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Perfusion Bioreactor And Related Methods Of Use - EP3697887

The patent EP3697887 was granted to Regeneron Pharmaceuticals on Apr 6, 2022. The application was originally filed on Oct 15, 2018 under application number EP18797333A. The patent is currently recorded with a legal status of "Revoked".

EP3697887

REGENERON PHARMACEUTICALS
Application Number
EP18797333A
Filing Date
Oct 15, 2018
Status
Revoked
Sep 6, 2024
Grant Date
Apr 6, 2022
External Links
Slate, Register, Google Patents

Patent Summary

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Patent Family

Patent Oppositions (2)

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SCHIWECK WEINZIERL KOCH PATENTANWALTE PARTNERSCHAFT MBBJan 9, 2023SCHIWECK WEINZIERL KOCH PATENTANWALTE PARTNERSCHAFT MBBADMISSIBLE
SARTORIUS STEDIM BIOTECHDec 21, 2022MICHALSKI HUTTERMANN & PARTNER PATENTANWALTE MBBADMISSIBLE

Patent Citations (18) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
INTERNATIONAL-SEARCH-REPORTUS2016145563
INTERNATIONAL-SEARCH-REPORTWO2006071716
INTERNATIONAL-SEARCH-REPORTWO2013103901
INTERNATIONAL-SEARCH-REPORTWO2016004322
INTERNATIONAL-SEARCH-REPORTWO2016196261
INTERNATIONAL-SEARCH-REPORTWO2016196315
INTERNATIONAL-SEARCH-REPORTWO2017132185
OPPOSITIONEP0211241
OPPOSITIONEP1500944
OPPOSITIONUS2016145563
OPPOSITIONWO2006071716
OPPOSITIONWO2006128908
OPPOSITIONWO2009023562
OPPOSITIONWO2011005773
OPPOSITIONWO2016196261
OPPOSITIONWO2016196315
OPPOSITIONWO2017132185
OPPOSITIONWO9721824

Non-Patent Literature (NPL) Citations (21) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- KIM, B J et al., Biotechnol Bioeng., (20120100), vol. 109, no. 1, pages 137 - 45
DESCRIPTION- OMASA et al., Current Pharmaceutical Biotechnology, (20100000), vol. 11, pages 233 - 240
DESCRIPTION- BAYER et al., "The Push to Low Approach for Optimization of High Density Perfusion Cultures of Animal Cells", Adv. BioChem. Engin./Biotechnol., (20060000), vol. 101, doi:doi:10.1007/10_016, pages 75 - 98, XP009107388
INTERNATIONAL-SEARCH-REPORT- INN H. YUK ET AL, "Controlling glycation of recombinant antibody in fed-batch cell cultures", BIOTECHNOLOGY AND BIOENGINEERING, (20110615), vol. 108, no. 11, doi:10.1002/bit.23218, ISSN 0006-3592, pages 2600 - 2610, XP055171183 [A] 1,16,17,35,36,47-50 * page 2600 - page 2603 *
INTERNATIONAL-SEARCH-REPORT- JESSICA WHELAN ET AL, "In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors", BIOTECHNOLOGY PROGRESS, (20120720), vol. 28, no. 5, doi:10.1002/btpr.1590, ISSN 8756-7938, pages 1355 - 1362, XP055447080 [A] 1,16,17,35,36,47-50 * page 1355 - page 1356 *
INTERNATIONAL-SEARCH-REPORT- KONSTANTINOV KONSTANTIN ET AL, "The "push-to-low" approach for optimization of high-density perfusion cultures of animal cells", ADVANCES IN BIOCHEMICAL ENGINEERING, BIOTECHNOL, SPRINGER, BERLIN, DE, (20060131), vol. 101, doi:10.1007/10_016, ISSN 0724-6145, pages 75 - 98, XP009107388 [AD] 1,16,17,35,36,47-50 * page 79 - page 80 *
OPPOSITION- Fenge C., Fraune E., Schugerl K., "PERFUSION BIOREACTOR PERFORMANCE AT DIFFERENT CELL BLEED RATES", Animal Cell Technology: Developments, Processes and Products, (19920101), pages 365 - 372, XP093017130
OPPOSITION- LIANG LU et al., "Design and Validation of a Bioreactor for Simulating the Cardiac Niche: A System Incorporating Cyclic Stretch, Electrical Stimulation, and Constant Perfusion", TISSUE ENGEINEERING, (20130000), vol. 19, no. 3, 4
OPPOSITION- Sargent Brandy, "Perfusion Bioreactors - With so much to offer they deserve a closer look", (20130612), pages 1 - 6, URL: https://cellculturedish.com/perfusion-bioreactors-with-so- much-to-offer-they-deserve-a-closer-look, XP055892373
OPPOSITION- SHERMAN et al., "Continuous Cell Culture Operation at 2,000-L Scale", BioProcess International, (20160000), vol. 14, XP055562266
OPPOSITION- DE DOBBELEER et al., "A High-Rate Perfusion Bioreactor for Plant Cells", Biotechnology and Bioengineering, (20061220), vol. 95, no. 6, doi:10.1002/bit.21077, pages 1126 - 37, XP003015870
OPPOSITION- ABU-ABSI et al., "Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe", Biotechnol Bioeng., (20110500), vol. 108, no. 5, doi:10.1002/bit.23023, pages 1215 - 21, XP071032923
OPPOSITION- Veena Warikoo; Rahul Godawat; Kevin Brower; Sujit Jain; Daniel Cummings; Elizabeth Simons; Timothy Johnson; Jason Walther; Marcella Yu; Benjamin Wright; Jean McLarty; Kenneth P. Karey; Chris Hwang; Weichang Zhou; Frank Riske; Konstantin Konstantinov, "Integrated continuous production of recombinant therapeutic proteins", Biotechnology and Bioengineering, Hoboken, USA, (20120806), vol. 109, no. 12, doi:10.1002/bit.24584, ISSN 0006-3592, pages 3018 - 3029, XP071129335
OPPOSITION- Thomas E. Matthews; Brandon N. Berry; John Smelko; Justin Moretto; Brandon Moore; Kelly Wiltberger, "Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20160609), vol. 113, no. 11, doi:10.1002/bit.26018, ISSN 0006-3592, pages 2416 - 2424, XP071166435
OPPOSITION- G.W. HILLER et al., "Cell Retention-Chemostat Studies of Hybridoma Cells - Analysis of Hybridoma Growth and Metabolism in Continuous Suspension Culture on Serum-Free Medium", Biotechnology and Bioengineering, (19930000), vol. 42, doi:10.1002/bit.260420206, pages 185 - 195, XP002599810
OPPOSITION- Gregory W. Hiller; Ana Maria Ovalle; Matthew P. Gagnon; Meredith L. Curran; Wenge Wang, "Cell‐controlled hybrid perfusion fed‐batch CHO cell process provides significant productivity improvement over conventional fed‐batch cultures", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20170209), vol. 114, no. 7, doi:10.1002/bit.26259, ISSN 0006-3592, pages 1438 - 1447, XP071114059
OPPOSITION- Jessica Whelan; Stephen Craven; Brian Glennon, "In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors", Biotechnology Progress, American Chemical Society, Hoboken, USA, Hoboken, USA, (20120720), vol. 28, no. 5, doi:10.1002/btpr.1590, ISSN 8756-7938, pages 1355 - 1362, XP072299238
OPPOSITION- XU et al., "High-density mammalian cell cultures in stirred-tank bioreactor without external pH control", Journal of Biotechnology, (20160000), vol. 231, doi:10.1016/j.jbiotec.2016.06.019, pages 149 - 159, XP029660378
OPPOSITION- BANIK et al., "Partial and Total Cell Retention in a Filtration-Based Homogeneous Perfusion Reactor", Biotechnol. Prog., (19950000), vol. 11, doi:10.1021/bp00035a013, pages 584 - 588, XP002332439
OPPOSITION- DOWD et al., "Optimization and control of perfusion cultures using a viable cell probe and cell specific perfusion rates", Cytotechnology, (20030000), vol. 42, doi:10.1023/A:1026192228471, pages 35 - 45, XP019236785
OPPOSITION- Korin Natanel, Bransky Avishay, Dinnar Uri, Levenberg Shulamit, "A parametric study of human fibroblasts culture in a microchannel bioreactor", Lab on a Chip, Royal Society of Chemistry, UK, UK , (20070101), vol. 7, no. 5, doi:10.1039/b702392h, ISSN 1473-0197, pages 611 - 617, XP093012464

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