Pneumococcal Polysaccharides And Their Use In Immunogenic Polysaccharide-Carrier Protein Conjugates - EP3678654

The patent EP3678654 was granted to Merck Sharp & Dohme on Jun 26, 2024. The application was originally filed on Sep 4, 2018 under application number EP18853342A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3678654

MERCK SHARP & DOHME
Application Number
EP18853342A
Filing Date
Sep 4, 2018
Status
Granted And Under Opposition
May 24, 2024
Grant Date
Jun 26, 2024
External Links
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Patent Oppositions (3)

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SANOFI PASTEURMar 18, 2025ZWICKERADMISSIBLE
SK BIOSCIENCEMar 18, 2025ZWICKERADMISSIBLE
BIOLOGICAL EMar 17, 2025BRAEUNING SCHUBERT PATENTANWALTE GBRADMISSIBLE

Patent Citations (84) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONEP0378881
DESCRIPTIONEP0427347
DESCRIPTIONEP0471177
DESCRIPTIONEP0497524
DESCRIPTIONEP0497525
DESCRIPTIONEP0594610
DESCRIPTIONUS2006228380
DESCRIPTIONUS2007184071
DESCRIPTIONUS2007184072
DESCRIPTIONUS2007231340
DESCRIPTIONUS2008286838
DESCRIPTIONUS2011195086
DESCRIPTIONUS2015231270
DESCRIPTIONUS4365170
DESCRIPTIONUS4673574
DESCRIPTIONUS4902506
DESCRIPTIONUS4912094
DESCRIPTIONUS4950740
DESCRIPTIONUS5057540
DESCRIPTIONUS5614382
DESCRIPTIONUS5773007
DESCRIPTIONUS5843711
DESCRIPTIONUS5847112
DESCRIPTIONUS5866135
DESCRIPTIONUS5917017
DESCRIPTIONUS6113918
DESCRIPTIONUS6146902
DESCRIPTIONUS6207646
DESCRIPTIONUS6248570
DESCRIPTIONUS6455673
DESCRIPTIONWO0061761
DESCRIPTIONWO0172337
DESCRIPTIONWO0198334
DESCRIPTIONWO02053761
DESCRIPTIONWO02083855
DESCRIPTIONWO02091998
DESCRIPTIONWO03054007
DESCRIPTIONWO2004081515
DESCRIPTIONWO2004083251
DESCRIPTIONWO2006110381
DESCRIPTIONWO2008079653
DESCRIPTIONWO2008143709
DESCRIPTIONWO2012173876
DESCRIPTIONWO2014097099
DESCRIPTIONWO9014837
DESCRIPTIONWO9101146
DESCRIPTIONWO9315760
DESCRIPTIONWO9317712
DESCRIPTIONWO9403208
DESCRIPTIONWO9508348
DESCRIPTIONWO9629094
DESCRIPTIONWO9842721
DESCRIPTIONWO9858668
INTERNATIONAL-SEARCH-REPORTUS2016007642
INTERNATIONAL-SEARCH-REPORTUS2017021006
INTERNATIONAL-SEARCH-REPORTWO2015011266
INTERNATIONAL-SEARCH-REPORTWO2017035412
INTERNATIONAL-SEARCH-REPORTWO2017083520
OPPOSITIONCN108159408
OPPOSITIONEP0497524
OPPOSITIONUS2014186390
OPPOSITIONUS2015374811
OPPOSITIONUS5847112
OPPOSITIONUS7217791
OPPOSITIONWO2007071710
OPPOSITIONWO2009023300
OPPOSITIONWO2011100151
OPPOSITIONWO2015110941
OPPOSITIONWO2015121783
OPPOSITIONWO2016020499
OPPOSITIONWO2017144394
OPPOSITIONWO2017173415
OPPOSITIONWO2018064444
OPPOSITIONWO2019050818
OPPOSITIONWO2019139692
OPPOSITIONWO9833521
SEARCHEP0497524
SEARCHEP3720483
SEARCHWO2017173415
SEARCHWO2019050813
SEARCHWO2019050814
SEARCHWO2019050816
SEARCHWO2019050818
SEARCHWO2019139692

Non-Patent Literature (NPL) Citations (23) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Anonymous, "PURIFIED PNEUMOCOCCAL CAPSULAR POLYSACCHARIDES for in vitro diagnostic use Information and ordering", Statens Serum Institut; Copenhagen, Denmark, 1st Edition, (20090301), page 1, XP093267110-
OPPOSITION- Anonymous, "WHO EXPERT COMMITTEE ON BIOLOGICAL STANDARDIZATION", WHO Technical Report Series, 927, World Health Organization, (20050101), pages 1 - 160, XP093267106-
OPPOSITION- Brown Paul W. et al, "Characterization of Complex Prophylactic Vaccines with Protein and Glycoconjugate Components", 9th CASSS Symposium, (20120912), pages 1 - 34, XP093267100-
OPPOSITION- D19: Letter of the proprietor dated October 15, 2021, in response to the European Search Opinion in the granting process of the European Patent-
OPPOSITION- D20: Written submission filed on June 6, 2024, by the proprietor of the European Patent after the post hearing in the Indian opposition procedure to IN 202017013736-
OPPOSITION- Hsieh C L, "Characterization of saccharide-CRM197 conjugate vaccines", DEVELOPMENTS IN BIOLOGICALS, KARGER, BASEL, CH, CH , (20000101), vol. 103, ISSN 1424-6074, pages 93 - 104, XP093267145-
OPPOSITION- Kamerling, Johannis P., "Pneumococcal Polysaccharides: A Chemical View", Streptococcus pneumoniae : molecular biology & mechanisms of disease ; [International Workshop on Streptococcus Pneumoniae: Molecular Biology and Mechanisms of Disease-Update, held from September 23 - 29, 1996, in Oeiras, Portugal], Mary Ann Liebert, Inc., Larchmont, NY, USA, Larchmont, NY, USA , (20000101), ISBN 0-913113-85-9, pages 81 - 114, XP009526062-
OPPOSITION- Lees Andrew R, Velupillai Puvanesarajah, Carl E. Frasch, "Conjugation Chemistry", Pneumococcal Vaccines, Chapter 11, (20080101), pages 163 - 174, XP093267122-
OPPOSITION- Plotkin Stanley A, Orenstein Walter A, Offit Pau A., "Pneumococcal conjugate vaccine and pneumococcal common protein vaccines", VACCINES, 6th Edition, (20130101), pages 504 - 541, XP093267128-
OPPOSITION- Skovs Ian C. et al, "Textbook in Diagnosis, Serotyping, Virulence Factors and Enzyme-linked Immunosorbent Assay (ELISA) for Measuring Pneumococcal Antibodies", STREPTOCOCCUS PNEUMONIAE, 4th Edition, (20170101), pages 1 - 48, XP093267162-
OPPOSITION- Lee C.-J, "Bacterial capsular polysaccharides—biochemistry, immunity and vaccine", Molecular Immunology, PERGAMON, GB, GB , (19871001), vol. 24, no. 10, doi:10.1016/0161-5890(87)90067-8, ISSN 0161-5890, pages 1005 - 1019, XP093267153
OPPOSITION- Varon Emmanuelle et al, "Invasive disease potential of pneumococci before and after the 13-valent pneumococcal conjugate vaccine implementation in children", Vaccine, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20151101), vol. 33, no. 46, doi:10.1016/j.vaccine.2015.10.015, ISSN 0264-410X, pages 6178 - 6185, XP093267135
OPPOSITION- Geno K. Aaron et al, "Pneumococcal Capsules and Their Types: Past, Present, and Future", Clinical Microbiology Review, WASHINGTON, DC., US, US , (20150701), vol. 28, no. 3, doi:10.1128/CMR.00024-15, ISSN 0893-8512, pages 871 - 899, XP055781906
OPPOSITION- Wang Q. et al, "Biochemical Characterization of the CDP-D-Arabinitol Biosynthetic Pathway in Streptococcus pneumoniae 17F", Journal of Bacteriology, American Society for Microbiology, US, US , (20120415), vol. 194, no. 8, doi:10.1128/JB.06487-11, ISSN 0021-9193, pages 1868 - 1874, XP055782889
OPPOSITION- Ganaie Feroze et al, "Structural, Genetic, and Serological Elucidation of Streptococcus pneumoniae Serogroup 24 Serotypes: Discovery of a New Serotype, 24C, with a Variable Capsule Structure", Journal of clinical microbiology, American Society for Microbiology, US, US , (20210618), vol. 59, no. 7, doi:10.1128/JCM.00540-21, ISSN 0095-1137, XP093186243
OPPOSITION- Myint Tin Tin Htar;Dina Christopoulou;Heinz-Josef Schmitt, "Pneumococcal serotype evolution in Western Europe", BMC Infections Diseases, BIOMED CENTRAL, LONDON, GB, GB , (20151014), vol. 15, no. 1, doi:10.1186/s12879-015-1147-x, ISSN 1471-2334, page 419, XP021230462
OPPOSITION- Ardanuy Carmen et al, "Epidemiology of Invasive Pneumococcal Disease in Older People in Spain (2007-2009): Implications for Future Vaccination Strategies", PLOS ONE, Public Library of Science, US, US , vol. 7, no. e43619, doi:10.1371/journal.pone.0043619, ISSN 1932-6203, pages 1 - 7, XP093267114
OPPOSITION- Kapatai Georgia et al, "Whole genome sequencing of Streptococcus pneumoniae : development, evaluation and verification of targets for serogroup and serotype prediction using an automated pipeline", PeerJ, PeerJ Inc., vol. 4, no. e2477, doi:10.7717/peerj.2477, ISSN 2167-8359, pages 1 - 35, XP093267150
SEARCH[ ] - ABEYGUNAWARDANA ET AL, "Determination of the chemical structure of complex polysaccharides by heteronuclear NMR spectroscopy", ADVANCES IN BIOPHYSICAL CHEMISTRY, JAI PRESS, GREENWICH, CT, US, (19930101), vol. 3, ISSN 1057-8943, pages 199 - 249, XP009526147 [ ] * the whole document *-
SEARCH- KAMERLING ET AL, "Pneumococcal Polysaccharides: A Chemical View", STREPTOCOCCUS PNEUMONIAE : MOLECULAR BIOLOGY & MECHANISMS OF DISEASE ; [INTERNATIONAL WORKSHOP ON STREPTOCOCCUS PNEUMONIAE: MOLECULAR BIOLOGY AND MECHANISMS OF DISEASE-UPDATE, HELD FROM SEPTEMBER 23 - 29, 1996, IN OEIRAS, PORTUGAL], MARY ANN LIEBERT,, (20000101), ISBN 978-0-913113-85-1, pages 81 - 114, XP009526062 [X] 1-4 * figure 1 * * page 12, line 5; table 2; compound 24F * [Y] 1-4-
SEARCH[ ] - MULLOY ED - LEI YU, "High-field NMR as a technique for the determination of polysaccharide structures", vol. 6, no. 3, doi:10.1007/BF02761706, ISSN 0273-2289, (19960101), pages 241 - 265, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, HUMANA PRESS INC, NEW YORK, URL: https://link.springer.com/article/10.1007/BF02761706, XP009526145 [ ] * the whole document *
SEARCH- GENO K. AARON ET AL, "Pneumococcal Capsules and Their Types: Past, Present, and Future", US, vol. 28, no. 3, doi:10.1128/CMR.00024-15, ISSN 0893-8512, (20150617), pages 871 - 899, CLINICAL MICROBIOLOGY REVIEW, URL: https://cmr.asm.org/content/cmr/28/3/871.full.pdf, XP055781906 [X] 1-4 * page 877; table 1; compound 24F * * paragraph [Polysaccharide vaccines] * [I] 5-24 [Y] 1-24
SEARCH[ ] - WANG Q. ET AL, "Biochemical Characterization of the CDP-D-Arabinitol Biosynthetic Pathway in Streptococcus pneumoniae 17F", vol. 194, no. 8, doi:10.1128/JB.06487-11, ISSN 0021-9193, (20120210), pages 1868 - 1874, JOURNAL OF BACTERIOLOGY, URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318453/pdf/zjb1868.pdf, XP055782889 [ ] * page 1868, column 2, line 3 - line 7 *

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