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| OPPOSITION | - E. John Wherry, Ha Sang-Jun, Kaech Susan M., Haining W. Nicholas, Sarkar Surojit, Kalia Vandana, Subramaniam Shruti, Blattman Joseph N., Barber Daniel L., Ahmed Rafi, "Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection", Immunity, Cell Press, AMSTERDAM, NL, AMSTERDAM, NL , (20071001), vol. 27, no. 4, doi:10.1016/j.immuni.2007.09.006, ISSN 1074-7613, pages 670 - 684, XP055294900 | |
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| OPPOSITION | - Liu Yang, Zheng Pan, "How Does an Anti-CTLA4 Antibody Promote Cancer Immunity? - PMC", Trend Immunol., doi:10.1016/j.it.2018.10.009, (20181201), pages 953 - 956, Trend Immunol., URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589807/, (20240409), XP093149790 | |
| OPPOSITION | - Korman Alan J; Peggs Karl S; Allison James P, "Checkpoint blockade in cancer immunotherapy.", ADVANCES IN IMMUNOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, US , (20060101), vol. 90, doi:10.1016/S0065-2776(06)90008-X, ISSN 0065-2776, pages 297 - 339, XP009101810 | |
| OPPOSITION | - KORMAN et al., "Checkpoint Blockade in Cancer D8 May 24, 2006 Immunotherapy", Adv Immunol, (20060000), vol. 90, doi:10.1016/S0065-2776(06)90008-X, pages 297 - 339, XP009101810 | |
| OPPOSITION | - Demeure, C.E. Wolfers, J. Martin-Garcia, N. Gaulard, P. Triebel, F., "T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts", European Journal of Cancer, Elsevier, 34th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona, Spain, 34th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona, Spain, (20010901), vol. 37, no. 13, doi:10.1016/S0959-8049(01)00184-8, ISSN 0959-8049, pages 1709 - 1718, XP004301143 | |
| OPPOSITION | - G. Tau; P. Rothman, "Biologic functions of the IFN‐γ receptors", ALLERGY, Wiley-Blackwell Publishing Ltd., United Kingdom, United Kingdom , (20011224), vol. 54, no. 12, doi:10.1034/j.1398-9995.1999.00099.x, ISSN 0105-4538, pages 1233 - 1251, XP071457196 | |
| OPPOSITION | - Daniel L. Barber, E. John Wherry, David Masopust, Baogong Zhu, James P. Allison, Arlene H. Sharpe, Gordon J. Freeman, Rafi Ahmed, "Restoring function in exhausted CD8 T cells during chronic viral infection", Nature, ¬Macmillan Journals Ltd., etc.|, (20060209), vol. 439, no. 7077, doi:10.1038/nature04444, ISSN 00280836, pages 682 - 687, XP055198624 | |
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| OPPOSITION | - Shawn D Blackburn, Shin Haina, Haining W Nicholas, Zou Tao, Workman Creg J, Polley Antonio, Betts Michael R, Freeman Gordon J, Vignali Dario A A, Wherry E John, "Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection", Nature Immunology, Nature America Inc., (20090101), vol. 10, no. 1, doi:10.1038/ni.1679, ISSN 15292908, pages 29 - 37, XP055047746 | |
| OPPOSITION | - IGNACIO MELERO, SANDRA HERVAS-STUBBS, MARTIN GLENNIE, DREW M PARDOLL, LIEPING CHEN, "Immunostimulatory monoclonal antibodies for cancer therapy.", Nature Reviews Cancer, Nature Pub. Group, London, London , (20070201), vol. 7, no. 2, doi:10.1038/NRC2051, ISSN 1474-175X, pages 95 - 106, XP002716002 | |
| OPPOSITION | - Kubli Shawn P.; Berger Thorsten; Araujo Daniel V.; Siu Lillian L.; Mak Tak W., "Beyond immune checkpoint blockade: emerging immunological strategies", Nature Reviews Drug Discovery, Nature Publishing Group, GB, GB , (20210308), vol. 20, no. 12, doi:10.1038/s41573-021-00155-y, ISSN 1474-1776, pages 899 - 919, XP037630513 | |
| OPPOSITION | - WALDMAN AD et al., "A guide to cancer immunotherapy: from T cell basic science to clinical practice", Nat Rev Immunol., (20201100), vol. 20, no. 11, doi:10.1038/s41577-020-0306-5, pages 651 - 668, XP037277893 | |
| OPPOSITION | - J Maher, "Targeting cytotoxic T lymphocytes for cancer immunotherapy", British Journal of Cancer, Nature Publishing Group UK, London, London, (20040801), vol. 91, no. 5, doi:10.1038/sj.bjc.6602022, ISSN 0007-0920, pages 817 - 821, XP093161907 | |
| OPPOSITION | - Wherry E. John, Barber Daniel L., Kaech Susan M., Blattman Joseph N., Ahmed Rafi, "Antigen-independent memory CD8 T cells do not develop during chronic viral infection", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20041109), vol. 101, no. 45, doi:10.1073/pnas.0407192101, ISSN 0027-8424, pages 16004 - 16009, XP093149711 | |
| OPPOSITION | - IWAI Y et al., "Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade", Proc Natl Acad Sci USA., (20020917), vol. 99, no. 19, doi:10.1073/pnas.192461099, pages 12293 - 7, XP055572034 | |
| OPPOSITION | - TRIEBEL F., ET AL., "LAG-3 A NOVEL LYMPHOCYTE ACTIVATION GENE CLOSELY RELATED TO CD4.", Journal of Experimental Medicine, Rockefeller University Press, US, US , (19900501), vol. 171., no. 05., doi:10.1084/jem.171.5.1393, ISSN 0022-1007, pages 1393 - 1405., XP000672284 | |
| OPPOSITION | - BAIXERAS E. ET AL., "CHARACTERIZATION OF THE LYMPHOCYTE ACTIVATION GENE 3-ENCODED PROTEIN. A NEW LIGAND FOR HUMAN LEUKOCYTE ANTIGEN CLASS II ANTIGENS", Journal of Experimental Medicine, Rockefeller University Press, US, US , (19920801), vol. 176, no. 02, doi:10.1084/jem.176.2.327, ISSN 0022-1007, pages 327 - 337, XP000672285 | |
| OPPOSITION | - SUTMULLER et al., "Synergism of Cytotoxic T Lymphocyte- associated Antigen 4 Blockade and Depletion of CD 25(+) Regulatory T Cells in antitumor Therapy September 17, D14 Reveals Alternative Pathways for Suppression of 2001 Autoreactive Cytotoxic T Lymphocyte Responses", J Exp Med, (20010000), vol. 194, no. 6, doi:10.1084/jem.194.6.823, pages 823 - 32, XP008040742 | |
| OPPOSITION | - Alejandro V. Villarino, Cristina M Tato, Jason S Stumhofer, Zhengju Yao, Yongzhi K Cui, Lothar Hennighausen, John J O'Shea, Christopher A Hunter, "Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals", Journal of Experimental Medicine, Rockefeller University Press, US, US , (20070122), vol. 204, no. 1, doi:10.1084/jem.20061198, ISSN 0022-1007, pages 65 - 71, XP093161917 | |
| OPPOSITION | - IWAI Y et al., "PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells", Int Immunol., (20050200), vol. 17, no. 2, doi:10.1093/intimm/dxh194, pages 133 - 44, XP055142463 | |
