IP Verse

Ribonucleic Acids Containing N1-Methyl-Pseudouracils And Uses Thereof - EP3590949

The patent EP3590949 was granted to Moderna on May 18, 2022. The application was originally filed on Oct 3, 2011 under application number EP19177059A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3590949

MODERNA
Application Number
EP19177059A
Filing Date
Oct 3, 2011
Status
Granted And Under Opposition
Apr 15, 2022
Grant Date
May 18, 2022
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (10)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

ETHERNA IMMUNOTHERAPIESFeb 20, 2023ARNOLD & SIEDSMAADMISSIBLE
MAIWALDFeb 20, 2023MAIWALDADMISSIBLE
GLAXOSMITHKLINEFeb 17, 2023RAVASIOADMISSIBLE
PFIZERFeb 17, 2023DORRIESADMISSIBLE
PFIZERFeb 17, 2023DORRIES, HANS ULRICH , DF-MP DORRIES FRANK-MOLNIA & POHLMANADMISSIBLE
WITHERS & ROGERSFeb 17, 2023GRAF VON STOSCH PATENTANWALTSGESELLSCHAFTADMISSIBLE
KILBURN & STRODEFeb 17, 2023KILBURN & STRODEWITHDRAWN
SANOFIOct 5, 2022CARPMAELS & RANSFORDADMISSIBLE
PATENT BOUTIQUESep 27, 2022PATENT BOUTIQUEADMISSIBLE
BIONTECHSep 23, 2022WILKADMISSIBLE

Patent Citations (48) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS20100404413
DESCRIPTIONUS4270537
DESCRIPTIONUS4596556
DESCRIPTIONUS4790824
DESCRIPTIONUS4886499
DESCRIPTIONUS4940460
DESCRIPTIONUS4941880
DESCRIPTIONUS5015235
DESCRIPTIONUS5064413
DESCRIPTIONUS5141496
DESCRIPTIONUS5190521
DESCRIPTIONUS5312335
DESCRIPTIONUS5328483
DESCRIPTIONUS5334144
DESCRIPTIONUS5339163
DESCRIPTIONUS5383851
DESCRIPTIONUS5417662
DESCRIPTIONUS5466220
DESCRIPTIONUS5480381
DESCRIPTIONUS5503627
DESCRIPTIONUS5520639
DESCRIPTIONUS5527288
DESCRIPTIONUS5569189
DESCRIPTIONUS5599302
DESCRIPTIONUS5649912
DESCRIPTIONUS5704911
DESCRIPTIONUS5893397
DESCRIPTIONUS5993412
DESCRIPTIONWO9713537
DESCRIPTIONWO9737705
DESCRIPTIONWO9934850
OPPOSITIONEP1979364
OPPOSITIONEP2578685
OPPOSITIONEP2622064
OPPOSITIONEP3590949
OPPOSITIONEP3611266
OPPOSITIONUS2009286852
OPPOSITIONUS8999380
OPPOSITIONWO2005039551
OPPOSITIONWO2007024708
OPPOSITIONWO2008083949
OPPOSITIONWO2011071931
OPPOSITIONWO2012019168
OPPOSITIONWO2012045075
OPPOSITIONWO2012135805
OPPOSITIONWO2012158736
OPPOSITIONWO2013039861
SEARCHWO2007024708

Non-Patent Literature (NPL) Citations (79) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- ALBRECHT, Immunotherapy, (20100000), vol. 2, no. 6, pages 795 - 8
DESCRIPTION- CARILLO et al., SIAM J. Applied Math., (19880000), vol. 48, page 1073
DESCRIPTION- FUKUHARA et al., Biochemistry, (19620000), vol. 1, no. 4, pages 563 - 568
DESCRIPTION- MUSUNURU K et al., "From noncoding variant to phenotype via SORT] at the lpl3 cholesterol locus", Nature, (20100000), vol. 466, pages 714 - 721
DESCRIPTION- OGATA et al., Journal of Organic Chemistry, (20090000), vol. 74, pages 2585 - 2588
DESCRIPTION- "Oligonucleotide synthesis: methods and applications", Methods in Molecular Biology, Humana Press, (20050000), vol. 288
DESCRIPTION- "Pro-drugs as Novel Delivery Systems", T. HIGUCHV. STELLA, A.C.S. Symposium Series, and in Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, (19870000), vol. 14
DESCRIPTION- PURMAL et al., Nucleic Acids Research, (19940000), vol. 22, no. 1, pages 72 - 78
DESCRIPTION- ROZENSKI, JCRAIN, PMCCLOSKEY, J, "The RNA Modification Database: 1999 update", Nucl Acids Res, (19990000), vol. 27, pages 196 - 197
DESCRIPTION- XU et al., Tetrahedron, (19920000), vol. 48, no. 9, pages 1729 - 1740
OPPOSITION- Anonymous, "2009 PRODUCT CATALOG - Dedicated to providing specialty chemicals to advance the life sciences", Berry & Associates, (20090101), Berry & Associates, XP093188306
OPPOSITION- Anonymous, "BNT162 COVID-19 Vaccine", BioNTech, (20200423), pages 1 - 15, BioNTech, URL: https://investors.biontech.de/static-files/398d9bd8-e2cb-49ca-9d6d-7dfd01c66b8a, (20220131), XP055885355
OPPOSITION- Anonymous, "CureVac’s COVID-19 vaccine (CVnCoV): Withdrawal from the rolling review process", CureVac’s COVID-19 vaccine (CVnCoV), European Medicines Agency, (20211012), pages 1 - 6, CureVac’s COVID-19 vaccine (CVnCoV), URL: https://www.ema.europa.eu/en/medicines/human/EPAR/curevacs-covid-19-vaccine-cvncov, (20240318), XP093142378
OPPOSITION- Anonymous, "Dedicated to providing specialty chemicals to advance the life sciences", Berry & Associates, (20090101), pages 1 - 288, XP093176759
OPPOSITION- Anonymous, "Elisa Catalog & Reference Guide 2007", R&D Systems, (20070101), pages 1 - 60, R&D Systems, XP093175592
OPPOSITION- Anonymous, "Human G-CSF Instant ELISA Kit - User Guide", invitrogen, (20190716), invitrogen, (20240322), XP093144527
OPPOSITION- Anonymous, "mMESSAGE mMACHINE ® Kit", mMESSAGE mMACHINE ® Kit, (20070101), pages 1 - 34, mMESSAGE mMACHINE ® Kit, URL: https://kirschner.med.harvard.edu/files/protocols/Ambion_mMessagemMachine.pdf, (20230317), XP093032714
OPPOSITION- Anonymous, "Quantikine® ELISA - Human G-CSF Immunoassay - Catalog Number DCS50 Catalog Number SCS50 Catalog Number PDCS50", R & D Systems, Inc., (20180101), R & D Systems, Inc., (20240322), XP093144536
OPPOSITION- Anonymous, "VeriKine Human IFN Beta ELISA Kit - Catalog No. 41410", pbl assay science, (20160101), pbl assay science, URL: https://fnkprddata.blob.core.windows.net/domestic/data/datasheet/RSD/41410-2.pdf, (20240322), XP093144538
OPPOSITION- Brand Reindert C. et al, " Biosynthesis of a Hypermodified Nucleotide in Saccharomyces carlsbergensis 17 S and HeLa-Cell 18 S Ribosomal Ribonucleic Acid", Biochem. J, (19780101), vol. 169, pages 71 - 77, XP055960175
OPPOSITION- Callie Daniel R, Caldwell Christian, Pitto Letizia, "Heat Shock Disrupts Cap and Poly(A) Tail Function during Translation and lncreases mRNA Stability of Introduced Reporter mRNA'", Plant Physiol, (19950101), pages 1703 - 1713, Plant Physiol, URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC157552/pdf/1081703.pdf, (20230317), XP093032724
OPPOSITION- CHARETTE M , GRAY M W, "Pseudouridine in RNA: What, where, how, and why", IUBMB Life, John Wiley & Sons, Inc., Hoboken, USA, Hoboken, USA, (20000101), vol. 49, no. 5, ISSN 1521-6543, pages 341 - 351, XP002598531
OPPOSITION- C. S. YARIAN et al., "Structural and functional roles of the N1- and N3- protons of PSI at tRNA's position 39", Nucleic Acid Research, (19990000), vol. 27, no. 17, pages 3543 - 3549, XP055959841
