Combination Of Factor Vii And An Anti-Factor Ix/X Bispecific Antibody - EP3806891

The patent EP3806891 was granted to Laboratoire Franais DU Fractionnement ET DES Biotechnologies on Aug 2, 2023. The application was originally filed on Jun 14, 2019 under application number EP19742443A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3806891

LABORATOIRE FRANAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES
Application Number
EP19742443A
Filing Date
Jun 14, 2019
Status
Granted And Under Opposition
Jun 30, 2023
Grant Date
Aug 2, 2023
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

STRAWMANApr 30, 2024VOSSIUS & PARTNERADMISSIBLE
STRAWMANApr 30, 2024VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBADMISSIBLE

Patent Citations (21) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONEP20120305882
DESCRIPTIONEP0200421
DESCRIPTIONEP0527063
DESCRIPTIONEP1688488
DESCRIPTIONUS4784950
DESCRIPTIONUS5997864
DESCRIPTIONUS6268487
DESCRIPTIONUS7695936
DESCRIPTIONWO2005035756
DESCRIPTIONWO2006109592
DESCRIPTIONWO2010149907
DESCRIPTIONWO2012067176
DESCRIPTIONWO2017188356
DESCRIPTIONWO2018047813
INTERNATIONAL-SEARCH-REPORTEP2687595
OPPOSITIONEP2687595
OPPOSITIONEP3690050
OPPOSITIONJP2017189647
OPPOSITIONUS2009311239
OPPOSITIONUS2011059510
OPPOSITIONWO2019065795

Non-Patent Literature (NPL) Citations (48) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- HERMENTIN et al., Glycobiology, (19960000), vol. 6, no. 2
DESCRIPTION- PERSSON et al., J. Biol. Chem., (19970000), vol. 272, pages 19919 - 19924
DESCRIPTION- PERSSON, FEBS letts, (19970000), vol. 413, pages 359 - 363
DESCRIPTION- QU et al., Blood, (20080000), vol. 111, pages 2211 - 2219
DESCRIPTION- R. HARTMANN et al., "OR36 / Synergistic Effects of a Procoagulant Bispecific Antibody and FEIBA or Factor VIIA on Thrombin Génération", Haemophilia, (20170000), vol. 23, no. 2, pages 11 - 27
DESCRIPTION- RIDGWAY et al., Protein Eng, (19960000), vol. 9, pages 617 - 21
DESCRIPTION- WANG et al., "Lyophilization and development of solid protein pharmaceuticals", International Journal of Pharmaceutics, (20000000), vol. 203, doi:doi:10.1016/S0378-5173(00)00423-3, pages 1 - 60, XP002428586
INTERNATIONAL-SEARCH-REPORT- SANTAGOSTINO ELENA ET AL, "Management of Joint Replacement in Hemophilia a with Inhibitors during Emicizumab Prophylaxis", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (20171207), Database accession no. PREV201900188250, XP002788934 [A] 1-13 * abstract *
INTERNATIONAL-SEARCH-REPORT- LANGER A L [0000-0002-0301-7073] ET AL, "Evaluating the safety of emicizumab in patients with hemophilia A", EXPERT OPINION ON DRUG SAFETY 20181202 TAYLOR AND FRANCIS LTD GBR, (20181202), vol. 17, no. 12, ISSN 1474-0338, pages 1233 - 1237, XP002788935 [T] * see abstract and page 1235 *
INTERNATIONAL-SEARCH-REPORT- HARTMANN R ET AL, "In vitro studies show synergistic effects of a procoagulant bispecific antibody and bypassing agents.", JOURNAL OF THROMBOSIS AND HAEMOSTASIS : JTH 11 JUN 2018, (20180611), ISSN 1538-7836, XP002788933 [A] 1-13 * se abstract and page 1589 left col. *
