| DESCRIPTION | - AKIL O. et al., Neuron, (20120000), vol. 75, pages 2213 - 2236 | - |
| DESCRIPTION | - ALTSCHUL et al., Nucleic Acids Res., (19970000), vol. 25, pages 3389 - 3402 | - |
| DESCRIPTION | - "A model of evolutionary change in proteins", DAYHOFF et al., Atlas of Protein Sequence and Structure, Natl. Biomed. Res. Found., (19780000), vol. 5, pages 345 - 352 | - |
| DESCRIPTION | - ASOKAN A. et al., Mol. Therapy, (20120000), vol. 20, no. 4, pages 699 - 708 | - |
| DESCRIPTION | - DAI C. et al., JARO, (20170000), vol. 18, pages 601 - 617 | - |
| DESCRIPTION | - DUAN M et al., Gene Ther, (20040000), vol. 11, no. 1, pages 51 - 56 | - |
| DESCRIPTION | - DYKA F.M. et al., Hum Gene Ther Methods, (20140000), vol. 25, no. 2, pages 166 - 177 | - |
| DESCRIPTION | - "GenBank", Database accession no. NM_001100395.1 | - |
| DESCRIPTION | - "Genbank", Database accession no. NP_001093865.1 | - |
| DESCRIPTION | - GHOSH A. et al., Hum Gene Ther, (20110000), vol. 22, no. 1, pages 77 - 83 | - |
| DESCRIPTION | - GHOSH et al., Hum Gene Ther., (20110100), vol. 22, no. l, pages 77 - 83 | - |
| DESCRIPTION | - GYORGY et al., Mol. Ther., (20170000), vol. 25, no. 2, pages 379 - 391 | - |
| DESCRIPTION | - HENIKOFF et al., Proc. Natl. Acad. Sci. USA, vol. 89, pages 10915 - 10919 | - |
| DESCRIPTION | - HEPPER PGSHAHIDULLAH BS, Arch Dis Child, (19940000), vol. 71, no. 2, pages F81 - 87 | - |
| DESCRIPTION | - JACOBSON SG et al., Molecular therapy: the journal of the American Society of Gene Therapy, (20060000), vol. 13, pages 1074 - 1084 | - |
| DESCRIPTION | - KOMMAREDDI, P. et al., J Assoc Res Otolaryngol, (20150000), vol. 16, pages 695 - 712 | - |
| DESCRIPTION | - KRAL AO'DONOGHUE GM, N Engl J Med, (20100000), vol. 363, no. 15, pages 1438 - 1450 | - |
| DESCRIPTION | - KROS CJ et al., Nature, (19980000), vol. 394, no. 6690, pages 281 - 284 | - |
| DESCRIPTION | - LAY Y et al., Hum Gene Ther, (20060000), vol. 17, pages 1036 - 1042 | - |
| DESCRIPTION | - LOPES V.S. et al., Gene Ther, (20130000), vol. 20, pages 824 - 833 | - |
| DESCRIPTION | - MARLIN S. et al., Biochemical and Biophysical Research Communications, (20100000), vol. 394, pages 737 - 742 | - |
| DESCRIPTION | - MICHALSKI et al., Elife, (20171107), vol. 6, page e31013 | - |
| DESCRIPTION | - PAN et al., Nature biotechnology, (20170000), vol. 35, no. 3, pages 264 - 272 | - |
| DESCRIPTION | - PETRS-SILVA H. et al., Molecular therapy: the journal of the American Society of Gene Therapy, (20110000), vol. 19, no. 2, pages 293 - 301 | - |
| DESCRIPTION | - PETRS-SILVA H et al., Mol. Ther., (20110000), vol. 19, pages 293 - 301 | - |
| DESCRIPTION | - ROUX I. et al., Cell, (20060000), vol. 127, no. 2, pages 277 - 289 | - |
| DESCRIPTION | - SHNERSONWILLOTT, J. Comp. Physiol. Psychol., (19800000), vol. 94, pages 36 - 40 | - |
| DESCRIPTION | - SHNERSONWILLOTT, J. Comp. Physiol. Psychol., (19800200), vol. 94, no. 1, pages 36 - 40 | - |
| DESCRIPTION | - SMITHWATERMAN, J. Mol. Evol., (19810000), vol. 18, no. 1, pages 38 - 46 | - |
| DESCRIPTION | - SONG L. et al., J Acoust Soc Am, (20060000), vol. 119, no. 4, pages 2242 - 2257 | - |
| DESCRIPTION | - SUZUKI et al., Sci. Rep., (20170000), vol. 7, page 45524 | - |
| DESCRIPTION | - VARGA R. et al., J. Med. Genet, (20060000), vol. 43, pages 576 - 581 | - |
| DESCRIPTION | - WONG AB et al., EMBO J, (20140000), vol. 33, no. 3, pages 247 - 264 | - |
| DESCRIPTION | - YOSHIMURA et al., Sci. Rep., (20180000), vol. 8, page 2980 | - |
| DESCRIPTION | - ZHANG et al., Frontiers in Molecular Neuroscience, (20180000), vol. 11 | - |
| DESCRIPTION | - ZOLOTUKHIN S. et al., Methods, (20020000), vol. 28, pages 158 - 167 | - |
| INTERNATIONAL-SEARCH-REPORT | - AHMED HENA ET AL, "Emerging Gene Therapies for Genetic Hearing Loss", JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, SPRINGER, NEW YORK, NY, US, vol. 18, no. 5, doi:10.1007/S10162-017-0634-8, ISSN 1525-3961, (20170816), pages 649 - 670, (20170816), XP036327909 [A] 1-12 | |
| INTERNATIONAL-SEARCH-REPORT | - HANAN AL-MOYED ET AL, "A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock-out mice", EMBO MOLECULAR MEDICINE (ONLINE), DE, (20190101), vol. 11, no. 1, doi:10.15252/emmm.201809396, ISSN 1757-4684, page e9396, XP055574125 [A] 1-12 | |
| OPPOSITION | - Akil Omar, Lustig Lawrence, "Chapter 16 - AAV-Mediated Gene Delivery to the Inner Ear", Akil Omar, Lustig Lawrence, MICHAEL J. CASTLE, Adeno-Associated Virus Vectors - Design and Delivery, Methods in Molecular Biology, Humana Press, (20190101), pages 271 - 282, ISBN 978-1-4939-9138-9, XP093189924 | - |
| OPPOSITION | - Alemi Aurash, "Progress Report: AOS Research Grant: Restoration of Hearing in the Otoferlin Knockout Mouse using Viral Gene Therapy", Program and Abstracts of the 145 Annual Meeting of the American Otological Society, Inc., (20120401), page 68, XP093190270 | - |
| OPPOSITION | - Anonymous, "Children’s Hospital of Philadelphia Performs First Gene Therapy Procedure to Treat Genetic Hearing Loss in United States", (20240126), URL: https://www.audiology.org/childrens-hospital-of-philadelphia-performs-first-gene-therapy-procedure-to-treat-genetic-hearing-loss-in-united-states/, XP093189933 | - |
| OPPOSITION | - Anonymous, "OTOFERLIN; OTOF", (20150729), URL: https://web.archive.org/web/20150729163826/http://omim.org/entry/603681, XP093189928 | - |
| OPPOSITION | - Anonymous, "Sensorion Announces Approval to Initiate Lead Gene Therapy Candidate SENS-501 (OTOF-GT) into a Phase 1/2 Clinical Trial in some European Countries", Sensorion Press Release, (20240119), XP093211591 | - |
| OPPOSITION | - Anonymous, "Sensorion Sensorion Submits Clinical Trial Application for OTOF-GT, its Lead Gene Therapy Candidate, in Europe", Sensorion Press Release, (20230719), XP093211589 | - |
| OPPOSITION | - "Chapter 2 - Basics of Sound, the Ear and Hearing", Dobie Robert A., Van Hemel Susan, Hearing Loss: Determining Eligibility for Social Security Benefits, NATIONAL ACADEMIES PRESS, (20040101), pages 42 - 68, ISBN 978-0-309-54514-3, XP093189926 | - |
| OPPOSITION | - Chung Yoojin, Fucci Quynh-Anh, Koehler Seth, Pan Ning, Kim Yehree, Yi Eun Young, Kim Min Young, Jung Sangyong, Han Kyu-Hee, Gibson Tyler, Becker Lars, Goodliffe Joseph, Kalker Molly, Barnes Madeline, Shaheen Luke, Valayannopoulos Vassili, Yoon Choi Byung, "Restoration of Auditory Function with OTOF Gene Transfer Therapy in Nonsense (Q828X) and Missense (R1934Q 1 and Deaf5) Models of Otoferlin Deficiency", Poster Presentation (ASGCT 2023), (20230501), XP093211599 | - |
| OPPOSITION | - D65a - CV Dr. Natalie Loundon | - |
| OPPOSITION | - D65 - EXPERT DECLARATION PROFESSOR N. LOUNDON | - |
| OPPOSITION | - D71 - EP 3510161 Communication pursuant to Article 94(3) EPC; 27th Nov 2024 | - |
| OPPOSITION | - D72 - EP 3635100 European Search Opinion; 22nd Feb 2021 | - |
| OPPOSITION | - D73 - Comparison of the domain structure of the human otoferlin isoforms with mini-otoferlins of D40 | - |
| OPPOSITION | - D74 - Comparison of the domain structure of the mouse and human otoferlin isoforms | - |
| OPPOSITION | - "DFNB9", Toriello Helga V., Smith Shelley D., Hearing Loss and its Syndromes, 3rd ed., Oxford University Press, (20130101), pages 164 - 165, XP093190266 | - |
| OPPOSITION | - Gao Yuan, Francis Shimon P, Ng Robert, Asai Yukako, Darcy Yuanzhao, Lenz Danielle, Chiang Hao, Davis Samantha, Kim Ye-Hyun, Mckenna Michael J, Lin Brian, Phillips Jean, Lennon Kathy, Tarapata Chris, Supina Christian, Graham Aaron, Tward Aaron D, Hickox Ann E, Simons Emmanuel J, Andres-Mateos Eva, Wellman Jennifer A, Valero Michelle D, "Preclinical Development of a Genetic Medicine for Otoferlin Gene-mediated Hearing Loss: AK-OTOF", AKOUOS, (20230212), AKOUOS, URL: https://akouos.com/wp-content/uploads/2023/02/Preclinical-Development-of-a-Genetic-Medicine-for-Otoferlin-Gene-mediated-Hearing-Loss-AK-OTOF.pdf, XP093211595 | - |
| OPPOSITION | - Olga Shubina-Oleinik et al., "Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss", Sci Adv., (202112), vol. 7, XP055921088 | - |
| OPPOSITION | - Palermo Adam, "Development of an AAV-Based Gene Therapy for Children With Congenital Hearing Loss Due to Otoferlin Deficiency (DB-OTO)", (20210223), pages 280 - 281, URL: http://www.decibeltx.com/wp-content/uploads/ARO-2021_Development-of-an-AAV-Based_Presentation-1.pdf, (20210607), XP055811159 | - |
| OPPOSITION | - Hosoya Makoto, Minami Shujiro B., Enomoto Chieko, Matsunaga Tatsuo, Kaga Kimitaka, "Elongated EABR wave latencies observed in patients with auditory neuropathy caused by OTOF mutation", Laryngoscope Investigative Otolaryngology, Wiley, (20181001), vol. 3, no. 5, doi:10.1002/lio2.210, ISSN 2378-8038, pages 388 - 393, XP093279363 | |
| OPPOSITION | - Ahmed Hena; Shubina-Oleinik Olga; Holt Jeffrey R., "Emerging Gene Therapies for Genetic Hearing Loss", JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, SPRINGER, NEW YORK, NY, US, US , (20170816), vol. 18, no. 5, doi:10.1007/s10162-017-0634-8, ISSN 1525-3961, pages 649 - 670, XP036327909 | |
| OPPOSITION | - Roux Isabelle, Safieddine Saaid, Nouvian Régis, Grati M'hamed, Simmler Marie-Christine, Bahloul Amel, Perfettini Isabelle, Le Gall Morgane, Rostaing Philippe, Hamard Ghislaine, Triller Antoine, Avan Paul, Moser Tobias, Petit Christine, "Otoferlin, Defective in a Human Deafness Form, Is Essential for Exocytosis at the Auditory Ribbon Synapse", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (20061001), vol. 127, no. 2, doi:10.1016/j.cell.2006.08.040, ISSN 0092-8674, pages 277 - 289, XP093190267 | |
| OPPOSITION | - Langouet-Astrie Christophe J.; Yang Zhiyong; Polisetti Sraavya M.; Welsbie Derek S.; Hauswirth William W.; Zack Donald J.; Merbs Shannath L.; Enke Raymond A., "Characterization of intravitreally delivered capsid mutant AAV2-Cre vector to induce tissue-specific mutations in murine retinal ganglion cells", Experimental Eye Research, LONDON. , (20160730), vol. 151, doi:10.1016/j.exer.2016.07.019, ISSN 0014-4835, pages 61 - 67, XP029749509 | |
| OPPOSITION | - Zhang Qiujing et al, "Temperature sensitive auditory neuropathy", Hearing Research, Elsevier science publishers , Amsterdam, NL, NL , (20160501), vol. 335, doi:10.1016/j.heares.2016.01.008, ISSN 0378-5955, pages 53 - 63, XP093190105 | |
| OPPOSITION | - Zhou Ning, Shi Xuyang, Dixit Omkar, Firszt Jill B., Holden Timothy A., "Relationship between electrode position and temporal modulation sensitivity in cochlear implant users: Are close electrodes always better?", Heliyon, Elsevier Ltd, GB, GB , (20230201), vol. 9, no. 2, doi:10.1016/j.heliyon.2022.e12467, ISSN 2405-8440, page e12467, XP093279360 | |
| OPPOSITION | - Zhou Ning, Shi Xuyang, Dixit Omkar, Firszt Jill B., Holden Timothy A., "Relationship between electrode position and temporal modulation sensitivity in cochlear implant users: Are close electrodes always better?", Heliyon, GB , (20230201), vol. 9, no. 2, doi:10.1016/j.heliyon.2022.e12467, ISSN 2405-8440, page e12467, XP093279360 | |
| OPPOSITION | - Rouillon, I. et al, "Results of cochlear implantation in two children with mutations in the OTOF gene", INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY., ELSEVIER, AMSTERDAM,, NL, NL , (20060401), vol. 70, no. 4, doi:10.1016/j.ijporl.2005.09.006, ISSN 0165-5876, pages 689 - 696, XP005303978 | |
| OPPOSITION | - Bankoti Kamakshi, Generotti Charles, Hwa Tiffany, Wang Lili, O’malley Bert W., Li Daqing, "Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss", Molecular therapy- methods & clinical development, Nature Publishing Group, GB, GB , (20210601), vol. 21, doi:10.1016/j.omtm.2021.03.005, ISSN 2329-0501, pages 209 - 236, XP093211561 | |
| OPPOSITION | - Pangršič Tina et al, "Otoferlin: a multi-C2 domain protein essential for hearing", Trends in Neurosciences, ELSEVIER, AMSTERDAM., NL, NL , (20121101), vol. 35, no. 11, doi:10.1016/j.tins.2012.08.002, ISSN 0166-2236, pages 671 - 680, XP055837725 | |
| OPPOSITION | - Pangrsic Tina, Reisinger Ellen, Moser Tobias, "Otoferlin: a multi-C2 domain protein essential for hearing", Trends in Neurosciences, ELSEVIER, AMSTERDAM., NL, NL , (20121101), vol. 35, no. 11, doi:10.1016/j.tins.2012.08.002, ISSN 0166-2236, pages 671 - 680, XP055837725 | |
| OPPOSITION | - Pangrsic; Tina, Reisinger Ellen, Moser Tobias, "Otoferlin: a multi-C2 domain protein essential for hearing", Trends in Neurosciences, ELSEVIER, AMSTERDAM., NL, NL , (20121101), vol. 35, no. 11, doi:10.1016/j.tins.2012.08.002, ISSN 0166-2236, pages 671 - 680, XP055837725 | |
| OPPOSITION | - Lopes-Pacheco Miquéias, Kitoko Jamil Z., Morales Marcelo M., Petrs-Silva Hilda, Rocco Patricia R.M., "Self-complementary and tyrosine-mutant rAAV vectors enhance transduction in cystic fibrosis bronchial epithelial cells", Experimental Cell Research, AMSTERDAM, NL , (20181101), vol. 372, no. 2, doi:10.1016/j.yexcr.2018.09.015, ISSN 0014-4827, pages 99 - 107, XP093187583 | |
| OPPOSITION | - Liu, Y. Okada, T. Sheykholeslami, K. Shimazaki, K. Nomoto, T. Muramatsu, S.I. Kanazawa, T. Takeuchi, K. Ajalli, R. Mizukami, H. Kume, A. Ichimura, K. Ozawa, K., "Specific and efficient transduction of cochlear inner hair cells with recombinant adeno-associated virus type 3 vector", Molecular Therapy, Elsevier Inc., US, US , (20051001), vol. 12, no. 4, doi:10.1016/j.ymthe.2005.03.021, ISSN 1525-0016, pages 725 - 733, XP005078452 | |
| OPPOSITION | - Yoshimura Hidekane, Shibata Seiji B., Ranum Paul T., Moteki Hideaki, Smith Richard J.H., "Targeted Allele Suppression Prevents Progressive Hearing Loss in the Mature Murine Model of Human TMC1 Deafness", Molecular Therapy, Elsevier Inc., US, US , (20190301), vol. 27, no. 3, doi:10.1016/j.ymthe.2018.12.014, ISSN 1525-0016, pages 681 - 690, XP093189911 | |
| OPPOSITION | - Lv Jun; Wang Hui; Cheng Xiaoting; Chen Yuxin; Wang Daqi; Zhang Longlong; Cao Qi; Tang Honghai; Hu Shaowei; Gao Kaiyu; Xun Mengzhao; Wang Jinghan; Wang Zijing; Zhu Biyun; Cui Chong; Gao Ziwen; Guo Luo; Yu Sha; Jiang Luoying; Yin Yanbo; Zhang Jiajia; Chen Bing; Wang Wuqing; Chai Renjie; Chen Zheng-Yi; Li Huawei; Shu Yilai, "AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial", The Lancet, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20240124), vol. 403, no. 10441, doi:10.1016/S0140-6736(23)02874-X, ISSN 0140-6736, pages 2317 - 2325, XP087536573 | |
| OPPOSITION | - Kilpatrick L A; Li Q; Yang J; Goddard J C; Fekete D M; Lang H, "Adeno-associated virus-mediated gene delivery into the scala media of the normal and deafened adult mouse ear", Gene Therapy, Nature Publishing Group, London, GB, GB , (20110106), vol. 18, no. 6, doi:10.1038/gt.2010.175, ISSN 0969-7128, pages 569 - 578, XP037772589 | |
| OPPOSITION | - Petrs-Silva Hilda, Dinculescu Astra, Li Qiuhong, Min Seok-Hong, Chiodo Vince, Pang Ji-Jing, Zhong Li, Zolotukhin Sergei, Srivastava Arun, Lewin Alfred S, Hauswirth William W, "High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors", Molecular Therapy, US , (20090301), vol. 17, no. 3, doi:10.1038/mt.2008.269, ISSN 1525-0016, pages 463 - 471, XP093187577 | |