OPPOSITION- Dolsten Mikael, "COVID-19 Vaccine Development Program", COVID-19 Vaccine Development Program, Pfizer, (20200701), pages 1 - 18, COVID-19 Vaccine Development Program, URL: https://s28.q4cdn.com/781576035/files/doc_presentation/2020/07/01/COVID-Vaccine-Analyst-Call-Deck-v15-presentation.pdf, (20240318), XP093142275
OPPOSITION- GALLIE et al., "Post-transcriptional regulation in higher eukaryotes: The role of the reporter gene in controlling expression", Mol. Gen. Genet., (19910800), vol. 228, pages 258 - 264
OPPOSITION- G. K. Jacobson, "Chapter 5b: Mutations", G. K. Jacobson, Rehm and Reed, Biotechnology; Vol. 1 Microbial Fundamentals, Weinheim, Verlag Chemie, (19810101), vol. 1, pages 279 - 304, ISBN 3-527-25763-2, XP009552807
OPPOSITION- Grunewald Stephanie, Santra Saikat, Koeberl Dwight, Schulze Andreas, Sondheimer Neal, Ahmad Ayesha, Lipshutz Gerald, Hiwot Tarekegn Geber, Liang Min, Li Lerong, Glaser Ruchira, Carrillo Nuria, "mRNA-3927 Therapy for Propionic Acidemia: Interim Data From a Phase 1/2 Study", American Society of Gene & Cell Therapy (ASGCT) 26th Annual Meeting, May 16-20, 2023; Los Angeles, CA, USA, American Society of Gene & Cell Therapy, (20230501), pages 1 - 14, XP093142424
OPPOSITION- Hames David, Hooper Nigel, "G7 Processing of eukaryotic PRE-mRNA", Biochemistry. 3rd Ed., Taylor & Francis Group, (20050101), pages 220 - 227, ISBN 978-0-415-36778-3, XP093190485
OPPOSITION- Jeremy M. Berg, John L. Tymoczko, Lubert Stryer, "Chapter 4: DNA, RNA, and the Flow of Genetic Information", Jeremy M. Berg, John L. Tymoczko, Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Lubert Stryer, Biochemistry. Sixth Ed., New York, W.H. Freeman, (20070101), pages 107 - 133, ISBN 0-7167-8724-5, XP009552806
OPPOSITION- Kariko, "Invention: Modified mRNA for life-saving vaccines and therapies", EPO, (20210101), pages 1 - 2, EPO, URL: https://www.epo.org/news-events/events/european-inventor/finalists/2022/kariko.html, (20230321), XP093033258
OPPOSITION- Karikó Katalin; Weissman Drew, "Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: implication for therapeutic RNA development.", CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, CURRENT DRUGS, LONDON, GB, GB , (20070101), vol. 10, no. 5, ISSN 1367-6733, pages 523 - 532, XP009154595
OPPOSITION- Khattak Adnan, Carlino Matteo, Meniawy Tarek, Ansstas George, Medina Theresa, Taylor Matthew H, Kim Kevin B, Mckean Meredith, Long Georgina V, Sullivan Ryan J, Faries Mark, Tran Thuy, Cowey Charles, Pecora Andrew, Segar Jennifer, Atkinson Victoria, Gibney Geoffrey T, Luke Jason, Thomas Sajeve, Buchbinder Elizabeth, Hou Peijie, Zhu Lili, Zaks Tal, Brown Michelle, Aanur Praveen, Meehan Robert S, Weber Jeffrey S, "A Personalized Cancer Vaccine, mRNA-4157 (V940), Combined With Pembrolizumab Versus Pembrolizumab Alone in Patients With Resected High-risk Melanoma: Efficacy and Safety Results From the Randomized, Open-label Phase 2 mRNA-4157-P201/KEYNOTE-942 Trial", AACR ANNUAL MEETING 2023 April 14 - 19, 2023, Orlando, Florida, USA, AACR, (20230401), pages 1 - 23, XP093142420
