| DESCRIPTION | - ABRAHAM et al., "Chaotic Mixer for Microchannels", Science, (20020000), vol. 295, pages 647651 - 651 | - |
| DESCRIPTION | - ALTSCHUL, S. F. et al., J. Molec. Biol., (19900000), vol. 215, page 403 | - |
| DESCRIPTION | - Br. J. Haematol., (19860000), vol. 62, pages 229 - 37 | - |
| DESCRIPTION | - Br J Radiol, (19970000), vol. 70, pages 1169 - 73 | - |
| DESCRIPTION | - Cancer Immunol Immunother, (19870000), vol. 25, pages 266 - 73 | - |
| DESCRIPTION | - CARILLO, H.LIPMAN, D., SIAM J Applied Math., (19880000), vol. 48, page 1073 | - |
| DESCRIPTION | - DEVEREUX, J. et al., Nucleic Acids Research, (19840000), vol. 12, no. 1, page 387 | - |
| DESCRIPTION | - FLECKENSTEIN, Cir. Res., (19830000), vol. 52, no. 1, pages 13 - 16 | - |
| DESCRIPTION | - Haematologica, (19920000), vol. 77, pages 40 - 3 | - |
| DESCRIPTION | - JAYARAMA et al., Angew. Chem., (20120000), vol. 51, pages 8529 - 8533 | - |
| DESCRIPTION | - J Cell Physiol, (19820000), vol. 112, pages 222 - 8 | - |
| DESCRIPTION | - J Dermatol, (19980000), vol. 25, pages 706 - 9 | - |
| DESCRIPTION | - J Lab Clin Med, (19970000), vol. 129, pages 231 - 8 | - |
| DESCRIPTION | - J. Pharmaceutical Sciences, (19770000), vol. 66, pages 2725 - 19 | - |
| DESCRIPTION | - MAIER et al., Molecular Therapy, (20130000), vol. 21, pages 1570 - 1578 | - |
| DESCRIPTION | - MCCALL, D., Curr Pract Cardiol, (19850000), vol. 10, pages 1 - 11 | - |
| DESCRIPTION | - MEYERSMILLER, CABIOS, (19890000), vol. 4, pages 11 - 17 | - |
| DESCRIPTION | - NEEDLEMAN, S.B.WUNSCH, C.D., "A general method applicable to the search for similarities in the amino acid sequences of two proteins", J. Mol. Biol., (19700000), vol. 48, pages 443 - 453 | - |
| DESCRIPTION | - N Engl J Med, (19950000), vol. 332, pages 1132 - 6 | - |
| DESCRIPTION | - Scand J. Haematol, (19860000), vol. 37, pages 306 - 9 | - |
| DESCRIPTION | - SEMPLE et al., Nat. Biotechnol., (20100000), vol. 28, pages 172 - 176 | - |
| DESCRIPTION | - WILEN, S.H., Tables of Resolving Agents and Optical Resolutions, Univ. of Notre Dame Press, (19720000), page 1962 | - |
| DESCRIPTION | - SMITH, T.F.WATERMAN, M.S., "Identification of common molecular subsequences", J. Mol. Biol., (19810000), vol. 147, doi:doi:10.1016/0022-2836(81)90087-5, pages 195 - 197, XP024015032 | |
| DESCRIPTION | - CHEN, D. et al., "Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation", JAm Chem Soc., (20120000), vol. 134, no. 16, doi:doi:10.1021/ja301621z, pages 6948 - 51, XP002715254 | |
| DESCRIPTION | - ZHIGALTSEV, I.V. et al., "Bottom-up design and synthesis of limit size lipid nanoparticle systems with aqueous and triglyceride cores using millisecond microfluidic mixing have been published", Langmuir, (20120000), vol. 28, doi:doi:10.1021/la204833h, pages 3633 - 40, XP055150435 | |
| DESCRIPTION | - BELLIVEAU, N.M. et al., "Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA", Molecular Therapy-Nucleic Acids, (20120000), vol. 1, doi:doi:10.1038/mtna.2012.28, page e37, XP002715253 | |
| DESCRIPTION | - GEORGE M., "The Origins and the Future of Microfluidics", Nature, (20060000), vol. 442, doi:doi:10.1038/nature05058, pages 368 - 373, XP055123139 | |
