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Arginine And Its Use As A T Cell Modulator - EP3525775

The patent EP3525775 was granted to Institute FOR Research IN Biomedicine on Jun 7, 2023. The application was originally filed on Oct 12, 2017 under application number EP17791612A. The patent is currently recorded with a legal status of "Revoked".

EP3525775

INSTITUTE FOR RESEARCH IN BIOMEDICINE
Application Number
EP17791612A
Filing Date
Oct 12, 2017
Status
Revoked
Dec 20, 2024
Grant Date
Jun 7, 2023
External Links
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Patent Summary

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Patent Oppositions (2)

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HAMPTON KNOWLESMar 7, 2024ADMISSIBLE
COHAUSZ & FLORACK PATENT UND RECHTSANWALTE PARTNERSCHAFTSGESELLSCHAFT MBBJan 25, 2024ADMISSIBLE

Patent Citations (5) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
INTERNATIONAL-SEARCH-REPORTWO2012019127
OPPOSITIONCN104818248
OPPOSITIONUS2004057926
OPPOSITIONUS5576351
OTHEREP3525775

Non-Patent Literature (NPL) Citations (34) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- L. A. Norian ET AL, "Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via L-Arginine Metabolism", Cancer research, US, (20090324), vol. 69, no. 7, doi:10.1158/0008-5472.CAN-08-2826, ISSN 0008-5472, pages 3086 - 3094, XP055348581
EXAMINATION- Patrick Raber ET AL, "Metabolism of L-Arginine by Myeloid-Derived Suppressor Cells in Cancer: Mechanisms of T cell suppression and Therapeutic Perspectives", IMMUNOLOGICAL INVESTIGATIONS., US, (20120801), vol. 41, no. 6-7, doi:10.3109/08820139.2012.680634, ISSN 0882-0139, pages 614 - 634, XP055348570
OPPOSITION- C. Huber, Krebs-immuntherapien - Standards und Innovationen, (20080101), pages 50 - 53, XP093169924-
OPPOSITION- MOORE et al., "Culture of normal human leukocytes", JAMA, (19670000), vol. 199, no. 8, doi:10.1001/jama.199.8.519, XP008058015
OPPOSITION- MOORE G E, GERNER R E, FRANKLIN H A, "CULTURE OF NORMAL HUMAN LEUKOCYTES", JAMA, American Medical Association, (19670220), vol. 199, no. 08, doi:10.1001/jama.199.8.519, ISSN 0098-7484, pages 519 - 524, XP008058015
OPPOSITION- Akihiro Hosoi; Hirokazu Matsushita; Kanako Shimizu; Shin‐ichiro Fujii; Satoshi Ueha; Jun Abe; Makoto Kurachi; Ryuji Maekawa; Kouji Matsushima; Kazuhiro Kakimi, "Adoptive cytotoxic T lymphocyte therapy triggers a counter‐regulatory immunosuppressive mechanism via recruitment of myeloid‐derived suppressor cells", International Journal of Cancer, John Wiley & Sons, Inc., US, US , (20131021), vol. 134, no. 8, doi:10.1002/ijc.28506, ISSN 0020-7136, pages 1810 - 1822, XP071288664
OPPOSITION- WIEBKE et al., "Effects of L-arginine supplementation on human lymphocyte proliferation in response to nonspecific and alloantigenic stimulation", Journal of Surgical Research, (19970000), vol. 70, doi:10.1006/jsre.1997.5082, pages 89 - 94, XP029589626
OPPOSITION- Geiger Roger; Rieckmann Jan C.; Wolf Tobias; Basso Camilla; Feng Yuehan; Fuhrer Tobias; Kogadeeva Maria; Picotti Paola; Meissner Felix; Mann Matthias; Zamboni Nicola; Sallusto Federica; Lanzavecchia Antonio, "L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (20161013), vol. 167, no. 3, doi:10.1016/j.cell.2016.09.031, ISSN 0092-8674, page 829, XP029773986
OPPOSITION- ZEA et al., "L-arginine modulates CD 3zeta expression and T cell function in activated human T lymphocytes", Cellular Immunology, (20040000), vol. 232, doi:10.1016/j.cellimm.2005.01.004, pages 21 - 31, XP004908896
OPPOSITION- ROSENBERG et al., "Adoptive cell therapy for the treatment of patients with Metastatic Melanoma", Curr Opin Immunol, (20090000), vol. 21, no. 2, doi:10.1016/j.coi.2009.03.002, pages 233 - 240, XP026058401
OPPOSITION- David O'sullivan, "Targeting T cell metabolism for therapy", Trends in immunology, Elsevier Ltd. Trends Journals, GB, GB , (20150201), vol. 36, no. 2, doi:10.1016/j.it.2014.12.004, ISSN 1471-4906, pages 71 - 80, XP093169915
OPPOSITION- Heys S. D., A. Segar, S. Payne, D.M. Bruce, N. Kernohan, O. Eremin, "Dietary supplementation with L-arginine: modulation of tumourinfiltrating lymphocytes in patients with colorectal cancer", British Journal of Surgery, (19970201), vol. 84, doi:10.1046/j.1365-2168.1997.02528.x, pages 238 - 241, XP093185861
OPPOSITION- Paulo C. Rodriguez, "Regulation of T Cell Receptor CD3ζ Chain Expression byl-Arginine", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20020601), vol. 277, no. 24, doi:10.1074/jbc.M110675200, ISSN 0021-9258, pages 21123 - 21129, XP093169916
OPPOSITION- Michael D. Buck, David O’sullivan, Erika L. Pearce, "T cell metabolism drives immunity", Journal of Experimental Medicine, Rockefeller University Press, US, US , (20150824), vol. 212, no. 9, doi:10.1084/jem.20151159, ISSN 0022-1007, pages 1345 - 1360, XP055374549
OPPOSITION- Juan F. Vera, Brenner Lara J., Gerdemann Ulrike, Ngo Minhtran C., Sili Uluhan, Liu Hao, Wilson John, Dotti Gianpietro, Heslop Helen E., Leen Ann M., Rooney Cliona M., "Accelerated Production of Antigen-specific T Cells for Preclinical and Clinical Applications Using Gas-permeable Rapid Expansion Cultureware (G-Rex)", Journal of Immunotherapy, (20100401), vol. 33, no. 3, doi:10.1097/CJI.0b013e3181c0c3cb, ISSN 15249557, pages 305 - 315, XP055031297
OPPOSITION- Sunitha Kakarla, Stephen Gottschalk, "CAR T Cells for Solid Tumors", CANCER JOURNAL, JONES AND BARTLETT PUBLISHERS, US, US , (20140101), vol. 20, no. 2, doi:10.1097/PPO.0000000000000032, ISSN 1528-9117, pages 151 - 155, XP055243488
OPPOSITION- Paulo C. Rodríguez, Augusto C. Ochoa, "Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives", Immunological Reviews, Wiley-Blackwell Publishing, Inc., US, US , (20080401), vol. 222, no. 1, doi:10.1111/j.1600-065X.2008.00608.x, ISSN 0105-2896, pages 180 - 191, XP055348575
OPPOSITION- RODRIGUEZ et al., "Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives", Immunol Rev, (20080000), vol. 222, doi:10.1111/j.1600-065X.2008.00608.x, pages 180 - 191, XP055348575
OPPOSITION- DUDLEY et al., "Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes", Science, (20020000), vol. 298, doi:10.1126/science.1076514, pages 850 - 854, XP009113075
OPPOSITION- L. A. Johnson, Et Al, "Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma", SCIENCE TRANSLATIONAL MEDICINE, American Association for the Advancement of Science, (20150218), vol. 7, no. 275, doi:10.1126/scitranslmed.aaa4963, ISSN 1946-6234, pages 1 - 16, XP055362795
OPPOSITION- Kristen Fousek, "The Evolution of T-cell Therapies for Solid Malignancies", Clinical Cancer Research, Association for Cancer Research, US, US, (20150801), vol. 21, no. 15, doi:10.1158/1078-0432.CCR-14-2675, ISSN 1078-0432, pages 3384 - 3392, XP093169912
OPPOSITION- Krishnamurthy Janani, Rabinovich Brian A., Mi Tiejuan, Switzer Kirsten C., Olivares Simon, Maiti Sourindra N., Plummer Joshua B., Singh Harjeet, Kumaresan Pappanaicken R., Huls Helen M., Wang-Johanning Feng, Cooper Laurence J.N., "Genetic Engineering of T Cells to Target HERV-K, an Ancient Retrovirus on Melanoma", Clinical Cancer Research, Association for Cancer Research, US, US, (20150331), vol. 21, no. 14, doi:10.1158/1078-0432.CCR-14-3197, ISSN 1078-0432, pages 3241 - 3251, XP055827073
OPPOSITION- ANDERSEN et al., "Long lasting complete responses in patients with metastatic melanoma after adoptive cell therapy with TIL and attenuated IL 2 regimen", Clin Cancer Res, (20160000), vol. 22, doi:10.1158/1078-0432.CCR-15-1879, pages 3734 - 3745, XP055762334
OPPOSITION- Ochoa Juan B., Strange Jennifer, Kearney Paul, Gellin Gloria, Endean Eric, Fitzpatrick Elizabeth, "Effects of L‐Arginine on the Proliferation of T Lymphocyte Subpopulations", JPEN - Journal of Parenteral and Enteral Nutrition, Sage Publications, Inc., US, US , (20010101), vol. 25, no. 1, doi:10.1177/014860710102500123, ISSN 0148-6071, pages 23 - 29, XP093185855
OPPOSITION- Kirk Stephen J., Regan Mark C., Wasserkrug Hannah L., Sodeyama Motohide, Barbul Adrian, "Arginine Enhances T‐Cell Responses in Athymic Nude Mice", JPEN - Journal of Parenteral and Enteral Nutrition, Sage Publications, Inc., US, US , (19920901), vol. 16, no. 5, doi:10.1177/0148607192016005429, ISSN 0148-6071, pages 429 - 432, XP093185862
OPPOSITION- Paulo C Rodriguez, "L-arginine availability regulates T-lymphocyte cell-cycle progression", Blood, (20070215), vol. 109, no. 4, doi:10.1182/blood-2006-, pages 1568 - 1573, XP093169921
OPPOSITION- RODRIGUEZ et al., "L-arginine availability regulates T- lymphocyte cell -cycle progression", Blood, (20070000), vol. 109, doi:10.1182/blood-2006-, pages 1568 - 1573, XP093169921
OPPOSITION- Cao Yu, Feng Yonghui, Zhang Yanjun, Zhu Xiaotong, Jin Feng, "L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo", BMC Cancer, BIOMED CENTRAL, LONDON, GB, LONDON, GB , (20161201), vol. 16, no. 1, doi:10.1186/s12885-016-2376-0, ISSN 1471-2407, page 343, XP093185863
OPPOSITION- B-S Choi, "Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages", Journal of Leukocyte Biology, John Wiley & Sons Ltd., GB, GB , (20090201), vol. 85, no. 2, doi:10.1189/jlb.0508310, ISSN 0741-5400, pages 268 - 277, XP093169914
OPPOSITION- CHOI et al., "Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages", J Leukoc Biol, (20090000), vol. 85, doi:10.1189/jlb.0508310, pages 268 - 277, XP093169914
OPPOSITION- Patrick Raber, Augusto C Ochoa, Paulo C Rodríguez, "Metabolism of L-Arginine by Myeloid-Derived Suppressor Cells in Cancer: Mechanisms of T cell suppression and Therapeutic Perspectives", IMMUNOLOGICAL INVESTIGATIONS., Informa Healthcare, US, US , (20120801), vol. 41, no. 6-7, doi:10.3109/08820139.2012.680634, ISSN 0882-0139, pages 614 - 634, XP055348570
OPPOSITION- RABER et al., "Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives", Immunol Invest, (20120000), vol. 41, doi:10.3109/08820139.2012.680634, pages 614 - 634, XP055348570
OPPOSITION- Yun Lin, "Optimization and validation of a robust human T-cell culture method for monitoring phenotypic and polyfunctional antigen-specific CD4 and CD8 T-cell responses", Cytotherapy, ISIS MEDICAL MEDIA, OXFORD,, GB, GB , (20090101), vol. 11, no. 7, doi:10.3109/14653240903136987, ISSN 1465-3249, pages 912 - 922, XP093169904
OPPOSITION- Stefanos Michaelides, "Migratory Engineering of T Cells for Cancer Therapy", VACCINES, M D P I AG, CH, CH , (20220101), vol. 10, no. 11, doi:10.3390/vaccines10111845, ISSN 2076-393X, page 1845, XP093169913

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