OPPOSITION- Kozak, M., "Regulation of translation via mRNA structure in prokaryotes and eukaryotes", Gene, Elsevier Amsterdam, NL, NL , (20051121), vol. 361, ISSN 0378-1119, pages 13 - 37, XP027872452
OPPOSITION- LIMBACH P A, CRAIN P F, MCCLOSKEY J A, "SUMMARY: THE MODIFIED NUCLEOSIDES OF RNA", Nucleic Acids Research, Oxford University Press, GB, GB , (19940625), vol. 22, no. 12, ISSN 0305-1048, pages 2183 - 2196, XP001152667
OPPOSITION- Modernatx, Inc., "A Study of mRNA-3745 in Adult and Pediatric Participants With Glycogen Storage Disease Type 1a (GSD1a)", ClinicalTrials.gov, NLM, (20231013), pages 1 - 13, ClinicalTrials.gov, URL: https://clinicaltrials.gov/study/NCT05095727?tab=history&a=13, (20240318), XP093142415
OPPOSITION- Moltmann David P., Nanette Pazdernik, "1. Grundlagen der Biotechnologie ", Molekulare Biotechnologie, Elsevier Inc. , (20090101), pages 1 - 6, ISBN 978-3-8274-2128-9, XP093190484
OPPOSITION- Nucleic Acids in Innate Immunity, (20080000), pages 1 - 304
OPPOSITION- Pang, Et Al., " Structure of a Modified Nucleoside in Archaebacterial tRNA Which Replaces Ribosylthymine. 1-Methylpseudouridine", The Journal of Biological Chemistry, (19820410), vol. 257, no. 7, pages 3589 - 3592, XP055959978
OPPOSITION- Roger J. Williams (ed.), "Passages", Roger J. Williams (ed.), Roger J. Williams (ed.), The Encyclopedia of Biochemistry, New York, Reinhold Publishing Company, (19670101), pages 513 - 693, XP009552808
OPPOSITION- S. A. Ivanov ; R. Welz ; M. B. Gottikh ; S. Müller, "RNA Synthesis by T7 RNA Polymerase Supported Primer Extension", Molecular Biology, Kluwer Academic Publishers-Plenum Publishers, Ne, Ne , (20040901), vol. 38, no. 5, ISSN 1608-3245, pages 674 - 679, XP019288266
OPPOSITION- WET DE J. R., ET AL., "FIREFLY LUCIFERASE GENE: STRUCTURE AND EXPRESSION IN MAMMALIAN CELLS.", MOLECULAR AND CELLULAR BIOLOGY, American Society for Pharmacology and Experimental Therapeutics, US, US , (19870201), vol. 07., no. 02., ISSN 0270-7306, pages 725 - 737., XP000563624
OPPOSITION- Pascolo Steve, "Vaccination with messenger RNA (mRNA)", Drug Transporters - Part of the Handbook of Experimental Pharmacology book series (HEP, volume 201) ISSN 0171-2004, SPRINGER VERLAG, BERLIN, DE, BERLIN, DE , (20080101), no. 183, doi:10.1007/978-3-540-72167-3_11, ISSN 0171-2004, ISBN 978-3-642-14540-7, pages 221 - 235, XP001538300
OPPOSITION- MILLIGAN J F, UHLENBECK O C, "SYNTHESIS OF SMALL RNAS USING T7 RNA POLYMERASE", Methods in Enzymology, NL , (19890101), vol. 180, doi:10.1016/0076-6879(89)80091-6, ISBN 978-0-12-805382-9, pages 51 - 62, XP008025566
OPPOSITION- Chang, Y.C. et al, "Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives", Bioorganic & Medicinal Chemistry, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20071119), vol. 16, no. 5, doi:10.1016/j.bmc.2007.11.039, ISSN 0968-0896, pages 2676 - 2686, XP022526163
OPPOSITION- Feng Qian et al, "MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells", Cell Reports, Elsevier Inc, US, US , (20121101), vol. 2, no. 5, doi:10.1016/j.celrep.2012.10.005, ISSN 2211-1247, pages 1187 - 1196, XP093032411
OPPOSITION- Karikó K. et al, "Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA", Immunity, Cell Press, AMSTERDAM, NL, AMSTERDAM, NL , (20050801), vol. 23, no. 2, doi:10.1016/J.IMMUNI.2005.06.008, ISSN 1074-7613, pages 165 - 175, XP002634064
OPPOSITION- Zhang Zhikuan et al, "Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA", Immunity, Cell Press, AMSTERDAM, NL, AMSTERDAM, NL , (20161011), vol. 45, no. 4, doi:10.1016/j.immuni.2016.09.011, ISSN 1074-7613, pages 737 - 748, XP029771338
OPPOSITION- Oliwia Andries, Séan Mc Cafferty, Stefaan C. De Smedt, Ron Weiss, Niek N. Sanders, Tasuku Kitada, "N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice", Journal of Controlled Release, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL , (20151101), vol. 217, doi:10.1016/j.jconrel.2015.08.051, ISSN 0168-3659, pages 337 - 344, XP055231071
OPPOSITION- KARIKO et al., "Phosphate-enhanced transfection of cationic lipid-complexed mRNA and plasmid DNA", Biochim Biophys Acta, (19980302), vol. 1369, doi:10.1016/S0005-2736(97)00238-1, pages 320 - 334, XP001030876
OPPOSITION- KARIKO K, ET AL., "PHOSPHATE-ENHANCED TRANSFECTION OF CATIONIC LIPID-COMPLEXED MRNA AND PLASMID DNA", BIOCHIMICA ET BIOPHYSICA ACTA., ELSEVIER, NL, NL , (19980101), vol. 1369, no. 02, doi:10.1016/S0005-2736(97)00238-1, ISSN 0006-3002, pages 320 - 334, XP001030876
OPPOSITION- MATSUMOTO MISAKO, ET AL., "Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.", Biochemical and Biophysical Research Communications, Elsevier, Amsterdam NL, Amsterdam NL , (20020524), vol. 293, no. 5, doi:10.1016/S0006-291X(02)00380-7, ISSN 0006-291X, pages 1364 - 1369, XP002974969
OPPOSITION- Kremsner Peter G; Ahuad Guerrero Rodolfo Andrés; Arana-Arri Eunate; Aroca Martinez Gustavo Jose; Bonten Marc; Chandler Reynaldo; Corral Gonzalo; De Block Eddie Jan Louis; Ecker Lucie; Gabor Julian Justin; Garcia Lopez Carlos Alberto; Gonzales Lucy; Granados González María Angélica; Gorini Nestor; Grobusch Martin P; Hrabar Adrian D; Junker Helga; Kimura Alan; Lanata Claudio F; Lehmann Clara; Leroux-Roels Isabel; Mann Philipp; Martinez-Reséndez Michel Fernando; Ochoa Theresa J; Poy Carlos Alberto; Reyes Fentanes Maria Jose; Rivera Mejia Luis Maria; Ruiz Herrera Vida Veronica; Sáez-Llorens Xavier; Schönborn-Kellenberger Oliver; Schunk Mirjam; Sierra Garcia Alexandra; Vergara Itziar; Verstraeten Thomas; Vico Marisa; Oostvogels Lidia, "Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial", The Lancet Infectious Diseases, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20211123), vol. 22, no. 3, doi:10.1016/S1473-3099(21)00677-0, ISSN 1473-3099, pages 329 - 340, XP086971161
OPPOSITION- Nance Kellie D., Meier Jordan L., "Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines", ACS Central Science, (20210526), vol. 7, no. 5, doi:10.1021/acscentsci.1c00197, ISSN 2374-7943, pages 748 - 756, XP093017009
OPPOSITION- ALEXOPOULOU L, ET AL., "Recognition of double-stranded RNA and activation of NF-kB by toll-like receptor 3", Nature, Nature Publishing Group UK, London, London, (20011018), vol. 413, doi:10.1038/35099560, ISSN 0028-0836, pages 732 - 738, XP002968529
OPPOSITION- Dolgin Elie, "TRIAL SETTLES DEBATE OVER BEST DESIGN FOR MRNA IN COVID VACCINES", Nature, Springer Nature Limited, (20230119), vol. 613, no. 7944, doi:10.1038/d41586-023-00042-z, ISSN 0028-0836, pages 419 - 420, XP093119100
OPPOSITION- KARIKÓ KATALIN ET AL, "Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability.", Molecular Therapy, Nature Publishing Group, GB, GB , (20081101), vol. 16, no. 11, doi:10.1038/mt.2008.200, ISSN 1525-0024, pages 1833 - 1840, XP002598556
OPPOSITION- Karikó Katalin, Hiromi Muramatsu, Frank A Welsh, János Ludwig, Hiroki Kato, Shizuo Akira, Drew Weissman, "Supplementary Material: Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability", Molecular Therapy, Nature Publishing Group, GB, GB , (20081101), vol. 16, no. 11, doi:10.1038/mt.2008.200, ISSN 1525-0024, pages 1 - 7, XP093142222
OPPOSITION- Karikó Katalin, Muramatsu Hiromi, Welsh Frank A, Ludwig János, Kato Hiroki, Akira Shizuo, Weissman Drew, "Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability /NIH Author Manuscript/", Molecular Therapy, Elsevier Inc., US, US , (20081101), vol. 16, no. 11, doi:10.1038/mt.2008.200, ISSN 1525-0016, pages 1833 - 1840, XP055920956
OPPOSITION- KARIKÓ K et al., "Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability", Mol Ther, (20081100), vol. 16, no. 11, doi:10.1038/mt.2008.200, pages 1833 - 40, XP055920956
OPPOSITION- Jiang Lei, Park Ji-Sun, Yin Ling, Laureano Rodrigo, Jacquinet Eric, Yang Jinsong, Liang Shi, Frassetto Andrea, Zhuo Jenny, Yan Xinhua, Zhu Xuling, Fortucci Steven, Hoar Kara, Mihai Cosmin, Tunkey Christopher, Presnyak Vlad, Benenato Kerry E., Lukacs Christine M., Martini Paolo G. V., Guey Lin T., "Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia", Nature Communications, (20201201), vol. 11, no. 1, doi:10.1038/s41467-020-19156-3, XP055979035
OPPOSITION- Cao Jingsong, Choi Minjung, Guadagnin Eleonora, Soty Maud, Silva Marine, Verzieux Vincent, Weisser Edward, Markel Arianna, Zhuo Jenny, Liang Shi, Yin Ling, Frassetto Andrea, Graham Anne-Renee, Burke Kristine, Ketova Tatiana, Mihai Cosmin, Zalinger Zach, Levy Becca, Besin Gilles, Wolfrom Meredith, Tran Barbara, Tunkey Christopher, Owen Erik, Sarkis Joe, Dousis Athanasios, Presnyak Vladimir, Pepin Christopher, Zheng Wei, Ci Lei, Hard Marjie, Miracco Edward, Rice Lisa, Nguyen Vi, Zimmer Mike, Rajarajacholan Uma, Finn Patrick F., Mithieux Gilles, Rajas Fabienne, Martini Paolo G. V., Giangrande Paloma H., "mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease", Nature Communications, (20210525), vol. 12, no. 1, doi:10.1038/s41467-021-23318-2, pages 3090 - 3103, XP055838215
OPPOSITION- Chen Tien-Hao, Potapov Vladimir, Dai Nan, Ong Jennifer L., Roy Bijoyita, "N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs", Scientific Reports, vol. 12, no. 1, doi:10.1038/s41598-022-17249-1, XP093066725
OPPOSITION- Lebre Maria C., Van Der Aar Angelic M.G., Van Baarsen Lisa, Van Capel Toni M.M., Schuitemaker Joost H.N., Kapsenberg Martien L., De Jong Esther C., "Human Keratinocytes Express Functional Toll-Like Receptor 3, 4, 5, and 9", Journal of Investigative Dermatology, Elsevier, NL, NL , (20070201), vol. 127, no. 2, doi:10.1038/sj.jid.5700530, ISSN 0022-202X, pages 331 - 341, XP093144547
OPPOSITION- KARIKO K ET AL, "mRNA Is an Endogenous Ligand for Toll-like Receptor 3", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20040326), vol. 279, no. 13, doi:10.1074/JBC.M310175200, ISSN 0021-9258, pages 12542 - 12550, XP002598534
OPPOSITION- Conrad Frank, Hanne Andreas, Gaur Rajesh K., Krupp Guido, "Enzymatic synthesis of 2′-modified nucleic acids: identification of important phosphate and ribose moieties in RNase P substrates", Nucleic Acids Research, GB , (19950101), vol. 23, no. 11, doi:10.1093/nar/23.11.1845, ISSN 0305-1048, pages 1845 - 1853, XP093033590
OPPOSITION- Mccloskey J. A., Graham David E, Zhou Shaolian, Crain Pamela F, Ibba Michael, Konisky Jordan, Söll Dieter, Olsen Gary J, "Post-transcriptional modification in archaeal tRNAs: identities and phylogenetic relations of nucleotides from mesophilic and hyperthermophilic Methanococcales", Nucleic Acids Research, (20011115), vol. 29, no. 22, doi:10.1093/nar/29.22.4699, pages 4699 - 4706, XP093032711
OPPOSITION- Sprinzl Mathias, Vassilenko Konstantin S., "Compilation of tRNA sequences and sequences of tRNA genes", Nucleic Acids Research, Oxford University Press, England, England, doi:10.1093/nar/gki012, (20050101), pages 148 - 153, Nucleic Acids Research, URL: https://watermark.silverchair.com/26-1-148.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAtUwggLRBgkqhkiG9w0BBwagggLCMIICvgIBADCCArcGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMoNLP7qBIwNEqjfciAgEQgIICiHNcIZyZBCFA3Z0ttK4G_EIDDZIfls0gK8p2CTrPMgaUovPzSPYuM8ithMDg4QmOH9KDS8x_tdY-sw9FLD5WwR84-FUu0W2tW5baC-SrgITtSXI1r_d37qwU1i_6nDia5koxmgxOvCv9Ff6yMGPp9M99IQnLqztV8InPlY4ilSXp6fvqUHqEOpLLtWKSugrJm_nz_B3vjPf40uW2qk3Imd7rlz6hNrkEjHroaE_bgdAwWDmTp45wTRcMunKDaTphWbwhYuYJOL1IPs1Y6JZaCnvo1o1ghn2cn5lQDIOFYJlTTM4uxlIyZ6gOiy-CaCDkMZWW6XsaHucJOodXv12AyfVdreuVPf8oBW5W93qd3H438ZlFASySj7sBzcRrqiOIwIZJ_ZSR7Fkl-OlZBcOzC4yxZMfVV16o3NTB7J6QdSL2NbqL0J5oDrCYFNoKhCCqmYr-XbLerUFb4WP423wbEWkWmkLy8UdHSdUY9gnEWbVNlu9htiRg_u14aPgeI5RjcTYMW3LT4wdXwjvTlTL34s4vm7u4bYQJ_4hnP3Lz3uiAa6RY7JingJTXs_-ltL1Ta_lRVBoQvbJrmEsJ-XwIY-iOjW-CVZMUoEQO0jTEq5A-o__uNlN7RV3mOeabPoiG4otJ4T7DT0YA_b7CMevHyviNWdKGvlxytGhezDC3q2AkJaed3QZXQvb4GjxhHjcXzfrz88tm44cljtGO87tcjR7_tHyyngO8qHV-RQr5LE_dUFr8k25kxaRl0GUroVtZGUd8f_oqWAflth6zVYN4UUv, (20230317), XP093032707
OPPOSITION- Helm M., "Post-transcriptional nucleotide modification and alternative folding of RNA", Nucleic Acids Research, Oxford University Press, GB, GB , (20060130), vol. 34, no. 2, doi:10.1093/nar/gkj471, ISSN 0305-1048, pages 721 - 733, XP093028815
OPPOSITION- Oliva R., Cavallo Luigi, Tramontano Anna, "Accurate energies of hydrogen bonded nucleic acid base pairs and triplets in tRNA tertiary interactions", Nucleic Acids Research, Oxford University Press, GB, GB , (20060206), vol. 34, no. 3, doi:10.1093/nar/gkj491, ISSN 0305-1048, pages 865 - 879, XP093028810
