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Cell Culture Methods - EP3717631

The patent EP3717631 was granted to UCB Biopharma on Aug 30, 2023. The application was originally filed on Nov 29, 2018 under application number EP18811257A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3717631

UCB BIOPHARMA
Application Number
EP18811257A
Filing Date
Nov 29, 2018
Status
Granted And Under Opposition
Jul 28, 2023
Grant Date
Aug 30, 2023
External Links
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Patent Summary

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Patent Family

Patent Oppositions (2)

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OETKEMay 29, 2024WALLINGER RICKER SCHLOTTER TOSTMANNADMISSIBLE
COHAUSZ & FLORACKApr 11, 2024COHAUSZ & FLORACKADMISSIBLE

Patent Citations (17) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS2006148074
DESCRIPTIONUS2013281355
DESCRIPTIONUS8765413
DESCRIPTIONWO2013158275
DESCRIPTIONWO9808934
INTERNATIONAL-SEARCH-REPORTWO2008033517
INTERNATIONAL-SEARCH-REPORTWO2017186654
OPPOSITIONEP2500415
OPPOSITIONKR20050070512
OPPOSITIONUS2013281355
OPPOSITIONUS2017204362
OPPOSITIONUS4927762
OPPOSITIONWO2008033517
OPPOSITIONWO2013158275
OPPOSITIONWO2013171156
OPPOSITIONWO2019106091
OPPOSITIONWO9808934

