IP Verse

Bispecific Antigen Binding Construct - EP3728328

The patent EP3728328 was granted to Argenx Bvba on Oct 23, 2024. The application was originally filed on Dec 21, 2018 under application number EP18830279A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3728328

ARGENX BVBA
Application Number
EP18830279A
Filing Date
Dec 21, 2018
Status
Granted And Under Opposition
Sep 19, 2024
Grant Date
Oct 23, 2024
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

SANOFIJul 23, 2025HOFFMANN EITLEADMISSIBLE
SIMMONS & SIMMONSJul 22, 2025SIMMONS & SIMMONS MUNICHADMISSIBLE

Patent Citations (33) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO2012EP71866-
DESCRIPTIONUS2009252729
DESCRIPTIONUS2010254989
DESCRIPTIONUS2010331527
DESCRIPTIONUS2011081345
DESCRIPTIONUS2014154254
DESCRIPTIONUS2015307628
DESCRIPTIONUS5821333
DESCRIPTIONUS5892019
DESCRIPTIONUS8216805
DESCRIPTIONUS8524231
DESCRIPTIONUS8703131
DESCRIPTIONUS9212230
DESCRIPTIONUS9499634
DESCRIPTIONWO2013064701
DESCRIPTIONWO2013136186
INTERNATIONAL-SEARCH-REPORTUS2010331527
INTERNATIONAL-SEARCH-REPORTWO2013064701
INTERNATIONAL-SEARCH-REPORTWO2014022540
INTERNATIONAL-SEARCH-REPORTWO2014124326
INTERNATIONAL-SEARCH-REPORTWO2015033223
INTERNATIONAL-SEARCH-REPORTWO2016086186
INTERNATIONAL-SEARCH-REPORTWO2016086189
INTERNATIONAL-SEARCH-REPORTWO2017218707
OPPOSITIONUS2014363426
OPPOSITIONUS8524231
OPPOSITIONUS9499634
OPPOSITIONWO2009068649
OPPOSITIONWO2012122528
OPPOSITIONWO2013070565
OPPOSITIONWO2014022540
OPPOSITIONWO2017165464
OPPOSITIONWO9404690

Non-Patent Literature (NPL) Citations (44) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BORROK et al., ACS Chem Biol., (20120000), vol. 7, no. 9, pages 1596 - 1602-
DESCRIPTION- CARTER P., J. Immunol. Methods, (20010000), vol. 248, pages 7 - 15-
DESCRIPTION- CHAN; CARTER, Nature Reviews: Immunology, (20100000), vol. 10, pages 301 - 316-
DESCRIPTION- CHOTHIA et al., J. Mol. Biol., (19870000), vol. 196, pages 901 - 917-
DESCRIPTION- CHOTHIA et al., J. Mol. Biol., (19920000), vol. 227, pages 799 - 817-
DESCRIPTION- EDELMAN et al., Proc. Natl. Acad. Sci. USA, (19690000), vol. 63, no. 1, pages 78 - 85-
DESCRIPTION- GRAHAM et al., J. Gen. Virol., (19770000), vol. 36, page 59-
DESCRIPTION- GUNASEKARAN K., J Biol Chem, (20100000), vol. 285, no. 25, pages 19637 - 19646-
DESCRIPTION- HAMERS-CASTERMAN et al., Nature, (19930000), vol. 363, pages 446 - 8-
DESCRIPTION- HINTON et al., J Immunol., (20060000), vol. 176, pages 346 - 356-
DESCRIPTION- KABAT et al., J. Biol. Chem., (19770000), vol. 252, pages 6609 - 6616-
DESCRIPTION- KLEIN C., mABs, (20120000), vol. 4, no. 6, pages 653 - 663-
DESCRIPTION- KLEIN et al., mAbs, (20120000), vol. 4, no. 6, pages 1 - 11-
DESCRIPTION- LABRIJN A.F., Proc Natl Acad Sci USA, (20130000), vol. 110, no. 13, pages 5145 - 5150-
DESCRIPTION- LEWIS et al., Nature Biotechnology, (20140000), vol. 32, pages 191 - 198-
DESCRIPTION- LINDHOFER et al., J Immunol., (19950000), vol. 155, pages 1246 - 1252-
DESCRIPTION- MACCALLUM et al., J. Mol. Biol., (19960000), vol. 262, pages 732 - 745-
DESCRIPTION- MATHER, Biol. Reprod., (19800000), vol. 23, pages 243 - 251-
DESCRIPTION- MATHER et al., Annals N.Y. Acad. Sci., (19820000), vol. 383, pages 44 - 68-
DESCRIPTION- MOREA et al., Methods, (20000000), vol. 20, pages 267 - 279-
DESCRIPTION- MUDA M., Protein Eng. Des. Sel., (20110000), vol. 24, no. 5, pages 447 - 454-
DESCRIPTION- PRESTA LG., Curr. Opin. Immunol., (20080000), vol. 20, pages 460 - 470-
DESCRIPTION- RIDGWAY et al., Protein Engineering, (19960000), vol. 9, pages 617 - 621-
DESCRIPTION- ROUX et al., J. Immunol., (19980000), vol. 161, page 4083-
DESCRIPTION- SPIESS et al., Nature Biotechnology, (20130000), vol. 31, pages 753 - 758-
DESCRIPTION- TRAMONTANO et al., J. Mol. Biol, (19900000), vol. 215, pages 175 - 182-
DESCRIPTION- URLAUB et al., Proc. Natl. Acad. Sci. USA, (19800000), vol. 77, page 4216-
DESCRIPTION- VACCARO et al., Nat. Biotechnol., (20050000), vol. 23, no. 10, pages 1283 - 88-
DESCRIPTION- WANG et al., J Pharm Sci, (20070000), vol. 96, pages 1 - 26-
DESCRIPTION- WRANIK B., J Biol Chem, (20120000), vol. 287, no. 52, pages 43331 - 43339-
DESCRIPTION- YEUNG et al., J Immunol., (20090000), vol. 182, pages 7663 - 7671-
DESCRIPTION- ZALEVSKY et al., Nat. Biotechnol., (20100000), vol. 28, no. 2, pages 157 - 9-
INTERNATIONAL-SEARCH-REPORT- STEVEN M LEWIS ET AL, "Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface", NATURE BIOTECHNOLOGY, New York, (20140201), vol. 32, no. 2, doi:10.1038/nbt.2797, ISSN 1087-0156, pages 191 - 198, XP055240003 [A] 1-20 * the whole document *
INTERNATIONAL-SEARCH-REPORT- M. MUDA ET AL, "Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono- and bispecific antibodies", PROTEIN ENGINEERING DESIGN AND SELECTION, (20110415), vol. 24, no. 5, doi:10.1093/protein/gzq123, ISSN 1741-0126, pages 447 - 454, XP055193599 [A] 1-20 * the whole document *
OPPOSITION- D3a - Printout of SEC Form-1 of Zymeworks Inc., Version of May 8, 2017 as evidenced by Wayback Machine-
OPPOSITION- D3 - Printout of SEC Form-1 of Zymeworks Inc.,Published at least by May 8, 2017-
OPPOSITION- Robert M. Hnasko & Jeffery A. McGarvey, "Chapter 3. Affinity Purification of Antibodies", ELISA : methods and protocols, (20150101), vol. 1318, pages 29 - 41, doi:10.1007/978-1-4939-2742- 5_3, ISBN 1-4939-2741-8, XP009562601
OPPOSITION- Cécile Vincke, Serge Muyldermans, "Introduction to Heavy Chain Antibodies and Derived Nanobodies", Methods in Molecular Biology, Humana Pr., US, US , (20120712), vol. 911, doi:10.1007/978-1-61779-968-6_2, ISBN 978-1-61779-291-5, pages 15 - 26, XP009185137
OPPOSITION- Hermans Pim, Adams Hendrik, Detmers Frank, "Purification of Antibodies and Antibody Fragments Using CaptureSelect™ Affinity Resins : Methods and Protocols", Monoclonal Antibodies : Methods and Protocols : Methods and Protocols, Totowa, NJ, Humana Press, (20140101), vol. 1131, pages 297 - 314, doi:10.1007/978-1-62703-992-5_19, ISSN 1064-3745, ISBN 978-1-62703-992-5, XP009562796
OPPOSITION- Stanimirovic Danica; Kemmerich Kristin; Haqqani Arsalan S; Farrington Graham K, "Engineering and pharmacology of blood-brain barrier-permeable bispecific antibodies.", Advances in pharmacology, Elsevier, USA, USA , (20140101), vol. 71, doi:10.1016/bs.apha.2014.06.005, ISSN 1557-8925, pages 301 - 335, XP009188677
OPPOSITION- Vera Neves, Frederico Aires-Da-Silva, Sofia Corte-Real, Miguel A.R.B. Castanho, "Antibody Approaches To Treat Brain Diseases", TRENDS IN BIOTECHNOLOGY., ELSEVIER PUBLICATIONS, CAMBRIDGE., GB, GB , (20160101), vol. 34, no. 1, doi:10.1016/j.tibtech.2015.10.005, ISSN 0167-7799, pages 36 - 48, XP055512549
OPPOSITION- Ulrich Brinkmann, Roland E. Kontermann, "The making of bispecific antibodies", mAbs, Landes Bioscience, US, US , (20170217), vol. 9, no. 2, doi:10.1080/19420862.2016.1268307, ISSN 1942-0862, pages 182 - 212, XP055374463
OPPOSITION- Pierre Moretti;Darko Skegro;Romain Ollier;Paul Wassmann;Christel Aebischer;Thibault Laurent;Miriam Schmid-Printz;Roberto Giovannini;Stanislas Blein;Martin Bertschinger, "BEAT® the bispecific challenge: a novel and efficient platform for the expression of bispecific IgGs ", BMC Proceedings, BioMed Central Ltd, London UK, London UK , (20131204), vol. 7, no. Suppl 6, doi:10.1186/1753-6561-7-S6-O9, ISSN 1753-6561, page O9, XP021170286
OPPOSITION- Klein C, Sustmann C, Thomas M, Stubenrauch K, Croasdale R, Schanzer J, Brinkmann U, Kettenberger H, Regula JT, Schaefer W., "Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies", MAbs, (2012), vol. 4, no. 6, doi:10.4161/mabs.21379, pages 653 - 663, XP055106060

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents