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The patent EP3897646 was granted to Actelion Pharmaceuticals on May 22, 2024. The application was originally filed on Dec 20, 2019 under application number EP19832954A. The patent is currently recorded with a legal status of "Granted And Under Opposition".
A combination therapy for pulmonary arterial hypertension (PAH) that targets patients with mild to moderate disease. The treatment involves administering macitentan at a high dose of 60-90 mg/day, with a preferred regimen of 75 mg/day. This combination therapy combines macitentan with phosphodiesterase type 5 inhibitors (PDE5is) and prostacyclin analogues, offering improved disease control and potential long-term benefits over traditional treatments.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
Patent citations refer to prior patents cited during different phases such as opposition or international search.
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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