| DESCRIPTION | - STEPHEN F. ALTSCHUL et al., "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res., (19970000), vol. 25, doi:doi:10.1093/nar/25.17.3389, pages 3389 - 3402, XP002905950 | |
| INTERNATIONAL-SEARCH-REPORT | - GLUZMAN M KH ET AL, "Esterification of stearic acid with polyethylene glycols", ZHURNAL PRIKLADNOI KHIMII, MAIK NAUKA: ROSSIISKAYA AKADEMIYA NAUK, RU, (19680101), vol. 41, no. 1, ISSN 0044-4618, pages 167 - 170, XP009517240 [X] 130 * the whole document * [Y] 141,142 [I] 131-140 | - |
| INTERNATIONAL-SEARCH-REPORT | - FREDRIK VIKLUND ET AL, "Enzymatic synthesis of surfactants based on polyethylene glycol and stearic or 12-hydroxystearic acid", JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC, (20040201), vol. 27, no. 2-3, doi:10.1016/j.molcatb.2003.09.006, ISSN 1381-1177, pages 51 - 53, XP055436986 [Y] 141,142 * point 2.4; page 52 * * figure 2 * | |
| INTERNATIONAL-SEARCH-REPORT | - LEE ET AL, "Separation and determination of polyethylene glycol fatty acid esters in cosmetics by a reversed-phase HPLC/ELSD", TALANTA, ELSEVIER, AMSTERDAM, NL, (20071018), vol. 74, no. 5, doi:10.1016/J.TALANTA.2007.10.020, ISSN 0039-9140, pages 1615 - 1620, XP022426387 [X] 1-3,6-25 * point 2.1; page 1616 * * page 1618; table 2 * [A] 26,39,41-127,129-142 [I] 4,5,128 | |
| INTERNATIONAL-SEARCH-REPORT | - WENRUI WANG ET AL, "Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles", INTERNATIONAL JOURNAL OF NANOMEDICINE, (20120701), vol. 7, doi:10.2147/IJN.S30428, pages 3667 - 3677, XP055563116 [A] 26 * materials; page 3668, column 1 * * preparation of curcumin SLNs; page 3368, column 2 * | |
| OPPOSITION | - Anonymous, "14:0 PEG1000 PE 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-1000] (ammonium salt) 880710", Avanti Polar Lipids:Polymers & Polymerizable Lipids - mPEG Phospholipids - mPEG 1000, Avanti Polar Lipids, Inc., pages 1 - 1, Avanti Polar Lipids:Polymers & Polymerizable Lipids - mPEG Phospholipids - mPEG 1000, URL: https://web.archive.org/web/20150602131732/http://avantilipids.com/index.php?option=com_content&view=article&id=1083&Itemid=447&catnumber=880710, XP093296107 | - |
| OPPOSITION | - Anonymous, "14:0 PEG3000 PE 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-3000] (ammonium salt) 880310", Avanti Polar Lipids: Polymers & Polymerizable Lipids - mPEG Phospholipids - mPEG 3000, Avanti Polar Lipids, Inc., pages 1 - 1, Avanti Polar Lipids: Polymers & Polymerizable Lipids - mPEG Phospholipids - mPEG 3000, URL: https://web.archive.org/web/20150602131244/http://avantilipids.com/index.php?option=com_content&view=article&id=1091&Itemid=449&catnumber=880310, XP093296114 | - |
| OPPOSITION | - Anonymous, "14:0 PEG350 PE 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-350] (ammonium salt) 880410 ", Avanti Polar Lipids: Polymers & Polymerizable Lipids - mPEG Phospholipids - mPEG 350, Avanti Polar Lipids, Inc., pages 1 - 1, Avanti Polar Lipids: Polymers & Polymerizable Lipids - mPEG Phospholipids - mPEG 350, URL: https://web.archive.org/web/20150602132220/http://avantilipids.com/index.php?option=com_content&view=article&id=1070&Itemid=444&catnumber=880410, XP093296099 | - |
| OPPOSITION | - Anonymous, "18:0 PEG2000 PE 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt) 880120", Avanti Polar Lipids: Polymers & Polymerizable Lipids - mPEG Phospholipids - mPEG 2000, Avanti Polar Lipids, Inc., pages 1 - 1, Avanti Polar Lipids: Polymers & Polymerizable Lipids - mPEG Phospholipids - mPEG 2000, URL: https://web.archive.org/web/20150602091319/http://avantilipids.com/index.php?option=com_content&view=article&id=1088&Itemid=448&catnumber=880120, XP093296118 | - |
| OPPOSITION | - Anonymous, "3. PEGylated Lipids | Phospholipids", NOF America, pages 1 - 9, NOF America, URL: https://web.archive.org/web/20170330215216/http://www.nofamerica.com/store/index.php?dispatch=categories.view&category_id=24, XP093296124 | - |
| OPPOSITION | - Anonymous, "Activated PEG for PEGylation SUNBRIGHT® and PUREBRIGHT® Series", Drug Delivery Products / Activated PEG for PEGylation, NOF America, pages 1 - 9, Drug Delivery Products / Activated PEG for PEGylation, URL: https://www.nofamerica.com/store/drug-delivery-products/activated-peg-for-pegylation.html, XP093296201 | - |
| OPPOSITION | - Anonymous, "Alnylam Announces First-Ever FDA Approval of an RNAi Therapeutic, ONPATTRO™ (patisiran) for the Treatment of the Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis in Adults", Alnylam Pharmaceuticals Press Release, Alnylam Pharmaceuticals, pages 1 - 11, Alnylam Pharmaceuticals Press Release, URL: https://investors.alnylam.com/press-release?id=22946, XP093296231 | - |
| OPPOSITION | - Anonymous, "Assessment report Onpattro International non-proprietary name: patisiran; EMA/554262/2018 ", Assessment report, European Medicines Agency, pages 1 - 188, Assessment report , URL: https://www.ema.europa.eu/en/documents/assessment-report/onpattro-epar-public-assessment-report_en.pdf, XP093296075 | - |
| OPPOSITION | - Anonymous, "C16 PEG2000 Ceramide N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)2000]} 880180", Polymers & Polymerizable Lipids - mPEG Ceramides, Avanti Polar Lipids Inc., pages 1 - 1, Polymers & Polymerizable Lipids - mPEG Ceramides, URL: https://web.archive.org/web/20150908102314/http://avantilipids.com/index.php?option=com_content&view=article&id=1101&Itemid=152&catnumber=880180, XP093296835 | - |
| OPPOSITION | - Anonymous, "C16 PEG750 Ceramide N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)750]} 880680", Polymers & Polymerizable Lipids - mPEG Ceramides, Avanti Polar Lipids Inc., pages 1 - 1, Polymers & Polymerizable Lipids - mPEG Ceramides, URL: https://web.archive.org/web/20150909200114/http://avantilipids.com/index.php?option=com_content&view=article&id=1099&Itemid=152&catnumber=880680, XP093296833 | - |
| OPPOSITION | - Anonymous, "Drug Approval Package: Onpattro (patisiran)", Drug Approvals and Databases Drugs@FDA, FDA, pages 1 - 2, Drug Approvals and Databases Drugs@FDA, URL: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210922Orig1s000TOC.cfm, XP093296223 | - |
| OPPOSITION | - Anonymous, "Liposome Drug Products Chemistry, Manufacturing, and Controls; Human Pharmacokinetics and Bioavailability; and Labeling Documentation", Guidance for Industry, U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER), pages 1 - 18, Guidance for Industry, URL: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/liposome-drug-products-chemistry-manufacturing-and-controls-human-pharmacokinetics-and, XP093296082 | - |
| OPPOSITION | - Anonymous, "mPEG Ceramides", Avanti Polar Lipids: Products - Polymers & Polymerizable Lipids - mPEG Ceramides, Avanti Polar Lipids, Inc., pages 1 - 1, Avanti Polar Lipids: Products - Polymers & Polymerizable Lipids - mPEG Ceramides, URL: https://web.archive.org/web/20150908095225/http://avantilipids.com/index.php?option=com_content&view=article&id=144&Itemid=152, XP093296830 | - |
| OPPOSITION | - Anonymous, "Myrj™ S40", Myrj™ S40, Croda Agriculture, pages 1 - 2, Myrj™ S40, URL: https://www.crodaagriculture.com/en-gb/product-finder/product/230-myrj_1_s40, XP093296864 | - |
| OPPOSITION | - Anonymous, "Myrj™ S50", Myrj™ S50, Croda Agriculture, pages 1 - 2, Myrj™ S50, URL: https://www.crodaagriculture.com/en-gb/product-finder/product/231-myrj_1_s50, XP093296862 | - |
| OPPOSITION | - Anonymous, "NDA 210922 -Patisiran -Cross-Discipline Team Leader Review", MULTI-DISCIPLINE REVIEW, FDA; CENTER FOR DRUG EVALUATION AND RESEARCH, pages 1 - 485, MULTI-DISCIPLINE REVIEW, URL: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210922Orig1s000MultiR.pdf, XP093296217 | - |
| OPPOSITION | - Anonymous, "ONPATTRO (patisiran) lipid complex injection, for intravenous use", HIGHLIGHTS OF PRESCRIBING INFORMATION, FDA, pages 1 - 14, HIGHLIGHTS OF PRESCRIBING INFORMATION, URL: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210922s000lbl.pdf, XP093296224 | - |
| OPPOSITION | - Anonymous, "Overview Onpattro (patisiran) ", Overview Onpattro (patisiran) EMA/521473/2018 EMEA/H/C/004699, European Medicines Agency, pages 1 - 3, Overview Onpattro (patisiran) EMA/521473/2018 EMEA/H/C/004699, URL: https://www.ema.europa.eu/en/documents/overview/onpattro-epar-medicine-overview_en.pdf, XP093296827 | - |
| OPPOSITION | - Anonymous, "Polyoxyethylene (40) stearate - Safety Data Sheet (Version 6.7)", Sigma-Aldrich, (20250506), XP093293509 | - |
| OPPOSITION | - Anonymous, "Q11 Development and Manufacture of Drug Substances (Chemical Entities and Biotechnological/Biological Entities) Questions and Answers", Guidance for Industry, Food and Drug Administration, pages 1 - 17, Guidance for Industry, URL: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/q11-development-and-manufacture-drug-substances-questions-and-answers-chemical-entities-and, XP093296852 | - |
| OPPOSITION | - Anonymous, "Q11 Development and Manufacture of Drug Substances", Guidance for Industry, Food and Drug Administration, pages 1 - 36, Guidance for Industry , URL: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/q11-development-and-manufacture-drug-substances, XP093296847 | - |
| OPPOSITION | - Anonymous, "Quantitative NMR Spectroscopy", Quantitative NMR Spectroscopy, Chemistry Department NMR Research Facility, University of Oxford, pages 1 - 8, Quantitative NMR Spectroscopy, URL: https://nmr.chem.ox.ac.uk/files/quantitativenmrpdf, XP093296214 | - |
| OPPOSITION | - Anonymous, "Reflection paper on the data requirements for intravenous liposomal products developed with reference to an innovator liposomal product", Data requirements for intravenous liposomal products developed with reference to an innovator liposomal product - Scientific guideline, European Medicines Agency, pages 1 - 13, Data requirements for intravenous liposomal products developed with reference to an innovator liposomal product - Scientific guideline, URL: https://www.ema.europa.eu/en/documents/scientific-guideline/reflection-paper-data-requirements-intravenous-liposomal-products-developed-reference-innovator-liposomal-product-revision-2_en.pdf, XP093296229 | - |
| OPPOSITION | - Anoynmous, "C16 PEG5000 Ceramide N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)5000]} 880280", Polymers & Polymerizable Lipids - mPEG Ceramides, Avanti Polar Lipids Inc., pages 1 - 1, Polymers & Polymerizable Lipids - mPEG Ceramides, URL: https://web.archive.org/web/20150322123627/http://avantilipids.com/index.php?option=com_content&view=article&id=1103&Itemid=152&catnumber=880280, XP093296836 | - |
| OPPOSITION | - Center Alison , S. Anne Montgomery, "mRNA ANALYTICAL DEVELOPMENT AND CMC SUPPORT", Messenger RNA Drugs: Engaging the Machinery of Patients’ Cells to Therapeutic Effect, BioProcess International, (20181201), pages 1 - 10, XP093296083 | - |
| OPPOSITION | - D10a - NOF Corporation certificate of analysis for Sunbright GM-020 September 2014 | - |
| OPPOSITION | - D10c - Certificate of Analysis of SUNBRIGHT GM-020 of D10b | - |
| OPPOSITION | - D10d - Certificates of Analysis “SUNBRIGHT GM-020”, 31 August 2012 - 15 February 2017 | - |
| OPPOSITION | - D13 - Expert declaration by Lingyao Li | - |
| OPPOSITION | - D20a - Screenshot of the website link to the document X1 (XP093296217) | - |
| OPPOSITION | - NOF DSGPEG2000 (Certificate of Analysis; 14 July 2021) | - |
| OPPOSITION | - Robert M. Silverstein; Francis X. Webster; David J. Kiemle; David L. Bryce, "Chapter 3 PROTON (1H) MAGNETIC RESONANCE SPECTROSCOPY", Spectrometric Identification of Organic Compounds, Wiley, (20150101), pages 126 - 190, ISBN 978-0-470-61637-6, XP009562069 | - |
| OPPOSITION | - Unger Ellis F., "NDA APPROVAL for Onpattro (patisiran) lipid complex injection 2mg/mL", NDA 210922 / Reference ID: 4305330, FDA Food and Drug Administration, pages 1 - 8, NDA 210922 / Reference ID: 4305330, URL: https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2018/210922Orig1s000ltr.pdf, XP093296826 | - |
| OPPOSITION | - Willis Randall C., "Done in a Flash A quiet workhorse of the synthesis lab, flash chromatography continues to make strides.", TODAY'S CHEMIST AT WORK, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC,, US, US , (20040301), vol. 2004, no. 3, ISSN 1062-094X, pages 51 - 52, XP093296204 | - |
| OPPOSITION | - William C. Stevens ; Daniel C. Hill, "General methods for flash chromatography using disposable columns", Molecular Diversity, Kluwer Academic Publishers, Do, Do , (20090113), vol. 13, no. 2, doi:10.1007/s11030-008-9104-x, ISSN 1573-501X, pages 247 - 252, XP019684579 | |
| OPPOSITION | - Tan Lu; Sun Xun, "Recent advances in mRNA vaccine delivery", NANO RESEARCH, TSINGHUA UNIVERSITY PRESS, CN, CN , (20180526), vol. 11, no. 10, doi:10.1007/s12274-018-2091-z, ISSN 1998-0124, pages 5338 - 5354, XP037125417 | |
| OPPOSITION | - Theresa M. Allen, Pieter R. Cullis, "Liposomal drug delivery systems: From concept to clinical applications", Advanced Drug Delivery Reviews, Elsevier, Amsterdam , NL, Amsterdam , NL , (20130101), vol. 65, no. 1, doi:10.1016/j.addr.2012.09.037, ISSN 0169-409X, pages 36 - 48, XP055113529 | |
