IP Verse

Inflammatory Disease Treatment With Complement Inhibitors - EP3980047

The patent EP3980047 was granted to RA Pharmaceuticals on Feb 14, 2024. The application was originally filed on Jun 4, 2020 under application number EP20749996A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3980047

RA PHARMACEUTICALS
Application Number
EP20749996A
Filing Date
Jun 4, 2020
Status
Granted And Under Opposition
Jan 12, 2024
Grant Date
Feb 14, 2024
External Links
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KRAUSSNov 11, 2024KRAUSSADMISSIBLE

Patent Citations (8) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS10106579
DESCRIPTIONUS2011172126
DESCRIPTIONUS2017137468
DESCRIPTIONUS9937222
DESCRIPTIONWO2017105939
DESCRIPTIONWO2018106859
OPPOSITIONUS2017137468
OPPOSITIONWO2012088247

Non-Patent Literature (NPL) Citations (17) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Anonymous, "Phase 2 Safety and Ecacy Study of Zilucoplan (RA101495) to Treat PNH Patients", ClinicalTrials.gov; NCT03078582, (20170308), ClinicalTrials.gov; NCT03078582, URL: https://clinicaltrials.gov/study/NCT03078582?term=NCT03078582&rank=1, XP093237713-
OPPOSITION- Anonymous, "Safety and Ecacy Study of Zilucoplan in Subjects With Immune-Mediated Necrotizing Myopathy", ClinicalTrials.gov; NCT04025632, (20190719), ClinicalTrials.gov; NCT04025632 , URL: https://clinicaltrials.gov/study/NCT04025632?term=NCT04025632&rank=1, XP093237710-
OPPOSITION- Cong Lu, Pu Chuan-Qiang, Shi Qiang, Wang Qian, Lu Xiang-Hui, "Complement membrane attack complex is related with immune-mediated necrotizing myopathy", International Journal of Clinical and Experimental Pathology, E-Century Publishing Corporation, US, US , (20140701), vol. 7, no. 7, ISSN 1936-2625, pages 4143 - 4149, XP093237699-
OPPOSITION- Rapharma, "Zilucoplan in*Generalized*Myasthenia*Gravis", URL: https://rapharma.com/wp-content/uploads/2018/12/Zilucoplan-in-Generalized-Myasthenia-Gravis-1.pdf, (20200827), XP055725510-
OPPOSITION- Bergua C.; Chiavelli H.; Simon J. P.; Boyer O.; Jouen F.; Stenzel W.; Martinet J., "Immune-mediated necrotizing myopathy", Zeitschrift für Rheumatologie, Springer, DE, DE , (20160118), vol. 75, no. 2, doi:10.1007/s00393-015-0029-3, ISSN 0340-1855, pages 151 - 156, XP035644888
OPPOSITION- Pinal-Fernandez Iago; Casal-Dominguez Maria; Mammen Andrew L., "Immune-Mediated Necrotizing Myopathy", CURRENT RHEUMATOLOGY REPORTS, CURRENT SCIENCE, PHILADELPHIA, PA, US, US , (20180326), vol. 20, no. 4, doi:10.1007/s11926-018-0732-6, ISSN 1523-3774, pages 1 - 10, XP036467030
OPPOSITION- Anquetil Céline, Boyer Olivier, Wesner Nadège, Benveniste Olivier, Allenbach Yves, "Myositis-specific autoantibodies, a cornerstone in immune-mediated necrotizing myopathy", AUTOIMMUNITY REVIEWS, ELSEVIER, AMSTERDAM, NL, NL , (20190301), vol. 18, no. 3, doi:10.1016/j.autrev.2018.09.008, ISSN 1568-9972, pages 223 - 230, XP093237702
OPPOSITION- Rojana-udomsart Arada; Mitrpant Chalermchai; Bundell Christine; Price Loren; Luo Yue-Bei; Fabian Victoria; Wilton Steve D; Hollingsworth Peter; Mastaglia Frank L., "Complement-mediated muscle cell lysis: A possible mechanism of myonecrosis in anti-SRP associated necrotizing myopathy (ASANM)", Journal of Neuroimmunology, ELSEVIER SCIENCE PUBLISHERS BV., NL, NL , (20130830), vol. 264, no. 1, doi:10.1016/j.jneuroim.2013.08.008, ISSN 0165-5728, pages 65 - 70, XP028761695
OPPOSITION- Howard James F; Utsugisawa Kimiaki; Benatar Michael; Murai Hiroyuki; Barohn Richard J; Illa Isabel; Jacob Saiju; Vissing John; Burns Ted M; Kissel John T; Muppidi Srikanth; Nowak Richard J; O'Brien Fanny; Wang Jing-Jing; Mantegazza Renato, "Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study", The Lancet Neurology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (19000101), vol. 16, no. 12, doi:10.1016/S1474-4422(17)30369-1, ISSN 1474-4422, pages 976 - 986, XP085267220
OPPOSITION- Mammen Andrew L, Amato Anthony A, Dimachkie Mazen M, Chinoy Hector, Hussain Yessar, Lilleker James B, Pinal-Fernandez Iago, Allenbach Yves, Boroojerdi Babak, Vanderkelen Mark, Delicha Eumorphia Maria, Koendgen Harold, Farzaneh-Far Ramin, Duda Petra W, Sayegh Camil, Benveniste Olivier, "Zilucoplan in immune-mediated necrotising myopathy: a phase 2, randomised, double-blind, placebo-controlled, multicentre trial", The Lancet Rheumatology, (20230201), vol. 5, no. 2, doi:10.1016/S2665-9913(23)00003-6, ISSN 2665-9913, pages e67 - e76, XP009558916
OPPOSITION- Bergua Cécile, Chiavelli Hélène, Allenbach Yves, Arouche-Delaperche Louiza, Arnoult Christophe, Bourdenet Gwladys, Jean Laetitia, Zoubairi Rachid, Guerout Nicolas, Mahler Michael, Benveniste Olivier, Drouot Laurent, Boyer Olivier, "In vivo pathogenicity of IgG from patients with anti-SRP or anti-HMGCR autoantibodies in immune-mediated necrotising myopathy", Annals of the Rheumatic Diseases, (20190101), vol. 78, no. 1, doi:10.1136/annrheumdis-2018-213518, ISSN 0003-4967, pages 131 - 139, XP009558918
OPPOSITION- Allenbach Yves, Arouche-Delaperche Louiza, Preusse Corinna, Radbruch Helena, Butler-Browne Gillian, Champtiaux Nicolas, Mariampillai Kuberaka, Rigolet Aude, Hufnagl Peter, Zerbe Norman, Amelin Damien, Maisonobe Thierry, Louis-Leonard Sarah, Duyckaerts Charles, Eymard Bruno, Goebel Hans-Hilmar, Bergua Cecile, Drouot Laurent, Boyer Olivier, Benveniste Olivier, Stenzel Werner, "Necrosis in anti-SRP + and anti-HMGCR + myopathies : Role of autoantibodies and complement", Neurology, Lippincott Williams & Wilkins, (20180206), vol. 90, no. 6, doi:10.1212/WNL.0000000000004923, ISSN 0028-3878, XP093237700
OPPOSITION- James Howard, "A Subcutaneously Administered Peptide Inhibitor of Complement Component 5 (C5) State of the art according 11 for the Treatment of Generalized Myasthenia Gravis (gMG): Phase 1 Results and Phase 2 Design (S31.006)", Neurology, (20180410), vol. 90, no. 15, doi:10.1212/WNL.90.15_supplement.S31.006, XP009558917
OPPOSITION- Tamura Takumi, Miyajima Keisuke, Watanabe Kazuki, Ito Kazuki, Kin Fumihiko, Okazaki Ayako, Takashima Yasuyo, Watanabe Tomoyuki, Kawaguchi Yoshitaka, Wakabayashi Yasushi, Miyajima Hiroaki, Maekawa Yuichiro, "An Autopsy Case of Antibody-negative Immune-mediated Necrotizing Myopathy with Severe Cardiac Involvement", INTERNAL MEDICINE., JAPANESE SOCIETY OF INTERNAL MEDICINE, TOKYO., JP, JP , (20211001), vol. 60, no. 19, doi:10.2169/internalmedicine.6355-20, ISSN 0918-2918, pages 3113 - 3119, XP093268435
OPPOSITION- Julien Sarah, Challier Inès, Malleter Marine, Jouen Fabienne, Drouot Laurent, Boyer Olivier, "Immune-Mediated Necrotizing Myopathy (IMNM): A Story of Antibodies", Antibodies, M D P I AG, CH, CH , vol. 13, no. 1, doi:10.3390/antib13010012, ISSN 2073-4468, page 12, XP093268436
OPPOSITION- Julien Sarah, Vadysirisack Douangsone, Sayegh Camil, Ragunathan Sharan, Tang Yalan, Briand Emma, Carrette Marion, Jean Laetitia, Zoubairi Rachid, Gondé Henri, Benveniste Olivier, Allenbach Yves, Drouot Laurent, Boyer Olivier, "Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model", Biomedicines, MDPI, Basel, Basel , vol. 10, no. 8, doi:10.3390/biomedicines10082036, ISSN 2227-9059, page 2036, XP093237706
OPPOSITION- Yuefang Zhou, "Anti-C5 antibody treatment ameliorates weakness in experimentally acquired myasthenia gravis", The Journal of Immunology, (2007), vol. 179, doi:10.4049/jimmunol.179.12.8562, XP055310140

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