Pct And Pro-Adm As Markers For Monitoring Antibiotic Treatment - EP3682241

The patent EP3682241 was granted to Brahms on Sep 10, 2025. The application was originally filed on Sep 13, 2018 under application number EP18765658A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP3682241

BRAHMS
Application Number
EP18765658A
Filing Date
Sep 13, 2018
Status
Patent Maintained As Amended
Aug 8, 2025
Publication Date
Sep 10, 2025
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

Patent Citations (5) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONEP0180492
DESCRIPTIONEP0539477
DESCRIPTIONUS4882733
INTERNATIONAL-SEARCH-REPORTWO2010139475
OPPOSITIONWO2019053117

Non-Patent Literature (NPL) Citations (57) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- ALBRICH WC; RUEGGER K; DUSEMUND F et al., "Biomarker-enhanced triage in respiratory infections: a proof-of-concept feasibility trial", Eur Respir J., (20131000), vol. 42, no. 4, pages 1064 - 1075
DESCRIPTION- ALBRICH WC; RUEGGER K; DUSEMUND F et al., "Optimised patient transfer using an innovative multidisciplinary assessment in Kanton Aargau (OPTIMA I): an observational survey in lower respiratory tract infections", Swiss Med Wkly, (20110000), vol. 141, page w13237
DESCRIPTION- ANDRIOLO BN; ANDRIOLO RB; SALOMAO R; ATALLAH AN, "Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or septic shock", Cochrane Database Syst Rev., (20170118), vol. 1, page CD010959
DESCRIPTION- BLOOS F; TRIPS E; NIERHAUS A et al., "Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial", JAMA Intern Med., (20160901), vol. 176, no. 9, pages 1266 - 1276
DESCRIPTION- BONE et al., CHEST, (19920000), vol. 101, no. 6, pages 1644 - 55
DESCRIPTION- BRELL B; HIPPENSTIEL S; DAVID I et al., "Adrenomedullin treatment abolishes ileal mucosal hypoperfusion induced by Staphylococcus aureus alpha-toxin--an intravital microscopic study on an isolated rat ileum", Crit Care Med., (20051200), vol. 33, no. 12, pages 2810 - 2016
DESCRIPTION- BRELL B; TEMMESFELD-WOLLBRUCK B; ALTZSCHNER I et al., "Adrenomedullin reduces Staphylococcus aureus alpha-toxin-induced rat ileum microcirculatory damage", Crit Care Med., (20050400), vol. 33, no. 4, pages 819 - 826
DESCRIPTION- GARROUSTE-ORGEAS M; MONTUCLARD L; TIMSIT JF et al., "Predictors of intensive care unit refusal in French intensive care units: a multiple-center study", Crit Care Med., (20050400), vol. 33, no. 4, pages 750 - 755
DESCRIPTION- GARROUSTE-ORGEAS M; MONTUCLARD L; TIMSIT JF; MISSET B; CHRISTIAS M; CARLET J, "Triaging patients to the ICU: a pilot study of factors influencing admission decisions and patient outcomes", Intensive Care Med., (20030500), vol. 29, no. 5, pages 774 - 781
DESCRIPTION- GEORGE F. REED et al., Clin Diagn Lab Immunol, (20020000), vol. 9, no. 6, pages 1235 - 1239
DESCRIPTION- GILLMANN HJ; MEINDERS A; LARMANN J et al., "Adrenomedullin Is Associated With Surgical Trauma and Impaired Renal Function in Vascular Surgery Patients", J Intensive Care Med., (20170101), page 885066616689554
DESCRIPTION- GONZALEZ-REY E; CHORNY A; VARELA N; ROBLEDO G; DELGADO M, "Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response", Am J Pathol. Jun, (20060000), vol. 168, no. 6, pages 1921 - 1930
DESCRIPTION- HANLEY et al., Radiology, (19820000), vol. 143, pages 29 - 36
DESCRIPTION- HARBARTH S; HOLECKOVA K; FROIDEVAUX C et al., "Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis", Am J Respir Crit Care Med., (20010801), vol. 164, no. 3, pages 396 - 402, XP002350238
DESCRIPTION- HERNANDEZ G; BRUHN A; INCE C, "Microcirculation in sepsis: new perspectives", Curr Vasc Pharmacol., (20130301), vol. 11, no. 2, pages 161 - 169
DESCRIPTION- KAUKONEN KM; BAILEY M; SUZUKI S; PILCHER D; BELLOMO R, "Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012", JAMA, (20140402), vol. 311, no. 13, pages 1308 - 1316
DESCRIPTION- KIP MM; KUSTERS R; MJ IJ; STEUTEN LM, "A PCT algorithm for discontinuation of antibiotic therapy is a cost-effective way to reduce antibiotic exposure in adult intensive care patients with sepsis", J Med Econ., (20150000), vol. 18, no. 11, pages 944 - 953
DESCRIPTION- KOPTERIDES P; SIEMPOS, II; TSANGARIS I; TSANTES A; ARMAGANIDIS A, "Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials", Crit Care Med., (20101100), vol. 38, no. 11, pages 2229 - 2241
DESCRIPTION- LE GALL JR et al., "A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study", JAMA, (19930000), vol. 270, no. 24, pages 2957 - 63
DESCRIPTION- LEVY MM et al., "SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference", Crit Care Med., (20010000), vol. 31, no. 4, pages 1250 - 6
DESCRIPTION- MARTIN GS; MANNINO DM; EATON S; MOSS M, "The epidemiology of sepsis in the United States from 1979 through 2000", N Engl J Med., (20030417), vol. 348, no. 16, pages 1546 - 1554
DESCRIPTION- MERY E; KAHN JM, "Does space make waste? The influence of ICU bed capacity on admission decisions", Crit Care, (20130508), vol. 17, no. 3, page 315
DESCRIPTION- ORSINI J; BLAAK C; YEH A et al., "Triage of Patients Consulted for ICU Admission During Times of ICU-Bed Shortage", J Clin Med Res., (20141200), vol. 6, no. 6, pages 463 - 468
DESCRIPTION- SCHOE A; SCHIPPERS EF; STRUCK J et al., "Postoperative pro-adrenomedullin levels predict mortality in thoracic surgery patients: comparison with Acute Physiology and Chronic Health Evaluation IV Score", Crit Care Med., (20150200), vol. 43, no. 2, pages 373 - 381
DESCRIPTION- TERENCE CHAN et al., Expert Rev.MoI.Diagn., (20110000), vol. 11, no. 5
DESCRIPTION- TYAGI A; SETHI AK; GIROTRA G; MOHTA M, "The microcirculation in sepsis", Indian J Anaesth., (20090600), vol. 53, no. 3, pages 281 - 293
DESCRIPTION- VALLET B, "Endothelial cell dysfunction and abnormal tissue perfusion", Crit Care Med., (20020500), vol. 30, no. 5, pages S229 - 234
DESCRIPTION- VIGUE B; LEBLANC PE; MOATI F et al., "Mid-regional pro-adrenomedullin (MR-proADM), a marker of positive fluid balance in critically ill patients: results of the ENVOL study", Crit Care, (20161109), vol. 20, no. 1, page 363
DESCRIPTION- VINCENT JL; SAKR Y; SPRUNG CL et al., "Sepsis in European intensive care units: results of the SOAP study", Crit Care Med., (20060200), vol. 34, no. 2, pages 344 - 353
DESCRIPTION- SINGER M; DEUTSCHMAN CS; SEYMOUR CW et al., "The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3", JAMA, (20160223), vol. 315, no. 8, doi:doi:10.1001/jama.2016.0287, pages 801 - 810, XP055456889
DESCRIPTION- TEMMESFELD-WOLLBRUCK B; BRELL B; DAVID I et al., "Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock", Intensive Care Med., (20070400), vol. 33, no. 4, doi:doi:10.1007/s00134-007-0561-y, pages 703 - 710, XP019510888
DESCRIPTION- SUBERVIOLA B; CASTELLANOS-ORTEGA A; RUIZ RUIZ A; LOPEZ-HOYOS M; SANTIBANEZ M, "Hospital mortality prognostication in sepsis using the new biomarkers suPAR and proADM in a single determination on ICU admission", Intensive Care Med., (20131100), vol. 39, no. 11, doi:doi:10.1007/s00134-013-3056-z, pages 1945 - 1952, XP009502346
DESCRIPTION- HARTMANN O; SCHUETZ P; ALBRICH WC; ANKER SD; MUELLER B; SCHMIDT T, "Time-dependent Cox regression: serial measurement of the cardiovascular biomarker proadrenomedullin improves survival prediction in patients with lower respiratory tract infection", Int J Cardiol, (20121129), vol. 161, no. 3, doi:doi:10.1016/j.ijcard.2012.09.014, pages 166 - 173, XP028959234
DESCRIPTION- ANDALUZ-OJEDA D; CICUENDEZ R; CALVO D et al., "Sustained value of proadrenomedullin as mortality predictor in severe sepsis", J Infect, (20150700), vol. 71, no. 1, doi:doi:10.1016/j.jinf.2015.02.002, pages 136 - 139, XP029234527
DESCRIPTION- CARRIZO GJ; WU R; CUI X; DWIVEDI AJ; SIMMS HH; WANG P, "Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion", Surgery, (20070200), vol. 141, no. 2, doi:doi:10.1016/j.surg.2006.05.017, pages 245 - 253, XP005859786
DESCRIPTION- DE JONG E; VAN OERS JA; BEISHUIZEN A et al., "Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial", Lancet Infect Dis., (20160700), vol. 16, no. 7, doi:doi:10.1016/S1473-3099(16)00053-0, pages 819 - 827, XP029618593
DESCRIPTION- ALBRICH WC; DUSEMUND F; RUEGGER K et al., "Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: derivation of a clinical algorithm", BMC Infect Dis., (20110000), vol. 11, doi:doi:10.1186/1471-2334-11-112, page 112, XP021099852
DESCRIPTION- WILKE MH; GRUBE RF; BODMANN KF, "The use of a standardized PCT-algorithm reduces costs in intensive care in septic patients - a DRG-based simulation model", Eur J Med Res., (20111202), vol. 16, no. 12, doi:doi:10.1186/2047-783X-16-12-543, pages 543 - 548, XP021094406
DESCRIPTION- MULLER-REDETZKY HC; WILL D; HELLWIG K et al., "Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin", Crit Care, (20140000), vol. 18, no. 2, doi:doi:10.1186/cc13830, page R73, XP021187214
DESCRIPTION- CHRIST-CRAIN M; MORGENTHALER NG; STRUCK J; HARBARTH S; BERGMANN A; MULLER B, "Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study", Crit Care, (20050000), vol. 9, no. 6, doi:doi:10.1186/cc3885, pages R816 - 824, XP021012417
INTERNATIONAL-SEARCH-REPORT- DE JONG EVELIEN ET AL, "Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial", LANCET INFECTIOUS DISEASES, ELSEVIER LTD, US, (20160302), vol. 16, no. 7, doi:10.1016/S1473-3099(16)00053-0, ISSN 1473-3099, pages 819 - 827, XP029618593 [Y] 1-15 * abstract *
INTERNATIONAL-SEARCH-REPORT- PHILIPP SCHUETZ ET AL, "Blood biomarkers for personalized treatment and patient management decisions in community-acquired pneumonia :", CURRENT OPINION ON INFECTIOUS DISEASES., GB, (20130401), vol. 26, no. 2, doi:10.1097/QCO.0b013e32835d0bec, ISSN 0951-7375, pages 159 - 167, XP055439092 [Y] 1-15 * abstract * * page 161, column 1, paragraph 2 - column 2, paragraph 1 * * page 163, column 1, paragraph l - page 164, column 2, paragraph 1 *
INTERNATIONAL-SEARCH-REPORT- SILVIA ANGELETTI ET AL, "Diagnostic and prognostic role of procalcitonin (PCT) and MR-pro-Adrenomedullin (MR-proADM) in bacterial infections", APMIS, DK, (20150608), vol. 123, no. 9, doi:10.1111/apm.12406, ISSN 0903-4641, pages 740 - 748, XP055439076 [X] 16 * page 741, column 2, paragraph 4 * * page 743, column 1, paragraph 4 - column 2, paragraph 3 * [Y] 1-15
INTERNATIONAL-SEARCH-REPORT- CHRIST-CRAIN M ET AL, "Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators", EUROPEAN RESPIRATORY JOURNAL, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK, (20070831), vol. 30, no. 3, doi:10.1183/09031936.00166106, ISSN 0903-1936, pages 556 - 573, XP009502611 [Y] 1-15 * page 560, column 1, paragraph 1 * * page 563, column 2, paragraph 3 *
INTERNATIONAL-SEARCH-REPORT- ANGELETTI SILVIA ET AL, "Procalcitonin and mid-regional pro-adrenomedullin test combination in sepsis diagnosis", CLINICAL CHEMISTRY AND LABORATORY MEDICINE, DE GRUYTER, DE, (20130430), vol. 51, no. 5, doi:10.1515/CCLM-2012-0595, ISSN 1434-6621, pages 1059 - 1067, XP009502330 [X] 16 * abstract * * page 1063, column 1, paragraph 1 * [Y] 1-15 [I] 1-15
OPPOSITION- Hyuk Lee, "Procalcitonin as a biomarker of infec- tious diseases", Korean J Intern Med, (20130501), vol. 28, XP093017895
OPPOSITION- PEREIRA et al., "Mid-regional proadrenomedullin: An early marker of response in critically ill patients with severe community- acquired pneumonia", Portuguese journal of pul-monology, (20160506), vol. 22, no. 6, doi:10.1016/j.rppnen.2016.03.012, pages 308 - 314, XP055445119
OPPOSITION- Munirah Al Shuaibi, Ramez R. Bahu, Anne-Marie Chaftari, Iba Al Wohoush, William Shomali, Ying Jiang, Labib Debiane, Sammy Raad, Joseph Jabbour, Fady Al Akhrass, Ray Y. Hachem, Issam Raad, "Pro-adrenomedullin as a Novel Biomarker for Predicting Infections and Response to Antimicrobials in Febrile Patients With Hematologic Malignancies", CLINICAL INFECTIOUS DISEASES, THE UNIVERSITY OF CHICAGO PRESS, CHICAGO, IL., US, US , (20130401), vol. 56, no. 7, doi:10.1093/cid/cis1029, ISSN 1058-4838, pages 943 - 950, XP055418326
OPPOSITION- Debiane Labib, Hachem Ray Y., Al Wohoush Iba, Shomali William, Bahu Ramez R., Jiang Ying, Chaftari Anne-Marie, Jabbour Joseph, Al Shuaibi Munirah, Hanania Alexander, Pravinkumar S. Egbert, Schuetz Philipp, Raad Issam, "The Utility of Proadrenomedullin and Procalcitonin in Comparison to C-Reactive Protein as Predictors of Sepsis and Bloodstream Infections in Critically Ill Patients With Cancer* : ", CRITICAL CARE MEDICINE., Lippincott Williams & Wilkins, US, US , (20141201), vol. 42, no. 12, doi:10.1097/CCM.0000000000000526, ISSN 0090-3493, pages 2500 - 2507, XP093007286
OPPOSITION- ANGELETTI et al., "Diagnostic and prognostic role of procalcitonin (PCT) and MR-pro- Adrenomedullin (MP-proADM) in bacterial infections", Acta pathologica, microbio-logica et immunologica scandinavica, (20150400), vol. 123, doi:10.1111/apm.12406, pages 740 - 748, XP055439076
OPPOSITION- Silvia Angeletti, Giordano Dicuonzo, Marta Fioravanti, Marina De Cesaris, Marta Fogolari, Alessandra Lo Presti, Massimo Ciccozzi, Lucia De Florio, "Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination", Disease Markers, WILEY, CHICHESTER., GB, GB , (20150101), vol. 2015, doi:10.1155/2015/951532, ISSN 0278-0240, pages 1 - 14, XP055418308
OPPOSITION- CHRIST-CRAIN et al., "Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study", Critical Care, (20051115), vol. 9, no. 6, doi:10.1186/cc3885, pages R816 - R834, XP055535895
OPPOSITION- Gunnar Elke, Bloos Frank, Wilson Darius Cameron, Brunkhorst Frank Martin, Briegel Josef, Reinhart Konrad, Loeffler Markus, Kluge Stefan, Nierhaus Axel, Jaschinski Ulrich, Moerer Onnen, Weyland Andreas, Meybohm Patrick, "The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis - a secondary analysis of a large randomised controlled trial", Critical Care, vol. 22, no. 1, doi:10.1186/s13054-018-2001-5, XP055556348
OPPOSITION- Alexandre Mebazaa, Christopher Geven, Alexa Hollinger, Xavier Wittebole, Benjamin Glen Chousterman, Alice Blet, Etienne Gayat, Oliver Hartmann, Paul Scigalla, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye, Salvatore Di Somma, Thierry Dugernier, Bruno François, Stephane Gaudry, Vincent Huberlant, Jean-Baptiste Lascarrou, Gernot Marx, Emmanuelle Mercier, Haikel Oueslati, Peter Pickkers, Romain Sonneville, Matthieu Legrand, Pierre-François Laterre, "Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study", Critical Care, (20181201), vol. 22, no. 1, doi:10.1186/s13054-018-2243-2, XP055718927
OPPOSITION- MORGENTHALER et al., "Measurement of Midregional Proadrenomedullin in Plasma with an Immunoluminometric Assay", Clinical Chemistry, (20050000), vol. 51, no. 10, doi:10.1373/CLINCHEM.2005.051110, pages 1823 - 1829, XP002510789
OPPOSITION- ANGELETTI et al., "Procalcitonin and mid-regional pro- adrenomedullin test combination in sepsis diagnosis", Clin Chem, (20121016), vol. 51, no. 5, doi:10.1515/cclm-2012-0595, pages 1059 - 1067, XP009502330
OPPOSITION- Francisco Valenzuela-Sánchez, Blanca Valenzuela-Méndez, Juan Francisco Rodríguez-Gutiérrez, Ángel Estella-García, María Ángela González-García, "New role of biomarkers: mid-regional pro-adrenomedullin, the biomarker of organ failure", Annals of Translational Medicine, AME Publishing Company, US, US , (20160901), vol. 4, no. 17, doi:10.21037/atm.2016.08.65, ISSN 2305-5839, pages 329 - 329, XP055312942

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents