Improved Muconic Acid Production From Genetically Engineered Microorganisms - EP3423563

The patent EP3423563 was granted to Myriant on May 24, 2023. The application was originally filed on Mar 1, 2017 under application number EP17760744A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3423563

MYRIANT
Application Number
EP17760744A
Filing Date
Mar 1, 2017
Status
Granted And Under Opposition
Apr 21, 2023
Grant Date
May 24, 2023
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Patent Citations (43) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

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Non-Patent Literature (NPL) Citations (112) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- AUSSELLAURENTFABIEN PIERRELLAURENT LOISEAUMURIELLE LOMBARDMARC FONTECAVEFREDERIC BARRAS., "Biosynthesis and Physiology of Coenzyme Q in Bacteria", Biochimica et Biophysica Acta - Bioenergetics, (20140000), vol. 1837, no. 7, pages 1004 - 11-
DESCRIPTION- BABATOMOYATAKESHI ARAMIKI HASEGAWAYUKI TAKAIYOSHIKO OKUMURAMIKI BABAKIRILL A DATSENKOMASARU TOMITABARRY L WANNER, "Construction of Escherichia Coli K-12 in-Frame, Single-Gene Knockout Mutants: The Keio Collection", Molecular Systems Biology, (20060000), vol. 2-
DESCRIPTION- BIRD, J. A.CAIN, R. B., "cis-cis-muconate, the product inducer of catechol 1,2-oxygenase in Pseudomonas aeruginosa.", Biochem. J., (19680000), vol. 109, pages 479 - 481-
DESCRIPTION- BONGAERTS, J.KRAMER, M.MULLER, U.RAVEN, L.WUBBOLTS, M., "Metabollic engineering for microbial producitnof aromatic acids and derived compunds", Met. Eng., (20010000), vol. 3, pages 289 - 300-
DESCRIPTION- CHEN, K.DOU, J.TANG, S.YANG, Y.WANG, H.FANG, H.ZHOU, C., "Deletion of the aroK gene is essential for high shikimic acid accumulation through the shikimate in E. coli.", Bioresource Technol, (20120000), vol. 119, pages 141 - 147-
DESCRIPTION- CHEN, R.HATZIMANIKATIS, V.YAP, W. M. G. J.POTMA, P. W.BAILEY, J. E., "Metabolic consequences of phosphotransferase (PTS) mutation in a phenylalanie-producing recombinatn Escherichia coli.", Biotechnol. Prog., (19970000), vol. 13, pages 768 - 775-
DESCRIPTION- CHOI, W. J.LEE, E. Y.CHO, M. H.CHOI, C. Y., "Enhanced production of cis, cis-muconate in a cell-recycle bioreactor.", J. Fermentation and Bioengineering., (19970000), vol. 84, pages 70 - 76-
DESCRIPTION- DE BERARDINIS, V.VALLENET, D.CASTELLI, VBESNARD, M.PINET, A.CRUAUD, C.SAMAIR, S.LECHAPLAIS, C.GYAPAY, G.RICHEZ, C., "A complete collection of single-gene deletion mutants of Acinetobacter baylyi ADP 1", Mol Syst Biol, (20080000), vol. 4, page 174-
DESCRIPTION- ESCALANTE, A.CALDERON, R.VALDIVA, A.DE ANDA, R.HERNANDEZ, G.RAMIREZ, O. T.GOSSET, G.BOLIVER, F., "Metabolic engineering for the production of shikimic acid in an evolved Escherichia coli strain lacking the phosphoenolpyrvate: carbohydrate phosphotransferase system", Microbial Cell Factories, (20100000), vol. 9, pages 21 - 33-
DESCRIPTION- FOX, D. T.HOTTA, K.KIM, C. Y.KOPPISCH, A. T., "The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase", Biochemistry, (20080000), vol. 47, pages 12251 - 12253-
DESCRIPTION- GER, Y.CHEN, S.CHIANG, H.SHIUAN, D., "A Single Ser-180 Mutation Desensitizes Feedback Inhibition of the Phyenylalanine-Sensitive 3-Deoxy-D-Arabino-Hepulosonate 7-Phosphate (DAHP) Synthetase in Eschericia coli", J Biochem, (19940000), vol. 116, pages 986 - 990-
DESCRIPTION- IWAGAMI, S. G.YANG, K.DAVIES, . J., "Characterization of the protocatechuic acid catabolic gene cluster from Streptomyces sp. strain 2065", Appl Environ Microbiol, (20000000), vol. 66, pages 1499 - 1508-
DESCRIPTION- JOHNSON, C. W.SALVACHUA, D.KHANNA, P.PETERSON, D. J.BECKHAM, G., "Enhancing muconic acid production from glucose and lignin-derived aromatic compound via increased protocatechuate decarboxylase activity", Metabolic Engineering Communication., (20160000), vol. 3, pages 111 - 119-
DESCRIPTION- KIKUCHI, Y.TSUJIMOTO, K.KURAHASHI, O., "Mutational analysis of the feedback sites of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli", Appl Environ Microbiol, (19970000), vol. 63, pages 761 - 762-
DESCRIPTION- KOJIMA, Y.FUJISAWA, HNAKAZAWA, A.NAKAZAWA, T.KANETSUNA, F.TANIUCHI, H.NOZAKI, M.HAYAISHI, O., "Studies on pyrocatechase. I. Purification and spectral properties", JBiol Chem, (19670000), vol. 242, pages 3270 - 3278-
DESCRIPTION- LERNER, C. G.INOUYE, M., "Low copy number plasmids for regulated low-level expression of cloned genes in Escherichia coli with blue/white insert screening capability", Nucleic Acids Res, (19900000), vol. 18, page 4631-
DESCRIPTION- LSEMORE, D. A.ORNSTON, L. N., "Unusual ancestry of dehydratases associated with quinate catabolism in Acinetobacter calcoaceticus", JBacteriol, (19950000), vol. 177, pages 5971 - 5978-
DESCRIPTION- LUPABOGUSLAWDELINA LYONMORELAND D. GIBBSROSALIND A. REEVESJUERGEN WIEGEL., "Distribution of Genes Encoding the Microbial Non-Oxidative Reversible Hydroxyarylic Acid Decarboxylases/phenol Carboxylases", Genomics, (20050000), vol. 86, no. 3, pages 342 - 51-
DESCRIPTION- NEIDLE, E. L.ORNSTON, L. N., "Cloning and expression of Acinetobacter calcoaceticus catechol 1,2-dioxygenase structural gene catA in Escherichia coli", J Bacteriol, (19860000), vol. 168, pages 815 - 820, XP002530149-
DESCRIPTION- PARSEK, M. R.SHINABARGER, D..L.RITHMEL, R. K.CHAKRABARTY, A. M., "Roles of CatR and cis, cis-Muconate in activation of the catBC operson, which is involved in benzoate degradationin Pseudomonas putida.", J. Bacteriol., (19920000), vol. 174, pages 7798 - 7806-
DESCRIPTION- PATNAIK, R.LIAO, J. C., "Engineering of Escherichia coli central metabolism for aromatic metabolite with near theoretical yield", App. Env. Microbiol., (19940000), vol. 60, pages 3903 - 3908-
DESCRIPTION- PEREZ-PANTOJA, D.DE LA IGLESIA, R.PIEPER, D. H.GONZALEZ, B., "Metabolic reconstruction of aromatic compounds degradation from the genome of the amazing pollutant-degrading bacterium Cupriavidus necator JMP134", FEMS Microbiol Rev, (20080000), vol. 32, pages 736 - 794-
DESCRIPTION- PEREZ-PANTOJA, D.DONOSO, R.AGULLO, L.CORDOVA, M.SEEGER, M.PIEPER, D. H.GONZALEZ, B., "Genomic analysis of the potential for aromatic compounds biodegradation in Burkholderiales", Environ Microbiol., (20110000), vol. 14.5, pages 1091 - 1117-
DESCRIPTION- PFLEGER, B. F.KIM, Y.NUSCA, T. D.MALTSEVA, NLEE, J. Y.RATH, C. M.SCAGLIONE, J. B.JANES, B. K.ANDERSON, E. C.BERGMAN, N. H., "Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis", Proc Natl Acad Sci U S A, (20080000), vol. 105, pages 17133 - 17138-
DESCRIPTION- PITTARD, J.WALLACE, B. J., "Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli.", J. Bacteriol., (19660000), vol. 91, pages 1494 - 1508-
DESCRIPTION- POLEN, T.SPELBERG, M.BOTT, M., "Toward bitechnological produciton of adipic acid and precursors from biorenewables", J. Biotechnol., (20130000), vol. 167, no. 2, pages 75 - 84-
DESCRIPTION- SCHIRMER, F.HILLEN, W., "The Acinetobacter calcoaceticus NCIB8250 mop operon mRNA is differentially degraded, resulting in a higher level of the 3' CatA-encoding segment than of the 5' phenolhydroxylase-encoding portion", Mol Gen Genet, (19980000), vol. 257, pages 330 - 337-
DESCRIPTION- SHUMILIN, I. A.ZHAO, C.BAUERLE, R.KRETSINGER, R. H., "Allosteric inhibition of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase alters the coordination of both substrates", J Mol Biol, (20020000), vol. 320, pages 1147 - 1156-
