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High Efficiency Targeted In Situ Genome-Wide Profiling - EP3688157
The patent EP3688157 was granted to Fred Hutchinson Cancer Center on Apr 27, 2022. The application was originally filed on Sep 25, 2018 under application number EP18858858A. The patent is currently recorded with a legal status of "Granted And Under Opposition".
EP3688157
- Application Number
- EP18858858A
- Filing Date
- Sep 25, 2018
- Status
- Granted And Under Opposition
- Mar 25, 2022
- Publication Date
- Apr 27, 2022
- External Links
- Slate, Register, Google Patents
Patent Summary
A method for chromatin profiling that enables the detection of protein-DNA interactions without the need for chromatin immunoprecipitation (ChIP). The method, called CUT&RUN, involves targeting a specific protein of interest with an antibody coupled to a transposase, which then cleaves the surrounding chromatin. The resulting DNA fragments are released into solution and can be sequenced to determine the protein's binding sites. CUT&RUN offers improved specificity and sensitivity compared to traditional ChIP methods, particularly when performed on magnetic beads, and enables the analysis of low-input samples.
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Patent Citations (42) New
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Dossier Documents
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