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Biosynthetic Heparin - EP3510147

The patent EP3510147 was granted to Rensselaer Polytechnic Institute on May 17, 2023. The application was originally filed on Sep 7, 2017 under application number EP17849497A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3510147

RENSSELAER POLYTECHNIC INSTITUTE
Application Number
EP17849497A
Filing Date
Sep 7, 2017
Status
Granted And Under Opposition
Apr 14, 2023
Grant Date
May 17, 2023
External Links
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Patent Summary

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Patent Oppositions (2)

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SANOFIFeb 16, 2024CABINET NONYADMISSIBLE
SANOFIFeb 16, 2024IPSILONADMISSIBLE

Patent Citations (5) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
INTERNATIONAL-SEARCH-REPORTUS2009197308
INTERNATIONAL-SEARCH-REPORTUS2012270834
INTERNATIONAL-SEARCH-REPORTUS2012322114
INTERNATIONAL-SEARCH-REPORTUS2014349962
INTERNATIONAL-SEARCH-REPORTWO2014204929

Non-Patent Literature (NPL) Citations (18) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
EXAMINATION- Desai Umesh, "Measurement of Antithrombin III binding sites", (19950101), URL: http://www-heparin.rpi.edu/main/files/papers/130.pdf, (20210225), XP55779768
EXAMINATION- T C Laurent ET AL, "The molecular-weight-dependence of the anti-coagulant activity of heparin", The Biochemical journal, ENGLAND, doi:10.1042/bj1750691, (19781101), pages 691 - 701, URL: http://www.ncbi.nlm.nih.gov/pubmed/743219, XP055126709
OPPOSITION- Akihiro Onishi, "Detailed physicochemical and biological analyses of heparins from various sources", Dissertation, Rensselaer Polytechnic Institute, (20151101), pages 1 - 97, ISBN 978-1-339-46692-7, XP093165490
OPPOSITION- Anonymous, "HEPARIN SODIUM", The United States Pharmacopeia 2014: USP 37 ; The National Formulary : NF 32, US, United States Pharmacopeial Convention, (20140801), pages 3222 - 3227, ISBN 978-1-936424-22-1, XP009554248
OPPOSITION- Ujjwal Bhaskar; Anne M. Hickey; Guoyun Li; Ruchir V. Mundra; Fuming Zhang; Li Fu; Chao Cai; Zhimin Ou; Jonathan S. Dordick; Robert J. Linhardt, "A purification process for heparin and precursor polysaccharides using the pH responsive behavior of chitosan", Biotechnology Progress, American Chemical Society, Hoboken, USA, Hoboken, USA, (20150716), vol. 31, no. 5, doi:10.1002/btpr.2144, ISSN 8756-7938, pages 1348 - 1359, XP072296006
OPPOSITION- Ujjwal Bhaskar, "Supporting Information: A purification process for heparin and precursor polysaccharides using the pH responsive behavior of chitosan", Biotechnology Progress, American Chemical Society, Hoboken, USA, Hoboken, USA, (20150901), vol. 31, no. 5, doi:10.1002/btpr.2144, ISSN 8756-7938, pages 1 - 3, XP093165487
OPPOSITION- Mellisa Ly, "Electronic Supplementary Material: Analysis of E. coli K5 capsular polysaccharide heparosan", Analytical and Bioanalytical Chemistry, Springer Berlin Heidelberg, Berlin/Heidelberg, Berlin/Heidelberg, (20110101), vol. 399, no. 2, doi:10.1007/s00216-010-3679-7, ISSN 1618-2642, pages 1 - 3, XP093165489
OPPOSITION- Mellisa Ly; Zhenyu Wang; Tatiana N. Laremore; Fuming Zhang; Weihong Zhong; Dennis Pu; Dmitri V. Zagorevski; Jonathan S. Dordick; Robert J. Linhardt, "Analysis of E. coli K5 capsular polysaccharide heparosan", Analytical and Bioanalytical Chemistry, Springer, Berlin, DE, Berlin, DE , (20100421), vol. 399, no. 2, doi:10.1007/s00216-010-3679-7, ISSN 1618-2650, pages 737 - 745, XP019869638