| OPPOSITION | - Hilda Petrs-Silva, Astra Dinculescu, Qiuhong Li, Wen-Tao Deng, Ji-Jing Pang, Seok-Hong Min, Vince Chiodo, Andy W Neeley, Lakshmanan Govindasamy, Antonette Bennett, Mavis Agbandje-Mckenna, Li Zhong, Baozheng Li, Giridhara R Jayandharan, Arun Srivastava, Alfred S Lewin, William W Hauswirth, "Novel Properties of Tyrosine-mutant AAV2 Vectors in the Mouse Retina", Molecular Therapy, (20110201), vol. 19, no. 2, doi:10.1038/mt.2010.234, ISSN 1525-0016, pages 293 - 301, XP055180872 | |
| OPPOSITION | - Hilda Petrs-Silva et al., "Novel Properties of Tyrosine-mutant AAV2 Vectors in the Mouse Retina", Molecular Therapy, (20112), vol. 19, doi:10.1038/mt.2010.234, page 2, XP055180872 | |
| OPPOSITION | - Bifeng Pan, Charles Askew, Alice Galvin, Selena Heman-Ackah, Yukako Asai, Artur A Indzhykulian, Francine M Jodelka, Michelle L Hastings, Jennifer J Lentz, Luk H Vandenberghe, Jeffrey R Holt, Gwenaëlle S Géléoc, "Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20170301), vol. 35, no. 3, doi:10.1038/nbt.3801, ISSN 1087-0156, pages 264 - 272, XP055637663 | |
| OPPOSITION | - Nist-Lund Carl A., Pan Bifeng, Patterson Amy, Asai Yukako, Chen Tianwen, Zhou Wu, Zhu Hong, Romero Sandra, Resnik Jennifer, Polley Daniel B., Géléoc Gwenaelle S., Holt Jeffrey R., "Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders", Nature Communications, Nature Publishing Group, UK, UK, vol. 10, no. 1, doi:10.1038/s41467-018-08264-w, ISSN 2041-1723, XP093211562 | |
| OPPOSITION | - Yoshimura Hidekane, Shibata Seiji B., Ranum Paul T., Smith Richard J. H., "Enhanced viral-mediated cochlear gene delivery in adult mice by combining canal fenestration with round window membrane inoculation", Scientific Reports, Nature Publishing Group, US, US , (20180101), vol. 8, no. 1, doi:10.1038/s41598-018-21233-z, ISSN 2045-2322, XP093189913 | |
| OPPOSITION | - Jun Suzuki et al., "Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction", Scientific Reports, (20170403), vol. 7, doi:10.1038/srep45524, page 45524 , XP055675065 | |
| OPPOSITION | - Jun Suzuki, Ken Hashimoto, Ru Xiao, Luk H. Vandenberghe, M. Charles Liberman, "Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction", Scientific Reports, (20170401), vol. 7, no. 1, doi:10.1038/srep45524, XP055675065 | |
| OPPOSITION | - Deep Nicholas, Dowling Eric, Jethanamest Daniel, Carlson Matthew, "Cochlear Implantation: An Overview", Journal of Neurological Surgery Part B: Skull Base, (20190401), vol. 80, no. 02, doi:10.1055/s-0038-1669411, ISSN 2193-6331, pages 169 - 177, XP093279353 | |
| OPPOSITION | - Rocha Larissa Veloso, Goffi-Gomez Maria Valéria Schmidt, Hoshino Ana Cristina, Tsuji Robinson Koji, Bento Ricardo Ferreira, "Hearing Performance in Cochlear Implant Users Who Have Facial Nerve Stimulation", International Archives of Otorhinolaryngology, (20240401), vol. 28, no. 02, doi:10.1055/s-0043-1775809, ISSN 1809-9777, pages e301 - e306, XP093279355 | |
| OPPOSITION | - Omar Akil, Frank Dyka, Charlotte Calvet, Alice Emptoz, Ghizlene Lahlou, Sylvie Nouaille, Jacques Boutet De Monvel, Jean-Pierre Hardelin, William W. Hauswirth, Paul Avan, Christine Petit, Saaid Safieddine, Lawrence R. Lustig, "Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20190305), vol. 116, no. 10, doi:10.1073/pnas.1817537116, ISSN 0027-8424, pages 4496 - 4501, XP055574122 | |
| OPPOSITION | - GAO GUANG-PING, ET AL, "Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20020903), vol. 99, no. 18, doi:10.1073/PNAS.182412299, ISSN 0027-8424, pages 11854 - 11859, XP002589975 | |
| OPPOSITION | - Ichiro Yasunaga Shin, 'hamed Grati M, ́bastien Chardenoux Se, Smith Tenesha N, Friedman Thomas B, Lalwani Anil K, Wilcox Edward R, Petit Christine, "OTOF Encodes Multiple Long and Short Isoforms: Genetic Evidence That the Long Ones Underlie Recessive Deafness DFNB9", Am J Hum Genet ., (20000101), vol. 67, no. 3, doi:10.1086/303049, pages 591 - 600, XP093190269 | |
| OPPOSITION | - Tao Yong, Huang Mingqian, Shu Yilai, Ruprecht Adam, Wang Hongyang, Tang Yong, Vandenberghe Luk H., Wang Qiuju, Gao Guangping, Kong Wei-Jia, Chen Zheng-Yi, "Delivery of Adeno-Associated Virus Vectors in Adult Mammalian Inner-Ear Cell Subtypes Without Auditory Dysfunction", HUMAN GENE THERAPY, Mary Ann Liebert, Inc. Publishers, GB, GB , (20180401), vol. 29, no. 4, doi:10.1089/hum.2017.120, ISSN 1043-0342, pages 492 - 506, XP055860224 | |
| OPPOSITION | - Zhao Xingle, Liu Huihui, Liu Hongchao, Cai Ruijie, Wu Hao, "Gene Therapy Restores Auditory Functions in an Adult Vglut3 Knockout Mouse Model", HUMAN GENE THERAPY, Mary Ann Liebert, Inc. Publishers, GB, GB , (20220701), vol. 33, no. 13-14, doi:10.1089/hum.2022.062, ISSN 1043-0342, pages 729 - 739, XP093211560 | |
| OPPOSITION | - Iizuka Takashi, Kamiya Kazusaku, Gotoh Satoru, Sugitani Yoshinobu, Suzuki Masaaki, Noda Tetsuo, Minowa Osamu, Ikeda Katsuhisa, "Perinatal Gjb2 gene transfer rescues hearing in a mouse model of hereditary deafness", Human Molecular Genetics, Oxford University Press, GB, GB , (20150315), vol. 24, no. 13, doi:10.1093/hmg/ddv109, ISSN 0964-6906, pages 3651 - 3661, XP055867994 | |
| OPPOSITION | - Li Yiming, Zhu Ping, Verma Amrisha, Prasad Tuhina, Deng Hongxin, Yu Dechao, Li Qiuhong, "A novel bispecific molecule delivered by recombinant AAV2 suppresses ocular inflammation and choroidal neovascularization", Journal of cellular and molecular medicine, RO , (20170801), vol. 21, no. 8, doi:10.1111/jcmm.13086, ISSN 1582-1838, pages 1555 - 1571, XP055951669 | |
| OPPOSITION | - Mathiesen Barbara K., Miyakoshi Leo M., Cederroth Christopher R., Tserga Evangelia, Versteegh Corstiaen, Bork Peter A. r., Hauglund Natalie L., Gomolka Ryszard Stefan, Mori Yuki, Edvall Niklas K., Rouse Stephanie, Møllgård Kjeld, Holt Jeffrey R., Nedergaard Maiken, Canlon Barbara, "Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice", SCIENCE TRANSLATIONAL MEDICINE, American Association for the Advancement of Science, (20230628), vol. 15, no. 702, doi:10.1126/scitranslmed.abq3916, ISSN 1946-6234, XP093211557 | |
| OPPOSITION | - Hyun-Joo Nam et al., "Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy Vector", J. Virol., (200711), vol. 81, doi:10.1128/JVI.01304-07, XP055675995 | |
| OPPOSITION | - Wright Samantha, Hwang Youngdeok, Oertel Donata, "Synaptic transmission between end bulbs of Held and bushy cells in the cochlear nucleus of mice with a mutation in Otoferlin", JOURNAL OF NEUROPHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, BETHESDA, MD, US, US , (20141215), vol. 112, no. 12, doi:10.1152/jn.00522.2014, ISSN 0022-3077, pages 3173 - 3188, XP093211556 | |
| OPPOSITION | - Tertrais Margot, Bouleau Yohan, Emptoz Alice, Belleudy Séverin, Sutton R Bryan, Petit Christine, Safieddine Saaid, Dulon Didier, "Viral transfer of mini-otoferlins partially restores the fast component of exocytosis and uncovers ultrafast endocytosis in auditory hair cells of otoferlin knock-out mice", THE JOURNAL OF NEUROSCIENCE, Society for Neuroscience, US, US , (20190501), vol. 39, no. 18, doi:10.1523/JNEUROSCI.1550-18.2018, ISSN 0270-6474, pages 3394 - 3411, XP093052166 | |
| OPPOSITION | - Hanan Al-moyed, Andreia P Cepeda, Sangyong Jung, Tobias Moser, Sebastian Kugler, Ellen Reisinger, "A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice", EMBO Molecular Medicine, Wiley-Blackwell, US, US , (20190101), vol. 11, no. 1, doi:10.15252/emmm.201809396, ISSN 1757-4676, XP055632681 | |
| OPPOSITION | - Hanan Al-moyed, Andreia P Cepeda, Sangyong Jung, Tobias Moser, Sebastian Kügler, Ellen Reisinger, "A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice", EMBO Molecular Medicine, Wiley-Blackwell, US, US , (20190101), vol. 11, no. 1, doi:10.15252/emmm.201809396, ISSN 1757-4676, XP055632681 | |
| OPPOSITION | - Jeffrey R Holt, Geleoc Gwenaelle Sg, "Split otoferlins reunited", EMBO Molecular Medicine (Online), Wiley - V C H Verlag GmbH & Co. KGaA, DE, DE , vol. 11, no. 1, doi:10.15252/emmm.201809995, ISSN 1757-4684, page e9995, XP055596187 | |
| OPPOSITION | - Stalmann Ursula, Franke Albert Justin, Al-Moyed Hanan, Strenzke Nicola, Reisinger Ellen, "Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9", FRONTIERS IN CELLULAR NEUROSCIENCE, Frontiers Research Foundation, CH, CH , vol. 15, doi:10.3389/fncel.2021.677543, ISSN 1662-5102, pages 677543 - 11, XP093303794 | |
| OPPOSITION | - Wenjuan Zhang, Et Al, "Cochlear Gene Therapy for Sensorineural Hearing Loss: Current Status and Major Remaining Hurdles for Translational Success", Frontiers in Molecular Neuroscience, (2018), vol. 11, doi:10.3389/fnmol.2018.00221, pages 1 - 15, XP055696898 | |
| OPPOSITION | - Thomas Jan Peter, Klein Hannah, Haubitz Imme, Dazert Stefan, Völter Christiane, "Intra- and Interrater Reliability of CT- versus MRI-Based Cochlear Duct Length Measurement in Pediatric Cochlear Implant Candidates and Its Impact on Personalized Electrode Array Selection", Journal of Personalized Medicine, Molecular Diversity Preservation International, vol. 13, no. 4, doi:10.3390/jpm13040633, ISSN 2075-4426, page 633, XP093279358 | |
| OPPOSITION | - Akil Omar, Stephanie L. Rouse, Dylan K. Chan, Lawrence R. Lustig, "Surgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane", Journal of Visualized Experiments, (20150316), vol. 97, doi:10.3791/52187, page e52187, XP093189922 | |
