Ret Inhibitor For Use In Treating Cancer Having A Ret Alteration - EP3773589

The patent EP3773589 was granted to Blueprint Medicines on Nov 1, 2023. The application was originally filed on Apr 3, 2019 under application number EP19718531A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3773589

BLUEPRINT MEDICINES
Application Number
EP19718531A
Filing Date
Apr 3, 2019
Status
Granted And Under Opposition
Sep 29, 2023
Grant Date
Nov 1, 2023
External Links
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Patent Citations (19) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS19830627416-
DESCRIPTIONUS19840626522-
DESCRIPTIONUS19970626562-
DESCRIPTIONUS20050626576-
DESCRIPTIONCN105255927
DESCRIPTIONEP3037547
DESCRIPTIONJP2015109806
DESCRIPTIONUS2014272951
DESCRIPTIONUS2015057335
DESCRIPTIONUS2015177246
DESCRIPTIONUS9216172
DESCRIPTIONUS9297011
DESCRIPTIONWO2017079140
INTERNATIONAL-SEARCH-REPORTWO2017079140
INTERNATIONAL-SEARCH-REPORTWO2018071447
INTERNATIONAL-SEARCH-REPORTWO2018213329
OPPOSITIONWO2017079140
OPPOSITIONWO2018071447
OPPOSITIONWO2018213329

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INTERNATIONAL-SEARCH-REPORT- VIVEK SUBBIAH ET AL, "Precision Targeted Therapy with BLU-667 for RET -Driven Cancers", CANCER DISCOVERY, US, (20180415), vol. 8, no. 7, doi:10.1158/2159-8290.CD-18-0338, ISSN 2159-8274, pages 836 - 849, XP055599279 [XP] 1,2,4,8,9,12,13,16-18,21,23,27-32,34,42-46,48-53,59-63 * abstract * * page 838, column 1, paragraph l - column 2, paragraph 1 * * page 839, column 2, paragraph l - page 841, column 1, paragraph 1 * * page 842, column 2, paragraph 2 - page 845, column 1, paragraph 1 * * page 845, column 2, paragraph 2 * * page 846, column 1, paragraphs 1-2 *
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OPPOSITION- Anonymous, "Guidance for Industry Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers", U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER, (20050701), pages 1 - 30, U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER, URL: https://www.fda.gov/media/72309/download, (20240815), XP093195537-
OPPOSITION- Anonymous, "Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors", Clinical trials, (20170421), pages 1 - 14, Clinical trials, URL: https://www.clinicaltrials.gov/ct2/history/NCT03037385?V_3=View#StudyPageTop, (20240815), XP093195466-
OPPOSITION- Noor Kamil , Saba Kamil, "Dose estimation, conversion and translation from animal to human and human to animal for clinical and animal studies", Int. J. Biol. Biotech., (20170701), vol. 14, no. 3, pages 311 - 317, XP093000013-
OPPOSITION- Subbiah Vivek, Cassier Philippe A., Siena Salvatore, Alonso Guzman, Paz-Ares Luis G., Garrido Pilar, Nadal Ernest, Curigliano Giuseppe, Vuky Jacqueline, Lopes Gilberto, Kalemkerian Gregory Peter, Bowles Daniel W., Seetharam Mahesh, Chang Jianhua, Zhang Hui, Ye Chaoyang, Green Jennifer, Zalutskaya Alena, Schuler Martin H., Fan Yun, "Clinical activity and safety of the RET inhibitor pralsetinib in patients with RET fusion-positive solid tumors: Update from the ARROW trial.", ASCO, (20210101), pages 1 - 1, XP093195495-
OPPOSITION- Gainor Justin F; Curigliano Giuseppe; Kim Dong-Wan; Lee Dae Ho; Besse Benjamin; Baik Christina S; Doebele Robert C; Cassier Philippe A; Lopes Gilberto; Tan Daniel S W; Garralda Elena; Paz-Ares Luis G; Cho Byoung Chul; Gadgeel Shirish M; Thomas Michael; Liu Stephen V; Taylor Matthew H; Mansfield Aaron S; Zhu Viola W; Clifford Corinne; Zhang Hui; Palmer Michael; Green Jennifer; Turner Christopher D; Subbiah Vivek, "Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study", The Lancet Oncology, AMSTERDAM, NL , (20210609), vol. 22, no. 7, doi:10.1016/S1470-2045(21)00247-3, pages 959 - 969, XP086683177
OPPOSITION- Alexander Drilon, Zishuo I. Hu, Gillianne G. Y. Lai, Daniel S. W. Tan, "Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes", Nature reviews clinical oncology, NY, US , (20180301), vol. 15, no. 3, doi:10.1038/nrclinonc.2017.175, ISSN 1759-4774, pages 151 - 167, XP055719825
OPPOSITION- Donna M, Graham, Aaron R. Hansen, Elizabeth A. Eisenhauer, Lillian L. Siu, "Basics of Phase I Design: First-in-Human Studies", Donna M, Graham, Aaron R. Hansen, Elizabeth A. Eisenhauer, Lillian L. Siu, Elizabeth A. Eisenhauer , Christopher Twelves , Marc Buyse, Phase I Cancer Clinical Trials: A Practical Guide (2 edn), Oxford University Press, (20150301), pages 58 - 91, ISBN 978-0-19-935901-1, XP093195538
OPPOSITION- Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad, "Dose translation from animal to human studies revisited", The FASEB Journal, US, (20080301), vol. 22, no. 3, doi:10.1096/fj.07-9574LSF, ISSN 0892-6638, pages 659 - 661, XP055542714
OPPOSITION- SUBBIAH V, "Highly potent and selective RET inhibitor, BLU-667, achieves proof of concept in a phase I study of advanced, RET-altered solid tumors", Cancer Research, US , (20180701), vol. 78, no. 13, Supplement 1, doi:10.1158/1538-7445.AM2018-CT043, ISSN 1538-7445, pages 1 - 4, XP002792435
OPPOSITION- Subbiah Vivek; Taylor Matthew; Lin Jessica; Hu Mimi; Ou Sai-Hong Ignatius; Brose Marcia S; Garralda Elena; Clifford Corinne; Palmer Michael; Evans Erica; Shi Hongliang; Wolf Beni; Gainor Justin F, "CT043: Highly potent and selective RET inhibitor, BLU-667, achieves proof of concept in a phase I study of advanced, RET-altered solid tumors", Cancer Research, American Association for Cancer Research, US, US , (20180701), vol. 78, no. 13, Supplement 1, doi:10.1158/1538-7445.AM2018-CT043, ISSN 1538-7445, page CT043, XP002792435
OPPOSITION- Vivek Subbiah, Justin F. Gainor, Rami Rahal, Jason D. Brubaker, Joseph L. Kim, Michelle Maynard, Wei Hu, Qiongfang Cao, Michael P. Sheets, Douglas Wilson, Kevin J. Wilson, Lucian Dipietro, Paul Fleming, Michael Palmer, Mimi I. Hu, Lori Wirth, Marcia S. Brose, Sai-Hong Ignatius Ou, Matthew Taylor, Elena Garralda, Stephen Miller, Beni Wolf, Christoph Lengauer, Timothy Guzi, Erica K. Evans, "Precision Targeted Therapy with BLU-667 for RET -Driven Cancers", Cancer discovery, US , (20180701), vol. 8, no. 7, doi:10.1158/2159-8290.CD-18-0338, ISSN 2159-8274, pages 836 - 849, XP055599279
OPPOSITION- Anonymous, "BLU-667 Targets RET-Altered Cancers.", Cancer discovery, vol. 8, no. 6, doi:10.1158/2159-8290.CD-NB2018-050, ISSN 2159-8290, (20180601), page 5pp, Cancer discovery, URL: http://cancerdiscovery.aacrjournals.org/content/8/6/OF8.long, XP002792436
OPPOSITION- Pound Pandora J, Ritskes‑hoitinga Merel, "Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail", Journal of Translational Medicine, (20180101), vol. 16, doi:10.1186/s12967‑018‑1678‑1, pages 1 - 8, XP093000231
OPPOSITION- Bruce G. Robinson, Luis Paz-Ares, Annetta Krebs, James Vasselli, Robert Haddad, "Vandetanib (100 mg) in Patients with Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer", Journal of Clinical Endocrinology and Metabolism, US , (20100601), vol. 95, no. 6, doi:10.1210/jc.2009-2461, ISSN 0021-972X, pages 2664 - 2671, XP055599340

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