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IP Verse

Genotype And Dose-Dependent Response To An Asbti In Patients With Bile Salt Export Pump Deficiency - EP3923943

The patent EP3923943 was granted to Mirum Pharmaceuticals on Jul 31, 2024. The application was originally filed on Feb 12, 2020 under application number EP20755296A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3923943

MIRUM PHARMACEUTICALS
Application Number
EP20755296A
Filing Date
Feb 12, 2020
Status
Granted And Under Opposition
Jun 27, 2024
Publication Date
Jul 31, 2024
External Links
Slate, Register, Google Patents

Patent Summary

Modulating bile acid transport in cholestatic liver disease through targeted inhibition of apical sodium-dependent bile acid transporters (ASBTIs). The ASBTIs specifically target the apical bile acid export pump (BSEP) to prevent bile acid reabsorption and promote bile acid excretion. The treatment modulates the ASBTI dosage to achieve optimal bile acid clearance while maintaining bile acid levels within therapeutic ranges. The method utilizes genetic testing to predict the response to ASBTI therapy based on the patient's ABCB11 gene sequence, which determines the functional status of the BSEP protein.

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

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GENERICS UKApr 30, 2025RUSSELLADMISSIBLE
SANDOZApr 30, 2025MAIWALDADMISSIBLE

Patent Citations (4) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
INTERNATIONAL-SEARCH-REPORTUS2014243281
INTERNATIONAL-SEARCH-REPORTUS9040518
INTERNATIONAL-SEARCH-REPORTWO2017167935
INTERNATIONAL-SEARCH-REPORTWO2018002827

Dossier Documents

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