Individualized Vaccines For Cancer - EP3473267

The patent EP3473267 was granted to Biontech on Sep 8, 2021. The application was originally filed on May 23, 2012 under application number EP18199105A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3473267

BIONTECH
Application Number
EP18199105A
Filing Date
May 23, 2012
Status
Granted And Under Opposition
Aug 6, 2021
Grant Date
Sep 8, 2021
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

WITHERS & ROGERSJun 7, 2022TOMBLINGADMISSIBLE

Patent Citations (9) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO2006EP09448-
DESCRIPTIONWO9633739
DESCRIPTIONWO9724447
OPPOSITIONWO0119408
OPPOSITIONWO03051401
OPPOSITIONWO03059381
OPPOSITIONWO2005028505
OPPOSITIONWO2010037539
SEARCHWO2011143656

Non-Patent Literature (NPL) Citations (137) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ABASTADO et al., J. Immunol., (19930000), vol. 151, no. 7, pages 3569 - 3575-
DESCRIPTION- ABASTADO JP et al., J Immunol., (19931001), vol. 151, no. 7, pages 3569 - 3575-
DESCRIPTION- ADZHUBEI IA et al., Nat Methods, (20100000), vol. 7, pages 248 - 249-
DESCRIPTION- AJAY, S.S. et al., Genome Res., (20110000), vol. 21, pages 1498 - 1505-
DESCRIPTION- ALLARD et al., Clin Cancer Res, (20040000), vol. 10, pages 6897 - 6904-
DESCRIPTION- ALLARD WJ. et al., Clinical Cancer Research, (20040000), vol. 10, pages 6897 - 6904-
DESCRIPTION- AZUMA et al., Nature, (19930000), vol. 366, pages 76 - 79-
DESCRIPTION- BAINBRIDGE, M.N. et al., Genome Biol., (20100000), vol. 11, page R62-
DESCRIPTION- BANSAL, V., Bioinformatics, (20100000), vol. 26, pages 318 - 324-
DESCRIPTION- BERGER MF. et al., "Integrative analysis of the melanoma transcriptome", Genome Res, (20100400), vol. 20, no. 4, pages 413 - 427-
DESCRIPTION- BIJKER MS et al., J Immunol, (20070000), vol. 179, pages 5033 - 5040-
DESCRIPTION- BLOOM MB et al., Exp Med, (19970000), vol. 185, pages 453 - 459-
DESCRIPTION- BREIMAN, L., Statist. Sci., (20010000), vol. 16, pages 199 - 231-
DESCRIPTION- CAMPBELL et al., Nature, (20100000), vol. 467, no. 7319, pages 1109 - 1113-
DESCRIPTION- CHOI et al., Proc. Natl. Acad. Sci USA, (20090000), vol. 106, pages 19096 - 19101-
DESCRIPTION- DALERBA P. et al., Nature Biotechnology, (20110000), vol. 29, pages 1120 - 1127-
DESCRIPTION- DATTA SK et al., J Immunol, (20030000), vol. 170, pages 4102 - 4110-
DESCRIPTION- DEPRISTO, M.A. et al., Nature Genetics, (20110000), vol. 43, pages 491 - 498-
DESCRIPTION- DEY N et al., Cancer Res, (20080000), vol. 68, pages 1862 - 1871-
DESCRIPTION- DING L et al., Hum Mol Genet, (20100000), vol. 19, pages R188 - R196-
DESCRIPTION- DRULEY, T.E. et al., Nature Methods, (20090000), vol. 6, pages 263 - 265-
DESCRIPTION- ECHCHAKIR H et al., Cancer Res, (20010000), vol. 61, pages 4078 - 4083-
DESCRIPTION- EWEN, K.R. et al., Am. J. Hum. Genet., (20000000), vol. 67, pages 727 - 736-
DESCRIPTION- FAWCETT, T., Pattern Recogn. Lett., (20060000), vol. 27, pages 861 - 874-
DESCRIPTION- FRUMKIN D. et al., Cancer Research, (20080000), vol. 68, page 5924-
DESCRIPTION- FUJITA, P.A., Nucleic Acids Res., (20110000), vol. 39, pages 876 - 882-
