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| OPPOSITION | - D100 - Ensembl - human UBE3A85 | - |
| OPPOSITION | - D102 - SEQ ID NO: 1 with SEQ ID NO: 2 as the query. Full length alignment of mouse and human sequences | - |
| OPPOSITION | - D103 - SEQ ID NO: 1 range 997,469 to 1,032,966 with SEQ ID NO: 2 range 446,213 to 513,602 regions described as interesting in the description | - |
| OPPOSITION | - D104 - SNORD 115-1 (HBII-52-1) sequence | - |
| OPPOSITION | - D105 - SNORD 115-1 aligned against SEQ ID NO: 2 37 ranges | - |
| OPPOSITION | - D106 - SNORD 115-48 (HBII-52-48) sequence | - |
| OPPOSITION | - D107 - SNORD 115-2 aligned against SEQ ID NO: 2 | - |
| OPPOSITION | - D115a - Supplemental figures for D115 | - |
| OPPOSITION | - D115b - Supplemental table for D115 | - |
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| OPPOSITION | - D26 - Declaration of Professor Claes Wahlestedt, 10 May 2019 | - |
| OPPOSITION | - D27 - Declaration of Dr. Frank Riga | - |
| OPPOSITION | - D31 - Declaration of Lykke Pedersen | - |
| OPPOSITION | - D33 - Entrez gene summary for SNORD109B (https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&do pt=full_report&list_uids=338429) | - |
| OPPOSITION | - D35 - Second Declaration of Claes Wahlestedt | - |
| OPPOSITION | - D37 - Search overview of documents teaching the targeting of non-overlapping regions | - |
| OPPOSITION | - D40 - CA/PL 4/00 | - |
| OPPOSITION | - D41 - CA 100/00 | - |
| OPPOSITION | - D43 - Declaration of Dr Stormy J. Chamberlain | - |
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| OPPOSITION | - D47 - Connecticut Stem Cell Research program grant agreement | - |
| OPPOSITION | - D48 - Material transfer agreements relating to the iPSC cells in D29 | - |
| OPPOSITION | - D49 - UConn communication from 2014 regarding deposit of AS iPSC cell line | - |
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| OPPOSITION | - D66 - EPO Communication dated 18 October 2021 in re EP2640853B (instant D65) | - |
| OPPOSITION | - D70 - T 1959/15 | - |
| OPPOSITION | - D71 - G 2/21 | - |
| OPPOSITION | - D72 - T 609/02 | - |
| OPPOSITION | - D73 - T 1599/06 | - |
| OPPOSITION | - D74 - T 760/12 | - |
| OPPOSITION | - D75 - T 1045/13 | - |
| OPPOSITION | - D76 - T 544/12 | - |
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| OPPOSITION | - D81 - Opposition to the first divisional patent | - |
| OPPOSITION | - D82 - Withdrawal of approval of text by patentees for the opposed first divisional patent | - |
| OPPOSITION | - D83 - EPO final communication for the opposed first divisional paten | - |
| OPPOSITION | - D85 - Opposition to granted parent patent | - |
| OPPOSITION | - D86 - Main Request before OD for the opposed parent patent | - |
| OPPOSITION | - D87 - Decision on the opposed parent patent | - |
| OPPOSITION | - D88 - Appeal to Decision on the opposed parent patent | - |
| OPPOSITION | - D89 - Claim Requests in Appeal for the opposed parent patent - Clean | - |
| OPPOSITION | - D90 - Claim Requests in Appeal for the opposed parent patent - Tracked | - |
| OPPOSITION | - D91 - Preliminary Opinion of Board of Appeal on the opposed parent patent | - |
| OPPOSITION | - D92 - Withdrawal of approval of text by patentees for the opposed parent patent | - |
| OPPOSITION | - D93 - Decision of EPO Board of Appeal for the opposed parent patent | - |
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| OPPOSITION | - D98 - Diagrammatic representation of the human regions of the claims | - |
| OPPOSITION | - D99 - Ensembl - murine UBE3A84 | - |
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| OPPOSITION | - C. A. Stein, J. B. Hansen, J. Lai, S. Wu, A. Voskresenskiy, A. Hog, J. Worm, M. Hedtjarn, N. Souleimanian, P. Miller, H. S. Soifer, D. Castanotto, L. Benimetskaya, H. Orum, T. Koch, "Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents", Nucleic Acids Research, Information Retrieval Ltd., (20100101), vol. 38, no. 1, doi:10.1093/nar/gkp841, ISSN 03051048, pages e3 - e3, XP055023570 | |
| OPPOSITION | - Guibert Mathilde, Marty-Capelle Hélène, Robert Anne, Charpentier Bruno, Labialle Stéphane, "Coordinated evolution of the SNORD115 and SNORD116 tandem repeats at the imprinted Prader-Willi/Angelman locus", Human Health Therapeutics, National Research Council Canada , Ottawa , Ontario K1A 0R6, Canada, (20240123), vol. 1, no. 1, doi:10.1093/narmme/ugad003, ISSN 2976-856X, XP093271281 | |
| OPPOSITION | - Chung Michael S., Langouët Maéva, Chamberlain Stormy J., Carmichael Gordon G., "Prader-Willi syndrome: reflections on seminal studies and future therapies", Open Biology, The Royal Society Publishing, (20200901), vol. 10, no. 9, doi:10.1098/rsob.200195, ISSN 2046-2441, XP093271202 | |
| OPPOSITION | - Germain Noelle D., Gorka Dea, Drennan Ryan, Jafar-Nejad Paymaan, Whipple Amanda, Core Leighton, Levine Eric S., Rigo Frank, Chamberlain Stormy J., "Antisense oligonucleotides targeting UBE3A-ATS restore expression of UBE3A by relieving transcriptional interference", bioRxiv, doi:10.1101/2021.07.09.451826, (20210710), pages 1 - 33, bioRxiv, URL: https://www.biorxiv.org/content/10.1101/2021.07.09.451826v1.full.pdf, (20211115), XP055861696 | |
| OPPOSITION | - Jagasia Ravi, Bon Charlotte, Rasmussen Soren V., Badillo Solveig, Tehler Disa, Buchy Danièle, Berrera Marco, Prasad Megana, Terrigno Marco, Pandya Nikhil J., Costa Veronica, Wang Congwei, Pedersen Lykke, Miller Meghan T., Dumong Erichsen Kamille, Joenson Lars, Hipp Joerg, Bonni Azad, Müller Lutz, Brändli-Baiocco Annamaria, Kremer Thomas, Koller Erich, Hoener Marius C., "Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey", bioRxiv, doi:10.1101/2022.06.09.495066, (20220612), bioRxiv, URL: https://www.biorxiv.org/content/10.1101/2022.06.09.495066v1, XP093271276 | |
| OPPOSITION | - Maryam Keshavarz; Yoland Savriama; Peter Refki; R. Guy Reeves; Diethard Tautz, "Expression of Concern: Natural copy number variation of tandemly repeated regulatory SNORD RNAs leads to individual phenotypic differences in mice", MOLECULAR ECOLOGY., BLACKWELL SCIENCE, OXFORD., GB, GB , (20210728), vol. 30, no. 19, doi:10.1111/mec.16076, ISSN 0962-1083, pages 4708 - 4722, XP072600419 | |
| OPPOSITION | - Dindot Scott V., Christian Sarah, Murphy William J., Berent Allyson, Panagoulias Jennifer, Schlafer Annalise, Ballard Johnathan, Radeva Kamelia, Robinson Ruth, Myers Luke, Jepp Thomas, Shaheen Hillary, Hillman Paul, Konganti Kranti, Hillhouse Andrew, Bredemeyer Kevin R., Black Lauren, Douville Julie, Weeber Edwin, Segal David, Anderson Anne, Nash Kevin, Silverman Jill, "An ASO therapy for Angelman syndrome that targets an evolutionarily conserved region at the start of the UBE3A-AS transcript", Science Translational Medicine(Supplementary Materials), American Association for the Advancement of Science, (20230322), vol. 15, no. 688, doi:10.1126/scitranslmed.abf4077, ISSN 1946-6234, XP093271182 | |
| OPPOSITION | - C. Frank Bennett, Eric E. Swayze, "RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform", Annual Review of Pharmacology and Toxicology, Annual Reviews Inc., (20100201), vol. 50, no. 1, doi:10.1146/annurev.pharmtox.010909.105654, ISSN 03621642, pages 259 - 293, XP055055378 | |
| OPPOSITION | - Anastasia Efthymiou, Atossa Shaltouki, Joseph P. Steiner, Balendu Jha, Sabrina M. Heman-Ackah, Andrzej Swistowski, Xianmin Zeng,Mahendra S. Rao, and Nasir Malik, "Functional screening assays with neurons generated from pluripotent stem cell-derived neural stem cells", Journal of Biomolecular Screening Society for Laboratory Automation and Screening, (20140101), vol. 19, no. 1, doi:10.1177/1087057113501869, pages 32 - 43, XP055340253 | |
| OPPOSITION | - Kevin V. Morris, Sharon Santoso, Anne-Marie Turner, Chiara Pastori, Peter G. Hawkins, "Bidirectional Transcription Directs Both Transcriptional Gene Activation and Suppression in Human Cells", PLoS Genetics, Public Library of Science, USA, USA, (20081101), vol. 4, no. 11, doi:10.1371/journal.pgen.1000258, ISSN 1553-7390, pages 1 - 9, XP055008804 | |
| OPPOSITION | - Smith Emily Y., Futtner Christopher R., Chamberlain Stormy J., Johnstone Karen A., Resnick James L., "Transcription Is Required to Establish Maternal Imprinting at the Prader-Willi Syndrome and Angelman Syndrome Locus", PLoS Genetics, Public Library of Science, US, US , vol. 7, no. 12, doi:10.1371/journal.pgen.1002422, ISSN 1553-7404, page e1002422, XP093271194 | |
| OPPOSITION | - Mohammad Ali Faghihi, Jannet Kocerha, Farzaneh Modarresi, Pär G. Engström, Alistair M. Chalk, Shaun P. Brothers, Eric Koesema, Georges St. Laurent Iii, Claes Wahlestedt, "RNAi Screen Indicates Widespread Biological Function for Human Natural Antisense Transcripts", PLos One, (20101004), vol. 5, no. 10, doi:10.1371/journal.pone.0013177CiteNPL, pages 1 - 10, XP055592454 | |
| OPPOSITION | - YANG D C, ELLIOTT R L, HEAD J F, "GENE TARGETS OF ANTISENSE THERAPIES IN BREAST CANCER", Expert Opinion on therapeutic targets, Informa Healthcare, UK, UK , (20020101), vol. 06, no. 03, doi:10.1517/14728222.6.3.375, ISSN 1472-8222, pages 375 - 385, XP008054424 | |
| OPPOSITION | - S. J. Chamberlain, M. Lalande, "Angelman Syndrome, a Genomic Imprinting Disorder of the Brain", THE JOURNAL OF NEUROSCIENCE, Society for Neuroscience, US, US , (20100728), vol. 30, no. 30, doi:10.1523/JNEUROSCI.1728-10.2010, ISSN 0270-6474, pages 9958 - 9963, XP055592458 | |
| OTHER | - Cavaillé et al., "Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization", PNAS, (20001219), vol. 97, no. 26, pages 14311 - 14316, XP055927684 | - |
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