OPPOSITION- Anonymous, "Organism - Definition", NCI Dictionary of Cancer Terms, NCI, pages 1 - 1, NCI Dictionary of Cancer Terms, URL: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/organism, XP093275542
OPPOSITION- Anonymous, "Thrombinoscope -  Products", Thrombinoscope.com, pages 1 - 2, Thrombinoscope.com, URL: https://www.thrombinoscope.com/method-products/products/#c4573, XP093275553
OPPOSITION- Anonymous, "Transgene", Wikipedia, pages 1 - 9, Wikipedia, URL: https://en.wikipedia.org/w/index.php?title=Transgene&oldid=1187734115, XP093275534
OPPOSITION- Anonymous, "Transgenic: Definition and Examples", Biology Online Dictionary, pages 1 - 2, Biology Online Dictionary, URL: https://www.biologyonline.com/dictionary/transgenic, XP093275530
OPPOSITION- Anonymous, "Transgenic", Genetic Glossary, National Human Genome Research Institute, pages 1 - 4, Genetic Glossary, URL: https://www.genome.gov/genetics-glossary/Transgenic, XP093275526
OPPOSITION- Anonymous, "Transgénique : Définition simple et facile du dictionnaire", linternaute.fr Dictionnaire Français, pages 1 - 3, linternaute.fr Dictionnaire Français, URL: https://www.linternaute.fr/dictionnaire/fr/definition/transgenique/, XP093275539
OPPOSITION- D31 - Déclaration du Dr Jean-Luc Plantier
OPPOSITION- EDMUNDS T., ET AL., "TRANSGENICALLY PRODUCED HUMAN ANTITHROMBIN: STRUCTURAL AND FUNCTIONAL COMPARISON TO HUMAN PLASMA-DERIVED ANTITHROMBIN.", Blood, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (19980615), vol. 91., no. 12., ISSN 0006-4971, pages 4561 - 4571., XP000892719
OPPOSITION- Hoffmann-La Roche, "NCT02622321 | A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants With Inhibitors (HAVEN 1), Version 17", ClinicalTrials.gov, NLM, pages 1 - 74, ClinicalTrials.gov, URL: https://clinicaltrials.gov/study/NCT02622321?tab=history&a=17#version-content-panel, XP093275544
OPPOSITION- Mercy Devasahayam, "Factors affecting the expression of recombinant glycoproteins", Indian Journal of Medical Research, Medknow Publications and Media Pvt. Ltd, IN, IN , (20070701), vol. 126, no. 1, ISSN 0971-5916, pages 22 - 27, XP009561058
OPPOSITION- Sutkeviciute, I. ; Mistiniene, E. ; Sereikaite, J. ; Bumelis, V.A., "The influence of different glycosylation patterns on factor VII biological activity", BIOCHIMIE, MASSON, PARIS, FR, FR , (20090901), vol. 91, no. 9, ISSN 0300-9084, pages 1123 - 1130, XP026396073
OPPOSITION- DROHAN W. N., ET AL., "INEFFICIENT PROCESSING OF HUMAN PROTEIN C IN THE MOUSE MAMMARY GLAND.", TRANSGENIC RESEARCH, Springer Netherlands, NL, NL , (19941101), vol. 03., no. 06., doi:10.1007/BF01976767, ISSN 0962-8819, pages 355 - 364., XP000575938
OPPOSITION- Houdebine, L.M., "Production of pharmaceutical proteins by transgenic animals", COMPARATIVE IMMUNOLOGY, MICROBIOLOGY AND INFECTIOUS DISEASES., PERGAMON PRESS, OXFORD., GB, GB , (20090301), vol. 32, no. 2, doi:10.1016/j.cimid.2007.11.005, ISSN 0147-9571, pages 107 - 121, XP025926097
OPPOSITION- Walski Tomasz; De Schutter Kristof; Van Damme Els J.M.; Smagghe Guy, "Diversity and functions of protein glycosylation in insects", Insects Biochemistry and Molecular Biology, Elsevier Ltd., AMSTERDAM, NL, AMSTERDAM, NL , (20170214), vol. 83, doi:10.1016/j.ibmb.2017.02.005, ISSN 0965-1748, pages 21 - 34, XP029960666
OPPOSITION- Niemann H, Halter R, Carnwath J.W, Herrmann D, Lemme E, Paul D, "Expression of human blood clotting factor VIII in the mammary gland of transgenic sheep", TRANSGENIC RESEARCH, Springer Netherlands, NL, NL , (19990601), vol. 8, no. 3, doi:10.1023/a:1008999622117, ISSN 0962-8819, pages 237 - 247, XP093275561
OPPOSITION- CLARK A. J., BESSOS H., BISHOP J. O., ET AL., "EXPRESSION OF HUMAN ANTI-HEMOPHILIC FACTOR IX IN THE MILK OF TRANSGENIC SHEEP.", Biotechnology, Nature Publishing Group, US, US , (19890501), vol. 07., no. 05., doi:10.1038/nbt0589-487, ISSN 0733-222X, pages 487 - 492., XP000026727
OPPOSITION- PALEYANDA R K, ET AL., "TRANSGENIC PIGS PRODUCE FUNCTIONAL HUMAN FACTOR VIII IN MILK", Nature Biotechnology, Nature Publishing Group US, New York, New York, (19971001), vol. 15, no. 10, doi:10.1038/nbt1097-971, ISSN 1087-0156, pages 971 - 975, XP001093842
OPPOSITION- Takehisa Kitazawa, Tomoyuki Igawa, Zenjiro Sampei, Atsushi Muto, Tetsuo Kojima, Tetsuhiro Soeda, Kazutaka Yoshihashi, Yukiko Okuyama-Nishida, Hiroyuki Saito, Hiroyuki Tsunoda, Tsukasa Suzuki, Hideki Adachi, Taro Miyazaki, Shinya Ishii, Mika Kamata-Sakurai, Takeo Iida, Aya Harada, Keiko Esaki, Miho Funaki, Chifumi Moriyama, Eriko Tanaka, Yasufumi Kikuchi, Tetsuya Wakabayashi, Manabu Wada, Masaaki Goto, Takeshi Toyoda, Atsunori Ueyama, Sachiyo Suzuki, Kenta Haraya, Tatsuhiko Tachibana, Yoshiki Kawabe, Midori Shima, Akira Yoshioka, Kunihiro Hattori, "A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model", Nature Medicine(Author manuscript ), Nature Publishing Group US, New York, New York, vol. 18, no. 10, doi:10.1038/nm.2942, ISSN 1078-8956, pages 1570 - 1574, XP055246561
OPPOSITION- Birgit Jurlander,, "Recombinant Activated Factor VII (rFVIIa): Characterization, Manufacturing, and Clinical Development", SEMINARS IN THROMBOSIS AND HEMOSTASIS/, (20010101), vol. 27, no. 4, doi:10.1055/s-2001-16890, pages 373 - 383, XP055226203
OPPOSITION- Johannes Oldenburg, Mahlangu Johnny N., Kim Benjamin, Schmitt Christophe, Callaghan Michael U., Young Guy, Santagostino Elena, Kruse-Jarres Rebecca, Negrier Claude, Kessler Craig, Valente Nancy, Asikanius Elina, Levy Gallia G., Windyga Jerzy, Shima Midori, "Emicizumab Prophylaxis in Hemophilia A with Inhibitors", The New England journal of medicine, Massachusetts Medical Society, US, US , (20170831), vol. 377, no. 9, doi:10.1056/NEJMoa1703068, ISSN 0028-4793, pages 809 - 818, XP055686025
OPPOSITION- Oldenburg Johannes, Mahlangu Johnny N., Kim Benjamin, Schmitt Christophe, Callaghan Michael U., Young Guy, Santagostino Elena, Kruse-Jarres Rebecca, Negrier Claude, Kessler Craig, Valente Nancy, Asikanius Elina, Levy Gallia G., Windyga Jerzy, Shima Midori, "Protocol: Emicizumab Prophylaxis in Hemophilia A with Inhibitors", The New England journal of medicine, Massachusetts Medical Society, US, US , (20170831), vol. 377, no. 9, doi:10.1056/NEJMoa1703068, ISSN 0028-4793, pages 1 - 343, XP093275548
OPPOSITION- Oldenburg Johannes, Mahlangu Johnny N., Kim Benjamin, Schmitt Christophe, Callaghan Michael U., Young Guy, Santagostino Elena, Kruse-Jarres Rebecca, Negrier Claude, Kessler Craig, Valente Nancy, Asikanius Elina, Levy Gallia G., Windyga Jerzy, Shima Midori, "Supplementary Appendix: Emicizumab Prophylaxis in Hemophilia A with Inhibitors", The New England journal of medicine, Massachusetts Medical Society, US, US , (20170831), vol. 377, no. 9, doi:10.1056/NEJMoa1703068, ISSN 0028-4793, pages 1 - 28, XP093275547
OPPOSITION- A. V. Nairn, W. S. York, K. Harris, E. M. Hall, J. M. Pierce, K. W. Moremen, "Regulation of Glycan Structures in Animal Tissues: TRANSCRIPT PROFILING OF GLYCAN-RELATED GENES", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, (20080417), vol. 283, no. 25, doi:10.1074/jbc.M801964200, ISSN 00219258, pages 17298 - 17313, XP055071321
OPPOSITION- GIL GEUN-CHEOL , VELANDER WILLIAM H, COTT VAN KEVIN E, "Analysis of the N-glycans of recombinant human Factor IX purified from transgenic pig milk", GLYCOBIOLOGY, Oxford University Press, US, US , (20080701), vol. 18, no. 7, doi:10.1093/GLYCOB/CWN035, ISSN 0959-6658, pages 526 - 539, XP002515191
OPPOSITION- G. Chevreux, Faid V., Scohyers J.-M., Bihoreau N., "N-/O-glycosylation analysis of human FVIIa produced in the milk of transgenic rabbits", Glycobiology, Oxford University Press, (20131201), vol. 23, no. 12, doi:10.1093/glycob/cwt085, ISSN 09596658, pages 1531 - 1546, XP055090715
OPPOSITION- Anonymous, "transgenic", Oxford reference, doi:10.1093/oi/authority.20110803105336299?print, pages 1 - 1, Oxford reference, URL: https://www.oxfordreference.com/display/10.1093/oi/authority.20110803105336299?print, XP093275522
OPPOSITION- J. Grandoni; G. Perret; C. Forier, "Kinetic analysis and binding studies of a new recombinant human factor VIIa for treatment of haemophilia", HAEMOPHILIA, BLACKWELL SCIENCE, OXFORD, GB, GB , (20161219), vol. 23, no. 2, doi:10.1111/hae.13110, ISSN 1351-8216, pages 300 - 308, XP072036039
OPPOSITION- Hartman R., S. Knappe, B. Goldstein, B. M. Ewenstein, L. Valentino, F. Scheiflinger, "OR36 Synergistic Effects of a Procoagulant Bispecific Antibody and FEIBA or Factor VIIA on Thrombin Generation", HAEMOPHILIA, BLACKWELL SCIENCE, OXFORD, GB, GB , (20170201), vol. 23, no. S2, doi:10.1111/hae.13158, ISSN 1351-8216, pages 26 - 26, XP093275550
OPPOSITION- G. Chevreux; N. Tilly; Y. Leblanc; C. Ramon; V. Faid; M. Martin; F. Dhainaut; N. Bihoreau, "Biochemical characterization of LR769, a new recombinant factor VIIa bypassing agent produced in the milk of transgenic rabbits", HAEMOPHILIA, BLACKWELL SCIENCE, OXFORD, GB, GB , (20170608), vol. 23, no. 4, doi:10.1111/hae.13253, ISSN 1351-8216, pages e324 - e334, XP072036015
OPPOSITION- K. E. Van Cott; P. E. Monahan; T. C. Nichols; W. H. Velander, "Haemophilic factors produced by transgenic livestock: abundance that can enable alternative therapies worldwide", HAEMOPHILIA, BLACKWELL SCIENCE, OXFORD, GB, GB , (20041008), vol. 10, doi:10.1111/j.1365-2516.2004.00983.x, ISSN 1351-8216, pages 70 - 76, XP072033722
OPPOSITION- SUBRAMANIAN A, ET AL., "RATE LIMITATIONS IN POSTTRANSLATIONAL PROCESSING BY THE MAMMARY GLAND OF TRANSGENIC ANIMALS", Annals of the New York Academy of Sciences, New York Academy of Sciences., US, US , (19960515), vol. 782, doi:10.1111/j.1749-6632.1996.tb40550.x, ISSN 0077-8923, pages 87 - 96, XP001094637
OPPOSITION- HARTMANN R ET AL, "In vitro studies show synergistic effects of a procoagulant bispecific antibody and bypassing agents.", Journal of thrombosis and haemostasis, John Wiley & Sons, (20180611), vol. 16, doi:10.1111/jth.14203, ISSN 1538-7836, pages 1580 - 1591, XP002788933
OPPOSITION- R. Hartmann , T. Feenstra , L. Valentino , M. Dockal , F. Scheiflinger, "In vitro studies show synergistic effects of a procoagulant bispecific antibody and bypassing agents.", Journal of thrombosis and haemostasis, (20180611), vol. 16, doi:10.1111/jth.14203, ISSN 1538-7836, pages 1580 - 1591, XP002788933
OPPOSITION- Lee Meng-Hwan, Lin Yin-Shen, Tu Ching-Fu, Yen Chon-Ho, "Recombinant Human Factor IX Produced from Transgenic Porcine Milk", BioMed Research International, Hindawi Publishing Corporation, vol. 2014, doi:10.1155/2014/315375, ISSN 2314-6133, pages 1 - 8, XP093275565
OPPOSITION- HEMKER H C, ET AL., "CALIBRATED AUTOMATED THROMBIN GENERATION MEASUREMENT IN CLOTTING PLASMA", Pathophysiology of Haemost Thrombosis, Karger, CH, CH , (20030601), vol. 33, no. 01, doi:10.1159/000071636, ISSN 1424-8832, pages 04 - 15, XP008053802
OPPOSITION- Gerotziafas Grigoris T; Depasse François; Busson Joël; Leflem Lena; Elalamy Ismail; Samama Meyer M, "Towards a standardization of thrombin generation assessment: The influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay", THROMBOSIS JOURNAL, BIOMED CENTRAL, LONDON, GB, GB , (20051026), vol. 3, no. 1, doi:10.1186/1477-9560-3-16, ISSN 1477-9560, page 16, XP021009554
OPPOSITION- Zenjiro Sampei, Igawa Tomoyuki, Soeda Tetsuhiro, Okuyama Nishida Yukiko, Moriyama Chifumi, Wakabayashi Tetsuya, Tanaka Eriko, Muto Atsushi, Kojima Tetsuo, Kitazawa Takehisa, Yoshihashi Kazutaka, Harada Aya, Funaki Miho, Haraya Kenta, Tachibana Tatsuhiko, Suzuki Sachiyo, Esaki Keiko, Nabuchi Yoshiaki, Hattori Kunihiro, Lenting Peter, "Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity", PLOS ONE, Public Library of Science, US, US , (20130201), vol. 8, no. 2, doi:10.1371/journal.pone.0057479, ISSN 1932-6203, pages 1 - 13, XP055127871
OPPOSITION- Jones C. J.P., M. Abd-Elnaeim, E. Bevilacqua, L. V. Oliveira, R. Leiser, "Comparison of uteroplacental glycosylation in the camel (Camelus dromedarius) and alpaca (Lama pacos) ", Journals of Reproduction & Fertility, BioScientifica Ltd., GB, GB , (20020101), vol. 123, no. 1, doi:10.1530/rep.0.1230115, ISSN 1470-1626, pages 115 - 126, XP093275575

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents