Methods For Treating Testicular And Ovarian Adrenal Rest Tumors - EP3784233

EP3784233

SPRUCE BIOSCIENCES
Application Number
EP19793181A
Filing Date
Apr 26, 2019
Status
Granted And Under Opposition
May 3, 2024
Grant Date
Jun 5, 2024
External Links
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The patent EP3784233B1 was granted to Spruce Biosciences on Jun 5, 2024 following the initial filing on Apr 26, 2019 under the application number EP19793181A . The current legal status of the patent is Granted And Under Opposition.

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NEUROCRINE BIOSCIENCESDec 10, 2024ADMISSIBLE

Patent Citations (9) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
INTERNATIONAL-SEARCH-REPORTUS2010196389
INTERNATIONAL-SEARCH-REPORTUS2010222339
INTERNATIONAL-SEARCH-REPORTUS2017020877
OPPOSITIONWO2008036579
OPPOSITIONWO2015112642
SEARCHWO2008036579
SEARCHWO2015112642
SEARCHWO2019036472
SEARCHWO2019036503

Non-Patent Literature (NPL) Citations (38) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Anonymous, "Proposed INN: List 119", WHO Drug Information, (20180101), vol. 32, no. 2, pages 369 - 370, XP093266543-
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OPPOSITION- D21: DECLARATION OF DR. BARNES (13TH DECEMBER 2021)-
OPPOSITION- D25: Spruce Biosciences news release of 13th March 2024. Spruce Biosciences announces toplineresults from CAHMELIA-203 in adult classic CAH and CAHPTAIN-205 in pediatric classic CAH-
OPPOSITION- D26: Spruce Biosciences news release of 10th December 2024. Spruce Biosciences announces topline results from CAHMELIA-204 in adult CAH and CAHPTAIN-205 in adult and pediatric CAH-
OPPOSITION- D33 - The Journal of Clinical Endocrinology & Metabolism Author Guidelines.-
OPPOSITION- D39 - Supplementary appendix to Auchus 2024 (D32)-
OPPOSITION- Spruce Biosciences, "A Ph2b to Evaluate Clinical Ecacy and Safety of Tildacerfont in Adult CAH - NCT04457336", Clinical Trials, clinicaltrials.gov, (20240606), Clinical Trials, URL: https://clinicaltrials.gov/study/NCT04457336?term=NCT04457336&rank=1&tab=history&a=20#version-content-panel, XP093301309-
OPPOSITION- Waldron James, "Spruce saws off only drug after 2nd hyperplasia fail, leaving biotech's direction in doubt", BIOTECH, (20241211), pages 1 - 2, XP093266564-
OPPOSITION- Yasir Muhammad, Goyal Amandeep, Sonthalia Sidharth, "Corticosteroid Adverse Effects", StatPearls [Internet], (20230703), StatPearls [Internet], URL: https://www.ncbi.nlm.nih.gov/books/NBK531462/, XP093301305-
OPPOSITION- Chen Hua-dong et al, "Ovarian Adrenal Rest Tumors Undetected by Imaging Studies and Identified at Surgery in Three Females with Congenital Adrenal Hyperplasia Unresponsive to Increased Hormone Therapy Dosage", ENDOCRINE PATHOLOGY, HUMANA PRESS, TOTOWA, NJ, US, US , (20161228), vol. 28, no. 2, doi:10.1007/s12022-016-9461-4, ISSN 1046-3976, pages 146 - 151, XP036232902
OPPOSITION- Turcu Adina F., Auchus Richard J., "Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia", ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA., W.B. SAUNDERS COMPANY, PHILADELPHIA, PHILADELPHIA , (20150601), vol. 44, no. 2, doi:10.1016/j.ecl.2015.02.002, ISSN 0889-8529, pages 275 - 296, XP093266272
OPPOSITION- Claahsen-van der Grinten, H.L. et al, "Repeated successful induction of fertility after replacing hydrocortisone with dexamethasone in a patient with congenital adrenal hyperplasia and testicular adrenal rest tumors", Fertility and Sterility, Elsevier, AMSTERDAM, NL, NL , (20070901), vol. 88, no. 3, doi:10.1016/j.fertnstert.2006.11.148, ISSN 0015-0282, pages 705.e5 - 705.e8, XP022238492
OPPOSITION- Auchus Richard J., "Management considerations for the adult with congenital adrenal hyperplasia", Molecular and cellular endocrinology, Elsevier Ireland Ltd, IE, IE , (20150601), vol. 408, doi:10.1016/j.mce.2015.01.039, ISSN 0303-7207, pages 190 - 197, XP093301307
OPPOSITION- Yasuki Yamada et al, "New class of corticotropin-releasing factor (CRF) antagonists: small peptides having high binding affinity for CRF receptor.", Journal of Medicinal Chemistry, American Chemical Society, (20040201), vol. 47, no. 5, doi:10.1021/jm034180+, ISSN 00222623, pages 1075 - 1078, XP055126462
OPPOSITION- Auchus Richard J., Hamidi Oksana, Pivonello Rosario, Bancos Irina, Russo Gianni, Witchel Selma F., Isidori Andrea M., Rodien Patrice, Srirangalingam Umasuthan, Kiefer Florian W., Falhammar Henrik, Merke Deborah P., Reisch Nicole, Sarafoglou Kyriakie, Cutler Gordon B., Sturgeon Julia, Roberts Eiry, Lin Vivian H., Chan Jean L., Farber Robert H., "Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia", New England Journal of Medicine, Massachusetts Medical Society, United States, United States, (20240808), vol. 391, no. 6, doi:10.1056/NEJMoa2404656, ISSN 0028-4793, pages 504 - 514, XP093301303
OPPOSITION- Wang Zhu, Yang Zheng, Wang Wei, Chen Li-Da, Huang Yang, Li Wei, Liu Jin-Ya, Xie Xiao-Yan, Lu Ming-De, Lin Man-Xia, "Diagnosis of Testicular Adrenal Rest Tumors on Ultrasound : A Retrospective Study of 15 Cases Report", Medicine, WILLIAMS AND WILKINS, BALTIMORE., US, US , (20150901), vol. 94, no. 36, doi:10.1097/MD.0000000000001471, ISSN 0025-7974, page e1471, XP093301302
OPPOSITION- Turcu Adina F, Auchus Richard J, "Novel Treatment Strategies in Congenital Adrenal Hyperplasia", Curr Cpin Endocrinol Diabetes Obes., (20160601), vol. 23, no. 3, doi:10.1097/MED, pages 225 - 232, XP093266514
OPPOSITION- Zehra Aycan et al, "Prevalence and long‐term follow‐up outcomes of testicular adrenal rest tumours in children and adolescent males with congenital adrenal hyperplasia", CLINICAL ENDOCRINOLOGY., BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD., GB, GB , (20130410), vol. 78, no. 5, doi:10.1111/cen.12033, ISSN 0300-0664, pages 667 - 672, XP071584943
OPPOSITION- B. A. Fleck, S. R. J. Hoare, R. R. Pick, M. J. Bradbury, D. E. Grigoriadis, "Binding Kinetics Redefine the Antagonist Pharmacology of the Corticotropin-Releasing Factor Type 1 Receptor", Journal of Pharmacology and Experimental Therapeutics, (20120501), vol. 341, no. 2, doi:10.1124/jpet.111.188714, pages 518 - 531, XP055487900
OPPOSITION- Mendes-Dos-Santos et al, "Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia", Hormone Research in Paediatrics, S. Karger AG, CH, CH , (20180101), vol. 90, no. 3, doi:10.1159/000492082, ISSN 1663-2818, pages 161 - 168, XP093266559
OPPOSITION- HL Claahsen-van der Grinten et al, "Testicular Adrenal Rest Tumours in Congenital Adrenal Hyperplasia", International Journal of Pediatric Endocrinology, BioMed Central Ltd, London, UK, London, UK , (20090126), vol. 2009, no. 1, doi:10.1186/1687-9856-2009-624823, ISSN 1687-9856, page 624823, XP021109225
OPPOSITION- Trygve Nissen;Rolf Wynn, "The clinical case report: a review of its merits and limitations", BMC Research Notes, BioMed Central Ltd, GB, GB , (20140423), vol. 7, no. 1, doi:10.1186/1756-0500-7-264, ISSN 1756-0500, page 264, XP021182346
OPPOSITION- Ma Li, et al, "Sonographic features of the testicular adrenal rests tumors in patients with congenital adrenal hyperplasia: a single-center experience and literature review", Orphanet Journal of Rare Diseases, BioMed Central Ltd, Lo, Lo , (20191201), vol. 14, no. 242, doi:10.1186/s13023-019-1231-1, ISSN 1750-1172, pages 1 - 8, XP093266551
OPPOSITION- Sarafoglou Kyriakie et al, "Tildacerfont in Adults With Classic Congenital Adrenal Hyperplasia: Results from Two Phase 2 Studies", Journal of Clinical Endocrinology and Metabolism, The Endocrine Society, US, US , (20211021), vol. 106, no. 11, doi:10.1210/clinem/dgab438, ISSN 0021-972X, pages e4666 - e4679, XP055867895
OPPOSITION- Engels Manon et al, "Testicular Adrenal Rest Tumors: Current Insights on Prevalence, Characteristics, Origin, and Treatment", ENDOCRINE REVIEWS, The Endocrine Society, US, US , (20190801), vol. 40, no. 4, doi:10.1210/er.2018-00258, ISSN 0163-769X, pages 973 - 987, XP093266521
OPPOSITION- Reisch Nicole et al, "High Prevalence of Reduced Fecundity in Men with Congenital Adrenal Hyperplasia", Journal of Clinical Endocrinology and Metabolism, The Endocrine Society, US, US , (20090501), vol. 94, no. 5, doi:10.1210/jc.2008-1414, ISSN 0021-972X, pages 1665 - 1670, XP093266557
OPPOSITION- Reisch Nicole et al, "Testicular Adrenal Rest Tumors Develop Independently of Long-Term Disease Control: A Longitudinal Analysis of 50 Adult Men With Congenital Adrenal Hyperplasia due to Classic 21-Hydroxylase Deficiency", Journal of Clinical Endocrinology and Metabolism, The Endocrine Society, US, US , (20131101), vol. 98, no. 11, doi:10.1210/jc.2012-3181, ISSN 0021-972X, pages E1820 - E1826, XP093266533
OPPOSITION- Adina F. Turcu et al, "Single-Dose Study of a Corticotropin-Releasing Factor Receptor-1 Antagonist in Women With 21-Hydroxylase Deficiency", Journal of Clinical Endocrinology and Metabolism, The Endocrine Society, US, US , (20160301), vol. 101, no. 3, doi:10.1210/jc.2015-3574, ISSN 0021-972X, pages 1174 - 1180, XP055572816
OPPOSITION- Speiser Phyllis W, Arlt Wiebke, Auchus Richard J, Baskin Laurence S, Conway Gerard S, Merke Deborah P, Meyer-Bahlburg Heino F L, Miller Walter L, Murad M Hassan, Oberfield Sharon E, White Perrin C, "Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society* Clinical Practice Guideline", Journal of Clinical Endocrinology and Metabolism, The Endocrine Society, US, US , (20181101), vol. 103, no. 11, doi:10.1210/jc.2018-01865, ISSN 0021-972X, pages 4043 - 4088, XP093301311
OPPOSITION- Stikkelbroeck Nike et al, "High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia", Journal of Clinical Endocrinology and Metabolism, The Endocrine Society, US, US , (20011201), vol. 86, no. 12, doi:10.1210/jc.86.12.5721, ISSN 0021-972X, pages 5721 - 5728, XP093266535
OPPOSITION- Claahsen-Van Der Grinten et al, "Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency", European Journal of Endocrinology, BioScientifica Ltd., GB, GB , (20070901), vol. 157, no. 3, doi:10.1530/EJE-07-0201, ISSN 0804-4643, pages 339 - 344, XP093266537
OPPOSITION- Fahmy Hesham, Kuppast Bhimanna, Ismail Mohamed Teleb, "Structure and Function of Small Non-Peptide CRF Antagonists and their Potential Clinical Use", Current Molecular Pharmacology, Bentham Science Publishers Ltd., NL, NL , (20171004), vol. 10, no. 4, doi:10.2174/1874467209666161101144155, ISSN 1874-4672, pages 270 - 281, XP093266538
OPPOSITION- Joseph Dana, Whirledge Shannon, "Stress and the HPA Axis: Balancing Homeostasis and Fertility", International journal of molecular sciences, Molecular Diversity Preservation International (MDPI), Basel, CH, Basel, CH , vol. 18, no. 2224, doi:10.3390/ijms18102224, ISSN 1422-0067, pages 1 - 15, XP093266517
OPPOSITION- Zaarour Magda et al, "Bilateral Ovary Adrenal Rest Tumor in a Congenital Adrenal Hyperplasia Following Adrenalectomy", ENDOCRINE PRACTICE, American Association of Clinical Endocrinology, US, US , (20140401), vol. 20, no. 4, doi:10.4158/EP13092.CR, ISSN 1530-891X, pages e69 - e74, XP093266525
OPPOSITION- Yu Min Kyung et al, "Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia", Annals of Pediatric Endocrinology & Metabolism, 대한소아내분비학회, (20150101), vol. 20, no. 3, doi:10.6065/apem.2015.20.3.155, ISSN 2287-1012, pages 155 - 161, XP093266529
OPPOSITION- Delfino Michele et al, "Testicular Adrenal Rest Tumors in Patients With Congenital Adrenal Hyperplasia Prevalence and Sonographic, Hormonal, and Seminal Characteristics", J Ultrasound Med, (20120101), vol. 31, doi:10.7863/jum.2012.3L3.383, pages 383 - 388, XP093266571
SEARCH- CHEN HUA-DONG ET AL, "Ovarian Adrenal Rest Tumors Undetected by Imaging Studies and Identified at Surgery in Three Females with Congenital Adrenal Hyperplasia Unresponsive to Increased Hormone Therapy Dosage", ENDOCRINE PATHOLOGY, HUMANA PRESS, TOTOWA, NJ, US, vol. 28, no. 2, doi:10.1007/S12022-016-9461-4, ISSN 1046-3976, (20161228), pages 146 - 151, (20161228), XP036564071 [I] 1-15 * abstract *

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