., J. Biol. Chem., (19820000), vol. 257, pages 286 - 288-
DESCRIPTION- MASUI et al., Cancer Research, (19840000), vol. 44, pages 1002 - 1007-
DESCRIPTION- MCCAFFERTY et al., Nature, (19900000), vol. 348, pages 552 - 553-
DESCRIPTION- MCCAFFERTY et al., Nature, (19900000), vol. 348, pages 552 - 554-
DESCRIPTION- MCCANN et al., Cancer, (19900000), vol. 65, pages 88 - 92-
DESCRIPTION- MCKENZIE et al., Oncogene, (19890000), vol. 4, pages 543 - 548-
DESCRIPTION- MILLSTEIN et al., Nature, (19830000), vol. 305, pages 537 - 539-
DESCRIPTION- MOLINA et al., Cancer Res., (20010000), vol. 61, pages 4744 - 4749-
DESCRIPTION- MORIMOTO et al., Journal of Biochemical and Biophysical Methods, (19920000), vol. 24, pages 107 - 117-
DESCRIPTION- MORRISON et al., Proc. Natl Acad. Sci. USA, (19840000), vol. 81, page 6851-
DESCRIPTION- MORRISON et al., Proc. Natl. Acad. Sci. USA, (19840000), vol. 81, pages 6851 - 6855-
DESCRIPTION- MORRISSEY et al., Proc. Natl. Acad. Sci. USA, (19950000), vol. 92, pages 1431 - 1435-
DESCRIPTION- MUNSON et al., Anal. Biochem., (19800000), vol. 107, page 220-
DESCRIPTION- MYERS et al., Meth. Enzym., (19910000), vol. 198, pages 277 - 290-
DESCRIPTION- PARK et al., Cancer Res., (19890000), vol. 49, page 6605-
DESCRIPTION- PELES et al., Cell, (19920000), vol. 69, pages 205 - 216-
DESCRIPTION- PIETRAS et al., Oncogene, (19940000), vol. 9, pages 1829 - 1838-
DESCRIPTION- PLOWMAN et al., Nature, (19930000), vol. 366, pages 473 - 475-
DESCRIPTION- PLOWMAN et al., Proc. Natl. Acad. Sci., (19930000), vol. 90, pages 1746 - 1750-
DESCRIPTION- PLOWMAN et al., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 1746 - 1750-
DESCRIPTION- PLUCKTHUN, Immunol. Revs., (19920000), vol. 130, pages 151 - 188-
DESCRIPTION- PLUCKTHUN, The Pharmacology of Monoclonal Antibodies, Springer-Verlag, (19940000), vol. 113, pages 269 - 315-
DESCRIPTION- PRESTA, Curr. Op. Struct. Biol., (19920000), vol. 2, pages 593 - 596-
DESCRIPTION- PRESTA et al., J. Immunol., (19930000), vol. 151, page 2623-
DESCRIPTION- RAVETCH; KINET, Annu. Rev. Immunol, (19910000), vol. 9, pages 457 - 92-
DESCRIPTION- RIECHMANN et al., Nature, (19880000), vol. 332, pages 323 - 327-
DESCRIPTION- RIECHMANN et al., Nature, (19880000), vol. 332, pages 323 - 329-
DESCRIPTION- ROSS et al., Cancer, (19970000), vol. 79, pages 2162 - 70-
DESCRIPTION- ROSS et al., Hum. Pathol., (19970000), vol. 28, pages 827 - 33-
DESCRIPTION- SADASIVAN et al., J. Urol., (19930000), vol. 150, pages 126 - 31-
DESCRIPTION- SARUP et al., Growth Regulation, (19910000), vol. 1, pages 72 - 82-
DESCRIPTION- SASADA et al., Biochem. Biophys. Res. Commun., (19930000), vol. 190, page 1173-
DESCRIPTION- SAVAGE et al., J. Biol. Chem., (19720000), vol. 247, pages 7612 - 7621-
DESCRIPTION- SCHAEFER et al., Oncogene, (19970000), vol. 15, pages 1385 - 1394-
DESCRIPTION- SCOTT et al., J. Biol. Chem., (19910000), vol. 266, pages 14300 - 5-
DESCRIPTION- SEMBA et al., PNAS (USA), (19850000), vol. 82, pages 6497 - 6501-
DESCRIPTION- SHALABY et al., J. Exp. Med., (19920000), vol. 175, pages 217 - 225-
DESCRIPTION- SHAWVER et al., Cancer Res., (19940000), vol. 54, pages 1367 - 1373-
DESCRIPTION- SHEPARD et al., J. Clin. Immunol., (19910000), vol. 11, no. 3, pages 117 - 127-
DESCRIPTION- SHING et al., Science, (19930000), vol. 259, pages 1604 - 1607-
DESCRIPTION- SHOPES, B. J. Immunol., (19920000), vol. 148, pages 2918 - 2922-
DESCRIPTION- SHOYAB et al., Science, (19890000), vol. 243, pages 1074 - 1076-
DESCRIPTION- SIAS et al., J. Immunol. Methods, (19900000), vol. 132, pages 73 - 80-
DESCRIPTION- SIMS et al., J. Immunol., (19930000), vol. 151, page 2296-
DESCRIPTION- SKERRA et al., Curr. Opinion in Immunol., (19930000), vol. 5, pages 256 - 262-
DESCRIPTION- SLAMON et al., Science, (19870000), vol. 235, pages 177 - 182-
DESCRIPTION- SLAMON et al., Science, (19890000), vol. 244, pages 707 - 712-
DESCRIPTION- SLIWKOWSKI et al., J. Biol. Chem., (19940000), vol. 269, no. 20, pages 14661 - 14665-
DESCRIPTION- STANCOVSKI et al., PNAS (USA), (19910000), vol. 88, pages 8691 - 8695-
DESCRIPTION- STEVENSON et al., Anti-Cancer Drug Design, (19890000), vol. 3, pages 219 - 230-
DESCRIPTION- STRAGLIOTTO et al., Eur. J. Cancer, (19960000), vol. 32A, pages 636 - 640-
DESCRIPTION- SURESH et al., Methods in Enzymology, (19860000), vol. 121, page 210-
DESCRIPTION- TAGLIABUE et al., Int. J. Cancer, (19910000), vol. 47, pages 933 - 937-
DESCRIPTION- TOYODA et al., J. Biol. Chem., (19950000), vol. 270, pages 7495 - 7500-
DESCRIPTION- TRAUNECKER et al., EMBO J., (19910000), vol. 10, pages 3655 - 3659-
DESCRIPTION- TUTT et al., J. Immunol., (19910000), vol. 147, page 60-
DESCRIPTION- VERHOEYEN et al., Science, (19880000), vol. 239, pages 1534 - 1536-
DESCRIPTION- VITETTA et al., Cancer Research, (19940000), vol. 54, pages 5301 - 5309-
DESCRIPTION- VITETTA et al., Science, (19870000), vol. 238, page 1098-
DESCRIPTION- WATERHOUSE et al., Nuc. Acids. Res., (19930000), vol. 21, pages 2265 - 2266-
DESCRIPTION- WEINER et al., Cancer Res., (19900000), vol. 50, pages 421 - 425-
DESCRIPTION- WILLIAMS et al., Pathobiology, (19910000), vol. 59, pages 46 - 52-
DESCRIPTION- WOLFF et al., Cancer Research, (19930000), vol. 53, pages 2560 - 2565-
DESCRIPTION- WU et al., J. Clin. Invest., (19950000), vol. 95, pages 1897 - 1905-
DESCRIPTION- XU et al., Int. J. Cancer, (19930000), vol. 53, pages 401 - 408-
DESCRIPTION- YAMAMOTO et al., Nature, (19860000), vol. 319, pages 230 - 234-
DESCRIPTION- YOKOTA et al., Lancet, (19860000), vol. 1, pages 765 - 767-
DESCRIPTION- YONEMURA et al., Cancer Res., (19910000), vol. 51, page 1034-
DESCRIPTION- ZHANG et al., PNAS (USA, (19970000), vol. 94, no. 18, pages 9562 - 7-
DESCRIPTION- ZHANG et al., Proc. Natl. Acad. Sci., (19970000), vol. 94, pages 9562 - 9567-
DESCRIPTION- ZHAU et al., Mol. Carcinog., (19900000), vol. 3, pages 254 - 257-
OPPOSITION- Anonymous, "CMC Forum: Standard Reference Materials for Biopharmaceutical Products", The Gold Sheet, (20060601), vol. 40, no. 6, pages 1 - 20, XP055775788-
OPPOSITION- Anonymous, "Glycation", Wikipedia, the free encyclopedia, (20071206), Wikipedia, the free encyclopedia, URL: https://en.wikipedia.org/w/index.php?title=Glycation&oldid=176148941, (20210215), XP055775783-
OPPOSITION- Anonymous, "ICH Topic Q 6 B Specifications: Test Procedures and Acceptance Criteria for Biotechnological/Biological Products ", EMEA European Medicines Agency, (19990901), pages 1 - 17, EMEA European Medicines Agency, URL: https://www.ema.europa.eu/en/documents/scientific-guideline/ich-q-6-b-test-procedures-acceptance-criteria-biotechnological/biological-products-step-5_en.pdf, (20220404), XP055908691-
OPPOSITION- Chowdhury Swapan K, Et Al, "Origin and removal of adducts (molecular mass = 98 u) attached to peptide and protein ions in electrospray ionization mass spectra", J Am Soc Mass Spectrom, (19900101), vol. 1, pages 382 - 388, XP055912422-
OPPOSITION- Emea, "ICH Topic Q 5 E Comparability of Biotechnological/Biological Products", European Medicines Agency, (20050601), pages 1 - 13, XP055912425-
OPPOSITION- Fda, "Guidance for Industry INDs for Phase 2 and 3 Studies of Drugs, Including Specified Therapeutic Biotechnology-Derived Products Chemistry, Manufacturing, and Controls Content and Format", FDA - Draft Guidance, (19990201), FDA - Draft Guidance, URL: http://www.msk.nclinnovations.org/medregulations/v1/html/Guidance/Guidance_IND%20Content%20Phase%20II%20&%20III.pdf, (20210215), XP055775791-
OPPOSITION- GIBCO BRL, "A Guide to Serum-Free Cell Culture", INVITROGEN CATALOGUE, XX, XX, XX , (20030101), pages 1 - 11, XP003001930-
OPPOSITION- HARRIS, "Heterogeneity of recombinant antibodies: linking structure to function", Develop Biol, (20050000), vol. 122, pages 117 - 127, XP008090894-
OPPOSITION- HARRIS, R.J., "Heterogeneity of Recombinant Antibodies: Linking structure to function", Dev. Biol., Basel, (20050000), vol. 122, pages 117 - 127, XP008090894-
OPPOSITION- Harris R J, "Heterogeneity of recombinant antibodies: linking structure to function", DEVELOPMENTS IN BIOLOGICALS, CH , (20050101), vol. 122, ISSN 1424-6074, pages 117 - 127, XP008090894-
OPPOSITION- Harris R J, "Heterogeneity of recombinant antibodies: linking structure to function.", DEVELOPMENTS IN BIOLOGICALS, CH , (20050101), vol. 122, ISSN 1424-6074, pages 117 - 127, XP008090894-
OPPOSITION- Ion Exchange Chromatography & Chromatofocusing - Principles and Methods, Amersham Biosciences, (20040101), XP055982380-
OPPOSITION- Motchnik Paul et al, "P-219-W Acidic variants of monoclonal antibodies: Origins, characteristics and impact on pharmacokinetics", Abstract, (20080101), pages 110 - 111, Abstract, (20210215), XP055775802-
OPPOSITION- Ozturk S S, Hu Wei-Shou (eds.), "Cell Culture Technology for Pharmaceutical and Cell-Based Therapies", (20060101), pages 41 - 79, XP055912400-
OPPOSITION- ROBINSON, N.E. et al., "Prediction of primary structure deamidation rates of asparaginyl and glutaminyl peptides through steric and catalytic effects", J Peptide Res, (20040000), vol. 63, pages 437 - 448, XP055912437-
OPPOSITION- "Specifications: Test Procedures and Acceptance Criteria for Biotechnological/Biological Products", ICH Topic Q 6 B, (19990901), XP055775816-
OPPOSITION- Wei Bingchuan, Et Al, "Glycation of antibodies: Modification, methods and potential effects on biological functions", MABS, (20170101), vol. 9, no. 4, pages 586 - 594, XP055912445-
OPPOSITION- Yuk et al., "Controlling glycation of recombinant antibody in fed-batch cell cultures", Biotechnol Bioeng, (20111100), vol. 108, no. 11, doi:10.1002/bit.23218, pages 2600 - 2610, XP055171183
OPPOSITION- L. C. Santora et al, "Characterization of maleuric acid derivatives on transgenic human monoclonal antibody due to post-secretional modifications in goat milk", Biomedical Chromatography, (20060901), vol. 20, no. 9, doi:10.1002/bmc.603, ISSN 02693879, pages 843 - 856, XP055169390
OPPOSITION- HARRIS et al., "Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies", Drug Dev Res, (20040000), vol. 61, doi:10.1002/ddr.10344, pages 137 - 154, XP002649544
OPPOSITION- HARRIS R J, SHIRE S J, WINTER C, "Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies", DRUG DEVELOPMENT RESEARCH, US , (20040301), vol. 61, no. 3, doi:10.1002/ddr.10344, ISSN 0272-4391, pages 137 - 154, XP002324970
OPPOSITION- WANG et al., "ANTIBODY STRUCTURE, INSTABILITY, AND FORMULATION", Journal of Pharmaceutical Sciences, US , (20070101), vol. 96, no. 1, doi:10.1002/jps.20727, ISSN 0022-3549, pages 1 - 26, XP009084505
OPPOSITION- WANG et al., "Antibody structure, instability, and formulation", J Pharmaceutical Sci, vol. 96, no. 1, doi:10.1002/jps.20727, (20070000), pages 1 - 26, XP009084505
OPPOSITION- WANG W; SINGH S; ZENG D L; KING K; NEMA S, "ANTIBODY STRUCTURE, INSTABILITY, AND FORMULATION", Journal of Pharmaceutical Sciences, American Chemical Society and American Pharmaceutical Association, US, US , (20070101), vol. 96, no. 1, doi:10.1002/jps.20727, ISSN 0022-3549, pages 1 - 26, XP009084505
OPPOSITION- WANG W; SINGH S; ZENG D L; KING K; NEMA S, "ANTIBODY STRUCTURE, INSTABILITY, AND FORMULATION", Journal of Pharmaceutical Sciences, US , (20070101), vol. 96, no. 1, doi:10.1002/jps.20727, ISSN 0022-3549, pages 1 - 26, XP009084505
