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Carbon-Source Regulated Protein Production In A Recombinant Host Cell - EP3874047
The patent EP3874047 was granted to Lonza on Dec 25, 2024. The application was filed on Jan 10, 2020 under application number EP20700131A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".
EP3874047
- Application Number
- EP20700131A
- Filing Date
- Jan 10, 2020
- Status
- Patent Maintained As Amended
- Nov 22, 2024
- Publication Date
- Dec 25, 2024
- External Links
- Slate, Register, Google Patents
Patent Summary
A method for producing a recombinant protein in a host cell that reduces the risk of cell morphology changes during production. The method involves genetically modifying the host cell to reduce expression of the FLO8 protein, which is involved in cell morphology regulation, and then expressing the recombinant protein under the control of a regulatable promoter that is repressed by a non-methanol carbon source. The modified host cell is cultured under conditions that induce protein production while maintaining cell morphology stability.
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