Non-Patent Literature (NPL) Citations (42) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
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OPPOSITION- Angela Maria Moraes, Ronaldo Zucatelli Mendonca, and Claudio Alberto Torres Suazo, "Chapter 5: Culture media for animal cells", Angela Maria Moraes, Ronaldo Zucatelli Mendonca, and Claudio Alberto Torres Suazo, Leda Castilho, Angela Moraes, Elisabeth Augusto, and Mike Butler, Animal Cell Technology: From Biopharmaceuticals to Gene Therapy, US, Taylor & Francis, (20080131), pages 111 - 128, ISBN 978-0-415-42304-5, XP009556215
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OPPOSITION- Declaration by Valentine Chevallier
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OPPOSITION- Feature overview re claims
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OPPOSITION- Michael C. Flickinger, "SUSPENSION CULTURE, ANIMAL CELLS", Michael C. Flickinger, Michael C. Flickinger, Stephen W. Drew, Encyclopedia of bioprocess technology : fermentation, biocatalysis, and bioseparation , N.Y., Wiley, (19990101), pages 2509 - 2516, ISBN 0-471-13822-3, XP009556333
OPPOSITION- S.A. Casnocha, R.A. Wolfe, "Media, animal cell culture", Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseparation, John Wiley &Sons, Inc. , (19990101), pages 1660 - 1676, XP055459867
OPPOSITION- Tyther Raymond; Jenkins Nigel, "Quality Issues Arising from Post-translational Modification of Recombinant Antibodies", Antibody Expression and Production, (20110101), pages 293 - 303, XP009192400
OPPOSITION- Von Hagen Jörg, Hecklau Caroline, Seibel Ronja, Pering Sascha, Schnellbaecher Alisa, Wehsling Maria, Eichhorn Thomas, Zimmer Aline, "Simplification of Fed-Batch Processes with a Single-Feed Strategy", BioProcess International, (20170119), BioProcess International, URL: https://www.bioprocessintl.com/cell-culture-media/simplification-of-fed-batch-processes-with-a-single-feed-strategy, XP093191221
OPPOSITION- Wlaschin Katie F; Hu Wei-Shou, "Fedbatch culture and dynamic nutrient feeding", ADVANCES IN BIOCHEMICAL ENGINEERING, BIOTECHNOLOGY., SPRINGER, BERLIN, DE, DE , (20060610), vol. 101, ISSN 0724-6145, pages 43 - 74, XP009092044
OPPOSITION- Xue Lijian, Xue Lijian, Li Jinhui, Li Yang, Chu Chu, Xie Guantao, Qin Jin, Yang Mingfeng, Zhuang Donggang, Cui Liuxin, Zhang Huizhen, Fu Xiaoli, "N-acetylcysteine protects Chinese Hamster ovary cells from oxidative injury and apoptosis induced by microcystin-LR", International Journal of Clinical and Experimental Medicine 2015, E-Century Publishing Corporation, US, US , (20150415), vol. 8, no. 4, ISSN 1940-5901, pages 4911 - 4921, XP093191319
OPPOSITION- Anne Kantardjieff, Weichang Zhou, "Mammalian Cell Cultures for Biologics Manufacturing", ADVANCES IN BIOCHEMICAL ENGINEERING, BIOTECHNOLOGY., SPRINGER, BERLIN, DE, DE , (20140101), vol. 139, doi:10.1007/10_2013_255, ISSN 0724-6145, pages 1 - 9, XP009556293
OPPOSITION- Ana Rita Costa, Maria Elisa Rodrigues, Mariana Henriques, Rosário Oliveira & Joana Azeredo, "Feed Optimization in Fed-Batch Culture", Animal Cell Biotechnology, Humana Press, Totowa, NJ, Totowa, NJ, (20140101), vol. 1104, doi:10.1007/978-1-62703-733-4_8, ISSN 1064-3745, ISBN 978-1-62703-733-4, pages 105 - 116, XP009556229
OPPOSITION- Andrew Salazar, "Amino acids in the cultivation of mammalian cells", Amino Acids, (2016), vol. 48, doi:10.1007/s00726-016-2181-8, XP035889636
OPPOSITION- Hangtian Song, "Investigation of Color in a Fusion Protein Using Advanced A n a l y t i c a l Te c h n i q u e s : D e l i n e a t i n g C o n t r i b u t i o n s from Oxidation Products and Process Related Impurities", Pharm. Res., (201512), vol. 33, doi:10.1007/s11095-015-1839-3, XP035927676
OPPOSITION- Daniela Giustarini, "N-Acetylcysteine ethyl ester (NACET): A novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential", Biochemical Pharmacology, (2012), vol. 84, doi:10.1016/j.bcp.2012.09.010, XP093093870
OPPOSITION- Hecklau Caroline; Pering Sascha; Seibel Ronja; Schnellbaecher Alisa; Wehsling Maria; Eichhorn Thomas; Hagen Joerg von; Zimmer Aline, "S-Sulfocysteine simplifies fed-batch processes and increases the CHO specific productivity via anti-oxidant activity", Journal of Biotechnology, Elsevier, Amsterdam NL, Amsterdam NL , (20151202), vol. 218, doi:10.1016/j.jbiotec.2015.11.022, ISSN 0168-1656, pages 53 - 63, XP029379422
OPPOSITION- Chevallier Valentine; Zoller Marvin; Kochanowski Nadine; Andersen Mikael R.; Workman Christopher T.; Malphettes Laetitia, "Use of novel cystine analogs to decrease oxidative stress and control product quality", Journal of Biotechnology, Elsevier, Amsterdam NL, Amsterdam NL , (20201226), vol. 327, doi:10.1016/j.jbiotec.2020.12.011, ISSN 0168-1656, pages 1 - 8, XP086476040
OPPOSITION- Chumsae, C. Gaza-Bulseco, G. Sun, J. Liu, H., "Comparison of methionine oxidation in thermal stability and chemically stressed samples of a fully human monoclonal antibody", Journal of Chromatography B, ELSEVIER, AMSTERDAM., NL, NL , (20070424), vol. 850, no. 1-2, doi:10.1016/j.jchromb.2006.11.050, ISSN 1570-0232, pages 285 - 294, XP022044072
OPPOSITION- Wei Wu a, Linu Abraham a, Joshua Ogony a, Richard Matthews b, Glenn Goldstein c, Nuran Ercal, "Effects of N-acetylcysteine amide (NACA), a thiol antioxidant on radiation-induced cytotoxicity in Chinese hamster ovary cells", Life Science, PERGAMON PRESS, OXFORD, GB, GB , (20080101), vol. 82, doi:10.1016/j.lfs.2008.03.016, ISSN 0024-3205, pages 1122 - 1130, XP007906191
OPPOSITION- Pedre Brandán, Barayeu Uladzimir, Ezeriņa Daria, Dick Tobias P., "The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species", Pharmacology & Therapeutics, ELSEVIER., GB, GB , (20211201), vol. 228, doi:10.1016/j.pharmthera.2021.107916, ISSN 0163-7258, page 107916, XP093191236
OPPOSITION- Manabu Kitazawa, "Intracellular redox regulation by a cystine derivative suppresses UV-induced NF-UB activation", FEBS Letters, (2002), vol. 526, doi:10.1016/S0014-5793(02)03152-6, XP004379234
OPPOSITION- Manabu Kitazawa; Takashi Nakano; Hiromi Chuujou; Eiji Shiojiri; Keiji Iwasaki; Kazutami Sakamoto, "Intracellular redox regulation by a cystine derivative suppresses UV‐induced NF‐κB activation", FEBS Letters, ELSEVIER, AMSTERDAM., NL, NL , (20020803), vol. 526, doi:10.1016/S0014-5793(02)03152-6, ISSN 0014-5793, pages 106 - 110, XP071244442
OPPOSITION- Li Yiming, Polozova Alla, Gruia Flaviu, Feng Jinhua, "Characterization of the Degradation Products of a Color-Changed Monoclonal Antibody: Tryptophan-Derived Chromophores", Analytical Chemistry, American Chemical Society, US, US , (20140715), vol. 86, no. 14, doi:10.1021/ac404218t, ISSN 0003-2700, pages 6850 - 6857, XP093191322
OPPOSITION- Margaret Butko, "Recombinant Antibody Color Resulting from Advanced Glycation End Product Modifications", Analytical Chemistry, (2014), vol. 86, doi:10.1021/ac5024099, XP055921030
OPPOSITION- Gomathinayagam Ponniah, Adriana Kita, Christine Nowak, Alyssa Neill, Yekaterina Kori, Saravanamoorthy Rajendran, Hongcheng Liu, "Characterization of the Acidic Species of a Monoclonal Antibody Using Weak Cation Exchange Chromatography and LC-MS", Analytical Chemistry, American Chemical Society, (20150901), vol. 87, no. 17, doi:10.1021/acs.analchem.5b02385, pages 9084 - 9092, XP055317372
OPPOSITION- Han Kyu Oh, "Effect of N-Acetylcystein on Butyrate-Treated Chinese Hamster Ovary Cells To Improve the Production of Recombinant Human Interferon-â-1a", Biotechnol. Prog., (2005), vol. 21, doi:10.1021/bp050057v, XP055034659
OPPOSITION- Han Kyu Oh, Moon Kyoung So, Jihye Yang, Ho Chul Yoon, Ji Soo Ahn, Jong Min Lee, Ji Tai Kim, Ji Uk Yoo, Tae Ho Byun, "Effect of N-Acetylcystein on Butyrate-Treated Chinese Hamster Ovary Cells To Improve the Production of Recombinant Human Interferon-&bgr;-1a", Biotechnology Progress, American Chemical Society, (20050101), vol. 21, no. 4, doi:10.1021/bp050057v, ISSN 87567938, pages 1154 - 1164, XP055034659
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OPPOSITION- Ronja Seibel, Sandra Maier, Alisa Schnellbaecher, Susanne Bohl, Maria Wehsling, Anne Zeck, Aline Zimmer, "Impact of S-sulfocysteine on fragments and trisulfide bond linkages in monoclonal antibodies", mAbs, Landes Bioscience, US, US , (20170818), vol. 9, no. 6, doi:10.1080/19420862.2017.1333212, ISSN 1942-0862, pages 889 - 897, XP055465718
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OPPOSITION- Pettersson Knut, Bergstrand Håkan, "The Antiatherogenic Effect of DiNAC: Experimental Findings Supporting Immunomodulation as a New Treatment for Atherosclerosis Related Diseases", CARDIOVASCULAR DRUG REVIEWS, NEVA PRESS, BRANFORD, CT, US, US , (20030601), vol. 21, no. 2, doi:10.1111/j.1527-3466.2003.tb00110.x, ISSN 0897-5957, pages 119 - 132, XP093235868
OPPOSITION- Knut S. Pettersson; Ulla Brandt Eliasson; Tommy Abrahamsson; Maria Wågberg; Martin Carrier; Ken M. Kengatharan, "N,N‐Diacetyl‐l‐cystine Improves Endothelial Function in Atherosclerotic Watanabe Heritable Hyperlipidaemic Rabbits", BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, NORDIC PHARMACOLOGICAL SOCIETY, COPENHAGEN, DK, COPENHAGEN, DK , (20061222), vol. 100, no. 1, doi:10.1111/j.1742-7843.2007.00007.x, ISSN 1742-7835, pages 36 - 42, XP072368666
OPPOSITION- Yamada Jun, Maruyama Kazuichi, Sano Yoichiro, Kinoshita Shigeru, Murata Yukie, Hamuro Junji, "Promotion of Corneal Allograft Survival by the Induction of Oxidative Macrophages", Investigative Opthalmology & Visual Science, Association for Research in Vision and Ophthalmology, US, US , (20040201), vol. 45, no. 2, doi:10.1167/iovs.03-0939, ISSN 1552-5783, page 448, XP093235872
OPPOSITION- Primas Nicolas, Lano Guillaume, Brun Damien, Curti Christophe, Sallée Marion, Sampol-Manos Emmanuelle, Lamy Edouard, Bornet Charleric, Burtey Stéphane, Vanelle Patrice, "Stability Study of Parenteral N-Acetylcysteine, and Chemical Inhibition of Its Dimerization", Pharmaceuticals, M D P I AG, CH, CH , vol. 16, no. 1, doi:10.3390/ph16010072, ISSN 1424-8247, page 72, XP093191224

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