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The patent EP3999180 was granted to Cytokinetics on May 8, 2024. The application was originally filed on Jul 16, 2020 under application number EP20753562A. The patent is currently recorded with a legal status of "Granted And Under Opposition".
Polymorphs of a therapeutic agent for treating cardiac diseases, particularly hypertrophic cardiomyopathy (HCM) and heart failure with preserved ejection fraction (HFpEF), that exhibit enhanced stability and therapeutic index compared to conventional forms. The polymorphs have distinct crystal structures that differ in physical properties, such as melting points, solubilities, and dissolution rates, which enable controlled manufacturing processes. These polymorphs retain the therapeutic activity of the parent compound while reducing adverse effects, making them a promising alternative for treating these conditions.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
Patent citations refer to prior patents cited during different phases such as opposition or international search.
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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