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Production Of A Mixture Of Neutral Non-Fucosylated Oligosaccharides By A Cell - EP3954778

The patent EP3954778 was granted to Inbiose on Oct 4, 2023. The application was originally filed on Aug 10, 2020 under application number EP20190203A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3954778

INBIOSE
Application Number
EP20190203A
Filing Date
Aug 10, 2020
Status
Granted And Under Opposition
Sep 1, 2023
Grant Date
Oct 4, 2023
External Links
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Patent Summary

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Patent Oppositions (3)

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OETKEJul 4, 2024ADMISSIBLE
GLYCOMJul 3, 2024ADMISSIBLE
CHR HANSEN HMOJun 25, 2024ADMISSIBLE

Patent Citations (12) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO2012007481
OPPOSITIONEP2722394
OPPOSITIONEP2971030
OPPOSITIONEP3177325
OPPOSITIONUS2009082307
OPPOSITIONUS2011014661
OPPOSITIONUS2017306373
OPPOSITIONWO2011035884
OPPOSITIONWO2014152137
OPPOSITIONWO2014153253
OPPOSITIONWO2016091268
SEARCHEP2722394

Non-Patent Literature (NPL) Citations (41) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BLAZECK, Biotechnology and Bioengineering, (20120000), vol. 109, no. 11-
DESCRIPTION- BODE, Early Hum. Dev., (20150000), pages 1 - 4-
DESCRIPTION- BRACHMANN et al., Yeast, (19980000), vol. 14, pages 115 - 32-
DESCRIPTION- CAMBRAY et al., Nucleic Acids Res., (20130000), vol. 41, no. 9, pages 5139 - 5148-
DESCRIPTION- CAMPBELL et al., Biochem. J., (19970000), vol. 326, pages 929 - 939-
DESCRIPTION- CHRISTIANSON et al., Gene, (19920000), vol. 110, pages 119 - 122-
DESCRIPTION- COUTINHO et al., J. Mol. Biol., (20030000), vol. 328, pages 307 - 317-
DESCRIPTION- DATSENKOWANNER, PNAS, (20000000), vol. 97, pages 6640 - 6645-
DESCRIPTION- FOX et al., Protein Sci., (20010000), vol. 10, no. 3, pages 622 - 630-
DESCRIPTION- GIETZ, Yeast, (19950000), vol. 11, pages 355 - 360-
DESCRIPTION- MUTALIK et al., Nat. Methods, (20130000), pages 354 - 360-
DESCRIPTION- REILY et al., Nat. Rev. Nephrol., (20190000), vol. 15, pages 346 - 366-
DESCRIPTION- VARKI, Glycobiology, (20170000), vol. 27, pages 3 - 49-
OPPOSITION- Anonymous, "Escherichia coli strain JM109 chromosome, complete genome", Nucleotide, (20240326), Database accession no. NZ_CP117962.1, XP093194366-
OPPOSITION- Baumgärtner: Biotechnologische Darstellung und strukturelle Charakterisierung fucosylierter Oligosaccharide. PhD thesis, Institut für Mikrobiologie der Universität Stuttgart - published: 2016-
OPPOSITION- Fda, "GRN No. 659 - Lacto-N-neotetraose ", FDA - GRAS Notice, (20160101), FDA - GRAS Notice, XP093194478-
OPPOSITION- Fda, "GRN No. 833 - Lacto-N-neotetraose ", FDA - GRAS Notice, (20190101), FDA - GRAS Notice, XP093194477-
OPPOSITION- Ludger N-glycan nomenclature; 2019 (https://www.ludger.com/docs/tables/ludger-n-glycan-nomenclature-table.pdf), XP093196457-
OPPOSITION- Nih, "Genes annotated on Escherichia coli DH1 ASM2336v1 (GCF_000023365.1)", Genome Annotation, National Library of Medicine, National Center for Biotechnology Information, (20230516), Genome Annotation, National Library of Medicine, National Center for Biotechnology Information, URL: https://www.ncbi.nlm.nih.gov/datasets/gene/GCF_000023365.1/?search=waa&gene_type=protein-coding, XP093194361-
OPPOSITION- Raetz Christian R.H., "Chapter 69 - Bacterial Lipopolysaccharides: a Remarkable Family of Bioactive Macroamphiphiles", Raetz Christian R.H., F. C. Neidhardt, Escherichia coli and Salmonella - Cellular and Molecular Biology, 2nd ed., ASM Press, (19960101), pages 1035 - 1071, 2140, 2141, XP093200120-
OPPOSITION- URASHIMA ET AL, "Human milk oligosaccharides as essential tools for basic and application studies on galectins", TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, (20180125), vol. 30, pages SE51 - SE65, XP002785727-
OPPOSITION- Varki Ajit, Cummings Richard, Esko Jeffrey, Freeze Hudson, Essentials of Glycobiology, (19990101), pages 4 - 10, 32, 33, 69, 70, 85 - 100, 253 - 257, XP093196498-
OPPOSITION- YAMANE-OHNUKI N, ET AL., "Establishment of FUT8 knockout chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20040905), vol. 87, no. 5, doi:10.1002/bit.20151, ISSN 0006-3592, pages 614 - 622, XP002983153
OPPOSITION- Yutaka Kanda; Naoko Yamane‐Ohnuki; Naoto Sakai; Kazuya Yamano; Ryosuke Nakano; Miho Inoue; Hirofumi Misaka; Shigeru Iida; Masako Wakitani; Yoshinobu Konno; Keiichi Yano; Kenya Shitara; Shinji Hosoi; Mitsuo Satoh, "Comparison of cell lines for stable production of fucose‐negative antibodies with enhanced ADCC", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20060411), vol. 94, no. 4, doi:10.1002/bit.20880, ISSN 0006-3592, pages 680 - 688, XP071113455
OPPOSITION- Laetitia Malphettes; Yevgeniy Freyvert; Jennifer Chang; Pei‐Qi Liu; Edmond Chan; Jeffrey C. Miller; Zhe Zhou; Thu Nguyen; Christina Tsai; Andrew W. Snowden; Trevor N. Collingwood; Philip D. Gregory; Gregory J. Cost, "Highly efficient deletion of FUT8 in CHO cell lines using zinc‐finger nucleases yields cells that produce completely nonfucosylated antibodies", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20100408), vol. 106, no. 5, doi:10.1002/bit.22751, ISSN 0006-3592, pages 774 - 783, XP071052145
OPPOSITION- Qiong Wang; Cheng‐Yu Chung; Sandra Chough; Michael J. Betenbaugh, "Antibody glycoengineering strategies in mammalian cells", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20180331), vol. 115, no. 6, doi:10.1002/bit.26567, ISSN 0006-3592, pages 1378 - 1393, XP071052585
OPPOSITION- RS Donovan et al., "Review: Optimizing inducer and culture conditions for expression of foreign proteins under the control of the lac promotor", Journal of Industrial Microbiology, (1996), vol. 16, doi:10.1007/BF01569997, XP008020707
OPPOSITION- Elif Yavuz, Carola Maffioli, Karin Ilg, Markus Aebi, Bernard Priem, "Glycomimicry: display of fucosylation on the lipo-oligosaccharide of recombinant Escherichia coli K12", Glycoconjugate Journal, Chapman & Hall, Boston, Boston , (20110101), vol. 28, no. 1, doi:10.1007/s10719-010-9322-1, ISSN 0282-0080, pages 39 - 47, XP055288405
OPPOSITION- Bosmann, H.B., "Bacterial glycoproteins: Identification and properties of glycoprotein glycosyltransferases in Escherichia coli", Biochimica et Biophysica Acta, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL , (19711112), vol. 252, no. 2, doi:10.1016/0304-4165(71)90018-3, ISSN 0304-4165, pages 369 - 387, XP023494095
OPPOSITION- Bernard R. Glick et al., "Metabolic load and heterologous gene expression", Biotechnology Advances, (1995), vol. 13, doi:10.1016/0734-9750(95)00004-A, XP004045671
OPPOSITION- Faijes Magda; Castejon-Vilatersana Mireia; Val-Cid Cristina; Planas Antoni, "Enzymatic and cell factory approaches to the production of human milk oligosaccharides", BIOTECHNOLOGY ADVANCES., ELSEVIER PUBLISHING, BARKING., GB, GB , (20190901), vol. 37, no. 5, doi:10.1016/j.biotechadv.2019.03.014, ISSN 0734-9750, pages 667 - 697, XP085733160
OPPOSITION- Florian Baumgärtner et al., "Synthesis of fucosylated lacto-N-tetraose using whole-cell biotransformation", Bioorganic & Medicinal Chemistry, (2015), vol. 23, doi:10.1016/j.bmc.2015.10.005, XP029299013
OPPOSITION- Walsh Clodagh; Lane Jonathan A.; van Sinderen Douwe; Hickey Rita M., "From lab bench to formulated ingredient: Characterization, production, and commercialization of human milk oligosaccharides", Journal of Functional Foods, Elsevier BV, NL, NL , (20200616), vol. 72, doi:10.1016/j.jff.2020.104052, ISSN 1756-4646, XP086219849
OPPOSITION- Jiangnan Peng, "Chemical Structure and Composition of Major Glycans Covalently Linked to Therapeutic Monoclonal Antibodies by Middle-Down Nuclear Magnetic Resonance", HHS Public Access, (20200225), XP093196478
OPPOSITION- Roy Jefferis, "Glycosylation as a strategy to improve antibody-based therapeutics", Macmillian Publishers Limited - Nature Reviews, (200903), vol. 8, doi:10.1038/NRD2804, XP002600969
OPPOSITION- Leipold Michael D., Vinogradov Evgeny, Whitfield Chris, "Glycosyltransferases Involved in Biosynthesis of the Outer Core Region of Escherichia coli Lipopolysaccharides Exhibit Broader Substrate Specificities Than Is Predicted from Lipopolysaccharide Structures", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20070901), vol. 282, no. 37, doi:10.1074/jbc.M704131200, ISSN 0021-9258, pages 26786 - 26792, XP093194354
OPPOSITION- PRIEM BERNARD ET AL, "A new fermentation process allows large-scale production of human milk oligosaccharides by metabolically engineered bacteria", GLYCOBIOLOGY, Oxford University Press, US, US , (20020401), vol. 12, no. 4, doi:10.1093/glycob/12.4.235, ISSN 0959-6658, pages 235 - 240, XP002380632
OPPOSITION- Ten Bruggencate Sandra, Bovee-Oudenhoven Ingeborg Mj, Feitsma Anouk L, Van Hoffen Els, Schoterman Margriet Hc, "Functional role and mechanisms of sialyllactose and other sialylated milk oligosaccharides", NUTRITION REVIEWS., ALLEN PRESS, LAWRENCE, KS., US, US , (20140601), vol. 72, no. 6, doi:10.1111/nure.12106, ISSN 0029-6643, pages 377 - 389, XP093194358
OPPOSITION- Cote Joy, Taylor Erika, "The Glycosyltransferases of LPS Core: A Review of Four Heptosyltransferase Enzymes in Context", International journal of molecular sciences, Molecular Diversity Preservation International (MDPI), Basel, CH, Basel, CH , (20170101), vol. 18, no. 11, doi:10.3390/ijms18112256, ISSN 1422-0067, page 2256, XP093200115
SEARCH- Lars Bode ET AL, "Making Human Milk Oligosaccharides Available for Research and Application - Approaches, Challenges, and Future Opportunities", Prebiotics and Probiotics in Human Milk, Elsevier, (20170101), pages 251 - 293, doi:10.1016/B978-0-12-802725-7.00009-9, ISBN 978-0-12-802725-7, XP055769719 [A] 1-15
SEARCH- PRIEM BERNARD ET AL, "A new fermentation process allows large-scale production of human milk oligosaccharides by metabolically engineered bacteria", GLYCOBIOLOGY, OXFORD UNIVERSITY PRESS, US, (20020401), vol. 12, no. 4, doi:10.1093/GLYCOB/12.4.235, ISSN 0959-6658, pages 235 - 240, XP002380632 [X] 1,4-9,11-15 * page 236, column 1, paragraph 3 - column 2, paragraph 3; figures 1,4 * * page 239, column 1, paragraph 5 - paragraph 6 *

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