| OPPOSITION | - Anonymous, "AGBT report: sample prep solutions", Geneng News, (20140214), pages 1 - 3, Geneng News, URL: https://www.genengnews.com/topics/omics/agbt-report-sample-prep-solutions/, (20250319), XP093261215 | - |
| OPPOSITION | - Anonymous, "KAPA HTP Library Preparation Kit Illumina® platforms KR0426 - V3.13", Kapa - Technical Data Sheet, (20130701), pages 1 - 20, Kapa - Technical Data Sheet, URL: https://www.utsouthwestern.edu/labs/next-generation-sequencing-core/assets/KAPA_HTP_Library_Preparation_Kit_TDS.pdf, (20220222), XP055894139 | - |
| OPPOSITION | - Anonymous, "KAPA HTP Library Preparation Kit Illumina platforms", Technical Data Sheet - KR0426 - v3.13, (20130701), pages 1 - 20, Technical Data Sheet - KR0426 - v3.13, URL: https://www.utsouthwestern.edu/research/core-facilities/next-generation-sequencing/assets/KAPA_HTP_Library_Preparation_Kit_TDS.pdf, (20250320), XP093261606 | - |
| OPPOSITION | - Anonymous, "KAPA HYPER PREP: A NEXT-GENERATION KIT FOR FAST AND EFFICIENT LIBRARY CONSTRUCTION FROM CHALLENGING DNA SAMPLES", Hyper Prep Poster - Sopachem Life Sciences at AGBT, (20140101), page 1, Hyper Prep Poster - Sopachem Life Sciences at AGBT, URL: https://www.sopachem.com/lifesciences/ag bt- 2014-hyper-prep-poster, (20220223), XP055894944 | - |
| OPPOSITION | - Anonymous, "Paired-End Sequencing Sample Preparation Guide", Illumina, (20090901), pages 1 - 34, URL: http://mmjggl.caltech.edu/sequencing/Paired-End_SamplePrep_Guide_1005063_B.pdf, (20190201), XP055550674 | - |
| OPPOSITION | - D21 - Declaration of Dr Christopher Mason, Ph.D. | - |
| OPPOSITION | - D25 - Extract of the laboratory notebook of Stefanie Mortimer | - |
| OPPOSITION | - D26 - proprietor’s letter of 25 April 2019, from examination of parent application 14771159.2 | - |
| OPPOSITION | - D27 - proprietor’s letter of 22 March 2022, from examination of the present patent | - |
| OPPOSITION | - D28 - Extract from proprietor’s letter of 4 July 2022 in opposition proceedings against parent application | - |
| OPPOSITION | - D32a- opachem Life Sciences AGBT 2014 Hyper Prep Poster -Sopachem Life Sciences | - |
| OPPOSITION | - D34 - First Declaration of Maryke Appel, PhD | - |
| OPPOSITION | - D35 - Second Declaration of Maryke Appel, PhD | - |
| OPPOSITION | - D44 - Communication of the applicant dated 22 March 2022 for EP3882362 | - |
| OPPOSITION | - D45 - Decision of Opposition Division dated July 3, 2023 to revoke EP2971168 | - |
| OPPOSITION | - D46 - Communication of the applicant dated 17 May 2021 for EP3882362 | - |
| OPPOSITION | - D47 - Proprietor’s Response to Notices of Opposition for EP2971168 dated July 4, 2022 | - |
| OPPOSITION | - D51 - Foundation Medicine, Inc. v. Guardant Health, Inc., IPR-2019-00652, Paper 47 (PTAB Aug. 18, 2020) | - |
| OPPOSITION | - D58 - Communication of the applicant, dated 20 September 2023 | - |
| OPPOSITION | - D59 - Preliminary Opinion of the Technical Board of Appeal against EP2971168, dated 17 July 2024 | - |
| OPPOSITION | - Genohub, "2014 AGBT Agenda Highlights", Genohub, (20140206), pages 1 - 5, Genohub.blog, URL: https://blog.genohub.com/2014/02/06/2014-agbt-agenda/, (20250319), XP093261205 | - |
| OPPOSITION | - Kivioja, "Counting absolute number of molecules using unique molecular identifiers", Nature Precedings, (20110414), pages 1 - 18, XP055448736 | - |
| OPPOSITION | - Kivioja Teemu, "Counting absolute number of molecules using unique molecular identifiers", Nature Precedings, (20110414), pages 1 - 18, Nature Precedings, (20180207), XP055448736 | - |