OPPOSITION- Barbara Mulloy, Alan Heath, Zachary Shriver, Fabian Jameison, Ali Al Hakim, Tina S. Morris, Anita Y. Szajek, "USP compendial methods for analysis of heparin: chromatographic determination of molecular weight distributions for heparin sodium", Analytical and Bioanalytical Chemistry, Springer Berlin Heidelberg, Berlin/Heidelberg, Berlin/Heidelberg, (20140801), vol. 406, no. 20, doi:10.1007/s00216-014-7940-3, ISSN 1618-2642, pages 4815 - 4823, XP055492858
OPPOSITION- Wang Zhenyu; Yang Bo; Zhang Zhenqing; Ly Mellisa; Takieddin Majde; Mousa Shaker; Liu Jian; Dordick Jonathan S.; Linhardt Robert J., "Control of the heparosan-deacetylation leads to an improved bioengineered heparin", Applied Microbiology and Biotechnology, Springer Berlin Heidelberg, Berlin/Heidelberg, Berlin/Heidelberg, (20110412), vol. 91, no. 1, doi:10.1007/s00253-011-3231-5, ISSN 0175-7598, pages 91 - 99, XP037058753
OPPOSITION- Bhaskar Ujjwal; Sterner Eric; Hickey Anne Marie; Onishi Akihiro; Zhang Fuming; Dordick Jonathan S.; Linhardt Robert J., "Engineering of routes to heparin and related polysaccharides", Applied Microbiology and Biotechnology, Springer Berlin Heidelberg, Berlin/Heidelberg, Berlin/Heidelberg, (20111103), vol. 93, no. 1, doi:10.1007/s00253-011-3641-4, ISSN 0175-7598, pages 1 - 16, XP037915184
OPPOSITION- Pierre Mourier, Pascal Anger, Céline Martinez, Fréderic Herman, Christian Viskov, "Quantitative compositional analysis of heparin using exhaustive heparinase digestion and strong anion exchange chromatography", Analytical Chemistry Research, (20150301), vol. 3, doi:10.1016/j.ancr.2014.12.001, ISSN 2214-1812, pages 46 - 53, XP055235954
OPPOSITION- Zhenyu Wang; Jennifer Li; Samantha Cheong; Ujjwal Bhaskar; Onishi Akihiro; Fuming Zhang; Jonathan S. Dordick; Robert J. Linhardt;, "Response surface optimization of the heparosan-deacetylation in producing bioengineered heparin", Journal of Biotechnology, Elsevier, Amsterdam NL, Amsterdam NL , (20110815), vol. 156, no. 3, doi:10.1016/j.jbiotec.2011.08.013, ISSN 0168-1656, pages 188 - 196, XP028317651
OPPOSITION- Zhenqing Zhang, Scott A. Mccallum, Jin Xie, Lidia Nieto, Francisco Corzana, Jesús Jiménez-Barbero, Miao Chen, Jian Liu, Robert J. Linhardt, "Solution Structures of Chemoenzymatically Synthesized Heparin and Its Precursors", Journal of the American Chemical Society, American Chemical Society, (20081001), vol. 130, no. 39, doi:10.1021/ja8026345, ISSN 0002-7863, pages 12998 - 13007, XP055237054
OPPOSITION- CHEN J, ET AL, "Enzymatic redesigning of biologically active heparan sulfate", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20051230), vol. 280, no. 52, doi:10.1074/JBC.M504338200, ISSN 0021-9258, pages 42817 - 42825, XP002609045
OPPOSITION- Kalib St Ange, "Analysis of Heparins Derived From Bovine Tissues and Comparison to Porcine Intestinal Heparins", CLINICAL AND APPLIED THROMBOSIS/HEMOSTASIS, HAGERSTOWN, MD, US, US , (20160901), vol. 22, no. 6, doi:10.1177/1076029616643822, ISSN 1076-0296, pages 520 - 527, XP093165488
SEARCH- BHASKAR UJJWAL ET AL, "Combinatorial one-pot chemoenzymatic synthesis of heparin", CARBOHYDRATE POLYMERS, APPLIED SCIENCE PUBLISHERS, LTD. BARKING, GB, (20141107), vol. 122, doi:10.1016/J.CARBPOL.2014.10.054, ISSN 0144-8617, pages 399 - 407, XP029150374 [DX] 1-6,8 * the whole document * [I] 7,9-15
SEARCH- CHEN J ET AL, "Enzymatic redesigning of biologically active heparan sulfate", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, (20051230), vol. 280, no. 52, doi:10.1074/JBC.M504338200, ISSN 0021-9258, pages 42817 - 42825, XP002609045 [X] 1-9,11 * the whole document * [I] 10,12-15

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