IP Verse

Methods And Compositions For Preparing Genetically Engineered Cells - EP3664835

The patent EP3664835 was granted to Juno Therapeutics on Oct 23, 2024. The application was originally filed on Aug 9, 2018 under application number EP18760160A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3664835

JUNO THERAPEUTICS
Application Number
EP18760160A
Filing Date
Aug 9, 2018
Status
Granted And Under Opposition
Sep 19, 2024
Grant Date
Oct 23, 2024
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

STRAWMANJul 18, 2025HANCOCKADMISSIBLE

Patent Citations (82) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO1991US08442-
DESCRIPTIONWO1994US05601-
DESCRIPTIONEP0452342
DESCRIPTIONEP2537416
DESCRIPTIONUS2002131960
DESCRIPTIONUS2002150914
DESCRIPTIONUS2003170238
DESCRIPTIONUS2003223994
DESCRIPTIONUS2003235908
DESCRIPTIONUS2004191260
DESCRIPTIONUS2006034850
DESCRIPTIONUS2007092530
DESCRIPTIONUS2007116690
DESCRIPTIONUS2009226474
DESCRIPTIONUS2009304679
DESCRIPTIONUS2011003380
DESCRIPTIONUS2013149337
DESCRIPTIONUS2013287748
DESCRIPTIONUS2014294841
DESCRIPTIONUS2016152723
DESCRIPTIONUS2017051035
DESCRIPTIONUS4452773
DESCRIPTIONUS4690915
DESCRIPTIONUS4795698
DESCRIPTIONUS5200084
DESCRIPTIONUS5219740
DESCRIPTIONUS6040177
DESCRIPTIONUS6060273
DESCRIPTIONUS6207453
DESCRIPTIONUS6410319
DESCRIPTIONUS6451995
DESCRIPTIONUS7070995
DESCRIPTIONUS7265209
DESCRIPTIONUS7354762
DESCRIPTIONUS7446179
DESCRIPTIONUS7446190
DESCRIPTIONUS7446191
DESCRIPTIONUS7977095
DESCRIPTIONUS8252592
DESCRIPTIONUS8324353
DESCRIPTIONUS8339645
DESCRIPTIONUS8389282
DESCRIPTIONUS8398282
DESCRIPTIONUS8479118
DESCRIPTIONUS8617884
DESCRIPTIONUS8802374
DESCRIPTIONUS8911993
DESCRIPTIONUS9528088
DESCRIPTIONWO0014257
DESCRIPTIONWO03020763
DESCRIPTIONWO03068201
DESCRIPTIONWO2004033685
DESCRIPTIONWO2006000830
DESCRIPTIONWO2009072003
DESCRIPTIONWO2010033140
DESCRIPTIONWO2011044186
DESCRIPTIONWO2012048340
DESCRIPTIONWO2012048341
DESCRIPTIONWO2012129514
DESCRIPTIONWO2013071154
DESCRIPTIONWO2013123061
DESCRIPTIONWO2013126726
DESCRIPTIONWO2013166321
DESCRIPTIONWO2014031687
DESCRIPTIONWO2014055668
DESCRIPTIONWO2014144495
DESCRIPTIONWO2016044227
DESCRIPTIONWO2016090312
DESCRIPTIONWO2016090320
DESCRIPTIONWO2016090327
DESCRIPTIONWO2016090329
DESCRIPTIONWO2016176322
DESCRIPTIONWO2017053902
DESCRIPTIONWO9613593
DESCRIPTIONWO9618105
DESCRIPTIONWO9918129
DESCRIPTIONWO9960120
INTERNATIONAL-SEARCH-REPORTWO2012129514
INTERNATIONAL-SEARCH-REPORTWO2015164675
OPPOSITIONUS2016362472
OPPOSITIONWO2015164675
OPPOSITIONWO2017068425