| OPPOSITION | - Van Kets Victoria, Appel Maryke, Kitzman Jacob, Snyder Matthew, Shendure Jay, Gray Phillip, Tsai Pei-Fang, Yan Hoo Jia, Van Der Walt Eric, Foskett1 John, Mcewan Paul, "KAPA HYPER PREP: A next-generation kit for fast and effi cient library construction from challenging DNA samples", KAPA Biosystems, (20140101), pages 1 - 8, XP093261448 | - |
| OPPOSITION | - Mathias Ehrich; Cosmin Deciu; Tricia Zwiefelhofer; John A. Tynan; Lesley Cagasan; Roger Tim; Vivian Lu; Ron McCullough; Erin McCarthy; Anders O.H. Nygren; Jarrod Dean; Lin Tang; Don Hutchison; Tim Lu; Huiquan Wang; Vach Angkachatchai; Paul Oeth; Charles R. Cantor; Allan Bombard; Dirk van den Boom;, "Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, US , (20101228), vol. 204, no. 3, doi:10.1016/j.ajog.2010.12.060, ISSN 0002-9378, pages 205.e1 - 205.e11, XP028184664 | |
| OPPOSITION | - Gang, F. ; Guorong, L. ; An, Z. ; Anne, G.P. ; Christian, G. ; Jacques, T., "Prediction of Clear Cell Renal Cell Carcinoma by Integrity of Cell-free DNA in Serum", UROLOGY, US , (20100201), vol. 75, no. 2, doi:10.1016/j.urology.2009.06.048, ISSN 0090-4295, pages 262 - 265, XP026885552 | |
| OPPOSITION | - Vermulst Marc, Bielas Jason H, Kujoth Gregory C, Ladiges Warren C, Rabinovitch Peter S, Prolla Tomas A, Loeb Lawrence A, "Mitochondrial point mutations do not limit the natural lifespan of mice", Nature Genetics - Author manuscript, New York, (20070401), vol. 39, no. 4, doi:10.1038/ng1988, ISSN 1061-4036, pages 540 - 543, XP093254609 | |
| OPPOSITION | - Rusk N, "The root of all evil - Über-accurate sequencing", Nature Methods, (20121001), vol. 9, no. 10, doi:10.1038/nmeth.218, pages 942 - 943, XP093261192 | |
| OPPOSITION | - Jia Qi, Xiang Ye, "Cryo-EM structure of a bacteriophage M13 mini variant", Nature Communications, UK, (20130101), vol. 14, no. 1, doi:10.1038/s41467-023-41151-7, ISSN 2041-1723, pages 1 - 14, XP093254613 | |
| OPPOSITION | - Haddock Naomi L., Barkal Layla J., Ram-Mohan Nikhil, Kaber Gernot, Chiu Charles Y., Bhatt Ami S., Yang Samuel, Bollyky Paul L., "Phage diversity in cell-free DNA identifies bacterial pathogens in human sepsis cases", Nature Microbiology (Author manuscript), UK , (20230801), vol. 8, no. 8, doi:10.1038/s41564-023-01406-x, ISSN 2058-5276, pages 1 - 35, XP093261610 | |
| OPPOSITION | - Diehl, F. ; Schmidt, K. ; Durkee, K.H. ; Moore, K.J. ; Goodman, S.N. ; Shuber, A.P. ; Kinzler, K.W. ; Vogelstein, B., "Analysis of Mutations in DNA Isolated From Plasma and Stool of Colorectal Cancer Patients", Gastroenterology, (20080801), vol. 135, no. 2, doi:10.1053/j.gastro.2008.05.039, ISSN 0016-5085, pages 489 - 498.e7, XP023610068 | |
| OPPOSITION | - Sarah-Jane Dawson, Dana W.Y. Tsui, Muhammed Murtaza, Heather Biggs, Oscar M. Rueda, Suet-Feung Chin, Mark J. Dunning, Davina Gale, Tim Forshew, Betania Mahler-Araujo, Sabrina Rajan, Sean Humphray, Jennifer Becq, David Halsall, Matthew Wallis, David Bentley, Carlos Caldas, Nitzan Rosenfeld, "Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer", The New England journal of medicine, US , (20130328), vol. 368, no. 13, doi:10.1056/NEJMoa1213261, ISSN 0028-4793, pages 1199 - 1209, XP055494258 | |
| OPPOSITION | - Fan H. Christina, Blumenfeld Yair J., Chitkara Usha, Hudgins Louanne, Quake Stephen R., "Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood", Proceedings of the National Academy of Sciences (PNAS), (20081021), vol. 105, no. 42, doi:10.1073/pnas.0808319105, ISSN 0027-8424, pages 16266 - 16271, XP093117217 | |
| OPPOSITION | - Chlu Rossa W K, "Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma", Proceedings of the National Academy of Sciences (PNAS), (20081223), vol. 105, no. 51, doi:10.1073/pnas.0810641105, ISSN 0027-8424, pages 20458 - 20463, XP002620454 | |
| OPPOSITION | - G. K. Fu, J. Hu, P.-H. Wang, S. P. A. Fodor, "Counting individual DNA molecules by the stochastic attachment of diverse labels", Proceedings of the National Academy of Sciences, (20110531), vol. 108, no. 22, doi:10.1073/pnas.1017621108, ISSN 0027-8424, pages 9026 - 9031, XP055164127 | |
| OPPOSITION | - I. Kinde, J. Wu, N. Papadopoulos, K. W. Kinzler, B. Vogelstein, "Detection and quantification of rare mutations with massively parallel sequencing", Proceedings of the National Academy of Sciences (PNAS), (20110607), vol. 108, no. 23, doi:10.1073/pnas.1105422108, ISSN 0027-8424, pages 9530 - 9535, XP055732702 | |
| OPPOSITION | - Schmitt Michael W., Kennedy Scott R., Salk Jesse J., Fox Edward J., Hiatt Joseph B., Loeb Lawrence A., "Detection of ultra-rare mutations by next-generation sequencing", Proceedings of the National Academy of Sciences (PNAS), (20120904), vol. 109, no. 36, doi:10.1073/pnas.1208715109, ISSN 0027-8424, pages 14508 - 14513, XP055928698 | |
| OPPOSITION | - Forchhammer L., Johansson C., Loft S., Moller L., Godschalk R. W. L., Langie S. A. S., Jones G. D. D., Kwok R. W. L., Collins A. R., Azqueta A., Phillips D. H., Sozeri O., Stepnik M., Palus J., Vogel U., Wallin H., Routledge M. N., Handforth C., Allione A., Matullo G., Teixeira J. P., Costa S., Riso P., Porrini M., Moller P., "Variation in the measurement of DNA damage by comet assay measured by the ECVAG inter-laboratory validation trial", Mutagenesis, GB , (20100301), vol. 25, no. 2, doi:10.1093/mutage/gep048, ISSN 0267-8357, pages 113 - 123, XP093261602 | |
| OPPOSITION | - Xie Hehuang, Wang Min, Bonaldo Maria De F., Smith Christina, Rajaram Veena, Goldman Stewart, Tomita Tadanori, Soares Marcelo B., "High-throughput sequence-based epigenomic analysis of Alu repeats in human cerebellum", Nucleic Acids Research, GB , (20090701), vol. 37, no. 13, doi:10.1093/nar/gkp393, ISSN 0305-1048, pages 4331 - 4340, XP093261459 | |
| OPPOSITION | - James A. Casbon, Robert J. Osborne, Sydney Brenner, and Conrad P. Lichtenstein, "A method for counting PCR template molecules with application to next-generation sequencing", Nucleic Acids Research, GB , (20110701), vol. 39, no. 12, doi:10.1093/nar/gkr217, ISSN 0305-1048, pages 1 - 8, XP002666160 | |
| OPPOSITION | - Cherbas Lucy, Willingham Aarron, Zhang Dayu, Yang Li, Zou Yi, Eads Brian D., Carlson Joseph W., Landolin Jane M., Kapranov Philipp, Dumais Jacqueline, Samsonova Anastasia, Choi Jeong-Hyeon, Roberts Johnny, Davis Carrie A., Tang Haixu, Van Baren Marijke J., Ghosh Srinka, Dobin Alexander, Bell Kim, Lin Wei, Langton Laura, Duff Michael O., Tenney Aaron E., Zaleski Chris, Brent Michael R., Hoskins Roger A., Kaufman Thomas C., Andrews Justen, Graveley Brenton R., Perrimon Norbert, Celniker Susan E., Gingeras Thomas R., Cherbas Peter, "The transcriptional diversity of 25 Drosophila cell lines", Genome Research, US , (20110201), vol. 21, no. 2, doi:10.1101/gr.112961.110, ISSN 1088-9051, pages 301 - 314, XP093239547 | |
| OPPOSITION | - T. Forshew, M. Murtaza, C. Parkinson, D. Gale, D. W. Y. Tsui, F. Kaper, S.-J. Dawson, A. M. Piskorz, M. Jimenez-Linan, D. Bentley, J. Hadfield, A. P. May, C. Caldas, J. D. Brenton, N. Rosenfeld, "Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA", Science translational medicine, (20120530), vol. 4, no. 136, doi:10.1126/scitranslmed.3003726, ISSN 1946-6234, pages 1 - 12, XP055450222 | |
| OPPOSITION | - T. Forshew, M. Murtaza, C. Parkinson, D. Gale, D. W. Y. Tsui, F. Kaper, S.-J. Dawson, A. M. Piskorz, M. Jimenez-Linan, D. Bentley, J. Hadfield, A. P. May, C. Caldas, J. D. Brenton, N. Rosenfeld, "Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA", SCIENCE TRANSLATIONAL MEDICINE, (20120530), vol. 4, no. 136, doi:10.1126/scitranslmed.3003726, ISSN 1946-6234, pages 1 - 12, XP055450222 | |
| OPPOSITION | - Rebecca J Leary, Sausen Mark, Kinde Isaac, Papadopoulos Nickolas, Carpten John D, Craig David, O'shaughnessy Joyce, Kinzler Kenneth W, Parmigiani Giovanni, Vogelstein Bert, Diaz, Velculescu Victor E, "Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing", SCIENCE TRANSLATIONAL MEDICINE, (20121128), vol. 4, no. 162, doi:10.1126/scitranslmed.3004742, ISSN 1946-6234, pages 1 - 14, XP055565752 | |
| OPPOSITION | - J. M. Rizzo, M. J. Buck, "Key Principles and Clinical Applications of "Next-Generation" DNA Sequencing", CANCER PREVENTION RESEARCH, United States , (20120701), vol. 5, no. 7, doi:10.1158/1940-6207.CAPR-11-0432, ISSN 1940-6207, pages 887 - 900, XP055486092 | |
| OPPOSITION | - Scott R. Kennedy, Salk Jesse J., Schmitt Michael W., Loeb Lawrence A., "Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage", PLoS Genetics, vol. 9, no. 9, doi:10.1371/journal.pgen.1003794, pages 1 - 10, XP055529664 | |
| OPPOSITION | - Nancy B. Y. Tsui, Peiyong Jiang, Katherine C. K. Chow, Xiaoxi Su, Tak Y. Leung, Hao Sun, K. C. Allen Chan, Rossa W. K. Chiu, Y. M. Dennis Lo, "High Resolution Size Analysis of Fetal DNA in the Urine of Pregnant Women by Paired-End Massively Parallel Sequencing", PLoS ONE, (20121001), vol. 7, no. 10, doi:10.1371/journal.pone.0048319, pages 1 - 7, XP055487179 | |
| OPPOSITION | - Gary J.W. Liao, Fiona M.F. Lun, Yama W.L. Zheng, K.C. Allen Chan, Tak Y. Leung, Tze K. Lau, Rossa W.K. Chiu, Y.M. Dennis Lo, "Targeted massively parallel sequencing of maternal plasma DNA permits efficient and unbiased detection of fetal alleles.", Clinical Chemistry, US , (20110101), vol. 57, no. 1, doi:10.1373/CLINCHEM.2010.154336, ISSN 0009-9147, pages 92 - 101, XP002674771 | |
| OPPOSITION | - A. J. Sehnert, B. Rhees, D. Comstock, E. De Feo, G. Heilek, J. Burke, R. P. Rava, "Optimal Detection of Fetal Chromosomal Abnormalities by Massively Parallel DNA Sequencing of Cell-Free Fetal DNA from Maternal Blood", Clinical Chemistry, (20110701), vol. 57, no. 7, doi:10.1373/clinchem.2011.165910, ISSN 00099147, pages 1042 - 1049, XP055035087 | |
| OPPOSITION | - Agostini M; Enzo M V; Bedin C; Belardinelli V; Goldin E; Del Bianco P; Maschietto E; D'Angelo E; Izzi Leo; Saccani A; Zavagno G; Nitti D, "Circulating cell-free DNA: A promising marker of regional lymphonode metastasis in breast cancer patients", Cancer biomarkers, NL , (20120101), vol. 11, no. 2-3, doi:10.3233/CBM-2012-0263, ISSN 1574-0153, pages 89 - 98, XP008174324 | |
| SEARCH | - M. W. SCHMITT ET AL, "Detection of ultra-rare mutations by next-generation sequencing", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20120801), vol. 109, no. 36, doi:10.1073/pnas.1208715109, ISSN 0027-8424, pages 14508 - 14513, XP055161683 [I] 1-15 * page 14509, column l, paragraph l - column r, paragraph 2 * * figure 1 * | |
| SEARCH | - SCHMITT M. W. ET AL, "Detection of ultra-rare mutations by next-generation sequencing - supporting information", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, US, vol. 109, no. 36, doi:10.1073/pnas.1208715109, ISSN 0027-8424, (20120904), URL: https://www.pnas.org/content/pnas/suppl/2012/08/01/1208715109.DCSupplemental/pnas.201208715SI.pdf?targetid=nameddest=STXT, XP055825591 [I] 1-15 * page 1, column l, paragraph l - page 2, column l, paragraph 1 * | |
