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Fenfluramine Compositions And Methods Of Preparing The Same - EP3800177
The patent EP3800177 was granted to Zogenix on Jan 29, 2025. The application was filed on Dec 20, 2016 under application number EP20210227A. The patent is currently recorded with a legal status of "Granted And Under Opposition".
EP3800177
- Application Number
- EP20210227A
- Filing Date
- Dec 20, 2016
- Status
- Granted And Under Opposition
- Dec 26, 2024
- Publication Date
- Jan 29, 2025
- External Links
- Slate, Register, Google Patents
Patent Summary
A method for preparing fenfluramine active pharmaceutical ingredient (API) with reduced levels of impurities, particularly trifluoromethyl regioisomers. The method involves hydrolyzing 2-(3-(trifluoromethyl)phenyl)acetonitrile to produce 2-(3-(trifluoromethyl)phenyl)acetic acid, reacting the acid with acetic anhydride to form 1-(3-(trifluoromethyl)phenyl)propan-2-one, and reductively aminating the ketone with ethylamine to produce fenfluramine. The resulting API has a purity profile of at least 90% fenfluramine, less than 0.2% 2-fenfluramine, less than 0.2% 4-fenfluramine, and less than 1% fenfluramine alcohol.
Patent Family
Patent Oppositions (2)
Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
Patent Citations (4) New
Patent citations refer to prior patents cited during different phases such as opposition or international search.
Dossier Documents
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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