OPPOSITION- Hongcheng Liu, Georgeen Haza-Bulseco, Dinesh Faldu, Chris Chumsae And Joanne Sun, "Heterogeneity of Monoclonal Antibodies", Journal of Pharmaceutical Sciences, (20080701), vol. 97, no. 7, doi:10.1002 /jps.21180, pages 2426 - 2447, XP055551051
OPPOSITION- Liu et al., "Heterogeneity of Monoclonal Antibodies", Journal of Pharmaceutical Sciences, (20080701), vol. 97, no. 7, doi:10.1002 /jps.21180, pages 2426 - 2447, XP055551051
OPPOSITION- LIU et al., "Heterogeneity of monoclonal antibodies", J Pharmaceutical Sci, (20070000), vol. 97, no. 7, pages 2426 - 2447, XP055551051
OPPOSITION- LIU H. et al., "Heterogeneity of Monoclonal Antibodies", Journal of Pharmaceutical Sciences, (20080700), vol. 97, no. 7, XP055551051
OPPOSITION- SANTORA L C et al, "Characterization of recombinant human monoclonal tissue necrosis factor-alpha antibody using cation-exchange HPLC and capillary isoelectric focusing", Analytical Biochemistry, Amsterdam, NL , (19991101), vol. 275, no. 1, doi:10.1006/abio.1999.4275, ISSN 0003-2697, pages 98 - 108, XP002433060
OPPOSITION- RAO et al., "Orthoclone OKT3 - Chemical mechanisms and functional effects of degradation of a therapeutic monoclonal antibody", Stability and Characterization of Protein and Peptide Drugs: Case Histories, (19930000), vol. 4, doi:10.1007/978-1-4899-1236-7_4, pages 135 - 158, XP055551359
OPPOSITION- MA et al., "Analysis of protein therapeutics by capillary electrophoresis", Chromatographia, (20010000), pages S-75 - S-89, XP055908674
OPPOSITION- Ma et al., "Analysis of Protein Therapeutics by Capillary Electrophoresis", Chromatographia Suppl., (20010101), vol. 53, pages 75 - 89, XP055908674
OPPOSITION- Ma S., Nashabeh W., "Analysis of Protein Therapeutics by Capillary Electrophoresis", CE in Biotechnology: Practical Applications for Protein and Peptide Analyses, Wiesbaden, Vieweg+Teubner Verlag, (20010101), vol. 5, pages 75 - 89, doi:10.1007/978-3-322-83021-0_9, ISSN 1615-2255, ISBN 978-3-322-83021-0, XP055908674
OPPOSITION- Hendrik Emons ; Ales Fajgelj ; Adriaan M. H. van der Veen ; Robert Watters, "New definitions on reference materials", Accreditation and Quality Assurance ; Journal for Quality, Comparability and Reliability in Chemical Measurement, Springer, Berlin, DE, Berlin, DE , (20060201), vol. 10, no. 10, doi:10.1007/s00769-006-0089-9, ISSN 1432-0517, pages 576 - 578, XP019351417
OPPOSITION- Hongcheng Liu ; Georgeen Gaza-Bulseco ; Chris Chumsae ; Abigail Newby-Kew, "Characterization of lower molecular weight artifact bands of recombinant monoclonal IgG1 antibodies on non-reducing SDS-PAGE", Biotechnology Letters, Springer Netherlands, Dordrecht, Dordrecht , (20070704), vol. 29, no. 11, doi:10.1007/s10529-007-9449-8, ISSN 1573-6776, pages 1611 - 1622, XP019523988
OPPOSITION- LIU et al., "Characterization of lower molecular weight artifact bands of recombinant monoclonal IgG1 antibodies on non-reducing SDS-PAGE", Biotechnol Lett, (20070000), vol. 29, doi:10.1007/s10529-007-9449-8, pages 1611 - 1622, XP019523988
OPPOSITION- WEINBERG et al., "Development and regulation of monoclonal antibody products: Challenges and opportunities", Cancer Metastasis Rev, (20050000), vol. 24, doi:10.1007/s10555-005-6196-y, pages 569 - 584, XP019205206
OPPOSITION- Virella, G. ; Parkhouse, R.M.E., "Sensitivity to reduction of human immunoglobulin G of different heavy chain sub-classes", Immunochemistry, Pergamon, GB, GB , (19730401), vol. 10, no. 4, doi:10.1016/0019-2791(73)90197-3, ISSN 0019-2791, pages 213 - 217, XP023935752
OPPOSITION- HUNT et al., "Capillary isoelectric focusing and sodium dodecyl sulfate capillary gel electrophoresis of recombinant humanized monoclonal antibody HER2", J Chromatog A, (19960000), vol. 744, doi:10.1016/0021-9673(96)00437-2, pages 295 - 301, XP004020331
OPPOSITION- Quan, C. Alcala, E. Petkovska, I. Matthews, D. Canova-Davis, E. Taticek, R. Ma, S., "A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior", Analytical Biochemistry, Academic Press, Amsterdam, NL, Amsterdam, NL , (20080105), vol. 373, no. 2, doi:10.1016/j.ab.2007.09.027, ISSN 0003-2697, pages 179 - 191, XP022411097
OPPOSITION- Quan, C. Alcala, E. Petkovska, I. Matthews, D. Canova-Davis, E. Taticek, R. Ma, S., "A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior", Analytical Biochemistry, Amsterdam, NL , (20080105), vol. 373, no. 2, doi:10.1016/j.ab.2007.09.027, ISSN 0003-2697, pages 179 - 191, XP022411097
OPPOSITION- QUAN et al., "A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior", Anal Biochem, vol. 373, doi:10.1016/j.ab.2007.09.027, (20070000), pages 179 - 191, XP022411097
OPPOSITION- Quan et al., "A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior", Analytical Biochemistry, Amsterdam, NL , (20080105), vol. 373, no. 2, doi:10.1016/j.ab.2007.09.027, ISSN 0003-2697, pages 179 - 191, XP022411097
OPPOSITION- RIDDLES et al., "Reassessment of Ellman's reagent", Meth Enzymol, (19830000), vol. 91, doi:10.1016/S0076-6879(83)91010-8, pages 49 - 60, XP055551047
OPPOSITION- RIDDLES P.W. et al., "Reassessment of Ellman's Reagent", Methods in Enzymology, (19830000), vol. 91, doi:10.1016/S0076-6879(83)91010-8, pages 49 - 60, XP055551047
OPPOSITION- Oscar Salas-Solano, Chantal Felten, "15 Capillary electrophoresis and bioanalysis", Capillary electrophoresis methods for pharmaceutical analysis, doi:10.1016/S0149-6395(07)00015-3, ISBN 978-0-12-372573-8, (20080101), pages 401 - 424, Capillary electrophoresis methods for pharmaceutical analysis, (20190204), XP055551375
OPPOSITION- Oscar Salas-Solano, Chantal Felten, "15 Capillary electrophoresis and bioanalysis", Capillary electrophoresis methods for pharmaceutical analysis, Elsevier, doi:10.1016/S0149-6395(07)00015-3, ISBN 978-0-12-372573-8, (20080101), pages 401 - 424, Capillary electrophoresis methods for pharmaceutical analysis, (20190204), XP055551375
OPPOSITION- Salas-Solano et al., "15 Capillary electrophoresis and bioanalysis", Salas-Solano et al., Ahuja et al., Capillary electrophoresis methods for pharmaceutical analysis, (20080101), pages 401 - 424, doi:10.1016/S0149-6395(07)00015-3, ISBN 978-0-12-372573-8, XP055551375
OPPOSITION- SALAS-SOLANO et al., "Capillary electrophoresis and bioanalysis", Capillary electrophoresis methods for pharmaceutical analysis, (20080726), vol. 15, doi:10.1016/S0149-6395(07)00015-3, pages 401 - 424, XP055551375
OPPOSITION- HARRIS et al., "Identification of multiple sources of charge heterogeneity in a recombinant antibody", J Chromatography B, (20010000), vol. 752, doi:10.1016/S0378-4347(00)00548-X, pages 233 - 245, XP004317158
OPPOSITION- Guillermo I. Tous, Ziping Wei, Jinhua Feng, Susanna Bilbulian, Stephen Bowen, Jaime Smith, Robert Strouse, Patrick Mcgeehan, Jose Casas-Finet, Mark A. Schenerman, "Characterization of a Novel Modification to Monoclonal Antibodies:  Thioether Cross-link of Heavy and Light Chains", Analytical Chemistry, American Chemical Society, US, US , (20050501), vol. 77, no. 9, doi:10.1021/ac0500582, ISSN 0003-2700, pages 2675 - 2682, XP055551114
OPPOSITION- Guillermo I. Tous, Ziping Wei, Jinhua Feng, Susanna Bilbulian, Stephen Bowen, Jaime Smith, Robert Strouse, Patrick Mcgeehan, Jose Casas-Finet, Mark A. Schenerman, "Characterization of a Novel Modification to Monoclonal Antibodies:  Thioether Cross-link of Heavy and Light Chains", Analytical Chemistry, US , (20050501), vol. 77, no. 9, doi:10.1021/ac0500582, ISSN 0003-2700, pages 2675 - 2682, XP055551114
OPPOSITION- TOUS et al., "Characterization of a novel modification to monoclonal antibodies: Thioether cross-link of heavy and light chains", Anal Chem, (20050000), vol. 77, no. 9, doi:10.1021/ac0500582, pages 2675 - 2682, XP055551114
OPPOSITION- Tous et al., "Characterization of a Novel Modification to Monoclonal Antibodies: Thioether Cross-link of Heavy and Light Chains", Analytical Chemistry, US , (20050501), vol. 77, no. 9, doi:10.1021/ac0500582, ISSN 0003-2700, pages 2675 - 2682, XP055551114
OPPOSITION- SALAS-SOLANO et al., "Optimization and validation of a quantitative capillary electrophoresis sodium dodecyl sulfate method for quality control and stability monitoring of monoclonal antibodies", Anal Chem, (20060000), vol. 78, no. 18, pages 6583 - 6594, XP002519390
OPPOSITION- SALAS-SOLANO et al., "Optimization and validation of a quantitative capillary electrophoresis sodium dodecyl sulfate method for quality control and stability monitoring of monoclonal antibodies.", Analytical Chemistry, US , (20060915), vol. 78, no. 18, doi:10.1021/AC060828P, ISSN 0003-2700, pages 6583 - 6594, XP002519390
OPPOSITION- SALAS-SOLANO OSCAR ET AL, "Optimization and validation of a quantitative capillary electrophoresis sodium dodecyl sulfate method for quality control and stability monitoring of monoclonal antibodies.", Analytical Chemistry, US , (20060915), vol. 78, no. 18, doi:10.1021/AC060828P, ISSN 0003-2700, pages 6583 - 6594, XP002519390
OPPOSITION- ZHANG et al., "Unveiling a glycation hot spot in a recombinant humanized monoclonal antibody", Anal Chem, (20080000), vol. 80, doi:10.1021/ac701810q, pages 2379 - 2390, XP002478266
OPPOSITION- HUNT et al., "Capillary electrophoresis sodium dodecyl sulfate nongel sieving analysis of a therapeutic recombinant monoclonal antibody: A biotechnology perspective", Anal Chem, (19990000), vol. 71, no. 13, doi:10.1021/ac981209m, pages 2390 - 2397, XP055534370
OPPOSITION- Hunt et al., "Capillary electrophoresis sodium dodecyl sulfate nongel sieving analysis of a therapeutic recombinant monoclonal antibody: a biotechnology perspective", Anal Chem., (19990101), vol. 71, no. 13, doi:10.1021/ac981209m, pages 2390 - 2397, XP055534370
OPPOSITION- Hunt, Et Al, "Capillary electrophoresis sodium dodecyl sulfate nongel sieving analysis of a therapeutic recombinant monoclonal antibody: a biotechnology perspective", Anal Chem., (19990101), vol. 71, no. 13, doi:10.1021/ac981209m, pages 2390 - 2397, XP055534370
OPPOSITION- ZHANG et al., "Free sulfhydryl in recombinant monoclonal antibodies", Biotechnology Progress, (20020501), vol. 18, no. 3, doi:10.1021/BP025511Z, ISSN 8756-7938, pages 509 - 513, XP002500112
OPPOSITION- ZHANG et al., "Free sulfhydryl in recombinant monoclonal antibodies", Biotechnol. Prog., (20020000), vol. 18, no. 3, doi:10.1021/BP025511Z, pages 509 - 513, XP002500112
OPPOSITION- ZHANG WEI, CZUPRYN M J, "Free sulfhydryl in recombinant monoclonal antibodies", Biotechnology Progress, (20020501), vol. 18, no. 3, doi:10.1021/BP025511Z, ISSN 8756-7938, pages 509 - 513, XP002500112
OPPOSITION- ZHANG WEI, CZUPRYN M J, "Free sulfhydryl in recombinant monoclonal antibodies", Biotechnology Progress, American Chemical Society, (20020501), vol. 18, no. 3, doi:10.1021/BP025511Z, ISSN 8756-7938, pages 509 - 513, XP002500112
OPPOSITION- ZHANG W. et al., "Free Sulfhydryl in Recombinant Monoclonal Antibodies", Biotechnol. Prag., (20021104), vol. 18, doi:10.1021/BP025511Z, pages 509 - 513, XP002500112
OPPOSITION- CHADERJIAN et al., "Effect of copper sulfate on performance of a serum-free CHO cell culture process and the level of free thiol in the recombinant antibody expressed", Biotechnol Prog, (20050000), vol. 21, no. 2, pages 550 - 553, XP009107034
OPPOSITION- CHADERJIAN W.B. et al., "Effect of Copper Sulfate on Performance of a serum-free CHO cell culture process and the level of Free Thiol in the recombinant Antibody expressed", Biotechnol. Progr., vol. 21, (20050000), pages 550 - 553, XP009107034
OPPOSITION- Catak et al., "Reaction Mechanism of Deamidation of Asparaginyl Residues in Peptides: Effect of Solvent Molecules", The Journal of Physical Chemistry A, US , (20060701), vol. 110, no. 27, doi:10.1021/jp056991q, ISSN 1089-5639, pages 8354 - 8365, XP055775790
OPPOSITION- Catak Saron et al, "Reaction Mechanism of Deamidation of Asparaginyl Residues in Peptides:  Effect of Solvent Molecules †", The Journal of Physical Chemistry, US , (20060701), vol. 110, no. 27, doi:10.1021/jp056991q, ISSN 1089-5639, pages 8354 - 8365, XP055775790
OPPOSITION- Catak Saron, Monard Gérald, Aviyente Viktorya, Ruiz-López Manuel F., "Reaction Mechanism of Deamidation of Asparaginyl Residues in Peptides:  Effect of Solvent Molecules †", The Journal of Physical Chemistry A, Washington DC, US, US , (20060701), vol. 110, no. 27, doi:10.1021/jp056991q, ISSN 1089-5639, pages 8354 - 8365, XP055775790
OPPOSITION- KROON et al., "Identification of sites of degradation in a therapeutic monoclonal antibody by peptide mapping", Pharmac Res, (19920000), vol. 9, no. 11, doi:10.1023/A:1015894409623, pages 1386 - 1393, XP002079908
OPPOSITION- JENKINS et al., "Getting the glycosylation right: Implications for the biotechnology industry", Nat Biotechnol, (19960000), vol. 14, doi:10.1038/nbt0896-975, pages 975 - 981, XP002133654
OPPOSITION- JENKINS et al., "Getting the glycosylation right: implications for the biotechnology industry", Nature Biotechnology, New York, (19960801), vol. 14, no. 8, doi:10.1038/nbt0896-975, ISSN 1087-0156, pages 975 - 981, XP002133654
OPPOSITION- JENKINS N. ET AL., "Getting the glycosylation right: implications for the biotechnology dustry.", Nature Biotechnology, New York, (19960801), vol. 14., no. 08., doi:10.1038/nbt0896-975, ISSN 1087-0156, pages 975 - 981., XP002133654
OPPOSITION- JENKINS N. ET AL., "Getting the glycosylation right: implications for the biotechnology industry.", Nature Biotechnology, Nature Publishing Group US, New York, New York, (19960801), vol. 14., no. 08., doi:10.1038/nbt0896-975, ISSN 1087-0156, pages 975 - 981., XP002133654
OPPOSITION- WURM, "Production of recombinant protein therapeutics in cultivated mammalian cells", Nat Biotechnol, (20040000), vol. 22, no. 11, pages 1393 - 1398, XP002514352
OPPOSITION- FAHRNER et al., "Industrial purification of pharmaceutical antibodies: Development, operation, and validation of chromatography processes", Biotechnol Genetic Eng Rev, (20010000), vol. 18, doi:10.1080/02648725.2001.10648017, pages 301 - 327, XP008034714
OPPOSITION- AGUS et al., "Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer", J Clin Oncol, (20050000), vol. 23, no. 11, doi:10.1200/JCO.2005.03.184, pages 2534 - 2543, XP008058275
OPPOSITION- BASELGA et al., "Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T", J Clin Oncol, (20070000), vol. 25, no. 8, page 1004, XP002778678
OPPOSITION- Vlasak et al., "Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods", CURRENT PHARMACEUTICAL BIOTECHNOLOGY, NL , (20081201), vol. 9, no. 6, doi:10.2174/138920108786786402, ISSN 1389-2010, pages 468 - 481, XP008116104
OPPOSITION- VLASAK et al., "Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods", Curr Pharmac Biotechnol, (20080000), vol. 9, doi:10.2174/138920108786786402, pages 468 - 481, XP008116104
