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The patent EP3626270 was granted to Novartis on Oct 11, 2023. The application was filed on Aug 26, 2014 under application number EP19202854A. The patent is currently recorded with a legal status of "Granted And Under Opposition".
Angiotensin Receptor Neprilysin Inhibitors (ARNIs) and combined ARBs with NEPi pro-drugs for the prevention or delay of cardiovascular mortality and hospitalization in heart failure patients. The ARNI/ARB combination therapy demonstrates significant mortality reduction in patients with reduced ejection fraction, a key population for heart failure treatment, compared to conventional ACE inhibitors. This dual-action approach combines the RAAS pathway's natural compensatory mechanisms with the NEP's N-terminal dipeptidyl peptidase-IV inhibitor properties, achieving sustained benefits beyond traditional treatments.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
| Company | Opposition Date | Representative | Opposition Status |
|---|---|---|---|
| ELPEN PHARMACEUTICAL | Jul 11, 2024 | HASELTINE LAKE KEMPNER | ADMISSIBLE |
| GENERICS UK | Jul 11, 2024 | ELKINGTON AND FIFE | ADMISSIBLE |
| LANYON OPPOSITIONS | Jul 11, 2024 | PINSENT MASONS | ADMISSIBLE |
| ZENTIVA KS | Jul 11, 2024 | GREINER | ADMISSIBLE |
| BULLE DR | Jul 10, 2024 | KUTZENBERGER WOLFF & PARTNER | ADMISSIBLE |
| CAMULON | Jul 10, 2024 | REDDIE & GROSE | ADMISSIBLE |
| DR SCHON | Jul 10, 2024 | DR SCHON | ADMISSIBLE |
| POLPHARMA | Jul 10, 2024 | HAMM & WITTKOPP | ADMISSIBLE |
| SYNTHON | Jul 10, 2024 | HOFFMANN EITLE | ADMISSIBLE |
| TEVA PHARMACEUTICALS | Jul 10, 2024 | D YOUNG | ADMISSIBLE |
| WUESTHOFF & WUESTHOFF | Jul 10, 2024 | SONNENHAUSER | ADMISSIBLE |
| HOFFMANN EITLE | Jul 9, 2024 | HOFFMANN EITLE | WITHDRAWN |
| EGIS | Jul 8, 2024 | STOLMAR & PARTNER | ADMISSIBLE |
| HAMM & WITTKOPP | Jul 5, 2024 | HAMM & WITTKOPP | ADMISSIBLE |
| HAMM & WITTKOPP | Jul 5, 2024 | HAMM & WITTKOPP | WITHDRAWN |
| BETAPHARM ARZNEIMITTEL | Jul 2, 2024 | HAMM & WITTKOPP | ADMISSIBLE |
| ALFRED E TIEFENBACHER | Jun 25, 2024 | HAMM & WITTKOPP | ADMISSIBLE |
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| DESCRIPTION | EP0443983 |
| DESCRIPTION | US5217996 |
| DESCRIPTION | US5399578 |
| DESCRIPTION | WO03059345 |
| DESCRIPTION | WO2007056546 |
| DESCRIPTION | WO2009061713 |
| DESCRIPTION | WO2014029848 |
| OPPOSITION | US2013158088 |
| OPPOSITION | WO03059345 |
| OPPOSITION | WO2007056546 |
| OPPOSITION | WO2015028941 |
| SEARCH | US2013158088 |
| SEARCH | WO2007056546 |
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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Oct 11, 2019
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