Non-Patent Literature (NPL) Citations (89) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ALONSO-CAMINO et al., Mol Ther Nucl Acids, (20130000), vol. 2, page e93-
DESCRIPTION- Autoimmun Rev., (20020800), vol. 1, no. 4, pages 190 - 7-
DESCRIPTION- BARRETT et al., Chimeric Antigen Receptor Therapy for Cancer Annual Review of Medicine, (20140000), vol. 65, pages 333 - 347-
DESCRIPTION- BORIS-LAWRIE; TEMIN, Cur. Opin. Genet. Develop., (19930000), vol. 3, pages 102 - 109-
DESCRIPTION- BRASH et al., Mol. Cell Biol.,, (19870000), vol. 7, pages 2031 - 2034-
DESCRIPTION- BRENTJENS et al., Sci Transl Med., (20130000), vol. 5, page 177-
DESCRIPTION- BURNS et al., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 8033 - 8037-
DESCRIPTION- CARLENS et al., Exp Hematol., (20000000), vol. 28, no. 10, pages 1137 - 46-
DESCRIPTION- CARRILLO et al., SIAM J Applied Math, (19880000), vol. 48, page 1073-
DESCRIPTION- CAVALIERI et al., Blood, (20030000), vol. 102, no. 2, pages 497 - 505-
DESCRIPTION- Cell Behavior In vitro and In vivo, Humana Press Inc., pages 17 - 25-
DESCRIPTION- CHAARA et al., Front Immunol, (20180000), vol. 9, page 1038-
DESCRIPTION- CHEADLE et al., Methods Mol Biol., (20120000), vol. 907, pages 645 - 66-
DESCRIPTION- CHERVIN et al., J Immunol Methods, (20080000), vol. 339, pages 175 - 84-
DESCRIPTION- CHICAYBAM et al., PLoS ONE, (20130000), vol. 8, no. 3, page e60298-
DESCRIPTION- CHO et al., Lab Chip, (20100000), vol. 10, pages 1567 - 1573-
DESCRIPTION- CHOTHIA et al., EMBO J., (19880000), vol. 7, page 3745-
DESCRIPTION- CLARKSON et al., Nature, (19910000), vol. 352, pages 624 - 628-
DESCRIPTION- COHEN CJ. et al., J Mol. Recogn., (20030000), vol. 16, pages 324 - 332-
DESCRIPTION- COOPER et al., Blood, (20030000), vol. 101, pages 1637 - 1644-
DESCRIPTION- Current Protocols in Molecular Biology, John Wiley & Sons-
DESCRIPTION- Curr Opin Immunol., (20021200), vol. 14, no. 6, pages 771 - 8-
DESCRIPTION- DAVILA et al., PLoS ONE, (20130000), vol. 8, no. 4, page e61338-
DESCRIPTION- DE FELIPE, Genetic Vaccines and Ther., (20040000), vol. 2, page 13-
DESCRIPTION- FEDOROV et al., Sci. Transl. Medicine, (20130000), vol. 5, page 215-
DESCRIPTION- FELIPE et al., Traffic, (20040000), vol. 5, pages 616 - 626-
DESCRIPTION- GODIN et al., J Biophoton., (20080000), vol. 1, no. 5, pages 355 - 376-
DESCRIPTION- HOLLER et al., Nat Immunol, (20030000), vol. 4, pages 55 - 62-
DESCRIPTION- HOLLER et al., Proc Natl Acad Sci USA, (20000000), vol. 97, pages 5387 - 92-
DESCRIPTION- HUANG et al., Methods Mol Biol, (20090000), vol. 506, pages 115 - 126-
DESCRIPTION- HUDECEK et al., Clin. Cancer Res., (20130000), vol. 19, page 3153-
DESCRIPTION- JOHNSTON, Nature, (19900000), vol. 346, pages 776 - 777-
DESCRIPTION- JORES et al., Proc. Nat'l Acad. Sci. U.S.A., (19900000), vol. 87, page 9138-
DESCRIPTION- KALAMASZ et al., J Immunother., (20040000), vol. 27, no. 5, pages 405 - 418-
DESCRIPTION- KIM et al., Nature Biotechnology, (20040000), vol. 22, pages 403 - 410-
DESCRIPTION- KINDT et al., Kuby Immunology, W.H. Freeman and Co., (20070000), page 91-
DESCRIPTION- KLEBANOFF et al., J Immunother., (20120000), vol. 35, no. 9, pages 651 - 660-
DESCRIPTION- KOCHENDERFER et al., Nature Reviews Clinical Oncology, (20130000), vol. 10, pages 267 - 276-
DESCRIPTION- KOTB, Clinical Microbiology Reviews, (19950000), vol. 8, pages 411 - 426-
DESCRIPTION- KURUCZ, I. et al., PNAS (USA, (19930000), vol. 90, page 3830-
DESCRIPTION- LEFRANC et al., Dev. Comp. Immunol., (20030000), vol. 27, page 55-
DESCRIPTION- LI et al., Nat Biotechnol, (20050000), vol. 23, pages 349 - 54-
DESCRIPTION- LING, N. R. et al., Leucocyte typing, (19870000), vol. III, page 302-
DESCRIPTION- LIU et al., Nature Biotech., (20160400), vol. 34, no. 4, pages 430 - 434-
DESCRIPTION- LUPTON S. D. et al., Mol. and Cell Biol.,, (19910000), vol. 11, no. 6-
DESCRIPTION- MANURI et al., Hum Gene Ther, (20100000), vol. 21, no. 4, pages 427 - 437-
DESCRIPTION- Metastasis Research Protocols, vol. 2-
DESCRIPTION- Methods in Molecular Medicine, vol. 58-
DESCRIPTION- MILLER, A. D., Human Gene Therapy,, (19900000), vol. 1, pages 5 - 14-
DESCRIPTION- MILLER; ROSMAN, BioTechniques, (19890000), vol. 7, pages 980 - 990-
DESCRIPTION- PARK et al., Trends Biotechnol., (20111100), vol. 29, no. 11, pages 550 - 557-
DESCRIPTION- PORTOLANO et al., J. Immunol., (19930000), vol. 150, pages 880 - 887-
DESCRIPTION- RIDDELL et al., Human Gene Therapy, (19920000), vol. 3, pages 319 - 338-
DESCRIPTION- ROSENBERG, Nat Rev Clin Oncol., (20110000), vol. 8, no. 10, pages 577 - 85-
DESCRIPTION- SADELAIN et al., Cancer Discov., (20130400), vol. 3, no. 4, pages 388 - 398-
DESCRIPTION- SCARPA et al., Virology, (19910000), vol. 180, pages 849 - 852-
DESCRIPTION- SCHLUETER, C. J. et al., J. Mol. Biol., (19960000), vol. 256, page 859-
DESCRIPTION- SCHULER et al., Immunoinformatics Methods in Molecular Biology, (20070000), vol. 409, no. 1, pages 75 - 93-
DESCRIPTION- SCHULER et al., "SYFPEITHI, Database for Searching and T-Cell Epitope Prediction", Immunoinformatics Methods in Molecular Biology, (20070000), vol. 409, no. 1, pages 75 - 93-
DESCRIPTION- SHARMA et al., Molec Ther Nucl Acids, (20130000), vol. 2, page e74-
DESCRIPTION- SINGH; RAGHAVA, Bioinformatics, (20010000), vol. 17, no. 12, pages 1236 - 1237-
DESCRIPTION- SOO HOO, W. F. et al., PNAS (USA, (19920000), vol. 89, page 4759-
DESCRIPTION- SUHOSKI et al., Molecular Therapy, (20070000), vol. 15, no. 5, pages 981 - 988-
DESCRIPTION- TERAKURA et al., Blood, (20120000), vol. 1, pages 72 - 82-
DESCRIPTION- THEMELI et al., Nat Biotechnol., (20130000), vol. 31, no. 10, pages 928 - 933-
DESCRIPTION- THOMAS et al., Clin Immunol, (20020000), vol. 105, no. 3, pages 259 - 72-
DESCRIPTION- TSUKAHARA et al., Biochem Biophys Res Commun, (20130000), vol. 438, no. 1, pages 84 - 9-
DESCRIPTION- TURTLE et al., Curr. Opin. Immunol., (20121000), vol. 24, no. 5, pages 633 - 39-
DESCRIPTION- VAN TEDELOO et al., Gene Therapy, (20000000), vol. 7, no. 16, pages 1431 - 1437-
DESCRIPTION- VERHOEYEN et al., Methods Mol Biol., (20090000), vol. 506, pages 97 - 114-
DESCRIPTION- WANG et al., J Immunother., (20120000), vol. 35, no. 9, pages 689 - 701-
DESCRIPTION- WANG et al., J. Immunother., (20120000), vol. 35, no. 9, pages 689 - 701-
DESCRIPTION- WANG et al., JImmunother., (20120000), vol. 35, no. 9, pages 689 - 701-
DESCRIPTION- WU et al., Cancer, (20120318), vol. 2, pages 160 - 75-
DESCRIPTION- WULFING, C.; PLUCKTHUN, A., J. Mol. Biol., (19940000), vol. 242, page 655-
DESCRIPTION- SINGH; RAGHAVA, "ProPred: prediction of HLA-DR binding sites", BIOINFORMATICS, (20010000), vol. 17, no. 12, doi:doi:10.1093/bioinformatics/17.12.1236, pages 1236 - 1237, XP002371461
INTERNATIONAL-SEARCH-REPORT- ULRIKE MOCK ET AL, "Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS Prodigy", CYTOTHERAPY, GB, (20160801), vol. 18, no. 8, doi:10.1016/j.jcyt.2016.05.009, ISSN 1465-3249, pages 1002 - 1011, XP055389683 [X] 1-91 * the whole document * * figure 1 * * Materials and methods * [Y] 1-91
INTERNATIONAL-SEARCH-REPORT- BRUCE L. LEVINE ET AL, "Global Manufacturing of CAR T Cell Therapy", MOLECULAR THERAPY - METHODS & CLINICAL DEVELOP, GB, (20170304), vol. 4, doi:10.1016/j.omtm.2016.12.006, ISSN 2329-0501, pages 92 - 101, XP055510414 [Y] 1-91 * the whole document * * figure 3 *
INTERNATIONAL-SEARCH-REPORT- REBECCA A. GARDNER ET AL, "Intent to treat leukemia remission by CD19CAR T cells of defined formulation and dose in children and young adults", BLOOD, US, (20170413), doi:10.1182/blood-2017-02-769208, ISSN 0006-4971, XP055509718 [X] 1-91 * figure 1 * * Methods * [Y] 1-91
INTERNATIONAL-SEARCH-REPORT- XIAO-JUN XU ET AL, "Multiparameter comparative analysis reveals differential impacts of various cytokines on CART cell phenotype and function ex vivo and in vivo", ONCOTARGET, United States, (20160709), vol. 7, no. 50, doi:10.18632/oncotarget.10510, ISSN 1949-2553, pages 82354 - 82368, XP055510394 [X] 1-91 * the whole document * * Materials and methods * [Y] 1-91
OPPOSITION- A Casati, Et Al, "Enrichment, stimulation, and viral transduction of naive and central memory CD8+ T cells under GMP conditions for translational research towards the development of adoptive cell therapy of cancer patients", MACS & More, pages 20 - 24, MACS & More, (20191129), XP055647710-
OPPOSITION- Anonymous, " Dynabeads™ Human T-Activator CD3/CD28 for T Cell Expansion and Activation", ThermoFisher, (20250101), XP093301290-
OPPOSITION- Anonymous, "The Heat Is On: Detecting Chemokine Receptors on Live Cells", rndsystems.com, rndsystems.com, URL: https://www.rndsystems.com/blog/heat-detecting-chemokine-receptors-live-cells, XP093301291-
OPPOSITION- Kishton Rigel J.; Sukumar Madhusudhanan; Restifo Nicholas P., "Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy", Cell Metabolism, Cell Press, United States, United States , (20170705), vol. 26, no. 1, doi:10.1016/j.cmet.2017.06.016, ISSN 1550-4131, pages 94 - 109, XP085115795
OPPOSITION- Luca Gattinoni, Daniel E Speiser, Mathias Lichterfeld, Chiara Bonini, "T memory stem cells in health and disease", Nature Medicine(Author manuscript ), Nature Publishing Group US, New York, New York, (20170101), vol. 23, no. 1, doi:10.1038/nm.4241, ISSN 1078-8956, pages 18 - 27, XP055744455
OPPOSITION- Gattinoni Luca, Klebanoff Christopher A., Restifo Nicholas P., "Paths to stemness: building the ultimate antitumour T cell", Nature Reviews Cancer, Nature Pub. Group, London, London , (20121001), vol. 12, no. 10, doi:10.1038/nrc3322, ISSN 1474-175X, pages 671 - 684, XP055822942
OPPOSITION- Hollie J. Jackson, Sarwish Rafiq, Renier J. Brentjens, "Driving CAR T-cells forward", NATURE REVIEWS CLINICAL ONCOLOGY, Nature, NY, US, NY, US , (20160601), vol. 13, no. 6, doi:10.1038/nrclinonc.2016.36, ISSN 1759-4774, pages 370 - 383, XP055542558
OPPOSITION- Rebecca A. Gardner, Olivia Finney, Colleen Annesley, Hannah Brakke, Corinne Summers, Kasey Leger, Marie Bleakley, Christopher Brown, Stephanie Mgebroff, Karen Spratt, Virginia Hoglund, Catherine Lindgren, Assaf P. Oron, Daniel Li, Stanley R. Riddell, Julie R. Park, Michael C. Jensen, "Intent to treat leukemia remission by CD19CAR T cells of defined formulation and dose in children and young adults", Blood, AMSTERDAM, NL, AMSTERDAM, NL, (20170622), vol. 129, no. 25, doi:10.1182/blood-2017-02-769208, pages 3322 - 3331, XP055509718
OPPOSITION- Alvarez-Fernández C., Escribà-Garcia L., Vidal S., Sierra J., Briones J., "A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy", Journal of Translational Medicine, BioMed Central, (20161201), vol. 14, no. 1, doi:10.1186/s12967-016-0973-y, ISSN 1479-5876, XP093301284

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents