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Methods And Compositions For Rna-Directed Target Dna Modification And For Rna-Directed Modulation Of Transcription - EP3401400

The patent EP3401400 was granted to Charpentier on Apr 3, 2019. The application was originally filed on Mar 15, 2013 under application number EP18152360A. The patent is currently recorded with a legal status of "Revoked".

EP3401400

CHARPENTIER
Application Number
EP18152360A
Filing Date
Mar 15, 2013
Status
Revoked
Nov 27, 2024
Publication Date
Apr 3, 2019
External Links
Slate, Register, Google Patents

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GREAVES BREWSTERJan 3, 2020-ADMISSIBLE
HGFJan 3, 2020HGFADMISSIBLE
TESTBIOTECH EVDec 17, 2019-ADMISSIBLE
DF MP DORRIES FRANK MOLNIA & POHLMAN PATENTANWALTE RECHTSANWALTE PARG MBBApr 4, 2019POHLMANADMISSIBLE

Patent Citations (70) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS2003022831
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DESCRIPTIONUS2003220334
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DESCRIPTIONUS2009047263
DESCRIPTIONUS2009068742
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DESCRIPTIONUS2009196903
DESCRIPTIONUS2009227032
DESCRIPTIONUS2009246875
DESCRIPTIONUS2009304646
DESCRIPTIONUS3687808
DESCRIPTIONUS5034506
DESCRIPTIONUS5222982
DESCRIPTIONUS5385582
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DESCRIPTIONUS7029913
DESCRIPTIONUS7078387
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DESCRIPTIONUS7169874
DESCRIPTIONWO0118048
DESCRIPTIONWO0151616
DESCRIPTIONWO03020920
DESCRIPTIONWO9303769
DESCRIPTIONWO9309239
DESCRIPTIONWO9319191
DESCRIPTIONWO9412649
DESCRIPTIONWO9428938
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OPPOSITIONWO2014093635
OPPOSITIONWO2014093655
OPPOSITIONWO2014093661
OPPOSITIONWO2014093701
OPPOSITIONWO2014093709
OPPOSITIONWO2014093712
OPPOSITIONWO2014093718
OPPOSITIONWO2014099744
SEARCHWO2010021692
SEARCHWO2011072246
SEARCHWO2014065596
SEARCHWO2014089290
SEARCHWO2014093661
SEARCHWO2014093712
SEARCHWO2014099744

Non-Patent Literature (NPL) Citations (365) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- AGUILERA et al., Integr Biol (Camb, (20090600), vol. 1, no. 5-6, pages 371 - 381
DESCRIPTION- A. HATOUM-ASLAN; I. MANIV; L. A. MARRAFFINI, Proc. Natl. Acad. Sci. U.S.A., (20110000), vol. 108, page 21218
DESCRIPTION- AKYIIREK et al., Mol. Med., (20000000), vol. 6, page 983
DESCRIPTION- ALI et al., Hum Gene Ther, (19980000), vol. 9, page 81 86
DESCRIPTION- ALI et al., Hum Mol Genet, (19960000), vol. 5, page 591 594
DESCRIPTION- ALI et al., Hum Mol Genet, (19960000), vol. 5, pages 591 - 594
DESCRIPTION- ALTSCHUL et al., J. Mol. Bioi., (19900000), vol. 215, pages 403 - 10
DESCRIPTION- ALTSCHUL et al., J. Mol. Biol., (19900000), vol. 215, pages 403 - 410
DESCRIPTION- ANGEL; YANIK, PLoS ONE, (20100000), vol. 5, no. 7, page el 1756
DESCRIPTION- BARBOUR et al., Biosci Rep, (20130118), vol. 33, no. 1
DESCRIPTION- BARTGE et al., Proc. Natl. Acad. Sci. USA, (19880000), vol. 85, pages 3648 - 3652
DESCRIPTION- BENNETT et al., Invest Opthalmol Vis Sci, (19970000), vol. 38, page 2857 2863
DESCRIPTION- BEUMER et al., "Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases", PNAS, (20080000), vol. 105, no. 50, pages 19821 - 19826
DESCRIPTION- BEVAN, Nucl Acid Res, (19840000), vol. 12, pages 8711 - 8721
DESCRIPTION- BITTER et al., Methods in Enzymology, (19870000), vol. 153, pages 516 - 544
DESCRIPTION- BORRAS et al., Gene Ther, (19990000), vol. 6, page 515 524
DESCRIPTION- BOUNDY et al., J. Neurosci., (19980000), vol. 18, page 9989
DESCRIPTION- BOYNTON et al., Methods in Enzymology, (19930000), vol. 217, pages 510 - 536
DESCRIPTION- B. P. LEWIS; C. B. BURGE; D. P. BARTEL, Cell, (20050000), vol. 120, page 15
DESCRIPTION- B. WIEDENHEFT et al., Nature, (20110000), vol. 477, page 486
DESCRIPTION- B. WIEDENHEFT et al., Proc. Natl. Acad. Sci. U.S.A., (20110000), vol. 108, page 10092
DESCRIPTION- B. WIEDENHEFT; S. H. STERNBERG; J. A. DOUDNA, Nature, (20120000), vol. 482, page 331
DESCRIPTION- CASANOVA et al., Genesis, (20010000), vol. 31, page 37
DESCRIPTION- C. FR0KJSER-JENSEN et al., "Single-copy insertion of transgenes in Caenorhabditis elegans", Nat. Genet., (20080000), vol. 40, page 1375
DESCRIPTION- CHAKRABARTI, Endocrinol, (20100000), vol. 151, page 2408
DESCRIPTION- CHANG et al., Proc. Natl. Acad Sci USA, (19870000), vol. 84, pages 4959 - 4963
DESCRIPTION- CHEN et al., Biochem. Biophys. Res. Comm., (19990000), vol. 262, page 187
DESCRIPTION- CHEN et al., Cell, (19870000), vol. 51, pages 7 - 19
DESCRIPTION- CHRISTOU, Bio/Technology, (19910000), vol. 9, pages 957 - 4462
DESCRIPTION- CHU et al., Bioorg Med Chem Lett., (20081115), vol. 18, no. 22, pages 5941 - 4
DESCRIPTION- CITARTAN et al., Biosens Bioelectron, (20120415), vol. 34, no. 1, pages 1 - 11
DESCRIPTION- CITARTAN et al., Biosens Bioelectron., (20120415), vol. 34, no. 1, pages 1 - 11
DESCRIPTION- COMB et al., EMBO J., (19880000), vol. 17, pages 3793 - 3805
DESCRIPTION- C. R. HALE et al., Cell, (20090000), vol. 139, page 945
DESCRIPTION- C. R. HALE et al., Mol. Cell, (20120000), vol. 45, page 292
DESCRIPTION- CROOKE et al., J. Pharmacol. Exp. Ther., (19960000), vol. 277, pages 923 - 937
DESCRIPTION- DANIELI et al., Nat. Biotechnol, (19980000), vol. 16, pages 345 - 348
DESCRIPTION- D. BHAYA; M. DAVISON; R. BARRANGOU, Annu. Rev. Genet., (20110000), vol. 45, page 273
DESCRIPTION- D. CARROLL, Gene Ther, (20080000), vol. 15, page 1463
DESCRIPTION- D. G. SASHITAL; B. WIEDENHEFT; J. A. DOUDNA, Mol. Cell, (20120000), vol. 46, page 606
DESCRIPTION- D. G. SASHITAL; M. JINEK; J. A. DOUDNA, Nat. Struct. Mol. Biol., (20110000), vol. 18, page 680
DESCRIPTION- DOHMEN et al., Science, (19940000), vol. 263, no. 5151, pages 1273 - 1276
DESCRIPTION- DWAINE A. BRAASCH; DAVID R. COREY, Biochemistry, (20020000), vol. 41, no. 14, pages 4503 - 4510
DESCRIPTION- E. DELTCHEVA et al., Nature, (20110000), vol. 471, page 602
DESCRIPTION- E. M. GESNER; M. J. SCHELLENBERG; E. L. GARSIDE; M. M. GEORGE; A. M. MACMILLAN, Nat. Struct. Mol. Biol., (20110000), vol. 18, page 688
DESCRIPTION- ENGLISCH et al., Angewandte Chemie, International Edition, (19910000), vol. 30, page 613
DESCRIPTION- E. R. WESTRA et al., Mol. Cell, (20120000), vol. 46, page 595
DESCRIPTION- E. SEMENOVA et al., Proc. Natl. Acad. Sci. U.S.A., (20110000), vol. 108, page 10098
DESCRIPTION- F. D. URNOV; E. J. REBAR; M. C. HOLMES; H. S. ZHANG; P. D. GREGORY, Nat. Rev. Genet., (20100000), vol. 11, page 636
DESCRIPTION- F. J. M. MOJICA; C. DIEZ-VILLASENOR; J. GARCIA-MARTINEZ; C. ALMENDROS, Microbiology, (20090000), vol. 155, page 733
DESCRIPTION- FLANNERY et al., PNAS, (19970000), vol. 94, page 6916 6921
DESCRIPTION- FLOTTE et al., PNAS, (19930000), vol. 90, pages 10613 - 10617
DESCRIPTION- FRANZ et al., Cardiovasc. Res., (19970000), vol. 35, pages 560 - 566
DESCRIPTION- FUTAKI et al., Curr Protein Pept Sci., (20030400), vol. 4, no. 2, pages 87 - 9,446
DESCRIPTION- GAMA et al., Brain Struct Funct, (20100300), vol. 214, no. 2-3, pages 91 - 109
DESCRIPTION- GenBank, Database accession no. NC_002163
DESCRIPTION- GenBank, Database accession no. NC_003116
DESCRIPTION- GenBank, Database accession no. NC_003212
DESCRIPTION- GenBank, Database accession no. NC_004350
DESCRIPTION- GenBank, Database accession no. NC_008601
DESCRIPTION- G. HUTVAGNER; M. J. SIMARD, Nat. Rev. Mol. Cell Biol., (20080000), vol. 9, page 22
DESCRIPTION- G. K. TAYLOR; D. F. HEITER; S. PIETROKOVSKI; B. L. STODDARD, Nucleic Acids Res., (20110000), vol. 39, page 9705
DESCRIPTION- GORDON-KAMM, Plant Cell, (19900000), vol. 2, pages 603 - 618
DESCRIPTION- GRISSA I et al., BMC Bioinformatics, (20070000), vol. 8, page 172
DESCRIPTION- H. DEVEAU et al., J. Bacteriol., (20080000), vol. 190, page 1390
DESCRIPTION- HERRERA-ESTRELLA et al., Nature, (19830000), vol. 303, page 209
DESCRIPTION- HUNTER et al., Hypertension, (19930000), vol. 22, pages 608 - 617
DESCRIPTION- HUSAINI et al., GM Crops, (20110601), vol. 2, no. 3, pages 150 - 62
DESCRIPTION- I. L. HOFACKER; P. F. STADLER, "Memory efficient folding algorithms for circular RNA secondary structures", Bioinformatics, (20060000), vol. 22, page 1172
DESCRIPTION- ISHIDA et al., Nature Biotech, (19960000), vol. 14, pages 745 - 750
DESCRIPTION- J. A. L. HOWARD; S. DELMAS; I. IVANCIC-BACE; E. L. BOLT, Biochem. J., (20110000), vol. 439, page 85
DESCRIPTION- J. CARTE; R. WANG; H. LI; R. M. TERNS; M. P. TERNS, Genes Dev, (20080000), vol. 22, page 3489
DESCRIPTION- J. C. MILLER et al., Nat. Biotechnol., (20110000), vol. 29, page 143
DESCRIPTION- J. E. GARNEAU et al., Nature, (20100000), vol. 468, page 67
DESCRIPTION- JOMARY et al., Gene Ther, (19970000), vol. 4, page 683 690
DESCRIPTION- JOMARY et al., Gene Ther, (19970000), vol. 4, pages 683 - 690
DESCRIPTION- J. ZHANG et al., Mol. Cell, (20120000), vol. 45, page 303
DESCRIPTION- KABANOV et al., FEBS Lett., (19900000), vol. 259, pages 327 - 330
DESCRIPTION- KANEDA et al., Neuron, (19910000), vol. 6, pages 583 - 594
DESCRIPTION- KAWAI et al., "Transformation of Saccharomyces cerevisiae and other fungi: methods and possible underlying mechanism", Bioeng Bugs., (20101100), vol. 1, no. 6, pages 395 - 403
DESCRIPTION- KIM et al., Mol. Cell. Biol., (19970000), vol. 17, pages 2266 - 2278
DESCRIPTION- KITA et al., Biochem. Biophys. Res. Comm., (20050000), vol. 331, page 484
DESCRIPTION- KLEE, Bio/Technolo, (19850000), vol. 3, pages 637 - 642
DESCRIPTION- KLEIN et al., Nature, (19870000), vol. 327, pages 70 - 73
DESCRIPTION- KNIGHT et al., Proc. Natl. Acad. Sci. USA, (20030000), vol. 100, page 14725
DESCRIPTION- KNOBLAUCH et al., Nat. Biotechnol, vol. 17, pages 906 - 909
DESCRIPTION- KOSHIMIZU, U. et al., Development, (19960000), vol. 122, page 1235
DESCRIPTION- KOSHKIN et al., Tetrahedron, (19980000), vol. 54, pages 3607 - 3630
DESCRIPTION- Kroschwitz, J. I., The Concise Encyclopedia Of Polymer Science And Engineering, John Wiley & Sons, (19900000), pages 858 - 859
DESCRIPTION- K. S. MAKAROVA et al., Nat. Rev. Microbiol., (20110000), vol. 9, page 467
DESCRIPTION- K. S. MAKAROVA; L. ARAVIND; Y. I. WOLF; E. V. KOONIN, Biol. Direct, (20110000), vol. 6, page 38
DESCRIPTION- K. S. MAKAROVA; N. V. GRISHIN; S. A. SHABALINA; Y. I. WOLF; E. V. KOONIN, Biol. Direct, (20060000), vol. 1, page 7
DESCRIPTION- KURIKI et al., Biol. Pharm. Bull., (20020000), vol. 25, page 1476
DESCRIPTION- L. A. MARRAFFINI; E. J. SONTHEIMER, Nature, (20100000), vol. 463, page 568
DESCRIPTION- LANGER, Science, (19900000), vol. 249, pages 1527 - 1533
DESCRIPTION- LETSINGER et al., Proc. Natl. Acad. Sci. USA, (19890000), vol. 86, pages 6553 - 6556
DESCRIPTION- LIBERMAN et al., Wiley Interdiscip Rev RNA, (20120500), vol. 3, no. 3, pages 369 - 84
DESCRIPTION- LI; DAVIDSON, PNAS, (19950000), vol. 92, page 7700 7704
DESCRIPTION- LI; DAVIDSON, PNAS, (19950000), vol. 92, pages 7700 - 7704
DESCRIPTION- LI et al., Invest Opthalmol Vis Sci, (19940000), vol. 35, page 2543 2549
DESCRIPTION- LI et al., Invest Opthalmol Vis Sci, (19940000), vol. 35, pages 2543 - 2549
DESCRIPTION- LI et al., J. Cell Biol., (19960000), vol. 132, pages 849 - 859
DESCRIPTION- LINN et al., Circ. Res., (19950000), vol. 76, pages 584 - 591
DESCRIPTION- LIU et al., Gene Therapy, (20040000), vol. 11, pages 52 - 60
DESCRIPTION- LLEWELLYN et al., Nat. Med., (20100000), vol. 16, no. 10, pages 1161 - 1166
DESCRIPTION- MANOHARAN et al., Ann. N.Y. Acad. Sci., (19920000), vol. 660, pages 306 - 309
DESCRIPTION- MANOHARAN et al., Bioorg. Med. Chem. Let., (19930000), vol. 3, pages 2765 - 2770
DESCRIPTION- MANOHARAN et al., Bioorg. Med. Chem. Let., (19940000), vol. 4, pages 1053 - 1060
DESCRIPTION- MANOHARAN et al., Nucleosides & Nucleotides, (19950000), vol. 14, pages 969 - 973
DESCRIPTION- MANOHARAN et al., Tetrahedron Lett., (19950000), vol. 36, pages 3651 - 3654
DESCRIPTION- MARTIN et al., Helv. Chim. Acta, (19950000), vol. 78, pages 486 - 504
DESCRIPTION- MASON et al., Endocrinol, (19980000), vol. 139, page 1013
DESCRIPTION- MATSUI, Y. et al., Cell, (19920000), vol. 70, page 841
DESCRIPTION- MAYFORD et al., Proc. Natl. Acad. Sci. USA, (19960000), vol. 93, page 13250
DESCRIPTION- MCBRIDE et al., Proc. Nati. Acad. Sci. USA, (19940000), vol. 91, pages 7301 - 7305
DESCRIPTION- M. CHRISTIAN et al., Genetics, (20100000), vol. 186, page 757
DESCRIPTION- MENDELSON et al., Virol., (19880000), vol. 166, pages 154 - 165
DESCRIPTION- M. G. CAPARON; J. R. SCOTT, "Genetic manipulation of pathogenic streptococci", Methods Enzymol., (19910000), vol. 204, page 556
DESCRIPTION- MISHRA et al., Biochim. Biophys. Acta, (19950000), vol. 1264, pages 229 - 237
DESCRIPTION- MIYAGISHI et al., Nature Biotechnology, (20020000), vol. 20, pages 497 - 500
DESCRIPTION- MIYOSHI et al., PNAS, (19970000), vol. 94, page 10319 23
DESCRIPTION- MOESSLER et al., Development, (19960000), vol. 122, pages 2415 - 2425
DESCRIPTION- MORRISON et al., Cell, (19970000), vol. 88, pages 287 - 298
DESCRIPTION- M. P. TERNS; R. M. TERNS, Curr. Opin. Microbiol., (20110000), vol. 14, page 321
DESCRIPTION- NAKAMURA et al., Genes Cells, (20120500), vol. 17, no. 5, pages 344 - 64
DESCRIPTION- NEHLS et al., Science, (19960000), vol. 272, pages 886 - 889
DESCRIPTION- N. G. LINTNER et al., J. Biol. Chem., (20110000), vol. 286, page 21643
DESCRIPTION- NICOUD et al., J. Gene Med., (20070000), vol. 9, page 1015
DESCRIPTION- NOGUCHI et al., Diabetes, (20030000), vol. 52, no. 7, pages 1732 - 1737
DESCRIPTION- OBERDICK et al., Science, (19900000), vol. 248, pages 223 - 226
DESCRIPTION- OBERHAUSER et al., Nucl. Acids Res., (19920000), vol. 20, pages 533 - 538
DESCRIPTION- OH et al., Gene Ther, (20090000), vol. 16, page 437
DESCRIPTION- O'NEILL et al., Plant J., (19930000), vol. 3, pages 729 - 738
DESCRIPTION- PANYAM, Adv Drug Deliv Rev, (20120913), vol. S0169-40, no. 12, pages 00283 - 9
DESCRIPTION- PANYAM, Adv Drug Deliv Rev., (20120913), vol. S0169-40, no. 12, pages 00283 - 9
DESCRIPTION- PARMACEK et al., Mol. Cell. Biol., (19940000), vol. 14, pages 1870 - 1885
DESCRIPTION- PAVJANI et al., Nat. Med., (20050000), vol. 11, page 797
DESCRIPTION- PLATT et al., Proc. Natl. Acad. Sci. USA, (19890000), vol. 86, page 7490
DESCRIPTION- RADOVICK et al., Proc. Natl. Acad. Sci. USA, (19910000), vol. 88, pages 3402 - 3406
DESCRIPTION- R. BARRANGOU et al., Science, (20070000), vol. 315, page 1709
DESCRIPTION- R. B. DENMAN, "Using RNAFOLD to predict the activity of small catalytic RNAs", Biotechniques, (19930000), vol. 15, page 1090
DESCRIPTION- R. E. HAURWITZ; M. JINEK; B. WIEDENHEFT; K. ZHOU; J. A. DOUDNA, Science, (20100000), vol. 329, page 1355
DESCRIPTION- ROBBINS et al., Ann. N.Y. Acad. Sci., (19950000), vol. 752, pages 492 - 505
DESCRIPTION- ROLLING et al., Hum Gene Ther, (19990000), vol. 10, page 641 648
DESCRIPTION- ROSS et al., Proc. Natl. Acad. Sci. USA, (19900000), vol. 87, page 9590
DESCRIPTION- R. SAPRANAUSKAS et al., Nucleic Acids Res., (20110000), vol. 39, page 9275
DESCRIPTION- R. WANG; G. PREAMPLUME; M. P. TERNS; R. M. TERNS; H. LI, Structure, (20110000), vol. 19, page 257
DESCRIPTION- SAISON-BEHMOARAS et al., EMBO J., (19910000), vol. 10, pages 1111 - 1118
DESCRIPTION- SAKAMOTO et al., H Gene Ther, (19990000), vol. 5, page 1088 1097
DESCRIPTION- SAMULSKI et al., J. Vir., (19890000), vol. 63, pages 3822 - 3828
DESCRIPTION- Sanghvi et al., Antisense Research and Applications, CRC Press, (19930000), pages 276 - 278
DESCRIPTION- SANGHVI, Y. S., "Chapter 15", SANGHVI, Y. S., Crooke, S. T. and Lebleu, B., Antisense Research and Applications, CRC Press, (19930000), pages 289 - 302
DESCRIPTION- SARTORELLI et al., Proc. Natl. Acad. Sci. USA, (19920000), vol. 89, pages 4047 - 4051
DESCRIPTION- SASAOKA et al., Mol. Brain Res., (19920000), vol. 16, page 274
DESCRIPTION- SATO et al., J. Biol. Chem., (20020000), vol. 277, page 15703
DESCRIPTION- SCHOEBER et al., Am J Physiol Renal Physiol., (20090100), vol. 296, no. 1, pages F204 - 11
DESCRIPTION- SEO et al., Molec. Endocrinol., (20030000), vol. 17, page 1522
DESCRIPTION- S. GOTTESMAN, Nature, (20110000), vol. 471, page 588
DESCRIPTION- SHAMBLOTT et al., Proc. Natl. Acad. Sci. USA, (19980000), vol. 95, page 13726
DESCRIPTION- SHAMBLOTT, M. et al., Proc. Natl. Acad. Sci. USA, (19980000), vol. 95, page 13726
DESCRIPTION- SHAMBLOTT, M. et al., Proc. Natl. Acad. Sci. USA, (20010000), vol. 98, page 113
DESCRIPTION- SHEA et al., Nucl. Acids Res., (19900000), vol. 18, pages 3777 - 3783
DESCRIPTION- SINGH et al., Chem. Commun., (19980000), vol. 4, pages 455 - 456
DESCRIPTION- S. J. J. BROUNS et al., Science, (20080000), vol. 321, page 960
DESCRIPTION- SMITH; WATERMAN, Adv. Appl. Math., (19810000), vol. 2, pages 482 - 489
DESCRIPTION- STAUB et al., Nat. Biotechnol, (20000000), vol. 18, pages 333 - 338
DESCRIPTION- SVAB et al., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 913 - 917
DESCRIPTION- SVINARCHUK et al., Biochimie, (19930000), vol. 75, pages 49 - 54
DESCRIPTION- TABOR et al., J. Biol. Chem., (19990000), vol. 274, page 20603
DESCRIPTION- TAKAHASHI, Cell, (20071130), vol. 131, no. 5, pages 861 - 72
DESCRIPTION- TAKAHASHI et al., J Virol, (19990000), vol. 73, page 7812 7816
DESCRIPTION- TAKAHASHI, Nat Protoc., (20070000), vol. 2, no. 12, pages 3081 - 9
DESCRIPTION- TANKA et al., Nature, (20040318), vol. 428, no. 6980, pages 323 - 8
DESCRIPTION- THOMSON et al., Biol. Reprod., (19960000), vol. 55, page 254
DESCRIPTION- THOMSON et al., Proc. Natl. Acad. Sci USA, (19950000), vol. 92, page 7844
DESCRIPTION- THOMSON et al., Science, (19980000), vol. 282, page 1145
DESCRIPTION- THOMSON, Science, (19981106), vol. 282, no. 5391, pages 1145 - 7
DESCRIPTION- TOZZO et al., Endocrinol, (19970000), vol. 138, page 1604
DESCRIPTION- TREHIN et al., Pharm. Research, (20040000), vol. 21, pages 1248 - 1256
DESCRIPTION- VASIL, Bio/Technolo, (19930000), vol. 10, pages 667 - 674
DESCRIPTION- VAVALLE et al., Future Cardiol., (20120500), vol. 8, no. 3, pages 371 - 82
DESCRIPTION- WAHLESTEDT et al., Proc. Natl. Acad. Sci. U.S.A., (20000000), vol. 97, pages 5633 - 5638
DESCRIPTION- WANG et al., J. Am. Chem. Soc., (20000000), vol. 122, pages 8595 - 8602
DESCRIPTION- WAN; LEMEAUX, Plant Physiol, (19940000), vol. 104, pages 37 - 48
DESCRIPTION- WEEKS et al., Plant Physiol, (19930000), vol. 102, pages 1077 - 1084
DESCRIPTION- WENDER et al., Proc. Natl. Acad. Sci. USA, (20000000), vol. 97, pages 13003 - 13008
DESCRIPTION- WENDER et al., Proc. Natl. Acad. Sci. U.S.A, (20001121), vol. 97, no. 24, pages 13003 - 8
DESCRIPTION- XIA et al., Nucleic Acids Res., (20030901), vol. 31, no. 17
DESCRIPTION- YANG et al., Mol Cell, (20121130), vol. 48, no. 4, pages 487 - 8
DESCRIPTION- YOKOYAMA et al., Exp Eye Res, (19920000), vol. 55, page 225
DESCRIPTION- YOKOYAMA et al., Exp Eye Res., (19920000), vol. 55, page 225
DESCRIPTION- YOUNG et al., Ophthalmol. Vis. Sci., (20030000), vol. 44, page 4076
DESCRIPTION- YU, Science, (20071221), vol. 318, no. 5858, pages 1917 - 20
DESCRIPTION- ZENDER et al., Cancer Gene Ther., (20020000), vol. 9, no. 6, pages 489 - 96
DESCRIPTION- ZHANG; MADDEN, Genome Res., (19970000), vol. 7, pages 649 - 656
DESCRIPTION- K. DARTY; A. DENISE; Y. PONTY, "VARNA: Interactive drawing and editing of the RNA secondary structure", Bioinformatics, (20090000), vol. 25, doi:doi:10.1093/bioinformatics/btp250, page 1974, XP055198531
OPPOSITION- Anonymous, "Listeria innocua", IGEM 2001 Home Project, (2011), URL: http://2011.igem.org/Team:Arizona_State/Project/L_innocua, XP055665901
OPPOSITION- Anonymous, "Vorschlag für eine Richtlinie des Europäischen Parlaments und des Rates über den rechtlichen Schutz biotechnologischer Erfindungen", Amtsblatt der Europäischen Gemeinschaften, (19961007), pages 1 - 9, XP055671122
OPPOSITION- BABINEAU D. et al., "The FLP Protein of the 2-micron Plasmid of Yeast PURIFICATION OF THE PROTEIN FROM ESCHERICHIA COLI CELLS EXPRESSING THE CLONED FLP GENE", J Biol Chem., (19851005), vol. 260, no. 22, pages 12313 - 12319, XP055613910
OPPOSITION- DINGERMANN, et al., "CRISPR/Cas9", Deutsche Apothekerzeitung, (20150705), no. 19, pages 47 - 51, XP055665920
OPPOSITION- "exogenous", Henderson's Dictionary of Biological Terms, (19950000), page 192, XP055666254
OPPOSITION- FERRARI, A., "Kapitel 3", Gentechnish verändere Tiere in der Biomedizin, (20080000), pages 60 - 108, XP055671120
OPPOSITION- HALL et al., "Effects of inert volume-excluding macromolecules on protein fiber formation. I. Equilibrium models", Biophys. Chem., (20020000), vol. 98, pages 93 - 104, XP055464108
OPPOSITION- "I GEM Learn About", iGEM, (20110000), Web Archive, URL: https://web.archive.org/web/20111008201737/ttps://igem.org
OPPOSITION- Jiaqiwu, "Wiki Freeze", (20111128), URL: https://asuigem.wordpress.com/2011/09/28/wiki-freeze/, XP055665910
OPPOSITION- KIMCHI-SARFATY et al., "A'Silent' Polymorphism in the MDR1 Gene Changes Substrate Specificity", Science, (20070000), vol. 315, pages 525 - 528, XP055464126
OPPOSITION- "Listeria Innocua", IGEM 2011 Home Project, (20110927), XP055665905
OPPOSITION- Melissa Pandika, "Jennifer Doudna, CRISPR Code Killer", (20140107), ZY, URL: http://www.ozy.com/risinq-stars/jennifer-doudna-crispr-code-killer/4690, XP055613817
OPPOSITION- MOHR et al., "Rules for DNA target-site recognition by a lactococcal group II intron enable retargeting of the intron to specific DNA sequences", Genes & Development, (20000000), vol. 14, pages 559 - 573, XP055464117
OPPOSITION- "Project Introduction", IGEM 2011 Home Project, Arizona State University, (2011), URL: http://2011.igem.org/Team:Arizona_State/Project/Introduction, XP055665897
OPPOSITION- Robert Sanders, "Cheap and easy technique to snip DNA could revolutionize gene therapy", Berkeley News, URL: http://news.berkeley.edu/2013/01/07/cheap-and-easy-technique-to-snip-dna-could-revolutionize-gene-therapy/, XP055543406
OPPOSITION- ROBERTSON HD et al., "Purification and Properties of a Specific Escherichia coli Ribonuclease which Cleaves a Tyrosine Transfer Ribonucleic Acid Precursor", J Biol Chem., (19720825), vol. 247, no. 16, pages 5243 - 5251, XP055613873
OPPOSITION- ROMANI et al., "Hormonal regulation of Mg2+ transport and homeostasis in eukaryotic cells", BioMetals, (20020000), vol. 15, pages 271 - 283, XP055613801
OPPOSITION- R SANDERS, "Cheap and easy technique to snip DNA could revolutionize gene therapy", Berkeley Press Release, (20130107), URL: http://news.berkeley.edu/ 2013/01/07 /cheap-and-easy-technique-to-snip-dna-could- revol ution ize- gene -thera py, XP055543406
OPPOSITION- "The CRISPR Revolution", CATALYST MAGAZINE, Berkeley, (20140709), URL: http://catalyst.berkeley.edu/slideshow/the-crisprrevolution/19/12/2014 12:40:53, XP055665429
OPPOSITION- "The CRISPR Revolution", Catalyst Magazine, vol. 9, no. 1, (20140000), URL: http://catalyst.berkeley.edu/slideshow/the-crispr-revolution/, XP055665429
OPPOSITION- THEN, CHRISTOPH, "Gentechnik, Patente und die Tierversuchsindustrie: Neue Gentechnik- Verfahren und Patente auf Säugetiere lassen die Zahl der Tierversuche weiter ansteigen", Test Biotech, (20160000), pages 1 - 27, XP055671126
OPPOSITION- VAN DEN BERG et al., "Effects of macromolecular crowding on protein folding and aggregation", EMBO J., (19990000), vol. 18, no. 24, pages 6927 - 6933, XP055464113
OPPOSITION- ZAHID et al., "Protein Transduction Domains: Applications for Molecular Medicine", Curr. Gene Ther., (20120000), vol. 12, pages 374 - 380
OPPOSITION- MCCALL et al., "Probes of chromatin accessibility in the Drosophila bithorax complex respond differently to Polycomb-mediated repression", EMBO J., (19960000), vol. 15, no. 3, doi:10.1002/j.1460-2075.1996.tb00389.x, pages 569 - 580, XP055613797
OPPOSITION- MAERTENS et al., "Gene optimization mechanisms: a multi- gene study reveals a high success rate of full-length human proteins expressed in Escherichia coli", Protein Sci., (20100000), vol. 19, doi:10.1002/pro.408, pages 1312 - 26, XP055441307
OPPOSITION- CORBI et al., "Chapter 9 Synthetic Zinc Finger Transcription Factors", CORBI et al., Shiro Iuchi, Zinc finger proteins: from atomic contact to cellular function, (20050000), pages 47 - 55, XP055344640
OPPOSITION- MOJICA et al., "Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements", J Mol Evolution, (20050000), vol. 60, pages 174 - 182, XP019363173
OPPOSITION- HEIDMANN et al., "Reduction of Cre recombinase toxicity in proliferating Drosophila cells by estrogen-dependent activity regulation", Dev. Genes & Evolution, (20010000), vol. 211, doi:10.1007/s004270100167, pages 458 - 465, XP055613807
OPPOSITION- TAN W. et al., "Gene targeting, genome editing: from Dolly to editors", Transgenic Research, (20160000), pages 273 - 287, XP035933686
OPPOSITION- STERNBERG et al., "Bacteriophage P1 site-specific recombination . I . Recombination between loxP sites", J. Mol. Biol., (19810000), vol. 150, doi:10.1016/0022-2836(81)90375-2, pages 467 - 486, XP024013080
OPPOSITION- STERNBERG et al., "Bacteriophage P1 site-specific recombination. II. Recombination between loxP and the bacterial chromosome", J. Mol. Biol., (19810000), vol. 150, doi:10.1016/0022-2836(81)90376-4, pages 487 - 507, XP024013081
OPPOSITION- O'NEILL et al., "Nucleosome Arrays Inhibit Both Initiation and Elongation of Transcripts by Bacteriophage T7 RNA Polymerase", J. Mol. Biol., (19920000), vol. 223, doi:10.1016/0022-2836(92)90716-W, pages 67 - 78, XP024018312
OPPOSITION- GUERRIER-TAKADA C. et al., "The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme", Cell, (19831200), vol. 35, pages 849 - 857, XP023876209
OPPOSITION- ZIMMERLY et al., "Group // Intron Mobility Occurs by Target DNA-Primed Reverse Transcription", Cell, (19950000), vol. 82, doi:10.1016/0092-8674(95)90027-6, pages 545 - 554, XP002911793
OPPOSITION- KIM K et al., "Inhibition of gene expression in human cells using RNase P-derived ribozymes and external guide sequences", Biochimica et Biophysica Acta, (20070000), vol. 1769, pages 603 - 612, XP022349461
OPPOSITION- HALL et al., "Effects of inert volume-excluding macromolecules on protein fiber formation. II. Kinetic models for nucleated fiber growth", Biophys. Chem., (20040000), vol. 107, doi:10.1016/j.bpc.2003.09.016, pages 299 - 316, XP055464109
OPPOSITION- NISHIMASU et al., "Crystal structure of Cas9 in complex with Guide RNA and Target DNA", Cell, (20140000), vol. 156, no. 5, doi:10.1016/j.cell.2014.02.001, pages 935 - 949, XP028667665
OPPOSITION- Nishimasu et al., "Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA, includes Supplemental Information)", Cell, (20140201), vol. 156, no. 5, pages 935 - 949,S1-S8, XP055423859
OPPOSITION- REN, X. et al., "Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in Drosophila", Cell Rep., (20140000), vol. 9, pages 1151 - 1162, XP055366968
OPPOSITION- MEI, YUE et al., "Recent Progress in CRISPR/Cas9 Technology", Genomics, (20160000), vol. 43, pages 63 - 72, XP029434259
OPPOSITION- LEENAY et al., "Identifying and Visualizing Functional PAM Diversity across CRISPR- Cas Systems", Mol. Cell, (20160000), vol. 62, pages 137 - 147, XP029496719
OPPOSITION- LEENAY et al., "Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems", Molecular Cell, (20160000), vol. 62, pages 137 - 147, XP029496719
OPPOSITION- MAURO et al., "A critical analysis of codon optimization in human therapeutics", Trends Mol Med., (20140000), vol. 20, no. 11, doi:10.1016/j.molmed.2014.09.003, pages 604 - 613, XP055391316
OPPOSITION- HENDRIX et al., "RNA structural motifs: building blocks of a modular biomolecule", Quarterly Reviews of Biophysics, (20050000), vol. 3, no. 38, pages 221 - 243, XP009098023
OPPOSITION- MARTIN, "Requirement for GroEL/GroES-Dependent Protein Folding under Nonpermissive Conditions of Macromolecular Crowding", Biochemistry, (20020000), vol. 41, doi:10.1021/bi015925l, pages 5050 - 5055, XP055464111
OPPOSITION- COPPOOLSE et al., "Cre recombinase expression can result in phenotypic aberrations in plants", Plant Molecular Biology, (20030000), vol. 51, doi:10.1023/A:1021174726070, pages 263 - 279, XP019262394
OPPOSITION- OLKE C . UHLENBECK, "Tetraloops and RNA folding", Nature, vol. 346, pages 613 - 614, XP055613699
OPPOSITION- YANG et al., "Efficient integration of an intron RNA into double-stranded DNA by reverse splicing", Nature, (19960000), vol. 381, doi:10.1038/381332a0, pages 332 - 335, XP002918949
OPPOSITION- Gottesman, Susan, "Dicing defence in bacteria", Nature, (20110331), vol. 471, pages 588 - 589, XP055613828
OPPOSITION- RODRIGUEZ CI. et al., "High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP", Nat Genet., (20000600), vol. 25, no. 2, pages 139 - 140, XP003034016
OPPOSITION- Horvath et al., "RNA-guided genome editing à la carte", Cell Research, (20130601), pages 733 - 734, XP055184973
OPPOSITION- SHEN B et al., "Generation of gene-modified mice via Cas9/RNA-mediated gene targeting", Cell Research, (20130000), vol. 23, pages 720 - 723, XP055141533
OPPOSITION- LINK et al., "Engineering ligand-responsive gene -control elements: lessons learned from natural riboswitches", Gene Therapy, (20090000), vol. 16, doi:10.1038/gt.2009.81, pages 1189 - 1201, XP008148752
OPPOSITION- CARROLL, "A CRISPR approach to gene targeting", Molecular Therapy, (20120000), vol. 20, no. 9, doi:10.1038/mt.2012.171, pages 1658 - 60, XP055106489
OPPOSITION- CARROLL, "A CRISPR Approach to Gene Targeting", Molecular Therapy, (20120000), vol. 20, no. 9, doi:10.1038/mt.2012.171, pages 1658 - 60, XP055106489
OPPOSITION- CARROLL, D., "A CRISPR Approach to Gene Targeting", Molecular Therapy, (20120000), vol. 20, no. 9, doi:10.1038/mt.2012.171, pages 1658 - 1660, XP055106489
OPPOSITION- GARNEAU et al., "The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA", Nature, (20100000), vol. 468, no. 7320, doi:10.1038/nature09523, pages 67 - 71, XP055181397
OPPOSITION- DELTCHEVA, E., "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", Nature, (20110000), vol. 471, doi:10.1038/nature09886, pages 602 - 607, XP055619637
OPPOSITION- DELTCHEVA et al., "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", Nature, (20110301), vol. 471, pages 602 - 609, XP055619637
OPPOSITION- STERNBERG et al., "DNA interrogation by the CRISPR RNA-guided endonuclease Cas9", Nature, (20140129), vol. 507, pages 62 - 67, XP055161285
OPPOSITION- ANDERS et al., "Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease", Nature, (20140900), vol. 513, pages 569 - 573, XP055240929
OPPOSITION- ANDERS et al., "Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease", Nature, (20140925), vol. 513, no. 7519, doi:10.1038/nature13579, pages 569 - 573, XP055240929
OPPOSITION- RAN et al., "In vivo genome editing using Staphylococcus aureus Cas9", Nature, (20150000), vol. 520, pages 186 - 191, XP055206733
OPPOSITION- Ran et al., "In vivo genome editing using Staphylococcus aureus Cas9 (Supplementary Information)", Nature, (20150401), vol. 520, no. 7546, pages 186 - 191, XP055304490
OPPOSITION- BUCHHOLZ et al., "Improved properties of FLP recombinase evolved by cycling mutagenesis", Nature Biotechnology, (19980000), vol. 16, no. 7, pages 657 - 662, XP000775868
OPPOSITION- BARRANGOU, "RNA-mediated programmable DNA cleavage", Nat. Biotechnol., (20120000), vol. 30, no. 9, doi:10.1038/nbt.2357, pages 836 - 838, XP055118675
OPPOSITION- BARRANGOU, R., "RNA-mediated programmable DNA cleavage", Nat. Biotechnology, (20120000), vol. 30, no. 9, doi:10.1038/nbt.2357, pages 836 - 838, XP055118675
OPPOSITION- Hwang et al., "Supplementary Material to: Efficient genome editing in zebrafish using a CRISPR-Cas system", Nature Biotechnology, pages 1 - 21, XP002718602
OPPOSITION- HWANG W.Y., "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nat Biotechnol., (20130300), vol. 31, no. 3, doi:10.1038/nbt.2501, pages 227 - 9, XP055540926
OPPOSITION- HWANG WY et al., "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nat Biotechnol., (20130300), vol. 31, no. 3, pages 227 - 229, XP055540933
OPPOSITION- CHO SW et al., "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease (includes Supplementary information)", Nat Biotechnol., (20130300), vol. 31, no. 3, pages 230 - 232,1-11, XP002699850
OPPOSITION- CHO, S. W., "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease", Nature Biotech., (20130000), vol. 31, no. 3, doi:10.1038/nbt.2507, XP002699850
OPPOSITION- HSU et al., "DNA targeting specificity of RNA-guided Cas9 nucleases", Nature Biotechnology, (20130900), vol. 31, no. 9, pages 827 - 832, XP002718604
OPPOSITION- DOENCH, J. G. et al., "Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9", Nature Biotech., (20160000), vol. 34, no. 2, pages 184 - 191, XP055551151
OPPOSITION- KIM, E. et al., "In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni", Nat Communcations, (20170000), pages 1 - 122, XP055435850
OPPOSITION- KIM et al., "In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni", Nature Communications, (20170000), vol. 8, pages 1 - 12, XP055435849
OPPOSITION- Ran et al., "Genome engineering using the CRISPR-Cas9 system", Nature Protocols, (20131101), vol. 8, no. 11, pages 2281 - 2308, XP002744123
OPPOSITION- MAKAROVA et al., "Evolution and classification of the CRISPR-Cas systems", Nature Reviews Microbiology, (20110000), vol. 9, pages 467 - 477, XP009155547
OPPOSITION- MAKAROVA, K.S. et al., "An Updated Evolutionary Classification of CRISPR- Cas Systems", Nature, (20150000), vol. 13, doi:10.1038/nrmicro3569, pages 722 - 736, XP055271841
OPPOSITION- IHRY et al., "P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells", Nature Medicine, (20170000), pages 939 - 946, XP036542073
OPPOSITION- GRYLLOS et al., "The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+", PNAS, (20030000), vol. 100, no. 7, doi:10.1073/pnas.0636231100, pages 4227 - 4232, XP055464121
OPPOSITION- YU B, "RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells", PNAS, (20020000), vol. 99, no. 9, doi:10.1073/pnas.092143499, pages 6047 - 6052, XP002332096
OPPOSITION- GASIUNAS et al., "Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", PNAS, vol. 109, no. 39, doi:10.1073/pnas.1208507109, (20120900), pages E2579 - E2586, URL: www.pnas.org/cgi/doi/10.1073/pnas.1208507109, XP055569955
OPPOSITION- GASIUNAS, G., "Cas9- crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", proc. nat. acad. sci., (20120000), vol. 109, no. 39, doi:10.1073/pnas.1208507109, pages E2579 - E2586, XP055569955
OPPOSITION- LOONSTRA et al., "Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells", Proc. Nat'l Acad. Sci. USA, (20010000), vol. 98, doi:10.1073/pnas.161269798, pages 9209 - 9214, XP055613805
OPPOSITION- SCHMIDT et al., "Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids", Proc. Nat'l Acad. Sci. USA, (20000000), vol. 97, doi:10.1073/pnas.240471297, pages 13702 - 13707, XP002607632
OPPOSITION- COX M M, "The FLP protein of the yeast 2-eum plasmid: Expression of a eukaryotic genetic recombination system in Escherichia coli", Proc Natl Acad Sci US A, (19830700), vol. 80, no. 14, pages 4223 - 4227, XP055613907
OPPOSITION- SAUER et al., "Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1", Proc. Nat'l Acad. Sci. USA, (19880000), vol. 85, doi:10.1073/pnas.85.14.5166, pages 5166 - 5170, XP000615552
OPPOSITION- LI Y. et al., "Targeted cleavage of mRNA in vitro by RNase P from Escherichia coli (external guide sequence/model substrates)", Proc Natl Acad Sci U S A., (19920415), vol. 89, no. 8, pages 3185 - 3189, XP055613884
OPPOSITION- REISS et al., "RecA protein stimulates homologous recombination in plants", Proceedings of the National Academy of Sciences, (19960400), vol. 93, pages 3094 - 3098, XP002023622
OPPOSITION- PLEHN-DUJOWICH D. et al., "Effective inhibition of influenza virus production in cultured cells by external guide sequences and ribonuclease P", Proc Natl Acad Sci U S A., (19980623), vol. 95, no. 13, pages 7327 - 7332, XP002939541
OPPOSITION- KILANI AF et al., "RNase P Ribozymes Selected in Vitro to Cleave a Viral mRNA Effectively Inhibit Its Expression in Cell Culture", J Biol Chem., (20000407), vol. 275, no. 14, pages 10611 - 10622, XP055613895
OPPOSITION- ZHOU T et al., "In Vitro Selection of External Guide Sequences for Directing RNase P-mediated Inhibition of Viral Gene Expression (includes Supplemental data)", J Biol Chem., (20020816), vol. 277, no. 33, pages 30112 - 30120,2-3, XP055613897
OPPOSITION- LACASSE et al., "Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins", Nucleic Acids Research, (19950000), vol. 23, no. 10, doi:10.1093/nar/23.10.1647, pages 1647 - 56, XP055464125
OPPOSITION- BUCHHOLZ F. et al., "Different Thermostabilities of FLP and Cre Recombinases: Implications for Applied Site-Specific Recombination", Nucleic Acids Res., (19961101), vol. 24, no. 21, pages 4256 - 4262, XP001004622
OPPOSITION- WIRTZ et al., "Regulated processive transcription of chromatin by T7 RNA polymerase in Trypanosoma brucei", Nucleic Acids Res., (19980000), vol. 26, no. 20, doi:10.1093/nar/26.20.4626, pages 4626 - 4634, XP000872845
OPPOSITION- Sapranauskas et al., "Supplementary data to The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli", Nucleic Acids Research, (20111101), vol. 39, no. 11, pages 1 - 10, XP055067807
OPPOSITION- SAPRANAUSKAS et al., "THE STREPTOCOCCUS THERMOPHILUS CRISPR/CAS SYSTEM PROVIDES IMMUNITY IN ESCHERICHIA COLI", Nucleic Acid Research, (20110000), vol. 39, no. 21, pages 9275 - 9282, XP055067807
OPPOSITION- SAPRANAUSKAS, R., "The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli", Nucleic Acids Research, (20110000), vol. 39, no. 21, doi:10.1093/nar/gkr606, page 9275 82, XP055265024
OPPOSITION- FONFARA et al., "Phylogeny of Cas9 determines functional exchangeability of dual- RNA and Cas9 among orthologous type II CRISPR-Cas systems", Nucleic Acids Research, (20140000), vol. 42, doi:10.1093/nar/gkt1074, pages 2577 - 2590, XP055399937
OPPOSITION- FONFARA et al., "Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-cas systems", Nucleic Acids Research, (20140000), vol. 42, no. 4, doi:10.1093/nar/gkt1074, pages 2577 - 2590, XP055399937
OPPOSITION- DICARLO, J. E., "Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems", Nucleic Acids Research, (20130000), vol. 41, no. 7, doi:10.1093/nar/gkt135, page 4336 43, XP055604254
OPPOSITION- POURCEL et al., "CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies", Microbiology, (20050000), vol. 151, pages 653 - 663, XP002460396
OPPOSITION- LAMBOWITZ et al., "Group // Introns: Mobil Ribozymes that Invade DNA", Cold Spring Harb Perspect Biol, (20110000), vol. 3, page a003616, XP055514471
OPPOSITION- JENUWEIN et al., "The immunoglobulin µ enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation", Genes & Dev., (19930000), vol. 7, doi:10.1101/gad.7.10.2016, pages 2016 - 2032, XP055336949
OPPOSITION- LIU F et al., "Inhibition of viral gene expression by the catalytic RNA subunlt o[ RNase P from Escherichia coli", Genes Dev., (19950215), vol. 9, no. 4, pages 471 - 480, XP055613887
OPPOSITION- PENG, R. et al., "Potential pitfalls of CRISPR/Cas9-mediated genome editing", FEBS Journal, (20160000), vol. 283, doi:10.1111/febs.13586, pages 1218 - 1231, XP055377561
OPPOSITION- BARRANGOU et al., "CRISPR provides acquired resistance against viruses in prokaryotes", Science, (20070000), vol. 315, pages 1709 - 1712, XP002428071
OPPOSITION- BROUNS et al., "Small CRISPR RNAs guide antiviral defense in prokaryotes", Science, (20080000), vol. 321, pages 960 - 964, XP002559962
OPPOSITION- MARRAFFINI et al., "CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA", Science, (20080000), vol. 322, no. 5909, pages 1843 - 1845, XP055613684
OPPOSITION- JINEK et al., "A programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120000), vol. 337, doi:10.1126/science.1225829, pages 816 - 821, XP055549487
OPPOSITION- Jinek et al., "Supplementary Materials for A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (2012), pages 1 - 37, XP055067747
OPPOSITION- JINEK, M et al., "A programmable Dual-RNA-Guided DNA Endonuclease in adaptive bacterial immunity", Science, (20120000), vol. 337, pages 816 - 821, XP055636516
OPPOSITION- JINEK M et al., "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120817), pages 816 - 821, XP055067740
OPPOSITION- CONG et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130000), vol. 339, doi:10.1126/science.1231143, pages 819 - 823, XP055458249
OPPOSITION- Cong et al., "Supplementary Material to : Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (2013), pages 1 - 28, XP055067744
OPPOSITION- CONG L et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130103), XP055458249
OPPOSITION- CONG, L., "Multiplex Genome Engineering Using CRISPR Cas Systems", Science, (20130215), vol. 339, no. 6121, doi:10.1126/science.1231143, pages 819 - 23, XP055458249
OPPOSITION- MALI et al., "RNA-Guided Human Genome Engineering via Cas9", Science, (20130000), vol. 339, doi:10.1126/science.1232033, pages 823 - 826, XP055469277
OPPOSITION- Mali et al., "Supplementary Materials for RNA-Guided Human Genome Engineering via Cas9", SCIENCE, (20130215), pages 1 - 36, XP002723674
OPPOSITION- MALI P et al., "RNA-Guided Human Genome Engineering via Cas9", Science, (20130103), XP055111247
OPPOSITION- MALI, P., "RNA Guided Human Genome Engineering via Cas9", Science, (20130000), vol. 339, pages 823 - 826, XP055636507
OPPOSITION- VAN DER OOST, "New Tool for Genome Surgery", Science, (20130215), pages 768 - 770, XP055185006
OPPOSITION- DOUDNA et al., "The new frontier of genome engineering with CRISPR-Cas9", Science, (20140000), vol. 346, no. 6213, doi:10.1126/science.1258096, XP055162699
OPPOSITION- JENNIFER DOUDNA, "The new frontier of genome engineering with CRISPR-Cas9", Catalyst Magazine, (20140709), pages 1 - 10, XP055162699
OPPOSITION- FORSTER AC. et al., "External Guide Sequences for an RNA Enzyme", Science, (19900817), vol. 249, no. 4970, pages 783 - 786, XP055613881
OPPOSITION- O'GORMAN S. et al., "Recombinase-mediated gene activation and site-specific integration in mammalian cells", Science, (19910315), vol. 251, no. 4999, pages 1351 - 1355, XP002032986
OPPOSITION- MCCLAIN WH et al., "Model substrates for an RNA enzyme", Science, (19871023), vol. 238, no. 4826, pages 527 - 530, XP055613876
OPPOSITION- YUAN Y et al., "Selection of guide sequences that direct efficient cleavage of mRNA by human ribonuclease P", Science, (19940304), vol. 263, no. 5151, pages 1269 - 1273, XP002104825
OPPOSITION- HOUSDEN, B. E. et al., "Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi", Science Signaling, (20150908), vol. 8, no. 393, doi:10.1126/scisignal.aab3729, pages 1 - 9, XP055665480
OPPOSITION- JIANG et al., "Successful transient expression of Cas9 and single guide RNA genes in Chlamydomonas reinhardtii", Eukaryot Cell, (20140000), vol. 13, doi:10.1128/EC.00213-14, pages 1465 - 9, XP055435460
OPPOSITION- NEEF et al., "Deletion of a cation transporter promotes lysis in Streptococcus pneumoniae", Infection and immunity, (20110000), vol. 79, no. 6, doi:10.1128/IAI.00677-10, pages 2314 - 2323, XP055464123
OPPOSITION- KOSEKI et al., "Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III", J. Virology, (19990000), vol. 73, pages 1868 - 1877, XP001027031
OPPOSITION- VARANI, "Exceptionally Stable Nucleic Acid Hairpins", Annu. Rev. Biophys. Biomol. Struct., (19950000), vol. 24, pages 379 - 404, XP055613701
OPPOSITION- WANG, H. et al., "CRISPR/Cas9 in Genome Editing and Beyond", Annu. Rev. Biochem., (20160000), vol. 85, doi:10.1146/annurev-biochem-060815-014607, pages 227 - 64, XP055290311
OPPOSITION- JIANG, F. et al., "CRISPR- Cas9 Structures and Mechanisms", Annu. Rev. Biophys., (20170000), vol. 46, pages 505 - 529, XP055362997
OPPOSITION- BARRANGOU R et al., "CRISPR: New Horizons in Phage Resistance and Strain Identification", Annu. Rev. Food Sci. Technol., (20120000), vol. 3, pages 143 - 162, XP055378159
OPPOSITION- AGUIRRE et al., "Genomic Copy Number Dictates a Gene -Independent Cell Response to CRISPR/Cas9 Targeting", Cancer Discovery, (20160000), vol. 6, doi:10.1158/2159-8290.CD-16-0154, pages 914 - 929, XP002795716
OPPOSITION- XU et al., "Accuracy and efficiency define Bxb1 integrase as the best of fifteen candidate serine recombinases for the integration of DNA into the human genome", BMC Biotechnology, (20130000), vol. 13, pages 1 - 17, XP021171155
OPPOSITION- Makarova et al., "Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems", Biology Direct, pages 1 - 27, XP021105829
OPPOSITION- ENYEART et al., "Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis", Mob DNA 2014, (20140000), vol. 5, no. 1, doi:10.1186/1759-8753-5-2, page 2, XP021175117
OPPOSITION- KUNIN, V et al., "Evolutionary conservation of sequence and secondary structures in CRISPR repeats", Genome biology, (20070000), vol. 8, pages 61.1 - 61.7, XP021027392
OPPOSITION- MINTON, "How can biochemical reactions within cells differ from those in test tubes?", J. Cell . Sci., (20060000), vol. 119, no. 14, pages 2863 - 2869+1pp, XP055464107
OPPOSITION- RAYMOND et al., "High-efficiency FLP and PHI03Y site-specific recombination in mammalian cells", PLOS ONE, (20070000), vol. 2, no. 1, doi:10.1371/journal.pone.0000162, page e162, XP055069825
OPPOSITION- MASTROIANNI et al., "Group II Intron-Based Gene Targeting Reactions in Eukaryotes", PLoS One, (20080000), vol. 3, no. 9, pages 1 - 15, XP055149290
OPPOSITION- MASTROIANNI et al., "Group // Intron-Based Gene Targeting Reactions in Eukaryotes", PLoS ONE, (20080000), vol. 3, no. 9, pages 1 - 15, XP055149290
OPPOSITION- NOZAWA T et al., "Crispr Inhibition of Prophage Acquisition in Streptococcus pyogenes", PLoS ONE, (20110000), vol. 6, no. 5, pages 1 - 10, XP055514497
OPPOSITION- YOUNG JC et al., "Phage-induced expression of CRISPR-associated proteins is revealed by shotgun proteomics in Streptococcus thermophilus.", PLoS One, (20120530), vol. 7, no. 5, pages 1 - 12, XP055665932
OPPOSITION- Davies et al., "Site Specific Mutation of the Zic2 Locus by Microinjection of TALEN mRNA in Mouse CD1, C3H and C57BL/6J Oocytes", PLoS ONE, (20130328), vol. 8, pages 1 - 7, XP055159248
OPPOSITION- Keith Joung, "Building with Biological LEGO", BioTechniques,, (20120601), vol. 52, no. 6, page 351, XP055613839
OPPOSITION- Zahid et al., "Protein Transduction Domains: Applications for Molecular Medicine", Current Gene Therapy, (2012), vol. 12, pages 374 - 380, XP055666717
OPPOSITION- RICHTER, C., "Function and Regulation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) / CRISPR Associated (Cas) Systems", Viruses, (20120000), vol. 4, doi:10.3390/v4102291, pages 2291 - 2311, XP055299758
OPPOSITION- RHUN AL et al., "Small RNAs in stretococci", RNA Biology, (20120401), vol. 9, no. 4, pages 414 - 426, XP055665925
OPPOSITION- SHAH et al., "Protospacer recognition motifs", RNA Biology, (20130500), vol. 10, no. 5, pages 891 - 899, XP055153088
OPPOSITION- JINEK et al., "RNA-programmed genome editing in human cells", eLife, (20130000), vol. 2, doi:10.7554/eLife.00471, page e00471, XP002699851
OPPOSITION- JINEK M et al., "RNA-programmed genome editing in human cells", eLife, (20130129), pages 1 - 9, XP002699851
OPPOSITION- JINEK, M., "RNA-programmed genome editing in human cells", eLife, (20130000), vol. 2, pages 1 - 9, XP055245475
SEARCH- PAPWORTH M ET AL, "Designer zinc-finger proteins and their applications", GENE, ELSEVIER, AMSTERDAM, NL, vol. 366, no. 1, doi:10.1016/J.GENE.2005.09.011, ISSN 0378-1119, (20060117), pages 27 - 38, (20060117), XP024934269 [A] 1-23 * the whole document *
SEARCH- ELITZA DELTCHEVA ET AL, "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", NATURE, (20110331), vol. 471, no. 7340, doi:10.1038/nature09886, ISSN 0028-0836, pages 602 - 607, XP055308803 [A] 1-23 * the whole document *
SEARCH- BLAKE WIEDENHEFT ET AL, "RNA-guided genetic silencing systems in bacteria and archaea", NATURE, (20120215), vol. 482, no. 7385, doi:10.1038/nature10886, ISSN 0028-0836, pages 331 - 338, XP055116249 [A] 1-23 * the whole document *
SEARCH- MAKAROVA KIRA S ET AL, "Evolution and classification of the CRISPR-Cas systems", NATURE REVIEWS. MICROBIO, NATURE PUBLISHING GROUP, GB, (20110509), vol. 9, no. 6, doi:10.1038/NRMICRO2577, ISSN 1740-1526, pages 467 - 477, XP009155547 [A] 1-23 * the whole document *
SEARCH- M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055299674 [XP] 11-14,18,19,22 * the whole document * [I] 1-23
SEARCH- M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity (Supplementary Material)", SCIENCE, US, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, page 821, XP055067747 [P] * the whole document *
SEARCH- L. CONG ET AL, "Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130215), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055067741 [XP] 1,3-7,9-14,16,18,19,22 * the whole document * [I] 1-23
SEARCH- L. CONG ET AL, "Supplementary Material to : Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055067744 [P] * the whole document *
SEARCH- P. MALI ET AL, "RNA-Guided Human Genome Engineering via Cas9", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055111247 [XP] 1,3-7,9-14,16,18,19,22 * the whole document * [I] 1-23
SEARCH- P. Mali ET AL, "Supplementary information for RNA-Guided Human Genome Engineering via Cas9 (XP 055337932)", Science, (20130103), vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055403737 [P] * the whole document *
SEARCH- MARTIN JINEK ET AL, "RNA-programmed genome editing in human cells", E-LIFE, SAM LTD, GB, vol. 2, doi:10.7554/ELIFE.00471, ISSN 2050-084X, (20130129), pages e00471 - 1, (20130628), XP002699851 [XP] 1,3-7,9-14,16,18,19,22 * the whole document * [I] 1-23
SEARCH- Martin Jinek ET AL, "RNA-programmed genome editing in human cells (Figures and figure supplements)", eLife, (20130129), vol. 2, doi:10.7554/eLife.00471, XP055167481 [P] * the whole document *

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