The patent EP3888674 was granted to Novartis on Apr 3, 2024. The application was originally filed on Apr 7, 2015 under application number EP21160203A. The patent is currently recorded with a legal status of "Revoked".

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| OPPOSITION | - Cammack, Richard ; Attwood, Teresa K., "Passage", Cammack, Richard ; Attwood, Teresa K., R. Cammack et al., Oxford Dictionary of Biochemistry and Molecular Biology (2 ed.), Oxford University Press, (20060101), page 95, ISBN 9780198529170, XP009559635 |
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| OPPOSITION | - Mazzarella Luca, "Tales from the Jazz ASH: highlights from the 2013 American Society of Haematology meeting ", ecancermedicalscience, Cancer Intelligence, (20140124), ISSN 1754-6605, XP093252926 |
| OPPOSITION | - Ahmad Ubaid, Khan Zafran, Ualiyeva Daniya, Amissah Obed Boadi, Noor Zohaib, Khan Asaf, Zaman Nasib, Khan Marwa, Khan Ayub, Ali Babar, "Chimeric antigen receptor T cell structure, its manufacturing, and related toxicities; A comprehensive review", Advances in Cancer Biology - Metastasis, (20220701), vol. 4, doi:10.1016/j.adcanc.2022.100035, ISSN 2667-3940, page 100035, XP093063040 |
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| OPPOSITION | - Heslop Helen E, "Combining Drugs and Biologics to Treat Nasopharyngeal Cancer", Molecular Therapy, (20140101), vol. 22, no. 1, doi:10.1038/mt.2013.272, ISSN 1525-0016, pages 8 - 9, XP093252930 |
| OPPOSITION | - P Viatour, M Bentires-Alj, A Chariot, V Deregowski, L De Leval, M-P Merville, V Bours, "NF-&kgr;B2/p100 induces Bcl-2 expression", Leukemia, Stockton Press, (20030701), vol. 17, no. 7, doi:10.1038/sj.leu.2402982, ISSN 08876924, pages 1349 - 1356, XP055184360 |
| OPPOSITION | - John C. Byrd, Richard R. Furman, Steven E. Coutre, Ian W. Flinn, Jan A. Burger, Kristie A. Blum, Barbara Grant, Jeff P. Sharman, Morton Coleman, William G. Wierda, Jeffrey A. Jones, Weiqiang Zhao, Nyla A. Heerema, Amy J. Johnson, Juthamas Sukbuntherng, Betty Y. Chang, Fong Clow, Eric Hedrick, Joseph J. Buggy, Danelle F. James, Susan O'brien, "Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia", The New England journal of medicine, Massachusetts Medical Society, US, US , (20130704), vol. 369, no. 1, doi:10.1056/NEJMoa1215637, ISSN 0028-4793, pages 32 - 42, XP055233941 |
| OPPOSITION | - Awan Farrukh T., Byrd John C., "New Strategies in Chronic Lymphocytic Leukemia: Shifting Treatment Paradigms", Cancer Research, Association for Cancer Research, US, US, (20141201), vol. 20, no. 23, doi:10.1158/1078-0432.CCR-14-1889, ISSN 1078-0432, pages 5869 - 5874, XP093252929 |
| OPPOSITION | - M. F. M. De Rooij, A. Kuil, C. R. Geest, E. Eldering, B. Y. Chang, J. J. Buggy, S. T. Pals, M. Spaargaren, "The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia", Blood, W.B. Saunders, AMSTERDAM, NL, AMSTERDAM, NL, (20120315), vol. 119, no. 11, doi:10.1182/blood-2011-11-390989, ISSN 0006-4971, pages 2590 - 2594, XP055355469 |
| OPPOSITION | - J. A. Dubovsky, K. A. Beckwith, G. Natarajan, J. A. Woyach, S. Jaglowski, Y. Zhong, J. D. Hessler, T.-M. Liu, B. Y. Chang, K. M. Larkin, M. R. Stefanovski, D. L. Chappell, F. W. Frissora, L. L. Smith, K. A. Smucker, J. M. Flynn, J. A. Jones, L. A. Andritsos, K. Maddocks, A. M. Lehman, R. Furman, J. Sharman, A. Mishra, M. A. Caligiuri, A. R. Satoskar, J. J. Buggy, N. Muthusamy, A. J. Johnson, J. C. Byrd, "Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes", Blood, (20131010), vol. 122, no. 15, doi:10.1182/blood-2013-06-507947, ISSN 00064971, pages 2539 - 2549, XP055213911 |
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