OPPOSITION- Wurm Jan Philip, Meyer Britta, Bahr Ute, Held Martin, Frolow Olga, Kötter Peter, Engels Joachim W., Heckel Alexander, Karas Michael, Entian Karl-Dieter, Wöhnert Jens, "The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase", Nucleic Acids Research, Oxford University Press, GB, GB , (20100401), vol. 38, no. 7, doi:10.1093/nar/gkp1189, ISSN 0305-1048, pages 2387 - 2398, XP093032700
OPPOSITION- Song Hyun-Joo, Gallie Daniel R., Duncan Roger F., "m7GpppG Cap Dependence for Efficient Translation of Drosophila 70-kDa Heat-Shock-Protein (Hsp70) mRNA", European Journal of Biochemistry, Published by Springer-Verlag on behalf of the Federation of European Biochemical Societies, (19950901), vol. 232, no. 3, doi:10.1111/j.1432-1033.1995.0778a.x, ISSN 0014-2956, pages 778 - 788, XP093032722
OPPOSITION- Sandra S. Diebold et al, "Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.", Science, American Association for the Advancement of Science, US, US , (20040305), vol. 303, no. 5663, doi:10.1126/science.1093616, ISSN 0036-8075, pages 1529 - 1531, XP002675306
OPPOSITION- HEIL F et al, "Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8", SCIENCE, (20040101), vol. 303, doi:10.1126/science.1093620, pages 1526 - 1529, XP002775831
OPPOSITION- Motorin Yuri, Grosjean Henri, "Appendix 1: Chemical Structures and Classification of Posttranscriptionally Modified Nucleosides in RNA ", Motorin Yuri, Grosjean Henri, Grosjean Henri; Benne Rob, Modification and Editing of RNA, ASM Press, (19980428), pages 543 - 549, doi:10.1128/9781555818296.app1, XP093176157
OPPOSITION- Zhou Y, Giordano T. J, Durbin R. K, Mcallister W. T, "Synthesis of functional mRNA in mammalian cells by bacteriophage T3 RNA polymerase", MOLECULAR AND CELLULAR BIOLOGY, American Society for Pharmacology and Experimental Therapeutics, US, US , (19900901), vol. 10, no. 9, doi:10.1128/MCB.10.9.4529, ISSN 0270-7306, pages 4529 - 4537, XP093178193
OPPOSITION- Zhou Y, Giordano T. J, Durbin R. K, Mcallister W. T, "Synthesis of functional mRNA in mammalian cells by bacteriophage T3 RNA polymerase", Molecular and cellular biology, US , (19900901), vol. 10, no. 9, doi:10.1128/MCB.10.9.4529, ISSN 0270-7306, pages 4529 - 4537, XP093178193
OPPOSITION- Pelletier Jerry, Sonenberg Nahum, "The involvement of mRNA secondary structure in protein synthesis", BIOCHEMISTRY AND CELL BIOLOGY. BIOCHIMIE ET BIOLOGIE CELLULAIRE., NRC Research Press, CA, CA , (19870601), vol. 65, no. 6, doi:10.1139/o87-074, ISSN 0829-8211, pages 576 - 581, XP009552798
OPPOSITION- PASCOLO, "Vaccination With Messenger RNA", DNA Vaccines: Methods and Protocols, (20060822), vol. 3, pages 23 - 40, XP009117840
SEARCH- KARIK� KATALIN ET AL, "Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability", MOLECULAR THERAPY, NATURE PUBLISHING GROUP, GB, vol. 16, no. 11, doi:10.1038/MT.2008.200, ISSN 1525-0024, (20081101), pages 1833 - 1840, (20080916), XP002598556 [A] 1-12 * the whole document *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents