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The patent EP3880197 was granted to Vertex Pharmaceuticals Incorporated on Jul 2, 2025. The application was filed on Nov 13, 2019 under application number EP19817037A. The patent is currently recorded with a legal status of "Granted And Under Opposition".
A CFTR modulator compound, (14S)-8-[3-(2-{Dispiro[2.0.2.1]heptan-7-yl}ethoxy)-1H-pyrazol-1-yl]-12,12-dimethyl-2λ6-thia-3,9,11,18,23-pentaazatetracyclo [17.3.1.111,14.05,10]tetracosa-1(22),5,7,9,19(23),20-hexaene-2,2,4-trione (Compound I), and pharmaceutical compositions containing the compound, for treating cystic fibrosis and other CFTR-mediated diseases. The compound is a CFTR modulator that can be used alone or in combination with other CFTR modulators to treat cystic fibrosis.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
| Company | Opposition Date | Representative | Opposition Status |
|---|---|---|---|
| TEVA PHARMACEUTICALS | Nov 22, 2023 | D YOUNG | ADMISSIBLE |
| GENERICS UK | Nov 21, 2023 | TER MEER STEINMEISTER & PARTNER | ADMISSIBLE |
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| DESCRIPTION | US2004006237 |
| DESCRIPTION | US8865902 |
| DESCRIPTION | US9181192 |
| DESCRIPTION | US9512079 |
| DESCRIPTION | WO2007134279 |
| DESCRIPTION | WO2010019239 |
| DESCRIPTION | WO2010037066 |
| DESCRIPTION | WO2011019413 |
| DESCRIPTION | WO2011119984 |
| DESCRIPTION | WO2011127241 |
| DESCRIPTION | WO2011133751 |
| DESCRIPTION | WO2011133951 |
| DESCRIPTION | WO2012027731 |
| DESCRIPTION | WO2013130669 |
| DESCRIPTION | WO2014014841 |
| DESCRIPTION | WO2014071122 |
| DESCRIPTION | WO2015160787 |
| DESCRIPTION | WO2016057572 |
| DESCRIPTION | WO2017053455 |
| DESCRIPTION | WO2018064632 |
| DESCRIPTION | WO2018080591 |
| INTERNATIONAL-SEARCH-REPORT | US2019248809 |
| INTERNATIONAL-SEARCH-REPORT | WO2019018353 |
| INTERNATIONAL-SEARCH-REPORT | WO2019018395 |
| INTERNATIONAL-SEARCH-REPORT | WO2019152940 |
| OPPOSITION | US62767202 |
| OPPOSITION | WO2016057572 |
| OPPOSITION | WO2019161078 |
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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Description
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Nov 10, 2025
Nov 10, 2025
Nov 6, 2025
(Electronic) Receipt
Appeal
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Appeal
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Appeal
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Appeal
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Search/Exam
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Decision to grant a European patent
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Jan 11, 2023
(Electronic) Receipt
Search/Exam
Jan 11, 2023
Filing of the translations of the claims
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Jan 11, 2023
French translation of claims
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Jan 11, 2023
German translation of the claims
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Jan 11, 2023
Letter accompanying subsequently filed items
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Intention to grant (signatures)
Search/Exam
Sep 8, 2022
Text intended for grant (clean copy)
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Examination started
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(Electronic) Receipt
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Amended claims with annotations
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Amended description with annotations
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Jan 4, 2022
Amendments received before examination
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Jan 4, 2022
Letter accompanying subsequently filed items
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Nov 29, 2021
Payment submission rejected
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Aug 25, 2021
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Letter accompanying subsequently filed items
Search/Exam
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(Electronic) Receipt
Search/Exam
Jun 1, 2021
Request for entry into the European phase
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Notification of the recording of a change
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Notification of the recording of a change
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Mar 26, 2021
Information on entry into European phase
Search/Exam
Oct 23, 2020
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Notification of the recording of a change
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Copy of the international search report
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May 22, 2020
Published international application - A1
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ISR: cited documents
PCTISA
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Dec 6, 2019
Abstract
PCTISA
Dec 6, 2019
Claims
PCTISA
Dec 6, 2019
Description
PCTISA
Dec 6, 2019