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Monitoring Mycotoxins And Its Metabolites In The Blood Of Pigs Or Broiler Chickens - EP3882629

The patent EP3882629 was granted to Innov AD on Nov 30, 2022. The application was originally filed on Mar 16, 2021 under application number EP21020152A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3882629

INNOV AD
Application Number
EP21020152A
Filing Date
Mar 16, 2021
Status
Granted And Under Opposition
Oct 28, 2022
Publication Date
Nov 30, 2022
External Links
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DSM NUTRITIONAL PRODUCTSAug 17, 2023SCHIWECK WEINZIERL KOCH PATENTANWALTE PARTNERSCHAFT MBBADMISSIBLE

Patent Citations (8) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
OPPOSITIONCN107741462
OPPOSITIONCN108593832
OPPOSITIONCN108760929
OPPOSITIONCN109001350
OPPOSITIONCN109142584
OPPOSITIONCN109521135
OPPOSITIONCN109781889
OPPOSITIONCN111366652

Non-Patent Literature (NPL) Citations (28) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- LAUWERSMARIANNE et al., "Multi LC-MS/MS and LC-HRMS Methods for Determination of 24 Mycotoxins Including Major Phase I and II Biomarker Metabolites in Biological Matrices from Pigs and Broiler Chickens", Toxins, (20190000), vol. 11, no. 3, page 171
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DESCRIPTION- OSTERESCHBERNDSUSANA VIEGASBENEDIKT CRAMERHANS ULRICH HUMPF, "Multi-Mycotoxin Analysis Using Dried Blood Spots and Dried Serum Spots", Analytical and Bioanalytical Chemistry, vol. 409, no. 13, doi:10.1007/s00216-017-0279-9, (20170000), pages 3369 - 82, URL: http://www.ncbi.nlm.nih.gov/pubmed/28299415, XP036213420
DESCRIPTION- MARIANNE LAUWERSSISKA CROUBELSSIEGRID DE BAEREMILENA SEVASTIYANOVAEVA MARIA ROMERO SIERRABEN LETORCHRISTOS GOUGOULIASMATHIAS DEVREESE, "Assessment of dried blood spots for multi-mycotoxin biomarker analysis in pigs and broiler chickens", Toxins, vol. 11, doi:10.3390/toxins11090541, (20190918), page 541, URL: www.mdpi.com/iournal/toxins, XP055744557
OPPOSITION- Wenkui Li, Tse Francis L. S., "Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules", Biomedical Chromatography, (20100101), vol. 24, no. 1, doi:10.1002/bmc.1367, ISSN 02693879, pages 49 - 65, XP055005748
OPPOSITION- Broekaert Nathan; Devreese Mathias; van Bergen Thomas; Schauvliege Stijn; De Boevre Marthe; De Saeger Sarah; Vanhaecke Lynn; Berthiller Franz; Michlmayr Herbert; Malachová Alexandra; Adam Gerhard; Vermeulen An; Croubels Siska, "In vivo contribution of deoxynivalenol-3-β-d-glucoside to deoxynivalenol exposure in broiler chickens and pigs: oral bioavailability, hydrolysis and toxicokinetics", Archives of Toxicology, SPRINGER, DE, DE , (20160421), vol. 91, no. 2, doi:10.1007/s00204-016-1710-2, ISSN 0340-5761, pages 699 - 712, XP036150423
OPPOSITION- Schwartz-Zimmermann Heidi E.; Hametner Christian; Nagl Veronika; Fiby Iris; Macheiner Lukas; Winkler Janine; Dänicke Sven; Clark Erica; Pestka James J.; Berthiller Franz, "Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows", Archives of Toxicology, SPRINGER, DE, DE , (20170621), vol. 91, no. 12, doi:10.1007/s00204-017-2012-z, ISSN 0340-5761, pages 3857 - 3872, XP036374803
OPPOSITION- Osteresch Bernd; Viegas Susana; Cramer Benedikt; Humpf Hans-Ulrich, "Multi-mycotoxin analysis using dried blood spots and dried serum spots", Analytical and Bioanalytical Chemistry, Springer Berlin Heidelberg, Berlin/Heidelberg, Berlin/Heidelberg, (20170315), vol. 409, no. 13, doi:10.1007/s00216-017-0279-9, ISSN 1618-2642, pages 3369 - 3382, XP036213420
OPPOSITION- Sulyok Michael; Stadler David; Steiner David; Krska Rudolf, "Validation of an LC-MS/MS-based dilute-and-shoot approach for the quantification of > 500 mycotoxins and other secondary metabolites in food crops: challenges and solutions", Analytical and Bioanalytical Chemistry, Springer Berlin Heidelberg, Berlin/Heidelberg, Berlin/Heidelberg, (20200220), vol. 412, no. 11, doi:10.1007/s00216-020-02489-9, ISSN 1618-2642, pages 2607 - 2620, XP037085326
OPPOSITION- Thanner S.; Czeglédi L.; Schwartz-Zimmermann H. E.; Berthiller F.; Gutzwiller A., "Urinary deoxynivalenol (DON) and zearalenone (ZEA) as biomarkers of DON and ZEA exposure of pigs", Mycotoxin Research, Springer Berlin Heidelberg, Berlin/Heidelberg, Berlin/Heidelberg , (20160218), vol. 32, no. 2, doi:10.1007/s12550-016-0241-2, ISSN 0178-7888, pages 69 - 75, XP035665530
OPPOSITION- S. De Baere, A. Osselaere, M. Devreese, L. Vanhaecke, P. De Backer, S. Croubels, "Development of a liquid-chromatography tandem mass spectrometry and ultra-high-performance liquid chromatography high-resolution mass spectrometry method for the quantitative determination of zearalenone and its major metabolites in chicken and pig plasma", Analytica Chimica Acta, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20121201), vol. 756, doi:10.1016/j.aca.2012.10.027, ISSN 0003-2670, pages 37 - 48, XP055744811
OPPOSITION- Steiner David; Sulyok Michael; Malachová Alexandra; Mueller Anneliese; Krska Rudolf, "Realizing the simultaneous liquid chromatography-tandem mass spectrometry based quantification of >1200 biotoxins, pesticides and veterinary drugs in complex feed", Journal of Chromatography A, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20200819), vol. 1629, doi:10.1016/j.chroma.2020.461502, ISSN 0021-9673, XP086270630
OPPOSITION- Zheng Han; Yiping Ren; Hailong Zhou; Lianjun Luan; Zengxuan Cai; Yongjiang Wu;, "A rapid method for simultaneous determination of zearalenone, -zearalenol, -zearalenol, zearalanone, -zearalanol and -zearalanol in traditional Chinese medicines by ultra-high-performance liquid chromatographytandem mass spectrometry", Journal of Chromatography B, ELSEVIER, AMSTERDAM., NL, NL , (20101223), vol. 879, no. 5, doi:10.1016/j.jchromb.2010.12.028, ISSN 1570-0232, pages 411 - 420, XP028137265
OPPOSITION- Belhassen H.; Jiménez-Díaz I.; Ghali R.; Ghorbel H.; Molina-Molina J.M.; Olea N.; Hedili A. , "Validation of a UHPLC-MS/MS method for quantification of zearalenone, α-zearalenol, β-zearalenol, α-zearalanol, β-zearalanol and zearal", Journal of Chromatography B, ELSEVIER, AMSTERDAM., NL, NL , (20140519), vol. 962, doi:10.1016/j.jchromb.2014.05.019, ISSN 1570-0232, pages 68 - 74, XP028855114
OPPOSITION- Osteresch Bernd; Cramer Benedikt; Humpf Hans-Ulrich, "Analysis of ochratoxin A in dried blood spots - Correlation between venous and finger‐prick blood, the influence of hematocrit and spotted volume", Journal of Chromatography B, ELSEVIER, AMSTERDAM., NL, NL , (20160321), vol. 1020, doi:10.1016/j.jchromb.2016.03.026, ISSN 1570-0232, pages 158 - 164, XP029497205
OPPOSITION- Amelie Catteuw, Nathan Broekaert, Siegrid De Baere, Marianne Lauwers, Elke Gasthuys, Bart Huybrechts, Alfons Callebaut, Lada Ivanova, Silvio Uhlig, Marthe De Boevre, Sarah De Saeger, Ronette Gehring, Mathias Devreese, Siska Croubels, "Insights into In Vivo Absolute Oral Bioavailability, Biotransformation, and Toxicokinetics of Zearalenone, α-Zearalenol, β-Zearalenol, Zearalenone-14-glucoside, and Zearalenone-14-sulfate in Pigs", Journal of Agricultural and Food Chemistry, American Chemical Society, US, US , (20190327), vol. 67, no. 12, doi:10.1021/acs.jafc.8b05838, ISSN 0021-8561, pages 3448 - 3458, XP055744560
OPPOSITION- Lauwers Marianne, De Baere Siegrid, Letor Ben, Rychlik Michael, Croubels Siska, Devreese Mathias, "Multi LC-MS/MS and LC-HRMS Methods for Determination of 24 Mycotoxins including Major Phase I and II Biomarker Metabolites in Biological Matrices from Pigs and Broiler Chickens", TOXINS, Molecular Diversity Preservation International (MDPI) AG., CH, CH , vol. 11, no. 3, doi:10.3390/toxins11030171, ISSN 2072-6651, page 171, XP093181681
OPPOSITION- Marianne Lauwers, Siska Croubels, Ben Letor, Christos Gougoulias, Mathias Devreese, "Biomarkers for Exposure as A Tool for Efficacy Testing of A Mycotoxin Detoxifier in Broiler Chickens and Pigs", TOXINS, Molecular Diversity Preservation International (MDPI) AG., CH, CH , (20190401), vol. 11, no. 4, doi:10.3390/toxins11040187, ISSN 2072-6651, page 187, XP055744558
OPPOSITION- Marianne Lauwers, Siska Croubels, Siegrid De Baere, Milena Sevastiyanova, Eva Maria Romera Sierra, Ben Letor, Christos Gougoulias, Mathias Devreese, "Assessment of Dried Blood Spots for Multi-Mycotoxin Biomarker Analysis in Pigs and Broiler Chickens", TOXINS, Molecular Diversity Preservation International (MDPI) AG., CH, CH , (20190101), vol. 11, no. 9, doi:10.3390/toxins11090541, ISSN 2072-6651, page 541, XP055744557
OPPOSITION- Binder Sabina, Schwartz-Zimmermann Heidi, Varga Elisabeth, Bichl Gerlinde, Michlmayr Herbert, Adam Gerhard, Berthiller Franz, "Metabolism of Zearalenone and Its Major Modified Forms in Pigs", TOXINS, Molecular Diversity Preservation International (MDPI) AG., CH, CH , vol. 9, no. 2, doi:10.3390/toxins9020056, ISSN 2072-6651, page 56, XP093181701
OPPOSITION- A. Veršilovskis, J. Geys, B. Huybrechts, E. Goossens, S. De Saeger, A. Callebaut, "Simultaneous determination of masked forms of deoxynivalenol and zearalenone after oral dosing in rats by LC-MS/MS", World Mycotoxin Journal, Wageningen Academic Publishers, Netherlands, Netherlands , (20120801), vol. 5, no. 3, doi:10.3920/WMJ2012.1411, ISSN 1875-0710, pages 303 - 318, XP009555846
SEARCH- S. DE BAERE ET AL, "Development of a liquid-chromatography tandem mass spectrometry and ultra-high-performance liquid chromatography high-resolution mass spectrometry method for the quantitative determination of zearalenone and its major metabolites in chicken and pig plasma", ANALYTICA CHIMICA ACTA, (2012), vol. 756, pages 37 - 48, XP055744811 [A] 12-13 * page 39, paragraph 2.2 *
SEARCH- DE RUYCK KARL ET AL, "Mycotoxin exposure assessments in a multi-center European validation study by 24-hour dietary recall and biological fluid sampling", ENVIRONMENT INTERNATIONAL, (20200205), vol. 137, XP086074506 [A] 1 * table 2 *
SEARCH- ULRIKE BREZINA ET AL, "Diagnosis of intoxications of piglets fed with Fusarium toxin-contaminated maize by the analysis of mycotoxin residues in serum, liquor and urine with LC-MS/MS", ARCHIVES OF ANIMAL NUTRITION, (2014), vol. 68, no. 6, pages 425 - 447, XP055744829 [A] 12-13 * page 429, paragraph 1 *
SEARCH- MARIANNE LAUWERS ET AL, "Biomarkers for Exposure as A Tool for Efficacy Testing of A Mycotoxin Detoxifier in Broiler Chickens and Pigs", TOXINS, (2019), vol. 11, no. 4, page 187, XP055744558 [A] 1,14-15 * pages 15,16 *
SEARCH- MARIANNE LAUWERS ET AL, "Assessment of Dried Blood Spots for Multi-Mycotoxin Biomarker Analysis in Pigs and Broiler Chickens", TOXINS, (2019), vol. 11, no. 9, page 541, XP055744557 [DA] 1-15 * page 16 *

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