OPPOSITION- Vlasak J; Ionescu R, "Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods", CURRENT PHARMACEUTICAL BIOTECHNOLOGY, BENTHAM SCIENCE PUBLISHERS,, NL, NL , (20081201), vol. 9, no. 6, doi:10.2174/138920108786786402, ISSN 1389-2010, pages 468 - 481, XP008116104
OPPOSITION- Vlasak J; Ionescu R, "Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods", CURRENT PHARMACEUTICAL BIOTECHNOLOGY, NL , (20081201), vol. 9, no. 6, doi:10.2174/138920108786786402, ISSN 1389-2010, pages 468 - 481, XP008116104
OPPOSITION- KHAWLI et al., "Charge variants in IgG1", MAbs, (20100000), vol. 2, no. 6, doi:10.4161/mabs.2.6.13333, pages 613 - 624, XP055366646
OPPOSITION- Leslie A. Khawli, Sirj Goswami, Ryan Hutchinson, Zephania W. Kwong, Jihong Yang, Xiangdan Wang, Zhenling Yao, Alavattam Sreedhara, Tony Cano, Devin B. Tesar, Ihsan Nijem, David E. Allison, Pin Yee Wong, Yung-Hsiang Kao, Cynthia Quan, Amita Joshi, Reed J. Harris, Paul Motchnik, "Charge variants in IgG1", mAbs, Landes Bioscience, US, US , (20101101), vol. 2, no. 6, doi:10.4161/mabs.2.6.13333, ISSN 1942-0862, pages 613 - 624, XP055366646
OPPOSITION- LIU et al., "Disulfide bond structures of IgG molecules - structural variations, chemical modifications and possible impacts to stability and biological function", mAbs, vol. 4, no. 1, doi:10.4161/mabs.4.1.18347, pages 17 - 23, XP055696189
OPPOSITION- R W Seward, "NBS standard reference materials catalog 1988-89 NBS SP 260e1988", (19880101), Database accession no. NBS SP 260e1988, XP061046830
SEARCH- HARRIS R J, "Heterogeneity of recombinant antibodies: linking structure to function", DEVELOPMENTS IN BIOLOGI, KARGER, BASEL, CH, (20050101), vol. 122, ISSN 1424-6074, pages 117 - 127, XP008090894 [A] 1-9 * the whole document *-
SEARCH- WANG W ET AL, "ANTIBODY STRUCTURE, INSTABILITY, AND FORMULATION", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN CHEMICAL SOCIETY AND AMERICAN PHARMACEUTICAL ASSOCIATION, US, (20070101), vol. 96, no. 1, doi:10.1002/JPS.20727, ISSN 0022-3549, pages 1 - 26, XP009084505 [A] 1-9 * the whole document *
SEARCH- H. LIU ET AL., "Heterogeneity of monoclonal antibodies.", JOURNAL OF PHARMACEUTICAL SCIENCES, USA, (200807), vol. 97, no. 7, pages 2426 - 2447, XP002530921 [PA] 1-9 * abstract * * sections 'disulfide bonds', 'C-terminal lysine processing', 'deamidation', 'oxidation' and 'glycation' *
SEARCH- R. HARRIS ET AL., "Identification of multiple sources of charge heterogeneity in a recombinant antibody.", JOURNAL OF CHROMATOGRAPHY. B, BIOMEDICAL SCIENCES AND APPLICATIONS, The Netherlands, (20010310), vol. 752, no. 2, pages 233 - 245, XP004317158 [A] 1-9 * abstract *
SEARCH- GUILLERMO I. TOUS ET AL, "Characterization of a Novel Modification to Monoclonal Antibodies:? Thioether Cross-link of Heavy and Light Chains", ANALYTICAL CHEMISTRY, (20050501), vol. 77, no. 9, doi:10.1021/ac0500582, ISSN 0003-2700, pages 2675 - 2682, XP055189954 [A] 1-9 * the whole document *
SEARCH- ZHANG WEI ET AL, "Free sulfhydryl in recombinant monoclonal antibodies", BIOTECHNOLOGY PROGRESS, AMERICAN INSTITUTE OF CHEMICAL ENGINEERS, US, (20020501), vol. 18, no. 3, doi:10.1021/BP025511Z, ISSN 8756-7938, pages 509 - 513, XP002500112 [A] 1-9 * the whole document *
SEARCH- M. PERKINS ET AL., "Determination of the origin of charge heterogeneity in a murine monoclonal antibody.", PHARMACEUTICAL RESEARCH, USA, (200009), vol. 17, no. 9, pages 1110 - 1117, XP002479461 [A] 1-9 * the whole document *
SEARCH- D. AGUS ET AL., "Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer.", JOURNAL OF CLINICAL ONCOLOGY, USA, (20050410), vol. 23, no. 11, pages 2534 - 2543, XP008058275 [A] 1-9 * abstract *

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