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Recombinant Proteins Derived From Genus Limulus, And Dna Molecules Encoding Same - EP3530670

The patent EP3530670 was granted to Seikagaku on Feb 28, 2024. The application was originally filed on Oct 18, 2017 under application number EP17862926A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3530670

SEIKAGAKU
Application Number
EP17862926A
Filing Date
Oct 18, 2017
Status
Granted And Under Opposition
Jan 26, 2024
Grant Date
Feb 28, 2024
External Links
Slate, Register, Google Patents

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POHLMANNov 22, 2024POHLMANADMISSIBLE

Patent Citations (21) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONJP20160204729
DESCRIPTIONJP2014510898
DESCRIPTIONUS5712144
DESCRIPTIONUS5716834
DESCRIPTIONUS5858706
DESCRIPTIONUS5985590
DESCRIPTIONUS6645724
DESCRIPTIONWO2008004674
DESCRIPTIONWO2014092079
INTERNATIONAL-SEARCH-REPORTJP2014510898
INTERNATIONAL-SEARCH-REPORTJP2015141088
INTERNATIONAL-SEARCH-REPORTJP2015536158
INTERNATIONAL-SEARCH-REPORTWO2014092079
OPPOSITIONEP2930241
OPPOSITIONUS10144923
OPPOSITIONUS5716834
OPPOSITIONUS6645724
OPPOSITIONWO03002976
OPPOSITIONWO2012118226
SEARCHEP2930241
SEARCHEP3591049

Non-Patent Literature (NPL) Citations (39) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
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OPPOSITION- Anonymous, "5' RACE System for Rapid Amplification of cDNA Ends, Version 2.0", Invitrogen life technologies, Catalog no. 18374-058, (20041206), pages 1 - 48, XP093242045
OPPOSITION- Anonymous, "〈85〉 BACTERIAL ENDOTOXINS TEST ", The United States Pharmacopoeial Convention (2011), Stage 6 Harmonization, (20121201), The United States Pharmacopoeial Convention (2011), Stage 6 Harmonization, URL: https://www.houshiji.com/Uploads/Download/5a27396519552.pdf, XP093279034
OPPOSITION- Anonymous, "Limulus polyphemus Annotation Report", Genome, (20140301), Database accession no. GCF_000517525, URL: NCBI, XP093242073
OPPOSITION- Anonymous, "pCI.neo Mammalian Expession Vector", Promaga, Technical Bulletin, (20090901), pages 1 - 13, XP093241268
OPPOSITION- Anonymous, "PREDICTED: Limulus polyphemus limulus clotting factor C-like (LOC106477041), mRNA", Nucleotide, (20150909), Database accession no. XM_013937646 , URL: NCBI, XP093242071
OPPOSITION- D03a: Inventor’s declaration accompanying the Proprietor’s submission
OPPOSITION- D03b: Claims accompanying the Proprietor’s submission
OPPOSITION- D03: Proprietor’s submission in US Application No. 14/650,767 dated Feb. 22, 2018
OPPOSITION- D07: A copy of the ESO
OPPOSITION- D08a: CV Professor Frohman
OPPOSITION- D08: Declaration of Professor Frohman
OPPOSITION- D15: Partial screenshot of search results for “cDNA RACE kits” before Oct. 18, 2016
OPPOSITION- D26a: Annex to the Communication in response to the Proprietor’s reply of Oct. 16, 2020,dated Oct 21, 2022
OPPOSITION- D26: Proprietor’s response to the communication pursuant to Rules 70(2) and 70a(2) dated Oct. 16, 2020
OPPOSITION- D29: A copy of the Annex to the Communication pursuant to Rule 71(3) EPC
OPPOSITION- D33 - Experimental report signed by Dr. Hikaru Mizumura on April 25, 2025
OPPOSITION- Ding Jeak L, Anthony M., Navas A., "Molecular cloning and sequence analysis of Factor C cDNA from the Singapore horseshoe crab, Carcinoscorpius rotundicauda", Molecular Marine Biology and Biotechnology, (19950101), vol. 4, no. 1, pages 90 - 103, XP093242077
OPPOSITION- Dorit Robert L, Ohara Osamu, "cDNA Amplification Using One-Sided (Anchored) PCR", Current Protocols in Molecular Biology, (19920101), pages 1 - 10, XP093241723
OPPOSITION- FROHMAN M A, "ON BEYOND CLASSIC RACE (RAPID AMPLIFICATION OF CDNA ENDS)", PCR METHODS & APPLICATIONS., COLD SPRING HARBOR LABORATORY PRESS., US, US , (19940801), vol. 04, no. 01, ISSN 1054-9803, pages S40 - S58, XP009012060
OPPOSITION- N/a, "Tandem mass spectrometry", Wikipedia, Wikipedia, URL: https://en.wikipedia.org/w/index.php?title=Tandem_mass_spectrometry&oldid=732352170, (20180525), XP055478658
OPPOSITION- Sandle Tim, "FDA guidance on pyrogens and endotoxin testing", GMP Review, (20130701), vol. 12, no. 2, pages 7 - 9, XP093241293
OPPOSITION- Wimbish Lakiya, "Advantages of recombinant Factor C based endotoxin testing", European PHARMCEUTICAL manufacturer, (20151117), pages 1 - 5, XP093241301
OPPOSITION- Chong Shaorong, "Overview of Cell‐Free Protein Synthesis: Historic Landmarks, Commercial Systems, and Expanding Applications", Current Protocols in Molecular Biology, Greene Pub. Associates, (20141001), vol. 108, no. 1, doi:10.1002/0471142727.mb1630s108, ISSN 1934-3639, XP055892446
OPPOSITION- K. Udeni Alwis; Donald K. Milton, "Recombinant factor C assay for measuring endotoxin in house dust: Comparison with LAL, and (1 → 3)‐β‐D‐glucans", AMERICAN JOURNAL OF INDUSTRIAL MEDICINE., JOHN WILEY, NEW YORK, NY., US, US , (20060320), vol. 49, no. 4, doi:10.1002/ajim.20264, ISSN 0271-3586, pages 296 - 300, XP071568146
OPPOSITION- Yeku Oladapo et al, "Rapid Amplification of cDNA Ends (RACE)", Methods in Molecular Biology, New York, NY, (20110101), vol. 703, doi:10.1007/978-1-59745-248-9_8, ISSN 1064-3745, pages 107 - 122, XP093241683
OPPOSITION- Ding Jeak Ling, Ho Bow, "Chapter 9: Endotoxin Detection - from Limulus Amebocyte Lysate to Recombinant Factor C", Ding Jeak Ling, Ho Bow, Wang X; Quinn PJ (eds.), Endotoxins: Structure, Function and Recognition - Series : Subcellular BiochemistryIN: Subcellular biochemistry : reviews and essays dealing with the function, genetics, biogenesis and evolution of sub-cellular components, ISSN 0096-8757 ; Vol. 53, US , SPRINGER , (20100101), pages 187 - 208, doi:10.1007/978-90-481-9078-2_9, ISBN 978-90-481-9077-5, XP009510157
OPPOSITION- DWARAKANATH ROOPASHREE S ET AL, "Recombinant COS-1 cells express Carcinoscorpius rotundicauda factor C", Biotechnology Letters, Kluwer Academic Publishers, Dordrecht, Dordrecht , (19970401), vol. 19, no. 4, doi:10.1023/A:1018307118879, ISSN 0141-5492, pages 357 - 361, XP002787576
OPPOSITION- FROHMAN M. A.et al, "RAPID PRODUCTION OF FULL-LENGTH CDNAS FROM RARE TRANSCRIPTS: AMPLIFICATION USING A SINGLE GENE-SPECIFIC OLIGONUCLEOTIDE PRIMER.", Proceedings of the National Academy of Sciences (PNAS), National Academy of Sciences, (19881201), vol. 85., doi:10.1073/pnas.85.23.8998, ISSN 0027-8424, pages 8998 - 9002., XP000604678
OPPOSITION- Fuminori Tokunaga et al, "Further Studies on Lipopolysaccharide-Sensitive Serine Protease Zymogen (Factor C): Its Isolation from Limulus polyphemus Hemocytes and Identification as an Intracellular Zymogen Activated by α-Chymotrypsin, Not by Trypsin1", Journal of Biochemistry, Oxford University Press, GB, GB , (19910101), vol. 109, no. 1, doi:10.1093/oxfordjournals.jbchem.a123337, ISSN 0021-924X, pages 150 - 157, XP055682343
OPPOSITION- Miura Yoshiki et al, "Preparation and Properties of Monoclonal Antibodies against Lipopolysaccharide-Sensitive Serine Protease Zymogen, Factor C, from Horseshoe Crab (Tachypleus tridentatus) Hemocytes1", Journal of Biochemistry, Oxford University Press, GB, GB , (19921001), vol. 112, no. 4, doi:10.1093/oxfordjournals.jbchem.a123924, ISSN 0021-924X, pages 476 - 481, XP093242239
OPPOSITION- Carlos W Nossa et al, "Joint assembly and genetic mapping of the Atlantic horseshoe crab genome reveals ancient whole genome duplication", GigaScience, BioMed Central Ltd, London, UK, London, UK , (20140514), vol. 3, no. 1, doi:10.1186/2047-217X-3-9, ISSN 2047-217X, page 9, XP021189758
SEARCH- "Limulus polyphemus factor C gene, SEQ ID 13.", Geneseq, (20181101), Database accession no. BFQ44745, URL: EBI [P] * sequence . *
SEARCH- "Limulus polyphemus factor C protein, SEQ ID 14.", Geneseq, (20181101), Database accession no. BFQ44746, URL: EBI [P] * sequence . *
SEARCH- DING JEAK LING ET AL, Chapter 9: Endotoxin Detection - from Limulus Amebocyte Lysate to Recombinant Factor C, ENDOTOXINS: STRUCTURE, FUNCTION AND RECOGNITION - SERIES : SUBCELLULAR BIOCHEMISTRY IN: SUBCELLULAR BIOCHEMISTRY : REVIEWS AND ESSAYS DEALING WITH THE FUNCTION, GENETICS, BIOGENESIS AND EVOLUTION OF SUB-CELLULAR COMPONENTS, ISSN 0096-8757 ; VOL. 53;, (20100101), ISBN 978-90-481-9077-5, XP009510157 [A] 1-4 * the whole document *
SEARCH- NAKAMURA S ET AL, "Fractionation of Limulus amebocyte lysate - Characterization of activation of the proclotting enzyme by an endotoxin-mediated activator", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM; NL, vol. 707, no. 2, doi:10.1016/0167-4838(82)90354-5, ISSN 0167-4838, (19821005), pages 217 - 225, (19821005), XP023476507 [A] 1-4 * the whole document *
SEARCH- FUMINORI TOKUNAGA ET AL, "Further Studies on Lipopolysaccharide-Sensitive Serine Protease Zymogen (Factor C): Its Isolation from Limulus polyphemus Hemocytes and Identification as an Intracellular Zymogen Activated by [alpha]-Chymotrypsin, Not by Trypsin1", JOURNAL OF BIOCHEMISTRY, GB, (19910101), vol. 109, no. 1, doi:10.1093/oxfordjournals.jbchem.a123337, ISSN 0021-924X, pages 150 - 157, XP055682343 [X] 1 * abstract * [Y] 2-4

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