DESCRIPTION- SHUMKOVA, E. S.SOLYANIKOVA, I. P.PLOTNIKOVA, E. G.GOLOVLEVA, L. A., "Phenol degrdation by Rhodococcus opacus Strain 1G.", App. Biocehm. Microbiol., (20090000), vol. 45, pages 43 - 49-
DESCRIPTION- SIETMANN, R.UEBE, RBOER, E.BODE, R.KUNZE, G.SCHAUER, F., "Novel metabolic routes during the oxidation of hydroxylated aromatic acids by the yeast Arxula adeninivorans", JAppl Microbiol, (20100000), vol. 108, pages 789 - 799-
DESCRIPTION- SMITH, M. R.RATLEDGE, C., "Quantitative biotransformation of catechol to cis, cis -muconate", Biotech. Lett., (19890000), vol. 11, pages 105 - 110-
DESCRIPTION- SNOEP, J. L.ARFMAN, N.YOMANO, L. P.FLIEGE, R. K.CONWAY, T.INGRAM, L. O., "Reconstruction of glucose uptake and phosphorylation in a glucose-negative mutant of Escherichia coli by using Zymomonas mobilis genes encoding the glucose facilitator protein and glucokinase", J Bacteriol, (19940000), vol. 176, pages 2133 - 2135, XP000990941-
DESCRIPTION- SONOKITOMONORIMIYUKI MOROOKAKIMITOSHI SAKAMOTOYUICHIRO OTSUKAMASAYA NAKAMURAJODY JELLISONBARRY GOODELL., "Enhancement of Protocatechuate Decarboxylase Activity for the Effective Production of Muconate from Lignin-Related Aromatic Compounds", Journal of Biotechnology, (20140000), vol. 192, page 71,77-
DESCRIPTION- SPRENGER, G. A., "Genetics of pentose-phosphate pathway enzymes of Escherichia coli K-12", Arch Microbiol, (19950000), vol. 164, pages 324 - 330-
DESCRIPTION- SPRENGER, G. A.SCHORKEN, U.SPRENGER, G.SAHM, H., "Transaldolase B of Escherichia coli K-12: cloning of its gene, talB, and characterization of the enzyme from recombinant strains", JBacteriol, (19950000), vol. 177, pages 5930 - 5936, XP002053305-
DESCRIPTION- SPRENGER, G. A.SCHORKEN, U.SPRENGER, G.SAHM, H., "Transketolase A of Escherichia coli K12. Purification and properties of the enzyme from recombinant strains", Eur JBiochem, (19950000), vol. 230, pages 525 - 532-
DESCRIPTION- STROMAN, P.REINERT, W. R.GILES, N. H., "Purification and characterization of 3-dehydroshikimate dehydratase, an enzyme in the inducible quinic acid catabolic pathway of Neurospora crassa", J BioI Chem, (19780000), vol. 253, pages 4593 - 4598-
DESCRIPTION- TATEOKA, T.YASUDA, I., "3-Dehydroshikimate dehydratase in mung hean cultured cells", Plant Cell Reports, (19950000), vol. 15, pages 212 - 217-
DESCRIPTION- WEAVER, L. M.HERRMANN, K. M., "Cloning of an aroF allele encoding a tyrosine-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase", J Bacteriol, (19900000), vol. 172, pages 6581 - 6584, XP002926165-
DESCRIPTION- WHEELER, K. A.LAMB, H. K.HAWKINS, A. R., "Control of metabolic flux through the quinate pathway in Aspergillus nidulans", Biochem J, (19960000), vol. 315, pages 195 - 205, XP002552223-
DESCRIPTION- WHITEMARK D.KARL A. P. PAYNEKARL FISHERSTEPHEN A. MARSHALLDAVID PARKERNICHOLAS J. W. RATTRAYDRUPAD K. TRIVEDI et al., "UbiX Is a Flavin Prenyltransferase Required for Bacterial Ubiquinone Biosynthesis", Nature, (20150000), vol. 522, no. 7557, pages 502 - 6-
DESCRIPTION- WU, C-M.WU, C-C.SU, C-C.LEE, S-N.LEE, Y-A.WU, J-Y., "Microbial synthesis of cis,cis-muconic acid form benzoate by Sphingobacterium sp. Mutants.", Biochem. Eng. J., (20060000), vol. 29, pages 35 - 40-
DESCRIPTION- JANTAMA, K.HAUPT, M. J.SVORONOS, S. A.ZHANG, X.MOORE, J. C.SHANMUGAM, K. T.INGRAM, L. O., "Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains of Escherichia coli C that produce succinate and malate", Biotechnol Bioeng, (20080000), vol. 99, doi:10.1002/bit.21694, pages 1140 - 1153, XP002574948
DESCRIPTION- JANTAMA, K.ZHANG, X.MOORE, J. C.SHANMUGAM, K. T.SVORONOS, S. A.INGRAM, L. O., "Eliminating side products and increasing succinate yields in engineered strains of Escherichia coli C", Biotechnol Bioeng, (20080000), vol. 101, doi:10.1002/bit.22005, pages 881 - 893, XP002551943
DESCRIPTION- HUCHANGYUNPEIHONG JIANGJIANFENG XUYONGQING WUWEIDA HUANG., "Mutation Analysis of the Feedback Inhibition Site of Phenylalanine-Sensitive 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase of Escherichia Coli", Journal of Basic Microbiology, (20030000), vol. 43, no. 5, doi:10.1002/JOBM.200310244, pages 399 - 406, XP002545783
DESCRIPTION- HU, C.JIANG, P.XU, J.WU, Y.HUANG, W., "Mutation analysis of the feedback inhibition site of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of Escherichia coli", J Basic Microbiol, (20030000), vol. 43, doi:10.1002/JOBM.200310244, pages 399 - 406, XP002545783
DESCRIPTION- LU, J. L.LIAO, J. C., "Metabolic engineering and control analysis for production of aromatics: Role of transaldolase", Biotechnol Bioeng, (19970000), vol. 53, doi:10.1002/(SICI)1097-0290(19970120)53:2<132::AID-BIT2>3.0.CO;2-P, pages 132 - 138, XP002053307
DESCRIPTION- ALTSCHUL, S. F.GISH, W.MILLER, W.MYERS, E. W.LIPMAN, D. J., "Basic local alignment search tool", J Mol Biol, (19900000), vol. 215, doi:10.1006/jmbi.1990.9999, pages 403 - 410, XP002949123
DESCRIPTION- MIZUNO, S.YOSHIKAWA, N.SEKI, M.MIKAWA, T.IMADA, Y., "Microbial production of cis, cis- muconic acid from benzoic acid", Appl Microbiol Biotechnol., (19880000), vol. 28, doi:10.1007/BF00250491, pages 20 - 25, XP035172007
DESCRIPTION- GRANT, D. J.PATEL, J. C., "The non-oxidative decarboxylation of p-hydroxybenzoic acid, gentisic acid, protocatechuic acid and gallic acid by Klebsiella aerogenes (Aerobacter aerogenes", Antonie Van Leeuwenhoek, (19690000), vol. 35, doi:10.1007/BF02219153, pages 325 - 343, XP001052857
DESCRIPTION- LUTKE-EVERSLOH, T.STEPHANOPOULOS, G., "L-tyrosine production by deregulated strains of Escherichia coli", Appl Microbiol Biotechnol, (20070000), vol. 75, doi:10.1007/s00253-006-0792-9, pages 103 - 110, XP019513622
DESCRIPTION- NAKAZAWA, A.KOJIMA, Y.TANIUCHI, H., "Purification and properties of pyrocatechase from Pseudomonas fluorescens", Biochim Biophys Acta, (19670000), vol. 147, doi:10.1016/0005-2795(67)90398-4, pages 189 - 199, XP023562471
DESCRIPTION- YOSHIKAWA, N.MIZUNO, S.OHTA, K.SUZUKI, M., "Microbial production of cis, cis-muconic acid.", J. Biotechno., (19900000), vol. 14, doi:10.1016/0168-1656(90)90009-Z, pages 203 - 210, XP023943970
DESCRIPTION- RUTLEDGE, B. J., "Molecular characterization of the qa-4 gene of Neurospora crassa", Gene, (19840000), vol. 32, doi:10.1016/0378-1119(84)90003-9, pages 275 - 287, XP025682437
DESCRIPTION- XIE, N.TANG, H.FENG, J.TAO, F.MA, C.XU, P., "Characterization of benzoate degradationby newly isolated bacterium Pseudomonas sp. XP-M2", Biochem. Eng. J., (20090000), vol. 46, doi:10.1016/j.bej.2009.04.019, pages 79 - 82, XP026224429
DESCRIPTION- XIE, N.HONG LIANGRI-BO HUANGPING XU., "Biotechnological Production of Muconic Acid: Current Status and Future Prospects", Biotechnology Advances, (20140000), vol. 32, no. 3, doi:10.1016/j.biotechadv.2014.04.001, pages 615 - 22, XP055356736
DESCRIPTION- HORWITZANDREW A.JESSICA M. WALTERMAX G. SCHUBERTSTEPHANIE H. KUNGKRISTY HAWKINSDARREN M. PLATTAARON D. HERNDAY et al., "Efficient Multiplexed Integration of Synergistic Alleles and Metabolic Pathways in Yeasts via CRISPR-Cas", Cell Systems., (20150000), vol. 1, no. 1, doi:10.1016/j.cels.2015.02.001, pages 88 - 96, XP055230552
DESCRIPTION- SHUMILIN, I. A.BAUERLE, R.WU, J.WOODARD, R. WKRETSINGER, R. H., "Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Thermotoga maritima refines the catalytic mechanism and indicates a new mechanism of allosteric regulation", J Mol Biol, (20040000), vol. 341, doi:10.1016/j.jmb.2004.05.077, pages 455 - 466, XP004522545
