Use Of Trl Agonist And Anti-Cd47 Agent To Enhance Phagocytosis Of Cancer Cells - EP3656443

The patent EP3656443 was granted to The Board OF Trustees OF The Leland Stanford Junior University on Sep 29, 2021. The application was originally filed on Jan 21, 2016 under application number EP19197485A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3656443

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Application Number
EP19197485A
Filing Date
Jan 21, 2016
Status
Granted And Under Opposition
Aug 27, 2021
Publication Date
Sep 29, 2021
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

GENMABJun 29, 2022J A KEMPADMISSIBLE
PFIZERJun 29, 2022PFIZERADMISSIBLE

Patent Citations (18) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONWO2013US21937
DESCRIPTIONUS2010239579
DESCRIPTIONUS5624659
DESCRIPTIONUS5945098
DESCRIPTIONUS6174708
DESCRIPTIONUS6187287
DESCRIPTIONWO2011143624
OPPOSITIONUS2011070269
OPPOSITIONUS2013309244
OPPOSITIONWO2009091601
OPPOSITIONWO2011136828
OPPOSITIONWO2013119714
OPPOSITIONWO2014179132
OPPOSITIONWO2015105995
OPPOSITIONWO2016118754
SEARCHUS2011070269
SEARCHUS2013309244
SEARCHWO2011136828

Non-Patent Literature (NPL) Citations (55) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- BIRD et al., Science, (19880000), vol. 242, pages 423 - 426
DESCRIPTION- "Genbank", Database accession no. NP_003257.1
DESCRIPTION- HUSTON et al., Proc. Natl. Acad, Sci. USA, (19880000), vol. 85, pages 5879 - 5883
DESCRIPTION- MANNAFRAZIER, Cancer Research, (20040000), vol. 64, pages 1026 - 1036
OPPOSITION- Feng et al., "Supporting Information to: Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk", Proceedings of the National Academy of Sciences, (20150217), pages 1 - 8, XP055941122
OPPOSITION- Feng Mingye, Chen James Y., Weissman-Tsukamoto Rachel, Volkmer Jens-Peter, Ho Po Yi, Mckenna Kelly M., Cheshier Samuel, Zhang Michael, Guo Nan, Gip Phung, Mitra Siddhartha S., Weissman Irving L., "Supporting Information to: Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk", Proceedings of the National Academy of Sciences, (20150217), pages 1 - 8, XP055941122
OPPOSITION- Nika Cyrus, "The role of tumor-associated macrophages in human skin cancer.", Thesis Yale University, (20130101), URL: https://elischolar.library.yale.edu/cgi/viewcontent.cgi?article=1784&context=ymtdl, XP002782999
OPPOSITION- Rabinovitch Michel, "Professional and non-professional phagocytes: an introduction", Trends in Biology, (19950301), vol. 5, no. 3, pages 85 - 87, XP055941498
OPPOSITION- Rakoff-Nahoum Seth, Ruslan Medzhitov, "Toll-like receptors and cancer", Nature Reviews Cancer, (20090101), vol. 9, pages 57 - 63, XP055941491
OPPOSITION- Tseng et al., "Supporting Information to: Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response", Proceedings of the National Academy of Sciences, (20130702), pages 1 - 6, XP055941170
OPPOSITION- MAJETI, R. et al., "CD 47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells", Cell, (20090000), vol. 138, doi:10.1016/j.cell.2009.05.045, pages 286 - 299, XP055277135
OPPOSITION- Chao et al., "The CD47-SIRPa; pathway in cancer immune evasion and potential therapeutic implications", Current Opinion in Immunology, (20120401), vol. 24, no. 2, doi:10.1016/j.coi.2012.01.010, ISSN 09527915, pages 225 - 232, XP055029985
OPPOSITION- Mark P Chao, Weissman Irving L, Majeti Ravindra, "The CD47-SIRP&a; pathway in cancer immune evasion and potential therapeutic implications", Current Opinion in Immunology, (20120401), vol. 24, no. 2, doi:10.1016/j.coi.2012.01.010, ISSN 09527915, pages 225 - 232, XP055029985
OPPOSITION- JIN, M.S. et al., "Structures of the toll-like receptor family and its ligand complexes", Immunity, (20080000), vol. 29, no. 2, doi:10.1016/J.IMMUNI.2008.07.007, pages 182 - 191, XP002633061
OPPOSITION- QU, J. et al., "Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs", International Immunopharmacology, (20130000), vol. 17, no. 3, doi:10.1016/j.intimp.2013.08.013, pages 814 - 820, XP028761135
OPPOSITION- Chanput Wasaporn, Mes Jurriaan J., Wichers Harry J., "THP-1 cell line: An in vitro cell model for immune modulation approach", International Immunopharmacology, NL , (20141101), vol. 23, no. 1, doi:10.1016/j.intimp.2014.08.002, ISSN 1567-5769, pages 37 - 45, XP055941506
OPPOSITION- JAISWAL, S. et al., "Macrophages as mediators of tumor immunosurveillance", Trends in Immunology, (20100000), vol. 31, no. 6, doi:10.1016/j.it.2010.04.001, pages 212 - 219, XP027079216
OPPOSITION- Houot et al., "Targeting immune effector cells to promote antibody-induced cytotoxicity in cancer immunotherapy", Trends in immunology, GB , vol. 32, no. 11, doi:10.1016/j.it.2011.07.003, ISSN 1471-4906, pages 510 - 516, XP028324046
OPPOSITION- Onier N, Hilpert S, Arnould L, Saint-Giorgio V, Davies J G, Jeannin J F, "Cure of colon cancer metastasis in rats with the new lipid A OM 174. Apoptosis of tumor cells and immunization of rats", CLINICAL & EXPERIMENTAL METASTASIS, Dordrecht , (19990601), vol. 17, no. 4, doi:10.1023/A:1006663017149, ISSN 0262-0898, pages 299 - 306, XP055941465
OPPOSITION- Fang Ma et al., "The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice", Cellular & Molecular Immunology, London, (20100901), vol. 7, no. 5, doi:10.1038/cmi.2010.30, ISSN 1672-7681, pages 381 - 388, XP055371598
OPPOSITION- Brown Guy C., Jonas J. Neher, "Microglial phagocytosis of live neurons", Nature Reviews, Neuroscience, (20140401), vol. 15, no. 4, doi:10.1038/nrn3710, pages 209 - 216, XP055941470
OPPOSITION- Redelman-Sidi Gil, Glickman Michael S., Bochner Bernard H., "The mechanism of action of BCG therapy for bladder cancer — a current perspective", Nature reviews. Urology, US , (20140301), vol. 11, no. 3, doi:10.1038/nrurol.2014.15, ISSN 1759-4812, pages 153 - 162, XP055941485
OPPOSITION- S. B. Willingham, Volkmer J.-P., Gentles A. J., Sahoo D., Dalerba P., Mitra S. S., Wang J., Contreras-Trujillo H., Martin R., Cohen J. D., Lovelace P., Scheeren F. A., Chao M. P., Weiskopf K., Tang C., Volkmer A. K., Naik T. J., Storm T. A., Mosley A. R., Edris B., Schmid S. M., Sun C. K., Chua M.-S., Murillo O., Rajendran P., Cha A. C., Chin R. K., Kim D., Adorno M., Raveh T., Tseng D., Jaiswal S., Enger P. O., Steinberg G. K., Li G., So S. K., Majeti R., Harsh G. R., Van De Rijn M., Teng N. N. H., Sunwoo J. B., Alizadeh A. A., Clarke M. F., Weissman I. L., "The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors", Proceedings of the National Academy of Sciences, (20120424), vol. 109, no. 17, doi:10.1073/pnas.1121623109, ISSN 00278424, pages 6662 - 6667, XP055029983
OPPOSITION- TSENG, D. et al., "Anti- CD 47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T- cell response", Proceedings of the National Academy of Sciences, (20130000), vol. 110, no. 27, doi:10.1073/pnas.1305569110, pages 11103 - 11108, XP055245737
OPPOSITION- Tseng et al., "Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response", Proceedings of the National Academy of Sciences, (20130702), vol. 110, no. 27, doi:10.1073/pnas.1305569110, ISSN 0027-8424, pages 11103 - 11108, XP055245737
OPPOSITION- Feng et al., "Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk", Proceedings of the National Academy of Sciences, (20150217), vol. 112, no. 7, doi:10.1073/pnas.1424907112, ISSN 0027-8424, pages 2145 - 2150, XP055470309
OPPOSITION- FENG, M. et al., "Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk", Proceedings of the National Academy of Sciences, (20150000), vol. 112, no. 7, doi:10.1073/pnas.1424907112, pages 2145 - 2150, XP055470309
OPPOSITION- Ogden Carol Anne, Decathelineau Aimee, Hoffmann Peter R., Bratton Donna, Ghebrehiwet Berhane, Fadok Valerie A., Henson Peter M., "C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells", Journal of Experimental Medicine,, US , (20010917), vol. 194, no. 6, doi:10.1084/jem.194.6.781, ISSN 0022-1007, pages 781 - 796, XP055941480
OPPOSITION- KONG, X-N. et al., "LPS-induced down-regulation of signal regulatory protein alpha contributes to innate immune activation in macrophages", Journal of Experimental Medicine, (20070000), vol. 204, no. 11, doi:10.1084/jem.20062611, pages 2719 - 2731, XP055456730
OPPOSITION- A. P. A. Theocharides, L. Jin, P.-Y. Cheng, T. K. Prasolava, A. V. Malko, J. M. Ho, A. G. Poeppl, N. Van Rooijen, M. D. Minden, J. S. Danska, J. E. Dick, J. C. Y. Wang, "Disruption of SIRPa; signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts", Blood, US , (20120924), vol. 119, no. 18, doi:10.1182/blood-2011-11-391367, ISSN 0006-4971, pages 1883 - 1899, XP055126663
OPPOSITION- Theocharides et al., "Disruption of SIRPa; signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts", Blood, US , (20120924), vol. 119, no. 18, doi:10.1182/blood-2011-11-391367, ISSN 0006-4971, pages 1883 - 1899, XP055126663
OPPOSITION- "Workshop Sessions", Immunology, GB , (20120912), vol. 137, doi:10.1111/imm.12001, ISSN 0019-2805, pages 1 - 184, XP071276260
OPPOSITION- K. Weiskopf et al., "Supplementary Materials for: Engineered SIRPa variants as immunotherapeutic adjuvants to anti-cancer antibodies", Science, US , (20130705), doi:10.1126/science.1238856, ISSN 0036-8075, pages 1 - 36, XP055488633
OPPOSITION- Weiskopf et al., "Engineered SIRP  Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies", Science, US , (20130705), vol. 341, no. 6141, doi:10.1126/science.1238856, ISSN 0036-8075, pages 88 - 91, XP055223925
OPPOSITION- WEISKOPF K. et al., "Engineered SIRP Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies", Science, (20130000), vol. 341, no. 6141, doi:10.1126/science.1238856, pages 88 - 91, XP055223925
OPPOSITION- OKUSAWA, T. et al., "Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6", Infection and Immunity, (20040000), vol. 72, no. 3, doi:10.1128/IAI.72.3.1657-1665.2004, pages 1657 - 1665, XP002468539
OPPOSITION- Guiducci et al., "Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection", Cancer research, US , (20050331), vol. 65, no. 8, doi:10.1158/0008-5472.CAN-04-4262, ISSN 0008-5472, pages 3437 - 3446, XP009510468
OPPOSITION- CHAO, M. P. et al., "Therapeutic Antibody Targeting of CD 47 Eliminates Human Acute Lymphoblastic Leukemia", Cancer Research, (20110000), vol. 71, no. 4, doi:10.1158/0008-5472.CAN-10-2238, pages 1374 - 1384, XP055029988
OPPOSITION- Lu et al., "Polysaccharide Krestin Is a Novel TLR2 Agonist that Mediates Inhibition of Tumor Growth via Stimulation of CD8 T Cells and NK Cells", Clinical Cancer Research, US, (20110101), vol. 17, no. 1, doi:10.1158/1078-0432.CCR-10-1763, ISSN 1078-0432, pages 67 - 76, XP055941460
OPPOSITION- ADAMS. S. et al., "Topical TLR7 Agonist Imiquimod Can Induce Immune-Mediated Rejection of Skin Metastases in Patients with Breast Cancer", Clinical Cancer Research, (20120000), vol. 18, no. 24, doi:10.1158/1078-0432.CCR-12-1149, pages 6748 - 6757, XP055185098
OPPOSITION- Antonio Sica, Alberto Mantovani, "Macrophage plasticity and polarization: in vivo veritas", Journal of Clinical Investigation, (20120301), vol. 122, no. 3, doi:10.1172/JCI59643, ISSN 00219738, pages 787 - 795, XP055111479
OPPOSITION- Han Ju-Hee, Lee Junglim, Jeon Soo-Jin, Choi Eun-Sun, Cho Sung-Dae, Kim Bo-Yeon, Kim Dong-Jae, Park Jae-Hak, Park Jong-Hwan, "In vitro and in vivo growth inhibition of prostate cancer by the small molecule imiquimod", International journal of oncology, GR , (20130601), vol. 42, no. 6, doi:10.3892/ijo.2013.1898, ISSN 1019-6439, pages 2087 - 2093, XP055941458
OPPOSITION- Hamilton et al., "TLR Agonists That Induce IFN-β Abrogate Resident Macrophage Suppression of T Cells (supplemental Information enclosed)", The Journal of Immunology, US , (20101015), vol. 185, no. 8, doi:10.4049/jimmunol.1002045, ISSN 0022-1767, pages 4545 - 4553, 3pp, XP055941221
OPPOSITION- FORTE, G. et al., "Polyinosinic-Polycytidylic Acid Limits Tumor Outgrowth in a Mouse Model of Metastatic Lung Cancer", Journal of Immunology, (20120000), vol. 188, doi:10.4049/jimmunol.1103811, pages 5357 - 5364, XP055391642
OPPOSITION- BYRNE, J. C. et al., "Bruton's Tyrosine Kinase Is Required for Apoptotic Cell Uptake via Regulating the Phosphorylation and Localization of Calreticulin", Journal of Immunology, (20130000), vol. 190, no. 10, doi:10.4049/jimmunol.1300057, pages 5207 - 5215, XP002782998
OPPOSITION- BYRNE JENNIFER C ET AL, "Bruton's Tyrosine Kinase Is Required for Apoptotic Cell Uptake via Regulating the Phosphorylation and Localization of Calreticulin", JOURNAL OF IMMUNOLOGY, (20130501), vol. 190, no. 10, doi:10.4049/jimmunol.1300057, pages 5207 - 5215, XP002782998
OPPOSITION- Wang et al., "Effect of TLR Agonists on the Differentiation and Function of Human Monocytic Myeloid-Derived Suppressor Cells", The Journal of Immunology, US , (20150501), vol. 194, no. 9, doi:10.4049/jimmunol.1402004, ISSN 0022-1767, pages 4215 - 4221, XP055941157
OPPOSITION- CHENG, Y-S. et al., "Anticancer function of polyinosinic- polycytidylic acid", Cancer Biology & Therapy, (20100000), vol. 10, no. 12, doi:10.4161/cbt.10.12.13450, pages 1219 - 1223, XP055108464
OPPOSITION- Kristen B Long et al., "Harnessing the antitumor potential of macrophages for cancer immunotherapy", OncoImmunology, (20131201), vol. 2, no. 12, doi:10.4161/onci.26860, pages 1 - 10, XP055470303
OPPOSITION- Wu John, "CD47 target: from theory to reality", Biomedical Research and Therapy, (20140501), vol. 1, no. 2, doi:10.7603/s40730-014-0007-4, pages 35 - 36, XP055941510
SEARCH- Nika Cyrus, "The role of tumor-associated macrophages in human skin cancer.", (2013), EliScholar, Yale University, URL: https://elischolar.library.yale.edu/cgi/viewcontent.cgi?article=1784&context=ymtdl, (20180711), XP002782999 [A] 1-9 * see abstract, pages 11-13 and 25 *
SEARCH- MARK P CHAO ET AL, "The CD47-SIRP[alpha] pathway in cancer immune evasion and potential therapeutic implications", CURRENT OPINION IN IMMUNOLOGY, (20120401), vol. 24, no. 2, doi:10.1016/j.coi.2012.01.010, ISSN 0952-7915, pages 225 - 232, XP055029985 [A] 1-9 * see abstract and pages 229-230 *
SEARCH- D. TSENG ET AL, "Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, US, (20130520), vol. 110, no. 27, doi:10.1073/pnas.1305569110, ISSN 0027-8424, pages 11103 - 11108, XP055245737 [A] 1-9 * abstract *
SEARCH- K. WEISKOPF ET AL, "Engineered SIRP Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies (supplementary materials)", SCIENCE, US, (20130705), vol. 341, no. 6141, doi:10.1126/science.1238856, ISSN 0036-8075, pages 88 - 91, XP055488633 [A] 1-9 * see abstract and figure 2 *
SEARCH- BYRNE JENNIFER C ET AL, "Bruton's Tyrosine Kinase Is Required for Apoptotic Cell Uptake via Regulating the Phosphorylation and Localization of Calreticulin", JOURNAL OF IMMUNOLOGY, (201305), vol. 190, no. 10, pages 5207 - 5215, XP002782998 [A] 1-9 * see abstract, pages 5207-5208, Fig.4 and 6 *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents