IP Verse

Treatment Of Sepsis And Septic Shock - EP3781210

The patent EP3781210 was granted to Combioxin on Aug 7, 2024. The application was originally filed on Apr 18, 2019 under application number EP19717944A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3781210

COMBIOXIN
Application Number
EP19717944A
Filing Date
Apr 18, 2019
Status
Granted And Under Opposition
Jul 5, 2024
Grant Date
Aug 7, 2024
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

BRAND MURRAY FULLERMay 6, 2025BRAND MURRAY FULLERADMISSIBLE

Patent Citations (11) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONWO2013186286
DESCRIPTIONWO2017216282
INTERNATIONAL-SEARCH-REPORTWO2013186286
INTERNATIONAL-SEARCH-REPORTWO2017216282
OPPOSITIONUS8906855
OPPOSITIONUS9439855
OPPOSITIONWO2013186286
OPPOSITIONWO2017222912
OTHERUS8906855
OTHERUS9439855
OTHERWO2017222912

Non-Patent Literature (NPL) Citations (40) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- AZEREDO DA SILVEIRA, S; PEREZ, A, Expert Rev. Anti Infect. Ther., (20150000), vol. 13, no. 5, pages 531 - 533
DESCRIPTION- AZEREDO DA SILVEIRA, S.; PEREZ, A., Expert Rev Anti Infect Ther, (20170000), vol. 15, pages 973 - 975
DESCRIPTION- "BTS Guidelines for the Management of Community Acquired Pneumonia in Adults", Thorax, (20010000), vol. 56, no. 4, pages 1 - 64
DESCRIPTION- CHEMICAL ABSTRACTS, Database accession no. 57-88-5
DESCRIPTION- CHEMICAL ABSTRACTS, Database accession no. 85187-10-6
DESCRIPTION- CID, (20070000), vol. 44, no. 2, page 27
DESCRIPTION- CILLONIZ et al., Thorax, (20110400), vol. 66, no. 4, pages 340 - 6
DESCRIPTION- COHEN, Nature, (20020000), vol. 420, pages 885 - 891
DESCRIPTION- HENRY BD et al., Nat Biotechnol, (20150000), vol. 33, no. 1, pages 81 - 88
DESCRIPTION- JONES RN, Clin Infect Dis, (20100800), vol. 51, no. l, pages S81 - 7
DESCRIPTION- KNAUS WA et al., "APACHE II: a severity of disease classification system", Crit Care Med., (19851000), vol. 13, no. 10, pages 818 - 29, XP009037293
DESCRIPTION- LEVY M et al., Intensive Care Med, (20030000), vol. 29, pages 530 - 38
DESCRIPTION- LIM WS et al., Thorax, (20030000), vol. 58, no. 5, pages 377 - 82
DESCRIPTION- MANDELL et al., CID, (20070000), vol. 44, no. 2, pages S27 - S72
DESCRIPTION- MANDELL et al., "Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults", Clin. Inf. Dis. 2007, (20070000), vol. 44, no. 2, pages 27 - 72
DESCRIPTION- SINGER M et al., JAMA, (20160000), vol. 315, no. 8, pages 801 - 10
DESCRIPTION- SINGER M et al., JAMA, (20160000), vol. 315, no. 8, pages 801 - 810
DESCRIPTION- S. VOSYLIUS; J. SIPYLAITE; J. IVASKEVICIUS, Croat Med J, (20040000), vol. 45, pages 715 - 20
DESCRIPTION- WENZEL; EDMOND, N Engl J Med, (20120000), vol. 366, pages 2122 - 2124
INTERNATIONAL-SEARCH-REPORT- Bruno François et al, "CAL02: a liposomal adjunctive anti-toxin therapy in infections. A new therapeutic approach for severe community-acquired pneumonia", (20170424), 27th ECCMID, The Congress of ESCMID, URL: https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=2ahUKEwjZ4IrB95XjAhWQUlAKHRQUA_gQFjAAegQICRAC&url=https%3A%2F%2Fwww.escmid.org%2Fescmid_publications%2Fescmid_elibrary%2Fmaterial%2F%3Fmid%3D40357&usg=AOvVaw3ZK_fNUazG2WZQYB8dlN3Y, (20190702), XP002792580 [X] 1,2,5-7,10-15,17-21 * the whole document * [Y] 1,5-7 [I] 3,4,8,9,22,23
INTERNATIONAL-SEARCH-REPORT- PIERRE-FRANÇOIS LATERRE ET AL, "CAL02, a novel antitoxin liposomal agent, in severe pneumococcal pneumonia: a first-in-human, double-blind, placebo-controlled, randomised trial", LANCET INFECT DIS, (20190502), vol. 19, pages 620 - 630, XP055598903 [T] * the whole document *
INTERNATIONAL-SEARCH-REPORT- BRIAN D HENRY ET AL, "Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice", NATURE BIOTECHNOLOGY, New York, (20141102), vol. 33, no. 1, doi:10.1038/nbt.3037, ISSN 1087-0156, pages 81 - 88, XP055251461 [X] 1,2,5-7,10,11,15,16 * page 84, column 2, paragraph 4 - page 86, column 1, paragraph 2 * * page 87, column 1, paragraph 2 * [I] 12-14,17-23
INTERNATIONAL-SEARCH-REPORT- SAMAREH AZEREDO DA SILVEIRA ET AL, "Liposomes as novel anti-infectives targeting bacterial virulence factors?", EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, GB, (20150504), vol. 13, no. 5, doi:10.1586/14787210.2015.1028367, ISSN 1478-7210, pages 531 - 533, XP055395248 [I] 1,5-7,10-15 * page 532, column 1, paragraph 3 - column 2, paragraph 2 *
OPPOSITION- Bruno François et al, "CAL02: a liposomal adjunctive anti-toxin therapy in infections. A new therapeutic approach for severe community-acquired pneumonia", 27th ECCMID, The Congress of ESCMID, (20170424), 27th ECCMID, The Congress of ESCMID, URL: https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=2ahUKEwjZ4IrB95XjAhWQUlAKHRQUA_gQFjAAegQICRAC&url=https%3A%2F%2Fwww.escmid.org%2Fescmid_publications%2Fescmid_elibrary%2Fmaterial%2F%3Fmid%3D40357&usg=AOvVaw3ZK_fNUazG2WZQYB8dlN3Y, (20190702), XP002792580
OPPOSITION- D15 - François et al: "CAL02: a liposomal adjunctive anti-toxin therapy in infections. A new therapeutic approach for severe community- acquired pneumonia", PowerPoint from the page 3 European Congress of Clinical Microbiology and Infectious Diseases, 22-25 April 201
OPPOSITION- Weinberg J. R., Wright.D.J.M.,Guz.A., "Interleukin-1 and tumour necrosis factor cause hypotension in the conscious rabbit", Clinical Science, (19880101), vol. 75, pages 251 - 255, XP093098388
OPPOSITION- Pierre-François Laterre, Colin Gwenhael, Dequin Pierre-François, Dugernier Thierry, Boulain Thierry, Azeredo Da Silveira Samareh, Lajaunias Frédéric, Perez Antonio, François Bruno, France, Boulain T, Combioxin Geneva, Switzerland, Azeredo S, Phd Silveira, Lajaunias F, Perez A, "CAL02, a novel antitoxin liposomal agent, in severe pneumococcal pneumonia: a first-in-human, double-blind, placebo-controlled, randomised trial", Lancet Infect Dis, (20190601), vol. 19, doi:10.1016/S1473-3099(18)30805-3, pages 620 - 630, XP055598903
OPPOSITION- TRACEY K J, ET AL., "ANTI-CACHECTIN/TNF MONOCLONAL ANTIBODIES PREVENT SEPTIC SHOCK DURING LETHAL BACTERAEMIA", Nature, (19871217), vol. 330, doi:10.1038/330662a0, pages 662 - 664, XP002947867
OPPOSITION- Brian Henry, "Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice", Nature Biotechnology, (20141102), vol. 33, doi:10.1038/nbt.3037, XP055251461
OPPOSITION- Hammond Naomi E., Zampieri Fernando G., Di Tanna Gian Luca, Garside Tessa, Adigbli Derick, Cavalcanti Alexandre B., Machado Flavia R., Micallef Sharon, Myburgh John, Ramanan Mahesh, Rice Todd W., Semler Matthew W., Young Paul J., Venkatesh Balasubramanian, Finfer Simon, Delaney Anthony, "Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis", NEJM Evidence, (20220125), vol. 1, no. 2, doi:10.1056/EVIDoa2100010, ISSN 2766-5526, pages 1 - 12, XP093066046
OPPOSITION- Jiachun Qu; Kui Xu, "Case report of rescue of a patient with COVID‐19 and shock after holmium laser lithotripsy", International Journal of Urological Nursing, John Wiley & Sons, Inc., Hoboken, USA, Hoboken, USA, (20220408), vol. 16, no. 3, doi:10.1111/ijun.12319, ISSN 1749-7701, pages 245 - 251, XP072588762
OPPOSITION- Braun Johann S., Novak Rodger, Gao Geli, Murray Peter J., Shenep Jerry L., "Pneumolysin, a Protein Toxin of Streptococcus pneumoniae , Induces Nitric Oxide Production from Macrophages", Infection and immunity, American Society for Microbiology, US, US , (19990801), vol. 67, no. 8, doi:10.1128/IAI.67.8.3750-3756.1999, ISSN 0019-9567, pages 3750 - 3756, XP093276830
OPPOSITION- Bolin Cai, "Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage", Mediators Inflamm, (20100608), vol. 2010, doi:10.1155/2010/642462, XP093098392
OPPOSITION- Xu Lili, Wei Wanrui, Ge Xiaohua, Wan Sibei, Yu Jing, Zhu Xiaodong, "Noma in a boy with septic shock: a case report", BMC PEDIATRICS, BIOMED CENTRAL, LONDON, GB, GB , (20191201), vol. 19, no. 1, doi:10.1186/s12887-019-1574-8, ISSN 1471-2431, XP093276837
OPPOSITION- Samareh Azeredo Da Silveira, "Liposomes as novel anti-infectives targeting bacterial virulence factors?", Expert Review of Anti-Infective Therapy, (20150504), vol. 13, doi:10.1586/14787210.2015.1028367, page 5, XP055395248
OPPOSITION- Lee Ching-Chi, Yang Chao-Yung, Su Bo-An, Hsieh Chih-Chia, Hong Ming-Yuan, Lee Chung-Hsun, Ko Wen-Chien, "The Hypotension Period after Initiation of Appropriate Antimicrobial Administration Is Crucial for Survival of Bacteremia Patients Initially Experiencing Severe Sepsis and Septic Shock", Journal of Clinical Medicine, Multidisciplinary Digital Publishing Institute (MDPI), CH, CH , vol. 9, no. 8, doi:10.3390/jcm9082617, ISSN 2077-0383, page 2617, XP093276834
OTHER- Weinberg J. R., Wright.D.J.M.,Guz.A., "Interleukin-1 and tumour necrosis factor cause hypotension in the conscious rabbit", Clinical Science, (19880101), vol. 75, pages 251 - 255, XP093098388
OTHER- Pierre-François Laterre, Colin Gwenhael, Dequin Pierre-François, Dugernier Thierry, Boulain Thierry, Azeredo Da Silveira Samareh, Lajaunias Frédéric, Perez Antonio, François Bruno, France, Boulain T, Combioxin Geneva, Switzerland, Azeredo S, Phd Silveira, Lajaunias F, Perez A, "CAL02, a novel antitoxin liposomal agent, in severe pneumococcal pneumonia: a first-in-human, double-blind, placebo-controlled, randomised trial", Lancet Infect Dis, (20190601), vol. 19, doi:10.1016/S1473-3099(18)30805-3, pages 620 - 630, XP055598903
OTHER- Hammond Naomi E., Zampieri Fernando G., Di Tanna Gian Luca, Garside Tessa, Adigbli Derick, Cavalcanti Alexandre B., Machado Flavia R., Micallef Sharon, Myburgh John, Ramanan Mahesh, Rice Todd W., Semler Matthew W., Young Paul J., Venkatesh Balasubramanian, Finfer Simon, Delaney Anthony, "Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis", NEJM Evidence, (20220125), vol. 1, no. 2, doi:10.1056/EVIDoa2100010, ISSN 2766-5526, pages 1 - 12, XP093066046
OTHER- Cai Bolin, Deitch Edwin A., Ulloa Luis, "Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage", MEDIATORS OF INFLAMMATION, GB , (20100101), vol. 2010, doi:10.1155/2010/642462, ISSN 0962-9351, pages 1 - 10, XP093098392

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents