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Methods For Increasing The Efficiency Of Homology Directed Repair (Hdr) In The Cellular Genome - EP3559230

The patent EP3559230 was granted to Bristol Myers Squibb on Sep 6, 2023. The application was originally filed on Dec 20, 2017 under application number EP17832436A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3559230

BRISTOL MYERS SQUIBB
Application Number
EP17832436A
Filing Date
Dec 20, 2017
Status
Granted And Under Opposition
Aug 4, 2023
Grant Date
Sep 6, 2023
External Links
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Patent Summary

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Patent Family

Patent Oppositions (2)

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OETKEJun 5, 2024WALLINGER RICKER SCHLOTTER TOSTMANNADMISSIBLE
STRAWMANJun 5, 2024HOFFMANN EITLEADMISSIBLE

Patent Citations (31) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
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DESCRIPTIONUS4774085
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DESCRIPTIONUS4897355
DESCRIPTIONUS4946787
DESCRIPTIONUS5049386
DESCRIPTIONUS6008336
DESCRIPTIONUS6534261
DESCRIPTIONUS6607882
DESCRIPTIONUS6824978
DESCRIPTIONUS6933113
DESCRIPTIONUS6979539
DESCRIPTIONUS7013219
DESCRIPTIONUS7163824
DESCRIPTIONWO9116024
DESCRIPTIONWO9117424
INTERNATIONAL-SEARCH-REPORTCN105734032
INTERNATIONAL-SEARCH-REPORTUS2011129898
INTERNATIONAL-SEARCH-REPORTWO2016154579
INTERNATIONAL-SEARCH-REPORTWO2016182959
OPPOSITIONUS2016326548
OPPOSITIONWO2016154579
OPPOSITIONWO2016154596
OPPOSITIONWO2016164356
OPPOSITIONWO2016182959
OPPOSITIONWO2018119060

Non-Patent Literature (NPL) Citations (17) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Chris J. Jung, "Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein", Transgenic Res, (20161130), vol. 26, doi:10.1007/s11248-016-9998-5, XP036188442
OPPOSITION- Hendriks William T.; Warren Curtis R.; Cowan Chad A., "Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions", Cell Stem Cell, Elsevier, Cell Press, AMSTERDAM, NL, AMSTERDAM, NL , (19000101), vol. 18, no. 1, doi:10.1016/j.stem.2015.12.002, ISSN 1934-5909, pages 53 - 65, XP029381742
OPPOSITION- Findlay Gregory M., Boyle Evan A., Hause Ronald J., Klein Jason C., Shendure Jay, "Saturation editing of genomic regions by multiplex homology-directed repair", Nature, Springer Nature Limited, (20140901), vol. 513, no. 7516, doi:10.1038/nature13695, ISSN 0028-0836, pages 120 - 123, XP093194172
OPPOSITION- Dominik Paquet, "Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9", Nature, (2016), vol. 533, doi:10.1038/nature17664, XP037707695
OPPOSITION- Paquet Dominik; Kwart Dylan; Chen Antonia; Sproul Andrew; Jacob Samson; Teo Shaun; Olsen Kimberly Moore; Gregg Andrew; Noggle Scott; Tessier-Lavigne Marc, "Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9", Nature, (20160427), vol. 533, no. 7601, doi:10.1038/nature17664, pages 125 - 129, XP037548205
OPPOSITION- Jeffrey C Miller, Siyuan Tan, Guijuan Qiao, Kyle A Barlow, Jianbin Wang, Danny F Xia, Xiangdong Meng, David E Paschon, Elo Leung, Sarah J Hinkley, Gladys P Dulay, Kevin L Hua, Irina Ankoudinova, Gregory J Cost, Fyodor D Urnov, H Steve Zhang, Michael C Holmes, Lei Zhang, Philip D Gregory, Edward J Rebar, "A TALE nuclease architecture for efficient genome editing", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20110201), vol. 29, no. 2, doi:10.1038/nbt.1755, ISSN 1087-0156, pages 143 - 148, XP055568321
OPPOSITION- Ayal Hendel, "Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells", Nature Biotechnology, (2015), vol. 33, doi:10.1038/nbt.3290, XP055548372
OPPOSITION- Christopher D. Richardson, "Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA", Nature Biotechnology, (20160120), vol. 34, doi:10.1038/nbt.3481, XP055401621
OPPOSITION- Yannick Doyon, Choi Vivian M, Xia Danny F, Vo Thuy D, Gregory Philip D, Holmes Michael C, "Transient cold shock enhances zinc-finger nuclease-mediated gene disruption", Nature Methods, Nature Publishing Group US, New York, New York, (20100601), vol. 7, no. 6, doi:10.1038/nmeth.1456, ISSN 1548-7091, pages 459 - 460, XP055460134
OPPOSITION- F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott & Feng Zhang, "Genome engineering using the CRISPR-Cas9 system", Nature Protocols, Nature Publishing Group, GB, GB , (20131101), vol. 8, no. 11, doi:10.1038/nprot.2013.143, ISSN 1754-2189, pages 2281 - 2308, XP002744123
OPPOSITION- Hyongbum Kim, Jin-Soo Kim, "A guide to genome engineering with programmable nucleases", Nature Reviews Genetics, Nature Pub. Group, vol. 15, no. 5, doi:10.1038/nrg3686, ISSN 14710056, pages 321 - 334, XP055177064
OPPOSITION- Q. Guo, "Cold shock’ increases the frequency of homology directed repair gene editing in induced pluripotent stem cells", Scientific Reports, (20180201), vol. 8, doi:10.1038/s41598-018-20358-5, XP055459756
OPPOSITION- Jae Seong Lee, Kallehauge Thomas Beuchert, Pedersen Lasse Ebdrup, Kildegaard Helene Faustrup, "Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway", Scientific Reports, (20150701), vol. 5, no. 1, doi:10.1038/srep08572, pages 1 - 11, XP055373118
OPPOSITION- Daniel F. Carlson, "Efficient TALEN-mediated gene knockout in livestock", Proceedings of the National Academy of Sciences, (2012), vol. 109, doi:10.1073/pnas.1211446109, XP002716843
OPPOSITION- Kathrin Schumann, "Generation of knock-in primary human T cells using Cas9 ribonucleoproteins", Proceedings of the National Academy of Sciences, (2015), vol. 112, doi:10.1073/pnas.1512503112, XP055769686
OPPOSITION- Kai Li, Gang Wang, Troels Andersen, Pingzhu Zhou, William T. Pu, "Optimization of Genome Engineering Approaches with the CRISPR/Cas9 System", PLoS ONE, vol. 9, no. 8, doi:10.1371/journal.pone.0105779, page e105779, XP055243646
OPPOSITION- Steven Lin, "Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery", eLife, (20141215), vol. 3, doi:10.7554/eLife.04766, XP055294945

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