DESCRIPTION- "Generation and use of high quality cDNA from small amounts of total RNA by SMART PCR", CHENCHIK, A., Y. et al., In Gene Cloning and Analysis, BioTechniques Books, (19980000), pages 305 - 319-
DESCRIPTION- GNIRKE A et al., Nat Biotechnol, (20090000), vol. 27, pages 182 - 189-
DESCRIPTION- GNIRKE A et al., "Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing", Nat Biotechnol, (20090000), vol. 27, pages 182 - 189-
DESCRIPTION- GNIRKE, A., Nat. Biotechnol., (20090000), vol. 27, pages 182 - 189-
DESCRIPTION- HAJRA KM et al., Apoptosis, (20040000), vol. 9, pages 691 - 704-
DESCRIPTION- HANSEN, K.D. et al., Nucleic. Acids. Res., (20100000), vol. 38, page e131-
DESCRIPTION- HODGES et al., Nat. Genet., (20070000), vol. 39, pages 1522 - 1527-
DESCRIPTION- HOLTKAMP et al., Blood, (20060000), vol. 108, pages 4009 - 4017-
DESCRIPTION- HOLTKAMP S et al., Blood, (20060000), vol. 108, pages 4009 - 4017-
DESCRIPTION- HOLTKAMP, S. et al., Blood, (20060000), vol. 108, pages 4009 - 4017-
DESCRIPTION- HOYT et al., EMBO J., (20060000), vol. 25, no. 8, pages 1720 - 1729-
DESCRIPTION- HOYT MA et al., EMBO J, (20060000), vol. 25, no. 8, pages 1720 - 1729-
DESCRIPTION- KIRCHER, M. et al., Genome Biol., (20090814), vol. 10, page R83-
DESCRIPTION- KREITER et al., Cancer Immunol Immunother, (20070000), vol. 56, pages 1577 - 1587-
DESCRIPTION- KREITER S et al., Cancer Immunol Immunother, (20070000), vol. 56, pages 1577 - 1587-
DESCRIPTION- KREITER, S. et al., Cancer Immunol. Immunother., (20070000), vol. 56, pages 1577 - 1587-
DESCRIPTION- KREITER S et al., Cancer Res, (20100000), vol. 70, pages 9031 - 9040-
DESCRIPTION- KREITER, S. et al., Cancer Research, (20100000), vol. 70, no. 22, pages 9031 - 9040-
DESCRIPTION- KREITER S. et al., J. Immunol., (20080000), vol. 180, pages 309 - 318-
DESCRIPTION- KREITER, S. et al., J. Immunol., (20080000), vol. 180, pages 309 - 318-
DESCRIPTION- KREITER, S. et al., J.Immunol., (20080000), vol. 180, pages 309 - 318-
DESCRIPTION- KRIEG et al., Nature, (19950000), vol. 374, pages 546 - 549-
DESCRIPTION- KUHN, A. N. et al., Gene Ther., (20100000), vol. 17, pages 961 - 971-
DESCRIPTION- KUMAR P et al., Nat Protoc, (20090000), vol. 4, pages 1073 - 1081-
DESCRIPTION- LASSMANN, T. et al., Bioinformatics, (20110000), vol. 27, pages 130 - 131-
DESCRIPTION- LEE YM et al., Gene, (20100000), vol. 466, pages 16 - 25-
DESCRIPTION- LIAW, A.; WIENER, M., R News, (20020000), vol. 2, pages 18 - 22-
DESCRIPTION- LI H, Bioinformatics, (20110000), vol. 27, pages 1157 - 1158-
DESCRIPTION- LI, H., Bioinformatics, (20110000), vol. 27, pages 1157 - 1158-
DESCRIPTION- LI H; DURBIN R, Bioinformatics, (20090000), vol. 25, pages 1754 - 1760-
DESCRIPTION- LI, H.; DURBIN, R., Bioinformatics, (20090000), vol. 25, pages 1754 - 1760-
DESCRIPTION- LI, H. et al., Bioinformatics, (20090000), vol. 25, pages 2078 - 2079-
DESCRIPTION- LI H., "Improving SNP discovery by base alignment quality", Bioinformatics, (20110415), vol. 27, no. 8, pages 1157 - 1158-
DESCRIPTION- LUTZ MB et al., J Immunol Methods, (19990000), vol. 223, pages 77 - 92-
DESCRIPTION- MAHVI et al., Immunology and cell Biology, (19970000), vol. 75, pages 456 - 460-
DESCRIPTION- MALOY et al., Proc Natl Acad Sci USA, (20010000), vol. 98, pages 3299 - 3303-
DESCRIPTION- MCKENNA A et al., Genome Res, (20100000), vol. 20, pages 1297 - 1303-
DESCRIPTION- MELIEF CJ; VAN DER BURG SH, Nat Rev Cancer, (20080000), vol. 8, pages 351 - 360-
DESCRIPTION- MORTAZAVI A et al., Nat Methods, (20080000), vol. 5, pages 621 - 628-
DESCRIPTION- MORTAZAVI, A. et al., Nat. Methods, (20080000), vol. 5, pages 621 - 628-
DESCRIPTION- "Mouse Genome Sequencing Consortium. Initial sequencing and comparative analysis of the mouse genome", Nature, (20020000), vol. 420, pages 520 - 562-
DESCRIPTION- "Mouse Genome Sequencing Consortium", Nature, (20020000), vol. 420, pages 520 - 562-
DESCRIPTION- NAGRATH et al., Nature, (20070000), vol. 450, pages 1235 - 1239-
DESCRIPTION- NG, PC et al., PLoS Gen., (20080000), vol. 4, no. 8, pages 1 - 15-
DESCRIPTION- PANTEL et al., Trends Mol Med, (20100000), vol. 16, no. 9, pages 398 - 406-
DESCRIPTION- PFEIFER GP et al., Mutat Res, (20050000), vol. 571, pages 19 - 31-
DESCRIPTION- POKROVSKAYA; GUREVICH, Anal. Biochem., (19940000), vol. 220, pages 420 - 423-
DESCRIPTION- PRUITT, K.D. et al., Nucleic Acids Res., (20050000), vol. 33, pages 501 - 504-
DESCRIPTION- PRUITT KD et al., Nucleic Acids Res, (20070000), vol. 35, pages D61 - D65-
DESCRIPTION- RAO CG. et al., International journal of oncology, (20050000), vol. 27, page 49-
DESCRIPTION- SATHIRAPONGSASUTI JF et al., Bioinformatics, (20110000), vol. 27, pages 2648 - 2654-
DESCRIPTION- SCHLESSINGER A; ROST B., Proteins, (20051001), vol. 61, no. 1, pages 115 - 126-
DESCRIPTION- SCHLESSINGER et al., Proteins, (20050000), vol. 61, no. 1, pages 115 - 126-
DESCRIPTION- SCHREURS MW et al., Cancer Res, (20000000), vol. 60, pages 6995 - 7001-
DESCRIPTION- SCHULZ O et al., Nature, (20050000), vol. 433, pages 887 - 892-
DESCRIPTION- Science, (19950000), vol. 268, pages 1432 - 1434-
DESCRIPTION- SESTER, Cancer Immunol. Immunother., (20070000), vol. 56, pages 1577 - 1587-
DESCRIPTION- SHERRY, S.T., Nucleic Acids Res., (20090000), vol. 29, pages 308 - 311-
DESCRIPTION- SO et al., Mol. Cells, (19970000), vol. 7, pages 178 - 186-
DESCRIPTION- SU MW et al., J Immunol, (19930000), vol. 151, pages 658 - 667-
DESCRIPTION- SUZUKI et al., Mol. Oncol., (20070000), vol. 1, no. 2, pages 172 - 180-
DESCRIPTION- TAUB, M.A. et al., Genome Med., (20100000), vol. 2, page 87-
DESCRIPTION- TEER; MULLIKIN, Human Mol Genet, (20100000), vol. 19, no. 2, pages RI45 - RI51-
DESCRIPTION- TOES RE et al., J Immunol, (19960000), vol. 156, pages 3911 - 3918-
DESCRIPTION- VAN TASSELL, C.P. et al., Nature Methods, (20080000), vol. 5, pages 247 - 252-
DESCRIPTION- VERHAAK RG et al., Cancer Cell, (20100000), vol. 17, pages 98 - 110-
DESCRIPTION- WATERSTON RH et al., Nature, (20020000), vol. 420, pages 520 - 562-
DESCRIPTION- WEIDE et al., J. Immunother., (20080000), vol. 31, pages 180 - 188-
DESCRIPTION- WEI X et al., Nat Genet, (20110000), vol. 43, pages 442 - 446-
DESCRIPTION- ZHANG et al., J. Biol. Chem., (20040000), vol. 279, no. 10, pages 8635 - 8641-
DESCRIPTION- ZHANG M.; COFFINO P., J Biol Chem, (20040000), vol. 279, no. 10, pages 8635 - 8641-
DESCRIPTION- ZHANG, Z.; GERSTEIN, M., Nucleic Acids Res, (20030000), vol. 31, pages 5338 - 5348-
DESCRIPTION- ZILFOU JT et al., Cold Spring Harb Perspect Biol, (20090000), vol. 1, page a001883-
DESCRIPTION- ZWAVELING S et al., Cancer Res, (20020000), vol. 62, pages 6187 - 6193-
DESCRIPTION- ZHANG et al., "The impact of next-generation sequencing on genomics", J. Genet Genomics, (20110000), vol. 38, no. 3, doi:doi:10.1016/j.jgg.2011.02.003, pages 95 - 109, XP028188028
DESCRIPTION- MORTAZAVI, A. et al., "Mapping and quantifying mammalian transcriptomes by rna-seq", Nat Methods, (20080000), vol. 5, no. 7, doi:doi:10.1038/nmeth.1226, pages 621 - 628, XP008148418
DESCRIPTION- MORTAZAVI A. et al., "Mapping and quantifying mammalian transcriptomes by RNA-Seq", Nat Methods, (20080700), vol. 5, no. 7, doi:doi:10.1038/nmeth.1226, pages 621 - 628, XP008148418
DESCRIPTION- LI H.; DURBIN R., "Fast and accurate short read alignment with Burrows-Wheeler Transform", Bioinformatics, (20090000), vol. 25, doi:doi:10.1093/bioinformatics/btp324, pages 1754 - 1760, XP055287430
DESCRIPTION- PRUITT KD. et al., "NCBI Reference Sequence (RefSeq): α curated non-redundant sequence database of genomes, transcripts and proteins", Nucleic Acids Res., (20050101), vol. 33, doi:doi:10.1093/nar/gki025, pages D501 - D504, XP055141992
DESCRIPTION- MCKENNA A. et al., "The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data", Genome Res, (20100900), vol. 20, no. 9, doi:doi:10.1101/gr.107524.110, pages 1297 - 1303, XP055175644
DESCRIPTION- RONAGHI et al., "A sequencing method based on real-time pyrophosphate", Science, (19980000), vol. 281, no. 5375, doi:doi:10.1126/science.281.5375.363, pages 363 - 365, XP002135869
DESCRIPTION- VOELKERDING et al., "Next generation sequencing: From basic research to diagnostics", Clinical chemistry, (20090000), vol. 55, doi:doi:10.1373/clinchem.2008.112789, pages 641 - 658, XP055057879
EXAMINATION- UGUR SAHIN ET AL, "Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer", vol. 547, no. 7662, doi:10.1038/NATURE23003, ISSN 1476-4687, (20170713), pages 222 - 226, NATURE, SPRINGER NATURE PUBLISHING AG, LONDON, URL: https://www.nature.com/articles/nature23003.pdf, (20170705), XP002780019
OPPOSITION- Gunder Marc, "Charakterisierung des HLA-Ligandoms und des Exoms von Hepato-und Cholangiozellulären Karzinomen im Hinblick auf eine patientenindividualisierte Peptidvakzinierung", Dissertation Universität Tübingen, (20120101), pages 1 - 216, XP055933238-
OPPOSITION- "The problem with neoantigen prediction", NATURE BIOTECHNOLOGY, (20170202), vol. 35, no. 2, page 97, XP055852277-
OPPOSITION- Thorsten H Ecke et al., "TP53 Gene Mutations in Prostate Cancer Progression", ANTICANCER RESEARCH, (20100101), vol. 30, pages 1579 - 1586, XP055744445-
OPPOSITION- Harpreet Singh-Jasuja et al., "The Tubingen approach: identification, selection, and validation of tumor-associated HLA peptides for cancer therapy", Cancer Immunology, (20040301), vol. 53, no. 3, doi:10.1007/s00262-003-0480-x, ISSN 03407004, pages 187 - 195, XP055015114
OPPOSITION- Hans-Georg Rammensee et al., "Cancer Vaccines: Some basic Considerations", Hans-Georg Rammensee et al., Willard & Ginsburg, GENOMIC AND PERSONALIZED MEDICINE, (20090101), pages 573 - 589, doi:10.1016/B978-0-12-369420-1.00050-0, XP055744440
OPPOSITION- Sebastian Kreiter et al., "Tumor vaccination using messenger RNA: prospects of a future therapy", Current Opinion in Immunology, GB , vol. 23, no. 3, doi:10.1016/j.coi.2011.03.007, ISSN 0952-7915, pages 399 - 406, XP028223964
OPPOSITION- SUHRBIER A., "MULTI-EPITOPE DNA VACCINES", IMMUNOLOGY AND CELL BIOLOGY, AU , (19970801), vol. 75, no. 04, doi:10.1038/icb.1997.63, ISSN 0818-9641, pages 402 - 408, XP000867239
OPPOSITION- MARGULIES MARCEL ET AL, "Genome sequencing in microfabricated high-density picolitre reactors.", Nature, London, (20050731), vol. 437, no. 7057, doi:10.1038/nature03959, ISSN 0028-0836, pages 376 - 380,120, XP002450641
OPPOSITION- Ugur Sahin et al., "Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer", NATURE, LONDON , (20170713), vol. 547, no. 7662, doi:10.1038/nature23003, ISSN 1476-4687, pages 222 - 226, XP002780019
OPPOSITION- Cornelis J.M. Melief et al., "Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines", Nature Reviews Cancer, (20080501), vol. 8, no. 5, doi:10.1038/nrc2373, ISSN 1474175X, pages 351 - 360, XP055019108
OPPOSITION- Kessler et al., "Identification of T-cell epitopes for cancer immunotherapy", Leukemia, London, (20070705), vol. 21, no. 9, doi:10.1038/sj.leu.2404787, ISSN 0887-6924, pages 1859 - 1874, XP037785409
OPPOSITION- L. Ding et al., "Analysis of next-generation genomic data in cancer: accomplishments and challenges", Human Molecular Genetics, (20101015), vol. 19, no. R2, doi:10.1093/hmg/ddq391, ISSN 09646906, pages R188 - R196, XP055113696
OPPOSITION- Rammensee H-G, "Some considerations on the use of peptides and mRNA for therapeutic vaccination against cancer", IMMUNOLOGY AND CELL BIOLOGY, AU , (20060101), vol. 84, no. 3, doi:10.1111/j.1440-1711.2006.01442.x, ISSN 0818-9641, pages 290 - 294, XP009092600
OPPOSITION- Ugur Sahin et al., "Personalized vaccines for cancer immunotherapy", Science, US , (20180323), vol. 359, no. 6382, doi:10.1126/science.aar7112, ISSN 0036-8075, pages 1355 - 1360, XP055744435
OPPOSITION- J. C. Castle et al., "Exploiting the Mutanome for Tumor Vaccination", Cancer research, US , (20120301), vol. 72, no. 5, doi:10.1158/0008-5472.CAN-11-3722, ISSN 0008-5472, pages 1081 - 1091, XP055524331
OPPOSITION- Carralot et al., "Production and characterization of amplified tumor-derived cRNA libraries to be used as vaccines against metastatic melanomas", GENETIC VACCINES AND THERAPY, GB , (20050822), vol. 3, no. 1, doi:10.1186/1479-0556-3-6, ISSN 1479-0556, page 6, XP021009760
OPPOSITION- Suhrbier A, "Polytope vaccines for the codelivery of multiple CD8 T-cell epitopes", EXPERT REVIEW OF VACCINES, GB , (20020801), vol. 1, no. 2, doi:10.1586/14760584.1.2.207, ISSN 1476-0584, pages 207 - 213, XP008094488
SEARCH- ANN CAI ET AL, "#887 Peptides Derived From Mutated BCR-ABL Elicit T Cell Immunity In CML Patients", BLOOD, (20101119), vol. 116, no. 21, pages 388 - 389, XP055549636 [X] 14,17 * the whole document * [I] 15-
SEARCH- Feng Jiang ET AL, "Construction of Evolutionary Tree Models for Renal Cell Carcinoma from Comparative Genomic Hybridization Data", Cancer Research, United States, (20001101), pages 6503 - 6509, URL: http://cancerres.aacrjournals.org/content/60/22/6503.full-text.pdf, XP055549699 [A] 1-17 * the whole document *-
SEARCH- NIELSEN J S ET AL, "An in vitro-transcribed-mRNA polyepitope construct encoding 32 distinct HLA class I-restricted epitopes from CMV, EBV, and Influenza for use as a functional control in human immune monitoring studies", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 360, no. 1-2, ISSN 0022-1759, (20100831), pages 149 - 156, (20100715), XP027222180 [A] 1-17 * the whole document *-
SEARCH- H-G Rammensee ET AL, "Cancer Vaccines: Some Basic Considerations", Genomic and Personalized Medicine, Elsevier, (20081111), page 573589, doi:10.1016/B978-0-12-369420-1.00050-0, XP055348899 [X] 1,4,14-17 * page 577, column l, paragraph l - page 578, column r, paragraph 2 * * figure 50.1 * [I] 2,3,5-13
SEARCH- RAMMENSEE H-G ET AL, "TOWARDS PATIENT-SPECIFIC TUMOR ANTIGEN SELECTION FOR VACCINATION", IMMUNOLOGICAL REVI, WILEY-BLACKWELL PUBLISHING, INC, US, (20021001), vol. 188, doi:10.1034/J.1600-065X.2002.18815.X, ISSN 0105-2896, pages 164 - 176, XP008026240 [Y] 1-17 * page 167, column r, paragraph 2 - page 168, column l, paragraph 1 *
SEARCH- TIMOTHY J. LEY ET AL, "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome", NATURE, (20081106), vol. 456, no. 7218, doi:10.1038/nature07485, ISSN 0028-0836, pages 66 - 72, XP055052871 [Y] 1-17 * abstract *
SEARCH- J. BOGOJESKA ET AL, "Rtreemix: an R package for estimating evolutionary pathways and genetic progression scores", BIOINFORMATICS., GB, (20080820), vol. 24, no. 20, doi:10.1093/bioinformatics/btn410, ISSN 1367-4803, pages 2391 - 2392, XP055549700 [A] 1-17 * the whole document *
SEARCH- TOBIAS SJÖBLOM ET AL, "The Consensus Coding Sequences of Human Breast and Colorectal Cancers", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, (20061013), vol. 314, doi:10.1126/SCIENCE.1133427, ISSN 0036-8075, pages 268 - 274, XP007901261 [Y] 1-17 * abstract * * page 268, column r, paragraph 3 - page 269, column r, paragraph 1 * * page 274, column l, paragraph 1 *
SEARCH- M. SENSI, "Unique Tumor Antigens: Evidence for Immune Control of Genome Integrity and Immunogenic Targets for T Cell-Mediated Patient-Specific Immunotherapy", CLINICAL CANCER RESEARCH, (20060901), vol. 12, no. 17, doi:10.1158/1078-0432.CCR-05-2682, ISSN 1078-0432, pages 5023 - 5032, XP055094295 [I] 14,15,17 * abstract * * page 5025, column l, paragraph 2 - page 5029, column l, paragraph 1 * * tables 1,3 *
SEARCH- CORY A BRENNICK ET AL, "Neoepitopes as cancer immunotherapy targets: key challenges and opportunities", IMMUNOTHERAPY, GB, (20170301), vol. 9, no. 4, doi:10.2217/imt-2016-0146, ISSN 1750-743X, pages 361 - 371, XP055471535 [T] 1-17 * the whole document *
SEARCH- GIORGIO PARMIANI ET AL, "Unique human tumor antigens: immunobiology and use in clinical trials.", THE JOURNAL OF IMMUNOLOGY, (20070201), vol. 178, no. 4, ISSN 0022-1767, pages 1975 - 1979, XP055044894 [Y] 1-17 * page 1977, column l, paragraph 2 * * page 1975, column r, paragraph l *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents