Methods Of Treating Conditions Related To The S1P1 Receptor - EP3801459

The patent EP3801459 was granted to Arena Pharmaceuticals on Aug 7, 2024. The application was originally filed on Jun 5, 2019 under application number EP19739424A. The patent is currently recorded with a legal status of "Revoked".

EP3801459

ARENA PHARMACEUTICALS
Application Number
EP19739424A
Filing Date
Jun 5, 2019
Status
Revoked
Oct 3, 2025
Grant Date
Aug 7, 2024
External Links
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MAIWALDMay 7, 2025MAIWALDADMISSIBLE
SYNTHONMay 7, 2025HAMM & WITTKOPPADMISSIBLE
TEVA PHARMACEUTICALSMay 7, 2025VON KAUFFMANNADMISSIBLE
SANDOZMay 6, 2025KRAUS & LEDERER PARTGMBBADMISSIBLE

Patent Citations (9) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO2010011316
DESCRIPTIONWO2011094008
INTERNATIONAL-SEARCH-REPORTWO2016112075
INTERNATIONAL-SEARCH-REPORTWO2018151834
INTERNATIONAL-SEARCH-REPORTWO2018151873
OPPOSITIONWO2010011316
OPPOSITIONWO2011094008
OPPOSITIONWO2016112075
OPPOSITIONWO2016209809

Non-Patent Literature (NPL) Citations (109) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BALATONI et al., Brain Research Bulletin, (20070000), vol. 74, pages 307 - 316-
DESCRIPTION- BAUMRUKER et al., Expert Opin. Investig. Drugs, (20070000), vol. 16, pages 505 - 518-
DESCRIPTION- BAUMRUKER, Expert. Opin. Investig. Drugs, (20070000), vol. 16, pages 283 - 289-
DESCRIPTION- BERGE et al., Journal of Pharmaceutical Sciences, (19770000), vol. 66, pages 1 - 19-
DESCRIPTION- BOLICK et al., Arterioscler. Thromb. Vase. Biol., (20050000), vol. 25, pages 976 - 981-
DESCRIPTION- BRINKMANN et al., J. BioI. Chem., (20020000), vol. 277, pages 21453 - 21457-
DESCRIPTION- BRINKMANN et al., Pharmacology & Therapeutics, (20070000), vol. 115, pages 84 - 105-
DESCRIPTION- BRINKMANN et al., Transplantation, (20010000), vol. 72, pages 764 - 769-
DESCRIPTION- BRINKMANN et al., Transplant Proc., (20010000), vol. 33, pages 530 - 531-
DESCRIPTION- BRINKMANN et al., Transplant. Proc., (20010000), vol. 33, pages 530 - 531-
DESCRIPTION- BUDDE et al., J. Am. Soc. Nephrol., (20020000), vol. 13, pages 1073 - 1083-
DESCRIPTION- CHIBA et al., Cell Mol. Biol., (20060000), vol. 3, pages 11 - 19-
DESCRIPTION- CHIBA, Pharmacology & Therapeutics, (20050000), vol. 108, pages 308 - 319-
DESCRIPTION- CHUN et al., Pharmacological Reviews, (20020000), vol. 54, pages 265 - 269-
DESCRIPTION- COELHO et al., J. Pharmacol. Exp. Ther., (20070000), vol. 323, pages 626 - 635-
DESCRIPTION- DANIEL et al., J. Immunol., (20070000), vol. 178, pages 2458 - 2468-
DESCRIPTION- DEGUCHI et al., Oncology Reports, (20060000), vol. 16, pages 699 - 703-
DESCRIPTION- DEV et al., Pharmacology and Therapeutics, (20080000), vol. 117, pages 77 - 93-
DESCRIPTION- D. NAKASHIMA et al., J. Investigative Dermatology, (20080000), vol. 128, no. 12, pages 2833 - 2841-
DESCRIPTION- E. BAR-HAIM et al., PLoS Pathogens, (20081121), vol. 4, no. 11, page e 1000211-
DESCRIPTION- FUJII et al., Am. J. Physiol. Gastrointest. Liver Physiol., (20060000), vol. 291, pages G267 - G274-
DESCRIPTION- FUJINO et al., J. Pharmacol. Exp. Ther., (20030000), vol. 305, pages 70 - 77-
DESCRIPTION- FUJISHIRO et al., J. Heart Lung Transplant, (20060000), vol. 25, pages 825 - 833-
DESCRIPTION- "Generation of Polymorphs, Hydrates, Solvates, and Amorphous Solids", K,J. GUILLORY, Polymorphism in Pharmaceutical Solids, Marcel Dekker. Inc., (19990000), vol. 95, pages 202 - 209-
DESCRIPTION- GERGELY, Br J Pharmacol, (20120000), vol. 167, no. 5, pages 1035 - 1047-
DESCRIPTION- HALE et al., Bioorg. Med Chem. Lett., (20040000), vol. 14, pages 3351 - 3355-
DESCRIPTION- HALE et al., Bioorg. Med. Chem. Lett., (20040000), vol. 14, pages 3351 - 3355-
DESCRIPTION- HERZINGER, Am. J. Clin. Dermatol., (20070000), vol. 8, pages 329 - 336-
DESCRIPTION- HWANG et al., Circulation, (19990000), vol. 100, pages 1322 - 1329-
DESCRIPTION- IDZKO et al., J. Clin. Invest., (20060000), vol. 116, pages 2935 - 2944-
DESCRIPTION- JOHAN GROENEVELD, Vascul. Pharmacol., (20030000), vol. 39, pages 247 - 256-
DESCRIPTION- JUNG et al., Glia, (20070000), vol. 55, pages 1656 - 1667-
DESCRIPTION- KANEIDER et al., FASEB J., (20040000), vol. 18, pages 309 - 311-
DESCRIPTION- KAPPOS et al., N. Engl. J. Med., (20060000), vol. 355, pages 1124 - 1140-
DESCRIPTION- KATAOKA et al., Cellular & Molecular Immunology, (20050000), vol. 2, pages 439 - 448-
DESCRIPTION- KAUDEL, Transplant. Proc., (20070000), vol. 39, pages 499 - 502-
DESCRIPTION- KEUL, Arterioscler. Thromb. Vasc. Biol, (20070000), vol. 27, pages 607 - 613-
DESCRIPTION- KIM, Cell Signal, (20040000), vol. 16, pages 89 - 95-
DESCRIPTION- KIMURA et al., Stem Cells, (20070000), vol. 25, pages 115 - 124-
DESCRIPTION- KIYABAYASHI et al., J. Cardiovasc. Pharmacol., (20000000), vol. 35, pages 410 - 416-
DESCRIPTION- KOHNO et al., Biol. Pharm. Bull., (20040000), vol. 27, pages 1392 - 1396-
DESCRIPTION- KORECK et al., Dermatology, (20030000), vol. 206, pages 96 - 105-
DESCRIPTION- KOVARIK et al., J Clin Pharmacol, (20040000), vol. 44, no. 5, pages 532 - 537-
DESCRIPTION- KUROSE et al., Exp. Eye Res., (20000000), vol. 70, pages 7 - 15-
DESCRIPTION- LAMONTAGNE et al., Cancer Res., (20060000), vol. 66, pages 221 - 231-
DESCRIPTION- LEE et al., Clin. Cancer Res., (20050000), vol. 11, page 84588466-
DESCRIPTION- LIMA et al., Transplant Proc., (20040000), vol. 36, pages 1015 - 1017-
DESCRIPTION- LIU et al., Microsurgery, (20070000), vol. 27, pages 300 - 304-
DESCRIPTION- MAKI et al., Transplantation, (20020000), vol. 74, pages 1684 - 1686-
DESCRIPTION- MAKI et al., Transplantation, (20050000), vol. 105, pages 1 - 1055-
DESCRIPTION- MARTINI et al., Am..J. Physiol. Renal Physiol., (20070000), vol. 292, pages F1761 - F1770-
DESCRIPTION- MATLOUBIAN et al., Nature, (20040000), vol. 427, pages 355 - 360-
DESCRIPTION- MATSUURA et al., Inflamm. Res., (20000000), vol. 49, pages 404 - 410-
DESCRIPTION- MATSUURA et al., Int. J. Immunopharmacol., (20000000), vol. 22, pages 323 - 331-
DESCRIPTION- MIRON et al., Ann. Neurol., (20080000), vol. 63, pages 61 - 71-
DESCRIPTION- MIYAMOTO et al., J. Am. Coll. Cardiol., (20010000), vol. 37, pages 1713 - 1718-
DESCRIPTION- MIZUSHIMA et al., Inflamm. Bowel Dis., (20040000), vol. 10, pages 182 - 192-
DESCRIPTION- NOFER et al., Circulation, (20070000), vol. 115, pages 501 - 508-
DESCRIPTION- O. COSTU et al., Journal of Cellular and Molecular Medicine, (20080000), vol. 12, no. 3, pages 995 - 1004-
DESCRIPTION- OGAWA et al., BBRC, (20070000), vol. 361, pages 621 - 628-
DESCRIPTION- OKAZAKI et al., J. Rheumatol., vol. 29, pages 707 - 716-
DESCRIPTION- OO et al., J. Biol. Chem., (20070000), vol. 282, pages 9082 - 9089-
DESCRIPTION- PAN et al., Chemistry & Biology, (20060000), vol. 13, pages 1227 - 1234-
DESCRIPTION- PREMENKO-LANIER et al., Nature, (20080000), vol. 454, page 894-
DESCRIPTION- "Prodrugs as Novel Delivery Systems", T. HIGUCHIV. STELLA, Bioreversihle Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, (19870000), vol. 14-
DESCRIPTION- RAUSCH, J. Magn. Reson. Imaging, (20040000), vol. 20, pages 16 - 24-
DESCRIPTION- RAVENEY et al., Arch. Ophthalmol., (20080000), vol. 126, no. 10, page 1390-
DESCRIPTION- ROSEN et al., Immunol. Rev., (20030000), vol. 195, pages 160 - 177-
DESCRIPTION- SAKAGAWA et al., Transpl. Immunol., (20040000), vol. 13, pages 161 - 168-
DESCRIPTION- SANNA et al., J. Biol. Chem., (20040000), vol. 279, pages 13839 - 13848-
DESCRIPTION- SANNA et al., Nat. Chem. Biol., (20060000), vol. 2, pages 434 - 441-
DESCRIPTION- SAUER et al., J. BioI. Chem., (20040000), vol. 279, pages 38471 - 38479-
DESCRIPTION- SAWICKA et al., J. Immunol., (20030000), vol. 171, pages 6206 - 6214-
DESCRIPTION- SCHMID, J. Cell Biochem., (20070000), vol. 101, pages 259 - 270-
DESCRIPTION- SCHWAB et al., Nature Immunol., (20070000), vol. 8, pages 1295 - 1301-
DESCRIPTION- SHIMIZU et al., Circulation, (20050000), vol. 11, no. 1, pages 222 - 229-
DESCRIPTION- SUZUKI et al., Transpl. Immunol., (19960000), vol. 4, pages 252 - 255-
DESCRIPTION- TAYLOR et al., Blood, (20070000), vol. 110, pages 3480 - 3488-
DESCRIPTION- T. KOHONO et al., Biological & Pharmaceutical Bulletin, (20050000), vol. 28, no. 4, pages 736 - 739-
DESCRIPTION- TNIONG et al., American Journal of Transplantation, (20070000), vol. 7, pages 2031 - 2038-
DESCRIPTION- T SANCHEZ et al., J. BioI. Chem., (20030000), vol. 278, no. 47, pages 47281 - 47290-
DESCRIPTION- WEBB et al., J. Neuroimmunol, (20040000), vol. 153, pages 108 - 121-
DESCRIPTION- WEBSTER, Cutis, (20050000), vol. 76, no. 2, pages 4 - 7-
DESCRIPTION- WHETZEL et al., Circ. Res., (20060000), vol. 99, pages 731 - 739-
DESCRIPTION- YANAGAWA et al., J. Immunol., (19980000), vol. 160, pages 5493 - 5499-
DESCRIPTION- YAN et al., Bioorg. & A-fed. Chem. Left., (20060000), vol. 16, pages 3679 - 3683-
DESCRIPTION- YANG et al., Clinical Immunology, (20030000), vol. 107, pages 30 - 35-
DESCRIPTION- ZHANG et al., J. Cell. Mol. Med., (20070000), vol. 11, pages 307 - 314-
DESCRIPTION- ZHANG et al., Mini-Reviews in Medicinal Chemistry, (20070000), vol. 7, pages 845 - 850-
INTERNATIONAL-SEARCH-REPORT- Anonymous, "Arena Pharmaceuticals Reports Positive Phase 2 Results from the OASIS Trial for Etrasimod in Patients with Ulcerative Colitis", Arena Pharmaceuticals Press releases, (20180319), URL: http://invest.arenapharm.com/node/18666/pdf, (20190902), XP055617285 [A] 1,23-79 * the whole document *-
OPPOSITION- Anonymous, "Arena Pharmaceuticals Reports Positive Phase 2 Results from the OASIS Trial for Etrasimod in Patients with Ulcerative Colitis", Arena Pharmaceuticals Press releases, (20180319), Arena Pharmaceuticals Press releases, URL: http://invest.arenapharm.com/node/18666/pdf, (20190902), XP055617285-
OPPOSITION- Anonymous, "Guidance for Industry - Bioavailability and Bioequivalence Studies Submitted in NDAs or INDs — General Considerations - DRAFT GUIDANCE ", U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), (20140301), U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), URL: https://www.fda.gov/media/88254/download, XP093276772-
OPPOSITION- Anonymous, "International Nonproprietary Names for Pharmaceutical Substances (INN) - Proposed INN: List 116", WHO Drug Information, Vol. 30, No. 4, (20161209), pages 605 - 710, WHO Drug Information, Vol. 30, No. 4, URL: https://www.who.int/publications/m/item/inn-pl-116, XP093276764-
OPPOSITION- Anonymous, "Velsipity - Swiss Public Assessment Report", Swissmedic, Swiss Agency for Therapeutic Products, (20241120), XP093276781-
OPPOSITION- D12 - T 0857/01 - 3.3.4-
OPPOSITION- D13 - Arena Pharmaceuticals/Mewburn Ellis, in the prosecution of EP3801459, 27 July 2021-
OPPOSITION- D9a - Tran et al. - proof of first publication on 10 November 2017-
OPPOSITION- D9b - J. Q. Tran, Am. J, Gastroenterol. 2016, 111(1), S298 Abstract 650-
OPPOSITION- Food And Drug Administration Fda, "Guidance for Industry Food-Effect Bioavailability and Fed Bioequivalence Studies", (20021201), URL: https://www.fda.gov/files/drugs/published/Food-Effect-Bioavailability-and-Fed-Bioequivalence-Studies.pdf, XP093270815-
OPPOSITION- Kovarik, Et Al., "Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects", British Journal of Clinical Pharmacology, (20040101), vol. 57, pages 586 - 591, XP093007128-
OPPOSITION- Jonathan Q. Tran; Jeffrey P. Hartung; Cindy‐Ann Tompkins; Paul A. Frohna, "Effects of High‐ and Low‐Fat Meals on the Pharmacokinetics of Ozanimod, a Novel Sphingosine‐1‐Phosphate Receptor Modulator", Clinical Pharmacology in Drug Development, Wiley-Blackwell Publishing Ltd., GB, GB , (20171110), vol. 7, no. 6, doi:10.1002/cpdd.409, ISSN 2160-763X, pages 634 - 640, XP072468146
OPPOSITION- Jianfeng Xu; Frank Gray; Alex Henderson; Kirsty Hicks; Jiansong Yang; Paul Thompson; Johann Oliver, "Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine‐1‐phosphate receptor modulator, in healthy volunteers", Clinical Pharmacology in Drug Development, Wiley-Blackwell Publishing Ltd., GB, GB , (20140210), vol. 3, no. 3, doi:10.1002/cpdd.98, ISSN 2160-763X, pages 170 - 178, XP072463579
OPPOSITION- Daniel J. Buzard, Sun Hee Kim, Luis Lopez, Andrew Kawasaki, Xiuwen Zhu, Jeanne Moody, Lars Thoresen, Imelda Calderon, Brett Ullman, Sangdon Han, Juerg Lehmann, Tawfik Gharbaoui, Dipanjan Sengupta, Lorene Calvano, Antonio Garrido Montalban, You-An Ma, Carleton Sage, Yinghong Gao, Graeme Semple, Jeff Edwards, Jeremy Barden, Michael Morgan, Weichao Chen, Khawja Usmani, Chuan Chen, Abu Sadeque, Ronald J. Christopher, Jayant Thatte, Lixia Fu, Michelle Solomon, David Mills, Kevin Whelan, Hussien Al-Shamma, Joel Gatlin, Minh Le, Ibragim Gaidarov, Todd Anthony, David J. Unett, Anthony Blackburn, Jaimie Rueter, Scott Stirn, Dominic P. Behan, Robert M. Jones, "Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor", ACS MEDICINAL CHEMISTRY LETTERS, American Chemical Society, US, US , (20141211), vol. 5, no. 12, doi:10.1021/ml500389m, ISSN 1948-5875, pages 1313 - 1317, XP055255692
OPPOSITION- Pierre-Eric Juif, Stephan Kraehenbuehl, Jasper Dingemanse, "Clinical pharmacology, efficacy, and safety aspects of sphingosine-1-phosphate receptor modulators", Expert Opinion on Drug Metabolism & Toxicology, Ashley Productions London, GB, GB , (20160802), vol. 12, no. 8, doi:10.1080/17425255.2016.1196188, ISSN 1742-5255, pages 879 - 895, XP055526297
OPPOSITION- Peyrin-Biroulet L; Adams J; Turner S; Trokan L; Panes J, "P573: Safety and immune modulatory properties of etrasimod (APD334), a next-generation oral, selective sphingosine 1-phosphate receptor (S1PR) modulator, in healthy volunteers", Journal of Crohn's and Colitis, Oxford University Press, NLD, NLD , (20180201), vol. 12, no. Supplement 1, doi:10.1093/ecco-jcc/jjx180.700, ISSN 1876-4479, page S397, XP009517578
OPPOSITION- Lentz Kimberley A., "Current Methods for Predicting Human Food Effect", The AAPS Journal, Springer US, Boston, Boston , (20080524), vol. 10, no. 2, doi:10.1208/s12248-008-9025-8, pages 282 - 288, XP035718943
OPPOSITION- ElShaer Amr; Khan Sheraz; Perumal Dhaya; Hanson Peter; Mohammed Afzal R, "Use of amino acids as counterions improves the solubility of the BCS II model drug, indomethacin.", CURRENT DRUG DELIVERY, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, NL , (20110701), vol. 8, no. 4, doi:10.2174/156720111795767924, ISSN 1567-2018, pages 363 - 372, XP009165495
OPPOSITION- Currò Diego, Pugliese Daniela, Armuzzi Alessandro, "Frontiers in Drug Research and Development for Inflammatory Bowel Disease", Frontiers in pharmacology, Frontiers Research Foundation, CH, CH , vol. 8, doi:10.3389/fphar.2017.00400, ISSN 1663-9812, XP093276765
OPPOSITION- Juif Pierre-Eric, Baldoni Daniela, Reyes Maribel, Wilbraham Darren, Febbraro Salvatore, Vaclavkova Andrea, Hoch Matthias, Dingemanse Jasper, "Pharmacokinetics, Pharmacodynamics, Tolerability, and Food Effect of Cenerimod, a Selective S1P1 Receptor Modulator in Healthy Subjects", International journal of molecular sciences, Molecular Diversity Preservation International (MDPI), Basel, CH, Basel, CH , vol. 18, no. 12, doi:10.3390/ijms18122636, ISSN 1422-0067, page 2636, XP093276776

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