| OPPOSITION | - James C Yang, Marybeth Hughes, Udai Kammula, Richard Royal, Richard M Sherry, Suzanne L Topalian, Kimberly B Suri, Catherine Levy, Tamika Allen, Sharon Mavroukakis, Israel Lowy, Donald E White, Steven A Rosenberg, "Ipilimumab (Anti-CTLA4 Antibody) Causes Regression of Metastatic Renal Cell Cancer Associated With Enteritis and Hypophysitis", Journal of Immunotherapy, US , (20071101), vol. 30, no. 8, doi:10.1097/CJI.0b013e318156e47e, ISSN 1524-9557, pages 825 - 830, XP009553384 | |
| OPPOSITION | - Christopher A. Klebanoff; Luca Gattinoni; Nicholas P. Restifo, "CD8+ T‐cell memory in tumor immunology and immunotherapy", Immunological Reviews, Wiley-Blackwell Publishing, Inc., US, US , (20060613), vol. 211, no. 1, doi:10.1111/j.0105-2896.2006.00391.x, ISSN 0105-2896, pages 214 - 224, XP071455494 | |
| OPPOSITION | - C. B. JAGO; J. YATES; N. OLSEN SARAIVA CÂMARA; R. I. LECHLER; G. LOMBARDI, "Differential expression of CTLA‐4 among T cell subsets", Clinical and experimental immunology, Wiley-Blackwell Publishing Ltd., GB, GB , (20040505), vol. 136, no. 3, doi:10.1111/j.1365-2249.2004.02478.x, ISSN 0009-9104, pages 463 - 471, XP071082495 | |
| OPPOSITION | - MACON-LEMAITRE L, TRIEBEL F, "The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells", Cancer research, Wiley-Blackwell Publishing Ltd., GB, GB , (20050601), vol. 115, no. 2, doi:10.1111/j.1365-2567.2005.02145.x, ISSN 0019-2805, pages 170 - 178, XP002453818 | |
| OPPOSITION | - HA et al., "Manipulating both the inhibitory and stimulatory immune system towards the success of D13 July 8, 2008 therapeutic vaccination against chronic viral infections", Immunol Rev, (20080000), vol. 223, doi:10.1111/j.1600-065X.2008.00638.x, pages 317 - 33, XP009163923 | |
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| OPPOSITION | - Patrick Schöffski, "Phase I/II study of the LAG-3 inhibitor ieramilimab (LAG525) ± anti-PD-1 spartalizumab (PDR001) in patients with advanced malignancies", Journal for ImmunoTherapy of Cancer, BioMed Central, London, GB, GB , (20220201), vol. 10, no. 2, doi:10.1136/jitc-2021-003776, ISSN 2051-1426, page e003776, XP093159113 | |
| OPPOSITION | - Charu Aggarwal, Amy Prawira, Scott Antonia, Osama Rahma, Anthony Tolcher, Roger B Cohen, Yanyan Lou, Ralph Hauke, Nicholas Vogelzang, Dan P Zandberg, Arash Rezazadeh Kalebasty, Victoria Atkinson, Alex A Adjei, ahesh Seetharam, Ariel Birnbaum, Andrew Weickhardt, Vinod Ganju, Anthony M Joshua, Rosetta Cavallo, Linda Peng, Xiaoyu Zhang, Sanjeev Kaul, Jan Baughman, Ezio Bonvini, Paul A Moore, Stacie M Goldberg, Fernanda I Arnaldez, Robert L Ferris, Nehal J Lakhani, "Dual checkpoint targeting of B7-H3 and PD-1 with enoblituzumab and pembrolizumab in advanced solid tumors: interim results from a multicenter phase I/II trial", Journal for ImmunoTherapy of Cancer, BioMed Central, London, GB, GB , (20220401), vol. 10, no. 4, doi:10.1136/jitc-2021-004424, ISSN 2051-1426, page e004424, XP093161911 | |
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| OPPOSITION | - Biagi Ettore, Rousseau Raphael, Yvon Eric, Schwartz Mary, Dotti Gianpietro, Foster Aaron, Havlik-Cooper Diana, Grilley Bambi, Gee Adrian, Baker Kelty, Carrum George, Rice Lawrence, Andreeff Michael, Popat Uday, Brenner Malcolm, "Responses to Human CD40 Ligand/Human Interleukin-2 Autologous Cell Vaccine in Patients with B-Cell Chronic Lymphocytic Leukemia", Clinical Cancer Research, Association for Cancer Research, US, US, (20051001), vol. 11, no. 19, doi:10.1158/1078-0432.CCR-05-0484, ISSN 1078-0432, pages 6916 - 6923, XP093149674 | |
| OPPOSITION | - BERGER RAANAN ET AL, "Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies.", Clinical Cancer Research, Association for Cancer Research, US, US, (20080515), vol. 14, no. 10, doi:10.1158/1078-0432.CCR-07-4079, ISSN 1078-0432, pages 3044 - 3051, XP002524925 | |
| OPPOSITION | - S. Chen, L.-F. Lee, T. S. Fisher, B. Jessen, M. Elliott, W. Evering, K. Logronio, G. H. Tu, K. Tsaparikos, X. Li, H. Wang, C. Ying, M. Xiong, T. Vanarsdale, J. C. Lin, "Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model", Cancer Immunology Research, American Association for Cancer Research, US, US , (20150201), vol. 3, no. 2, doi:10.1158/2326-6066.CIR-14-0118, ISSN 2326-6066, pages 149 - 160, XP055373998 | |
| OPPOSITION | - GROSSO et al., "LAG-3 regulates CD 8+ T cell accumulation October 11, D6 and effector function in murine self- and tumor- - 2007 tolerance systems", J Clin Invest, (20070000), vol. 117, no. 11, doi:10.1172/JCI31184, pages 3383 - 92, XP055463609 | |
| OPPOSITION | - GROSSO JF et al., "LAG-3 regulates CD 8+ T cell accumulation and effector function in murine self- and tumor-tolerance system s", J Clin Invest., (20071100), vol. 117, no. 11, doi:10.1172/JCI31184, pages 3383 - 92, XP055463609 | |
| OPPOSITION | - Joseph F. Grosso, Kelleher Cristin C., Harris Timothy J., Maris Charles H., Hipkiss Edward L., De Marzo Angelo, Anders Robert, Netto George, Getnet Derese, Bruno Tullia C., Goldberg Monica V., Pardoll Drew M., Drake Charles G., "LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems", The Journal of Clinical Investigation, B M J Group, (20071101), vol. 117, no. 11, doi:10.1172/JCI31184, pages 3383 - 3392, XP055463609 | |
| OPPOSITION | - Fumihiko Tsushima, Sheng Yao, Tahiro Shin, Andrew Flies, Sarah Flies, Haiying Xu, Koji Tamada, Drew M Pardoll, Lieping Chen, "Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy", Blood, American Society of Hematology, US, US , (20070701), vol. 110, no. 1, doi:10.1182/blood-2006-11-060087, ISSN 0006-4971, pages 180 - 185, XP093161914 | |
| OPPOSITION | - M. V. Goldberg, C. H. Maris, E. L. Hipkiss, A. S. Flies, L. Zhen, R. M. Tuder, J. F. Grosso, T. J. Harris, D. Getnet, K. A. Whartenby, D. G. Brockstedt, T. W. Dubensky, L. Chen, D. M. Pardoll, C. G. Drake, "Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells", Blood, (20070701), vol. 110, no. 1, doi:10.1182/blood-2006-12-062422, ISSN 00064971, pages 186 - 192, XP055053809 | |
| OPPOSITION | - Wenyan Zhong, Jeremy S Myers, Fang Wang, Kai Wang, Justin Lucas, Edward Rosfjord, Judy Lucas, Andrea T Hooper, Sharon Yang, Lu Anna Lemon, Magali Guffroy, Chad May, Jadwiga R Bienkowska, Paul A Rejto , "Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors", BMC Genomics, BioMed Central Ltd, London, UK, London, UK , (20201201), vol. 21, no. 1, doi:10.1186/s12864-019-6344-3, ISSN 1471-2164, XP093161919 | |
| OPPOSITION | - W Gerritsen, A J Van Den Eertwegh, T De Guiijl, G Giaccone, R J Scheper, I Lowy Et Al., "A dose-escalation trial of GM-CSF- gene transduced allogeneic prostate cancer cellular immunotherapy in combination with a fully human anti-CTLA antibody", Journal of Clinical Oncology, doi:10.1200/jco.2006.24. 18_suppl.2500, (20060101), pages 1 - 5, Journal of Clinical Oncology, URL: https://ascopubs.org/doi/abs/10.1200/jco.2006.24.18_suppl.2500, (20190320), XP055571934 | |
| OPPOSITION | - A. Ribas, D. C. Hanson, D. A. Noe, R. Millham, D. J. Guyot, S. H. Bernstein, P. C. Canniff, A. Sharma, J. Gomez-Navarro, "Tremelimumab (CP-675,206), a Cytotoxic T Lymphocyte Associated Antigen 4 Blocking Monoclonal Antibody in Clinical Development for Patients with Cancer", THE ONCOLOGIST, (20070701), vol. 12, no. 7, doi:10.1634/theoncologist.12-7-873, ISSN 1083-7159, pages 873 - 883, XP055479375 | |
| OPPOSITION | - Xin Chen, Xiaomin Song, Kang Li, Tong Zhang, "FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy", Frontiers in Immunology, (20190101), vol. 10, doi:10.3389/fimmu.2019.00292, page 292, XP055672861 | |
| OPPOSITION | - Gajewski Thomas, Fallarino Francesca, Fields Patrick, Rivas Fabiola, Alegre Maria-Luisa, "Absence of CTLA-4 Lowers the Activation Threshold of Primed CDS* TCR- Transgenic T Cells: Lack of Correlation with Src Homology Domain 2- Containing Protein Tyrosine Phosphatase", The Journal of Immunology, Williams & Wilkins Co., US, US , (20010315), vol. 166, no. 6, doi:10.4049/jimmunol.166.6.3900, ISSN 0022-1767, pages 3900 - 3907, XP009554125 | |
| OPPOSITION | - Workman Creg J., Cauley Linda S., Kim In-Jeong, Blackman Marcia A., Woodland David L., Vignali Dario A. A., "Lymphocyte Activation Gene-3 (CD223) Regulates the Size of the Expanding T Cell Population Following Antigen Activation In Vivo", The Journal of Immunology, Williams & Wilkins Co., US, US , (20040501), vol. 172, no. 9, doi:10.4049/jimmunol.172.9.5450, ISSN 0022-1767, pages 5450 - 5455, XP093189536 | |
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| OPPOSITION | - Workman Creg J., Vignali Dario A. A., "Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)", The Journal of Immunology, Williams & Wilkins Co., US, US , (20050115), vol. 174, no. 2, doi:10.4049/jimmunol.174.2.688, ISSN 0022-1767, pages 688 - 695, XP055795103 | |
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| OPPOSITION | - Alan Korman, Bing Chen; Changyu Wang; Linda Wu; Pina Cardarelli; Mark Selby, "Activity of Anti-PD-1 in Murine Tumor Models: Role of “Host” PD-L1 and Synergistic Effect of Anti-PD-1 and Anti-CTLA-4 (48.37)", The Journal of Immunology, Williams & Wilkins Co., US, US , (20070401), vol. 178, no. 1_Supplement, doi:10.4049/jimmunol.178.Supp.48.37, ISSN 0022-1767, pages S82 - S82, XP093161905 | |
| OPPOSITION | - Angin Mathieu, Brignone Chrystelle, Triebel Frédéric, "A LAG-3-Specific Agonist Antibody for the Treatment of T Cell-Induced Autoimmune Diseases", The Journal of Immunology, Williams & Wilkins Co., US, US , (20200215), vol. 204, no. 4, doi:10.4049/jimmunol.1900823, ISSN 0022-1767, pages 810 - 818, XP093149677 | |
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