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Inhibition Of Hsd17B13 In The Treatment Of Liver Disease In Patients Expressing The Pnpla3 I148M Variation - EP3695012

The patent EP3695012 was granted to Regeneron Pharmaceuticals on Mar 8, 2023. The application was originally filed on Oct 11, 2018 under application number EP18803806A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3695012

REGENERON PHARMACEUTICALS
Application Number
EP18803806A
Filing Date
Oct 11, 2018
Status
Granted And Under Opposition
Feb 3, 2023
Grant Date
Mar 8, 2023
External Links
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STRAWMANDec 8, 2023CMS CAMERON MCKENNA NABARRO OLSWANGADMISSIBLE

Patent Citations (36) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
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DESCRIPTIONWO2018136702
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INTERNATIONAL-SEARCH-REPORTWO2017048620
OPPOSITIONCN103520724
OPPOSITIONWO2016130806
OPPOSITIONWO2017048620
OPPOSITIONWO2018136702
OPPOSITIONWO2018136758
OPPOSITIONWO2019183164
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Non-Patent Literature (NPL) Citations (60) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

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EXAMINATION- Chambers John C ET AL, "Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma", New York, vol. 43, no. 11, doi:10.1038/ng.970, ISSN 1061-4036, (20111016), pages 1131 - 1138, Nature Genetics, URL: http://www.nature.com/articles/ng.970, XP055806421
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INTERNATIONAL-SEARCH-REPORT- JIAN-HUA SHEN ET AL, "The rs738409 (I148M) variant of the PNPLA3 gene and cirrhosis: a meta-analysis", JOURNAL OF LIPID RESEARCH, US, (20141105), vol. 56, no. 1, doi:10.1194/jlr.M048777, ISSN 0022-2275, pages 167 - 175, XP055530673 [Y] 1-16,19,20,22,25-76,78,81 * table 1 * * abstract * * the whole document * [A] 17,18,21,23,24,77,79,80
INTERNATIONAL-SEARCH-REPORT- KENTARO ONIKI ET AL, "Influence of the PNPLA3 rs738409 Polymorphism on Non-Alcoholic Fatty Liver Disease and Renal Function among Normal Weight Subjects", PLOS ONE, (20150722), vol. 10, no. 7, doi:10.1371/journal.pone.0132640, page e0132640, XP055530677 [Y] 1-16,19,20,22,25-76,78,81 * table 2 * * abstract * * the whole document * [A] 17,18,21,23,24,77,79,80
OPPOSITION- Ma Yanling, Brown Philip M., Lin Dennis D., Ma Jing, Feng Dechun, Belyaeva Olga V., Podszun Maren C., Roszik Jason, Allen Joselyn N., Umarova Regina, Kleiner David E., Kedishvili Natalia Y., Gavrilova Oksana, Gao Bin, Rotman Yaron, "Hsd17b13 Deficiency Does not Protect Mice From Obesogenic Diet Injury", Hepatology, US , (20210501), vol. 73, no. 5, doi:10.1002/hep.31517, ISSN 0270-9139, pages 1 - 22, XP093150496
OPPOSITION- Deborah Edelman, Harmit Kalia, Maria Delio, Mustafa Alani, Karthik Krishnamurthy, Mortadha Abd, Adam Auton, Tao Wang, Allan W. Wolkoff, Bernice E. Morrow, "Genetic analysis of nonalcoholic fatty liver disease within a Caribbean-Hispanic population", Molecular Genetics & Genomic Medicine, (20151101), vol. 3, no. 6, doi:10.1002/mgg3.168, ISSN 2324-9269, pages 558 - 569, XP055530684
OPPOSITION- Mak Lung-Yi, Gane Ed, Schwabe Christian, Yoon Ki Tae, Heo Jeong, Scott Russell, Lee Jeong-Hoon, Lee Jung Il, Kweon Young Oh, Weltman Martin, Harrison Stephen A., Neuschwander-Tetri Brent A., Cusi Kenneth, Loomba Rohit, Given Bruce D., Christianson Dawn R., Garcia-Medel Eric, Yi Min, Hamilton James, Yuen Man-Fung, "A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis", Journal of Hepatology, AMSTERDAM, NL , (20230701), vol. 78, no. 4, doi:10.1016/j.jhep.2022.11.025, ISSN 0168-8278, pages 684 - 692, XP093150517
OPPOSITION- Thamm Sven, Willwacher Marina K., Aspnes Gary E., Bretschneider Tom, Brown Nicholas F., Buschbom-Helmke Silke, Fox Thomas, Gargano Emanuele M., Grabowski Daniel, Hoenke Christoph, Matera Damian, Mueck Katja, Peters Stefan, Reindl Sophia, Riether Doris, Schmid Matthias, Tautermann Christofer S., Teitelbaum Aaron M., Trünkle Cornelius, Veser Thomas, Winter Martin, Wortmann Lars, "Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science", Journal of Medicinal Chemistry, US , (20230223), vol. 66, no. 4, doi:10.1021/acs.jmedchem.2c01884, ISSN 0022-2623, pages 2832 - 2850, XP093064026
OPPOSITION- Chambers John C, Zhang Weihua, Sehmi Joban, Li Xinzhong, Wass Mark N, Van Der Harst Pim, Holm Hilma, Sanna Serena, Kavousi Maryam, Baumeister Sebastian E, Coin Lachlan J, Deng Guohong, Gieger Christian, Heard-Costa Nancy L, Hottenga Jouke-Jan, Kühnel Brigitte, Kumar Vinod, Lagou Vasiliki, Liang Liming, Luan Jian'an, Vidal Pedro Marques, Leach Irene Mateo, O'reilly Paul F, Peden John F, Rahmioglu Nilufer, Soininen Pasi, Speliotes Elizabeth K, Yuan Xin, Thorleifsson Gudmar, Alizadeh Behrooz Z, Atwood Larry D, Borecki Ingrid B, Brown Morris J, Charoen Pimphen, Cucca Francesco, Das Debashish, De Geus Eco J C, Dixon Anna L, Döring Angela, Ehret Georg, Eyjolfsson Gudmundur I, Farrall Martin, Forouhi Nita G, Friedrich Nele, Goessling Wolfram, Gudbjartsson Daniel F, Harris Tamara B, Hartikainen Anna-Liisa, Heath Simon, Hirschfield Gideon M, Hofman Albert, Homuth Georg, Hyppönen Elina, Janssen Harry L A, Johnson Toby, Kangas Antti J, Kema Ido P, Kühn Jens P, Lai Sandra, Lath, "Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma", Nature Genetics, New York, (20111101), vol. 43, no. 11, doi:10.1038/ng.970, ISSN 1061-4036, pages 1131 - 1138, XP055806421
OPPOSITION- Anstee Quentin M.; Seth Devanshi; Day Christopher P., "Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease", Gastroenterology, US , (20160210), vol. 150, no. 8, doi:10.1053/j.gastro.2016.01.037, ISSN 0016-5085, pages 1728 - 1744+7, XP029557260
OPPOSITION- Bratati Kahali, Brian Halligan, Elizabeth Speliotes, "Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease", Seminars in liver disease, US , vol. 35, no. 04, doi:10.1055/s-0035-1567870, ISSN 0272-8087, pages 375 - 391, XP055530703
OPPOSITION- Noura S. Abul-Husn, Xiping Cheng, Alexander H. Li, Yurong Xin, Claudia Schurmann, Panayiotis Stevis, Yashu Liu, Julia Kozlitina, Stefan Stender, G. Craig Wood, Ann N. Stepanchick, Matthew D. Still, Shane Mccarthy, Colm O’dushlaine, Jonathan S. Packer, Suganthi Balasubramanian, Nehal Gosalia, David Esopi, Sun Y. Kim, Semanti Mukherjee, Alexander E. Lopez, Erin D. Fuller, John Penn, Xin Chu, Jonathan Z. Luo, Uyenlinh L. Mirshahi, David J. Carey, Christopher D. Still, Michael D. Feldman, Aeron Small, Scott M. Damrauer, Daniel J. Rader, Brian Zambrowicz, William Olson, Andrew J. Murphy, Ingrid B. Borecki, Alan R. Shuldiner, Jeffrey G. Reid, John D. Overton, George D. Yancopoulos, Helen H. Hobbs, Jonathan C. Cohen, Omri Gottesman, Tanya M. Teslovich, Aris Baras, Tooraj Mirshahi, Jesper Gromada, Frederick E. Dewey, "A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease", The New England journal of medicine, US , (20180322), vol. 378, no. 12, doi:10.1056/NEJMoa1712191, ISSN 0028-4793, pages 1096 - 1106, XP055474833
OPPOSITION- W. Su, Y. Wang, X. Jia, W. Wu, L. Li, X. Tian, S. Li, C. Wang, H. Xu, J. Cao, Q. Han, S. Xu, Y. Chen, Y. Zhong, X. Zhang, P. Liu, J.-A. Gustafsson, Y. Guan, "Comparative proteomic study reveals 17 -HSD13 as a pathogenic protein in nonalcoholic fatty liver disease", Proceedings of the National Academy of Sciences, (20140805), vol. 111, no. 31, doi:10.1073/pnas.1410741111, ISSN 0027-8424, pages 11437 - 11442, XP055473911
OPPOSITION- Adam Marion, Heikelä Hanna, Sobolewski Cyril, Portius Dorothea, Mäki-Jouppila Jenni, Mehmood Arfa, Adhikari Prem, Esposito Irene, Elo Laura L., Zhang Fu-Ping, Ruohonen Suvi T., Strauss Leena, Foti Michelangelo, Poutanen Matti, "Hydroxysteroid (17β) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice", The FASEB Journal, US, (20180601), vol. 32, no. 6, doi:10.1096/fj.201700914R, ISSN 0892-6638, pages 3434 - 3447, XP055881738
OPPOSITION- Hotta Kikuko; Yoneda Masato; Hyogo Hideyuki; Ochi Hidenori; Mizusawa Seiho; Ueno Takato; Chayama Kazuaki; Nakajima Atsushi; Nakao Kazuwa; Sekine Akihiro, "Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease", BMC medical genetics, GB , (20101222), vol. 11, no. 1, doi:10.1186/1471-2350-11-172, ISSN 1471-2350, page 172, XP021087019
OPPOSITION- Jian-Hua Shen, Yi-Ling Li, Dan Li, Ning-Ning Wang, Lei Jing, Yu-Hong Huang, "The rs738409 (I148M) variant of the PNPLA3 gene and cirrhosis: a meta-analysis", Journal of lipid research, US , (20150101), vol. 56, no. 1, doi:10.1194/jlr.M048777, ISSN 0022-2275, pages 167 - 175, XP055530673
OPPOSITION- Kentaro Oniki, Saruwatari Junji, Izuka Tomoko, Kajiwara Ayami, Morita Kazunori, Sakata Misaki, Otake Koji, Ogata Yasuhiro, Nakagawa Kazuko, "Influence of the PNPLA3 rs738409 Polymorphism on Non-Alcoholic Fatty Liver Disease and Renal Function among Normal Weight Subjects", PLOS ONE, (20150722), vol. 10, no. 7, doi:10.1371/journal.pone.0132640, pages 1 - 14, XP055530677
OPPOSITION- Vilar-Gomez Eduardo, Pirola Carlos J., Sookoian Silvia, Wilson Laura A., Liang Tiebing, Chalasani Naga, "The Protection Conferred by HSD17B13 rs72613567 Polymorphism on Risk of Steatohepatitis and Fibrosis May Be Limited to Selected Subgroups of Patients With NAFLD", Clinical and Translational Gastroenterology, (20210910), vol. 12, no. 9, doi:10.14309/ctg.0000000000000400, ISSN 2155-384X, pages 1 - 13, XP093150527
OPPOSITION- Zhang Hai-Bo, Su Wen, Xu Hu, Zhang Xiao-Yan, Guan You-Fei, "HSD17B13: A Potential Therapeutic Target for NAFLD", Frontiers in Molecular Biosciences, (20220107), vol. 8, doi:10.3389/fmolb.2021.824776, pages 1 - 8, XP055972947

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