DESCRIPTION- KRAMER, M.BONGAERTS, J.BOVENBERG, R.KREMER, S.MULLER, U.ORF, S.WUBBOLTS, M.RAEVEN, L., "Metabolic engineering for microbial production of shikimic acid", Metabol. Eng., (20030000), vol. 5, doi:10.1016/j.ymben.2003.09.001, pages 277 - 283, XP055433205
DESCRIPTION- CURRANKATHLEEN A.JOHN M. LEAVITTASHTY S. KARIMHAL S. ALPER., "Metabolic Engineering of Muconic Acid Production in Saccharomyces Cerevisiae", Metabolic Engineering, (20130000), vol. 15, no. 1, doi:10.1016/J.YMBEN.2012.10.003, pages 55 - 66, XP002729251
DESCRIPTION- SHUMILIN, I. A.KRETSINGER, R. H.BAUERLE, R. H., "Crystal structure of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli", Structure, (19990000), vol. 7, doi:10.1016/S0969-2126(99)80109-9, pages 865 - 875, XP004741995
DESCRIPTION- NIU, W.DRATHS, K. M.FROST, J. W., "Benzene-free synthesis of adipic acid", Biotechnol Prog, (20020000), vol. 18, doi:10.1021/BP010179X, pages 201 - 211, XP002568326
DESCRIPTION- CHANDRAN, S. S.YI, J.DRATHS, K. M.VON DAENIKEN, R.WEBER, W.FROST, J. W., "Phosphoenolpyruvate availability and the biosynthesis of shikimic acid", Biotechnol. Prog., (20030000), vol. 19, doi:10.1021/bp025769p, pages 808 - 814, XP055045223
DESCRIPTION- YI, J.DRATHS, K. M.LI, K.FROST, J. W., "Altered Glucose Transport and Shikimate Pathway Product Yields in E. coli.", Biotechnol. Prog., (20030000), vol. 19, doi:10.1021/bp0340584, pages 1450 - 1459, XP055045226
DESCRIPTION- LIN, H.RAVISHANKAR V VADALI, R. V.GEORGE N BENNETT,G. N.SAN, K. Y., "Increasing the Acetyl-CoA Pool in the Presence of Overexpressed Phosphoenolpyruvate Carboxylase or Pyruvate Carboxylase Enhances Succinate Production in Escherichia Coli.", Biotechnology Progress, (20040000), vol. 20, no. 5, doi:10.1021/bp049843a, pages 1599 - 1604, XP055006788
DESCRIPTION- LI, K.FROST, J.W., "Microbial synthesis of 3-dehydroshikimic acid: A comparative analysis of D-xylose, L-arabinose, and D-glucose carbon sources", Biotechnol. Prog., (19990000), vol. 15, doi:10.1021/bp990095c, pages 876 - 883, XP055178510
DESCRIPTION- LINFENGMINGKYLE L. FERGUSONDAVID R. BOYERXIAOXIA NINA LINE. NEIL G. MARSH., "Isofunctional Enzymes PAD1 and UbiX Catalyze Formation of a Novel Cofactor Required by Ferulic Acid Decarboxylase and 4-Hydroxy-3-Polyprenylbenzoic Acid Decarboxylase", ACS Chemical Biology, (20150000), vol. 11, no. 4, doi:10.1021/cb5008103, pages 1137 - 1144, XP055393584
DESCRIPTION- DRATHS, K. M.POMPLIANO, D. L.CONLEY, D. L.FROST, J. W.BERRY, A.DISBROW, G. L.STAVERSKY, R. J.LIEVENSE, J. C., "Biocatalytic Synthesis of Aromatics from D- Glucose - the Role of Transketolase", Journal of the American Chemical Society, (19920000), vol. 114, doi:10.1021/ja00036a050, pages 3956 - 3962, XP002053308
DESCRIPTION- DRATHS, K. M.FROST, J. W., "Environmentally Compatible Synthesis of Catechol from D-Glucose", Journal of the American Chemical Society, (19950000), vol. 117, doi:10.1021/ja00114a003, pages 2395 - 2400, XP002926169
DESCRIPTION- PAYNE, KARL A. P.MARK D. WHITEKARL FISHERBASILE KHARASAMUEL S. BAILEYDAVID PARKERNICHOLAS J. W. RATTRAY et al., "New Cofactor Supports A,p-Unsaturated Acid Decarboxylation via 1,3-Dipolar Cycloaddition", Nature, (20150000), vol. 522, no. 7557, doi:10.1038/nature14560, pages 497 - 501, XP055393569
DESCRIPTION- FLORES, N.XIAO, J.BERRY, A.BOLIVAR, F.VALLE, F., "Pathway engineering for the production of aromatic compounds in Escherichia coli.", Nature Biotechn., (19960000), vol. 14, doi:10.1038/nbt0596-620, pages 620 - 623, XP002053707
DESCRIPTION- DATSENKO KAWANNER BL, "One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products", Proc Natl Acad Sci USA, (20000000), vol. 97, doi:10.1073/pnas.120163297, pages 6640 - 6645, XP002210218
DESCRIPTION- ALTSCHUL, S. F.MADDEN, T. L.SCHAFFER, A. AZHANG, J.ZHANG, ZMILLER, W.LIPMAN, D. J., "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res, (19970000), vol. 25, doi:10.1093/nar/25.17.3389, pages 3389 - 3402, XP002905950
DESCRIPTION- BARBE, V.VALLENET, D.FONKNECHTEN, N.KREIMEYER, A.OZTAS, S.LABARRE, LCRUVEILLER, S.ROBERT, CDUPRAT, S.WINCKER, P., "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium", Nucleic Acids Res, (20040000), vol. 32, doi:10.1093/nar/gkh910, pages 5766 - 5779, XP002336521
DESCRIPTION- PARKER, C.BARNELL, W. O.SNOEP, J. L.INGRAM, L. O.CONWAY, T., "Characterization of the Zymomonas mobilis glucose facilitator gene product (glf) in recombinant Escherichia coli: examination of transport mechanism, kinetics and the role of glucokinase in glucose transport", Mol Microbiol, (19950000), vol. I5, doi:10.1111/j.1365-2958.1995.tb02350.x, pages 795 - 802, XP002054312
DESCRIPTION- JIMENEZNATALIAJOSE ANTONIO CURIELINES REVERONBLANCA DE LAS RIVASROSARIO MUNOZ., "Uncovering the Lactobacillus Plantarum WCFS I Gallate Decarboxylase Involved in Tannin Degradation", Applied and Environmental Microbiology, (20130000), vol. 79, no. 14, doi:10.1128/AEM.00840-13, pages 4253 - 63, XP055705970
DESCRIPTION- WEBER, C.BRUCKNER, C.WEINREB, S.LEHR, C.ESSL, C.BOLE, E., "Biosynthesis of cis, cis-muconic acid and its aromatic precursors catechol and proteocatechuic acid, from renewable feedstocks by Saccharomyces cerevisiae", App Environ Microbiol., (20120000), vol. 78, doi:10.1128/AEM.01983-12, pages 8421 - 8430, XP055294700
DESCRIPTION- HANSEN, E. H.MOLLER, B. L.KOCK, G. R.BUNNER, C. M.KRISTENSEN, C.JENSEN, O. R.OKKELS, F. T.OLSEN, C. E.MOTAWIA, M. S.HANSEN, J., "De novo biosynthesis of vanillin in fission yeast (Schizosaccharomyces pombe) and baker's yeast (Saccharomyces cerevisiae", Appl Environ Microbiol, (20090000), vol. 75, doi:10.1128/aem.02681-08, pages 2765 - 2774, XP002666446
DESCRIPTION- VEMURI, G. N.M. A. EITEMANE. ALTMAN., "Effects of Growth Mode and Pyruvate Carboxylase on Succinic Acid Production by Metabolically Engineered Strains of Escherichia Coli", Applied and Environmental Microbiology, (20020000), vol. 68, no. 4, doi:10.1128/AEM.68.4.1715-1727.2002, pages 1715 - 27, XP002987293
DESCRIPTION- ESCALANTEADELFOROCIO CALDERONARACELI VALDIVIARAMON DE ANDAGEORGINA HERNANDEZOCTAVIO T RAMIREZGUILLERMO GOSSETFRANCISCO BOLIVAR, "Metabolic Engineering for the Production of Shikimic Acid in an Evolved Escherichia Coli Strain Lacking the Phosphoenolpyruvate: Carbohydrate Phosphotransferase System", Microbial Cell Factories, (20100000), vol. 9, doi:10.1186/1475-2859-9-21, page 21, XP021077173
DESCRIPTION- KANEKO, A.ISHII, Y.KIRIMURA, K., "High-yield production of cis, cis-muconic acid from catechol in aqueous solution by biocatalyst", Chem. Lett., (20110000), vol. 40, doi:10.1246/cl.2011.381, pages 381 - 383, XP055111452
EXAMINATION- TIAN W ET AL, "How Well is Enzyme Function Conserved as a Function of Pairwise Sequence Identity?", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, (20031031), vol. 333, no. 4, doi:10.1016/J.JMB.2003.08.057, ISSN 0022-2836, pages 863 - 882, XP004466373
INTERNATIONAL-SEARCH-REPORT- GULMEZIAN et al., "The Role of UbiX in Escherichia coli Coenzyme Q Biosynthesis", Arch Biochem Biophys, (20071115), vol. 467, no. 2, pages 144 - 153, XP022332310 [Y] 6 * . Especially Abstract; p8, para 4. *
INTERNATIONAL-SEARCH-REPORT- SONOKI et al., "Enhancement of protocatechuate decarboxylase activity for the effective production of muconate from lignin-related aromatic compounds", J Biotechnol, (20141220), vol. 192, pages 71 - 77, XP029104839 [Y] 1-15 * . Especially Abstract. *
OPPOSITION- Anonymous, "A0A066QJF8 · A0A066QJF8_ECOLX", UNIPROTKB, (20240101), Database accession no. A0A066QJF8, URL: UNIPROT, XP093166933-
OPPOSITION- Anonymous, "A0A140N9L4 · A0A140N9L4_ECOBD", UNIPROTKB, (20240101), Database accession no. A0A140N9L4 , URL: UNIPROT, XP093166931-
OPPOSITION- Anonymous, "B subunit of 4-hydroxybenzoate decarboxylase [Klebsiella pneumoniae subsp. pneumoniae]", Protein, (20140328), Database accession no. BAO57180, URL: Genbank, XP093166945-
OPPOSITION- Anonymous, "Klebsiella pneumoniae subsp. pneumoniae kpdB, kpdC, kpdD genes for B subunit of 4-hydroxybenzoate decarboxylase, C subunit of 4-hydroxybenzoate decarboxylase, D subunit of 4-hydroxybenzoate decarboxylase, complete cds, culture_collection: NBRC:14940", Nucleotide , (20140328), Database accession no. AB920346, URL: Genbank, XP093166944-
OPPOSITION- Anonymous, "P0AG03 · UBIX_ECOLI ", UNIPROTKB, (20240201), Database accession no. UBIX_ECOLI, URL: UNIPROT, XP093166861-
OPPOSITION- Anonymous, "P32449 · AROG YEAST", UNIPROTKB, (20240101), Database accession no. AROG YEAST, URL: UNIPROT, XP093166867-
OPPOSITION- Anonymous, "putative flavoprotein [Enterobacter cloacae subsp. cloacae ATCC 13047]", Protein, (20170322), Database accession no. ADF63617, URL: Genbank, XP093166834-
OPPOSITION- Anonymous, "putative flavoprotein [Enterobacter cloacae subsp. cloacae ATCC 13047]", Protein, (20170322), Database accession no. ADF63617, URL: Genbank, XP093166951-
OPPOSITION- Anonymous, "Q462H4_KLEPN ", UNIPROTKB, (20240101), Database accession no. Q462H4, URL: UNIPROT, XP093166932-
OPPOSITION- D30 - Annex A-
OPPOSITION- Tomonori Sonoki, "Enhancement of a platform chemical (catechol) production from cellulosic materials ", Noda Institute for Scientific Research, (20140101), pages 33 - 34, XP093166954-
OPPOSITION- R.R. Gokarn , J D. Evans , J.R. Walker , S.A. Martin , M.A. Eiteman , E. Altman, "The physiological effects and metabolic alterations caused by the expression of Rhizobium etli pyruvate carboxylase in Escherichia coli.", Applied Microbiology and Biotechnology, Berlin/Heidelberg, (20010701), vol. 56, no. 1-2, doi:10.1007/s002530100661, ISSN 0175-7598, pages 188 - 195, XP002287974
OPPOSITION- Tomonori Sonoki, Miyuki Morooka, Kimitoshi Sakamoto, Yuichiro Otsuka, Masaya Nakamura, Jody Jellison, Barry Goodell, "Enhancement of protocatechuate decarboxylase activity for the effective production of muconate from lignin-related aromatic compounds", Journal of Biotechnology, Amsterdam NL , (20141201), vol. 192, doi:10.1016/j.jbiotec.2014.10.027, ISSN 0168-1656, pages 71 - 77, XP093166937
OPPOSITION- Christopher W. Johnson, Davinia Salvachúa, Payal Khanna, Holly Smith, Darren J. Peterson, Gregg T. Beckham, "Enhancing muconic acid production from glucose and lignin-derived aromatic compounds via increased protocatechuate decarboxylase activity", Metabolic Engineering Communications, NL , (20161201), vol. 3, doi:10.1016/j.meteno.2016.04.002, ISSN 2214-0301, pages 111 - 119, XP055537131
OPPOSITION- Kathleen A.Curran, John M.Leavitt, Ashty S.Karim, Hal S.Alper, "Metabolic engineering of muconic acid production in Saccharomyces cerevisiae", Metabolic Engineering, AMSTERDAM, NL, (20130101), vol. 15, doi:10.1016/J.YMBEN.2012.10.003, ISSN 1096-7176, pages 55 - 66, XP002729251
OPPOSITION- Niu Wei , Draths K M , Frost J W, "Benzene-free synthesis of adipic acid.", Biotechnology Progress, American Chemical Society, Hoboken, USA, Hoboken, USA, (20020301), vol. 18, no. 2, doi:10.1021/BP010179X, ISSN 8756-7938, pages 201 - 211, XP002568326
OPPOSITION- Draths K M , Frost J W, "Environmentally compatible synthesis of adipic from D-glucose", Journal of the American Chemical Society, American Chemical Society, (19940101), vol. 116., no. 01., doi:10.1021/ja00080a057, ISSN 0002-7863, pages 399 - 400, XP002069694
OPPOSITION- Karen M. Draths, "Draths 399-400, Supplementary material", Journal of the American Chemical Society, (19940101), vol. 116, no. 1, doi:10.1021/ja00080a057, pages 1 - 2, XP093166855
OPPOSITION- Haoran Zhang, Brian Pereira, Zhengjun Li, Gregory Stephanopoulos, "Engineering Escherichia coli coculture systems for the production of biochemical products", Proceedings of the National Academy of Sciences, (20150707), vol. 112, no. 27, doi:10.1073/pnas.1506781112, ISSN 0027-8424, pages 8266 - 8271, XP055291442
OPPOSITION- M. Stratford, Plumridge A., Archer D. B., "Decarboxylation of Sorbic Acid by Spoilage Yeasts Is Associated with the PAD1 Gene", Applied and Environmental Microbiology, (20071015), vol. 73, no. 20, doi:10.1128/AEM.01246-07, ISSN 0099-2240, pages 6534 - 6542, XP055048733
OPPOSITION- Sudeshna Sengupta, Sudhakar Jonnalagadda, Lakshani Goonewardena, Veeresh Juturu, "Metabolic Engineering of a Novel Muconic Acid Biosynthesis Pathway via 4-Hydroxybenzoic Acid in Escherichia coli", Applied and environmental microbiology, US , (20151201), vol. 81, no. 23, doi:10.1128/AEM.01386-15, ISSN 0099-2240, pages 8037 - 8043, XP055358177
OPPOSITION- Sudeshna Sengupta, Sudhakar Jonnalagadda, Lakshani Goonewardena, Veeresh Juturu, "Metabolic Engineering of a Novel Muconic Acid Biosynthesis Pathway via 4-Hydroxybenzoic Acid in Escherichia coli", Applied end environmental microbiology, US , (20151201), vol. 81, no. 23, doi:10.1128/AEM.01386-15, ISSN 0099-2240, pages 8037 - 8043, XP055358177
OPPOSITION- C. Weber, C. Bruckner, S. Weinreb, C. Lehr, C. Essl, E. Boles, "Biosynthesis of cis,cis-Muconic Acid and Its Aromatic Precursors, Catechol and Protocatechuic Acid, from Renewable Feedstocks by Saccharomyces cerevisiae", Applied and environmental microbiology, US , (20121201), vol. 78, no. 23, doi:10.1128/AEM.01983-12, ISSN 0099-2240, pages 8421 - 8430, XP055294700
OPPOSITION- J. C. March, M. A. Eiteman, E. Altman, "Expression of an Anaplerotic Enzyme, Pyruvate Carboxylase, Improves Recombinant Protein Production in Escherichia coli", Applied and environmental microbiology, US , (20021101), vol. 68, no. 11, doi:10.1128/AEM.68.11.5620-5624.2002, ISSN 0099-2240, pages 5620 - 5624, XP055365634
OPPOSITION- Haoran Zhang, Zhengjun Li, Brian Pereira , Gregory Stephanopoulos, "Engineering E. coli-E. coli cocultures for production of muconic acid from glycerol", Microbial Cell Factories, (20150101), vol. 14, doi:10.1186/s12934-015-0319-0, pages 1 - 10, XP002796637
SEARCH- SONOKI TOMONORI ET AL, "Enhancement of protocatechuate decarboxylase activity for the effective production of muconate from lignin-related aromatic compounds", JOURNAL OF BIOTECHNOLOGY, ELSEVIER, AMSTERDAM, NL, (20141030), vol. 192, doi:10.1016/J.JBIOTEC.2014.10.027, ISSN 0168-1656, pages 71 - 77, XP029104839 [Y] 1-15 * abstract * * page 76, column l, paragraph l - page 77, column l, paragraph 2; figure 4 *
SEARCH[ ] - CHRISTOPHER W. JOHNSON ET AL, "Enhancing muconic acid production from glucose and lignin-derived aromatic compounds via increased protocatechuate decarboxylase activity", METABOLIC ENGINEERING COMMUNICATIONS, NL, (20161201), vol. 3, doi:10.1016/j.meteno.2016.04.002, ISSN 2214-0301, pages 111 - 119, XP055537227 [ ] * the whole document *
SEARCH- FENGMING LIN ET AL, "Isofunctional Enzymes PAD1 and UbiX Catalyze Formation of a Novel Cofactor Required by Ferulic Acid Decarboxylase and 4-Hydroxy-3-polyprenylbenzoic Acid Decarboxylase", ACS CHEMICAL BIOLOGY, (20150417), vol. 10, no. 4, doi:10.1021/cb5008103, ISSN 1554-8929, pages 1137 - 1144, XP055393584 [DY] 1-15 * page 1142 * * page 1142, column l, paragraph 3 - column r, paragraph 1 *

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