| OPPOSITION | - Cheng Xinwei; Lee Robert J., "The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery", Advanced Drug Delivery Reviews, Elsevier, Amsterdam , NL, Amsterdam , NL , (20160218), vol. 99, doi:10.1016/j.addr.2016.01.022, ISSN 0169-409X, pages 129 - 137, XP029445785 | |
| OPPOSITION | - Suzuki Yuta, Ishihara Hiroshi, "Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs", DRUG METABOLISM AND PHARMACOKINETICS, JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS (JSSX), TOKYO, JP, JP , (20211201), vol. 41, doi:10.1016/j.dmpk.2021.100424, ISSN 1347-4367, page 100424, XP093190216 | |
| OPPOSITION | - Delmas T, Couffin A C, Bayle P A, de Crécy F, Neumann E, Vinet F, Bardet M, Bibette J, Texier I., "Preparation and characterization of highly stable lipid nanoparticles with amorphous core of tuneable viscosity", Journal of Colloid and Interface Science, Academic Press,Inc., US, US , (20110815), vol. 360, no. 2, doi:10.1016/j.jcis.2011.04.080, ISSN 0021-9797, pages 471 - 481, XP002686819 | |
| OPPOSITION | - Dézsi László, Fülöp Tamás, Mészáros Tamás, Szénási Gábor, Urbanics Rudolf, Vázsonyi Csenge, Őrfi Erik, Rosivall László, Nemes Réka, Kok Robbert Jan, Metselaar Josbert M., Storm Gert, Szebeni János, "Features of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: Comparison of the porcine and rat responses", Journal of Controlled Release, Elsevier, NL, NL , (20141201), vol. 195, doi:10.1016/j.jconrel.2014.08.009, ISSN 0168-3659, pages 2 - 10, XP093296838 | |
| OPPOSITION | - Chen Sam; Tam Yuen Yi C.; Lin Paulo J.C.; Sung Molly M.H.; Tam Ying K.; Cullis Pieter R., "Influence of particle size on thein vivopotency of lipid nanoparticle formulations of siRNA", Journal of Controlled Release, Elsevier, NL, NL , (20160526), vol. 235, no. 1, doi:10.1016/j.jconrel.2016.05.059, ISSN 0168-3659, pages 236 - 244, XP029633339 | |
| OPPOSITION | - Pieter R. Cullis, Michael J. Hope, "Lipid Nanoparticle Systems for Enabling Gene Therapies", Molecular Therapy, Elsevier Inc, United States, United States, (20170701), vol. 25, no. 7, doi:10.1016/j.ymthe.2017.03.013, ISSN 1525-0016, pages 1467 - 1475, XP055548712 | |
| OPPOSITION | - Staci Sabnis, E. Sathyajith Kumarasinghe, Timothy Salerno, Cosmin Mihai, Tatiana Ketova, Joseph J. Senn, Andy Lynn, Alex Bulychev, Iain Mcfadyen, Joyce Chan, Örn Almarsson, Matthew G. Stanton, Kerry E. Benenato, "A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates", Molecular Therapy, Elsevier Inc, United States, United States, (20180601), vol. 26, no. 6, doi:10.1016/j.ymthe.2018.03.010, ISSN 1525-0016, pages 1509 - 1519, XP055644778 | |
| OPPOSITION | - Robinson Ema, Macdonald Kelvin D., Slaughter Kai, Mckinney Madison, Patel Siddharth, Sun Conroy, Sahay Gaurav, "Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis", Molecular Therapy, Elsevier Inc, United States, United States, (20180801), vol. 26, no. 8, doi:10.1016/j.ymthe.2018.05.014, ISSN 1525-0016, pages 2034 - 2046, XP093252260 | |
| OPPOSITION | - Tenchov Rumiana, Bird Robert, Curtze Allison E., Zhou Qiongqiong, "Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement", ACS Nano, American Chemical Society, US, US , (20211123), vol. 15, no. 11, doi:10.1021/acsnano.1c04996, ISSN 1936-0851, pages 16982 - 17015, XP093009618 | |
| OPPOSITION | - Matthias A. Oberli, Andreas M. Reichmuth, J. Robert Dorkin, Michael J. Mitchell, Owen S. Fenton, Ana Jaklenec, Daniel G. Anderson, Robert Langer, Daniel Blankschtein, "Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy", Nano Letters,20200311American Chemical Society, US, American Chemical Society, (20170308), vol. 17, no. 3, doi:10.1021/acs.nanolett.6b03329, ISSN 1530-6984, pages 1326 - 1335, XP055614115 | |
| OPPOSITION | - Oberli Matthias A, Oberli Matthias A, Reichmuth Andreas M, Dorkin J. Robert, Mitchell Michael J, Fenton Owen S, Jaklenec Ana, Anderson Daniel G, Langer Robert, Blankschtein Daniel, "Supporting Information - Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy", Nano Letters, American Chemical Society, (20161123), vol. 17, no. 3, doi:10.1021/acs.nanolett.6b03329, ISSN 1530-6984, pages 1 - 9, XP093194132 | |
| OPPOSITION | - Paunovska Kalina, Sago Cory D., Monaco Christopher M., Hudson William H., Castro Marielena Gamboa, Rudoltz Tobi G., Kalathoor Sujay, Vanover Daryll A., Santangelo Philip J., Ahmed Rafi, Bryksin Anton V., Dahlman James E., "A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation", Nano Letters, American Chemical Society, (20180314), vol. 18, no. 3, doi:10.1021/acs.nanolett.8b00432, ISSN 1530-6984, pages 2148 - 2157, XP093114315 | |
| OPPOSITION | - CHOI JOON SIG, MACKAY J A, SZOKA F C, "Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: Preparation and characterization.", Bioconjugate Chemistry - Author Manuscript, American Chemical Society, US, US , (20030401), vol. 14, no. 2, doi:10.1021/bc025625w, ISSN 1043-1802, pages 420 - 429, XP002316970 | |
| OPPOSITION | - Shinji Takeoka, Katsura Mori, Haruki Ohkawa, Keitaro Sou, And Eishun Tsuchida, "Synthesis and Assembly of Poly(ethylene glycol)-Lipids with Mono-, Di-, and Tetraacyl Chains and a Poly(ethylene glycol) Chain of Various Molecular Weights", J. Am. Chem. Soc., (20000101), vol. 122, doi:10.1021/ja000835+, pages 7927 - 7935, XP055036794 | |
| OPPOSITION | - Whitehead Kathryn A, Matthews Jonathan, Chang Philip H, Niroui Farnaz, Dorkin J. Robert, Severgnini Mariano, Anderson Daniel G, "In Vitro-In Vivo Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery", ACS Nano, American Chemical Society, US, US , (20120828), vol. 6, no. 8, doi:10.1021/nn301922x, ISSN 1936-0851, pages 6922 - 6929, XP093296858 | |
| OPPOSITION | - DeRosa F; Guild B; Karve S; Smith L; Love K; Dorkin J R; Kauffman K J; Zhang J; Yahalom B; Anderson D G; Heartlein M W, "Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system", Gene Therapy, Nature Publishing Group, London, GB, GB , (20160930), vol. 23, no. 10, doi:10.1038/gt.2016.46, ISSN 0969-7128, pages 699 - 707, XP009512837 | |
| OPPOSITION | - Mui Barbara L, Tam Ying K, Jayaraman Muthusamy, Ansell Steven M, Du Xinyao, Tam Yuen Yi C, Lin Paulo Jc, Chen Sam, Narayanannair Jayaprakash K, Rajeev Kallanthottathil G, Manoharan Muthiah, Akinc Akin, Maier Martin A, Cullis Pieter, Madden Thomas D, Hope Michael J, "Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles", Molecular Therapy-Nucleic Acids, Cell Press, US, US , (20130101), vol. 2, doi:10.1038/mtna.2013.66, ISSN 2162-2531, page e139, XP055898080 | |
| OPPOSITION | - Hou Xucheng, Zaks Tal, Langer Robert, Dong Yizhou, "Lipid nanoparticles for mRNA delivery", Nature Reviews Materials, Nature, (20210810), doi:10.1038/s41578-021-00358-0, ISSN 2058-8437, XP055861763 | |
| OPPOSITION | - Arshad Muhammad, Saied Sumayya, Ullah Aman, "PEG-lipid telechelics incorporating fatty acids from canola oil: synthesis, characterization and solution self-assembly", RSC Advances, Royal Society of Chemistry, GB, GB , (20140606), vol. 4, no. 50, doi:10.1039/c4ra03583f, ISSN 2046-2069, pages 26439 - 26446, XP093296206 | |
| OPPOSITION | - Dong Yao-Da, Tchung Estefania, Nowell Cameron, Kaga Sadik, Leong Nathania, Mehta Dharmini, Kaminskas Lisa, Boyd Ben, "Microfluidic preparation of drug-loaded PEGylated liposomes, and the impact of liposome size on tumour retention and penetration", JOURNAL OF LIPOSOME RESEARCH., TAYLOR & FRANCIS, PHILADELPHIA, PA., US, US , (20190102), vol. 29, no. 1, doi:10.1080/08982104.2017.1391285 , ISSN 0898-2104, pages 1 - 9, XP009562070 | |
| OPPOSITION | - Jayesh A. Kulkarni, Pieter R. Cullis, Roy Van Der Meel, "Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility", Nucleic Acid Therapeutics, Mary Ann Liebert, Inc. Publishers, US, US , (20180601), vol. 28, no. 3, doi:10.1089/nat.2018.0721, ISSN 2159-3337, pages 146 - 157, XP055551908 | |
| OPPOSITION | - Beiranvand Siavash, Eatemadi Ali, Karimi Arash, "New Updates Pertaining to Drug Delivery of Local Anesthetics in Particular Bupivacaine Using Lipid Nanoparticles", NANOSCALE RESEARCH LETTERS, Springer, US, US , (20161201), vol. 11, no. 1, doi:10.1186/s11671-016-1520-8, ISSN 1931-7573, pages 307 - 10, XP093296239 | |
| OPPOSITION | - Gindy Marian E, Leone Anthony M, Cunningham James J, "Challenges in the pharmaceutical development of lipid-based short interfering ribonucleic acid therapeutics", Expert Opinion on Drug Delivery, Informa Healthcare, GB, GB , (20120201), vol. 9, no. 2, doi:10.1517/17425247.2012.642363, ISSN 1742-5247, pages 171 - 182, XP093231564 | |
| OPPOSITION | - Talluri Siddartha Venkata, Kuppusamy Gowthamarajan, Karri Veera, Tummala Shashank, Madhunapantula Subbarao V., "Lipid-based nanocarriers for breast cancer treatment - comprehensive review", Drug Delivery, ACADEMIC PRESS, ORLANDO, FL., US, US , (20160501), vol. 23, no. 4, doi:10.3109/10717544.2015.1092183, ISSN 1071-7544, pages 1291 - 1305, XP093296822 | |
| OPPOSITION | - Wen Xianchun, Li Jiping, Cai Defu, Yue Liling, Wang Qi, Zhou Li, Fan Li, Sun Jianwen, Wu Yonghui, "Anticancer Efficacy of Targeted Shikonin Liposomes Modified with RGD in Breast Cancer Cells", Molecules, MDPI AG, CH, CH , (20180201), vol. 23, no. 2, doi:10.3390/molecules23020268, ISSN 1420-3049, pages 268 - 15, XP093296843 | |
| OPPOSITION | - Ichihara Masako, Shimizu Taro, Imoto Ami, Hashiguchi Yuki, Uehara Yumi, Ishida Tatsuhiro, Kiwada Hiroshi, "Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats", Pharmaceutics, MDPI AG, Switzerland, Switzerland, (20110301), vol. 3, no. 1, doi:10.3390/pharmaceutics3010001, ISSN 1999-4923, pages 1 - 11, XP093296856 | |
| OPPOSITION | - Yuen Tam, Chen Sam, Cullis Pieter, "Advances in Lipid Nanoparticles for siRNA Delivery", Pharmaceutics, MDPI AG, Switzerland, Switzerland, (20130901), vol. 5, no. 3, doi:10.3390/pharmaceutics5030498, ISSN 1999-4923, pages 498 - 507, XP055246895 | |
