Virion-Like Delivery Particles For Self-Replicating Rna Molecules - EP4005592

The patent EP4005592 was granted to Glaxosmithkline on Oct 12, 2022. The application was originally filed on Jul 6, 2011 under application number EP21204155A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP4005592

GLAXOSMITHKLINE
Application Number
EP21204155A
Filing Date
Jul 6, 2011
Status
Granted And Under Opposition
Sep 9, 2022
Grant Date
Oct 12, 2022
External Links
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MARGARET DIXONJul 12, 2023MEWBURN ELLISWITHDRAWN
THOMANNJul 11, 2023THOMANNADMISSIBLE

Patent Citations (17) New

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Citation PhasePublication NumberPublication Link
OPPOSITIONEP2590676
OPPOSITIONUS2011200667
OPPOSITIONWO0000617
OPPOSITIONWO02095023
OPPOSITIONWO0209645
OPPOSITIONWO2007047749
OPPOSITIONWO2009146867
OPPOSITIONWO2010015098
OPPOSITIONWO2012006369
OPPOSITIONWO2012006372
OPPOSITIONWO2012006376
OPPOSITIONWO2012006377
OPPOSITIONWO2012006378
OPPOSITIONWO2012030901
OPPOSITIONWO2012031043
OPPOSITIONWO2012031046
SEARCHWO02061113

Non-Patent Literature (NPL) Citations (81) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BOXUS et al., J Virol, (20070000), vol. 81, pages 6879 - 89-
DESCRIPTION- EL OUAHABI et al., FEBS Letts, (19960000), vol. 380, pages 108 - 12-
DESCRIPTION- GIULIANI et al., Proc Natl Acad Sci USA, (20060000), vol. 1, 2, 3, no. 29, pages 10834 - 9-
DESCRIPTION- Handbook of Experimental Immunology,, Scientific Publications, (19860000), vol. I-IV-
DESCRIPTION- HEYES et al., J Controlled Release, (20050000), vol. 107, pages 276 - 87-
DESCRIPTION- IAVARONE et al., J Immunol, (20110000), vol. 186, pages 4213 - 22-
DESCRIPTION- JEFFS et al., Pharmaceutical Research, (20050000), vol. 22, no. 3, pages 362 - 372-
DESCRIPTION- JOHANNING et al., Nucleic Acids Res, (19950000), vol. 23, pages 1495 - 1501-
DESCRIPTION- Liposomes: Methods and Protocols, Humana Press, (20090000), vol. Pharmaceutical Nanocarriers: Methods and Protocols-
DESCRIPTION- MARTINON et al., Eur J Immunol, (19930000), vol. 23, pages 1719 - 22-
DESCRIPTION- MAURER et al., Biophysical Journal, (20010000), vol. 80, pages 2310 - 2326-
DESCRIPTION- "Microspheres, microcapsules & liposomes", Functional Polymer Colloids and Microparticles, Citus Books, (20020000), vol. 4-
DESCRIPTION- Molecular BioProducts-
DESCRIPTION- O'HAGAN et al., J Virology, (20010000), vol. 75, pages 9037 - 9043-
DESCRIPTION- PERRI et al., J Virol, (20030000), vol. 77, pages 10394 - 10403-
DESCRIPTION- "Short protocols in molecular biology,", Current Protocols-
DESCRIPTION- SINGH et al., Pharmaceutical Research, (20030000), vol. 20, pages 247 - 251-
DESCRIPTION- TAYLOR et al., Vaccine, (20050000), vol. 23, pages 1242 - 50-
OPPOSITION- "About Us", Print-out of the TriLink Biotechnologies, URL: https://www.trilinkbiotech.com/about-us-
OPPOSITION- Anonymous, "High Yield Capped RNA Transcription Kit", mMessage mMachine Kit, Ambion, by life technologies, (20120101), pages 1 - 36, XP093137992-
OPPOSITION- Anonymous, "ScriptCapâ„¢ 2*-O-Methyltransferase", EPICENTRE* Biotechnologies, (20061113), pages 1 - 1, EPICENTRE* Biotechnologies, URL: http://www.epibio.com/item.asp?lD=500&CatlD=l2&SubCatlD=26, (20240305), XP093137965-
OPPOSITION- Anonymous, "ScriptCap™ m7G Capping System", EPICENTRE® Biotechnologies, (20061101), pages 1 - 2, EPICENTRE® Biotechnologies, URL: https://web.archive.org/web/20061116032247/http://www.epibio.com/item.asp?ID=498&CatlD=26 , (20240305), XP093137925-
OPPOSITION- Charles A. Janeway, Jr, "Appendix I Immunologists' Toolbox", Immunobiology, 5th Edition, New York, Garland Science, (20010101), pages 613 - 660, ISBN 0-8153-3642-X, XP009561422-
OPPOSITION- Cheng K., Qin B., "Cationic Lipids and Polymers", Cheng K., Qin B., Yi Lu • Ram L Mahato, Pharmaceutical Perspectives of Cancer Therapeutics, New York, NY, Springer US, (20090101), page 420, ISBN 978-1-4419-0131-6, XP093137979-
OPPOSITION- D94 - Expert opinion Prof. Peter Liljeström (2018), incl. Annexes A to K.-
OPPOSITION- Immordino Maria Laura; Dosio Franco; Cattel Luigi, "Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential", INTERNATIONAL JOURNAL OF NANOMEDICINE, DOVE MEDICAL PRESS LTD., AUCKLAND, NZ, AUCKLAND, NZ , (20060101), vol. 1, no. 3, ISSN 1176-9114, pages 297 - 315, XP009145524-
OPPOSITION- MacLachlan, Ian, "Chapter 9: Liposomal Formulations for Nucleic Acid Delivery", MacLachlan, Ian, CROOKE STANLEY T, ANTISENSE DRUG TECHNOLOGY: PRINCIPLES, STRATEGIES, AND APPLICATIONS, 2ND ED., US , CRC PRESS , (20070725), pages 237 - 270, ISBN 978-0-8493-8796-8, XP055915899-
OPPOSITION- MacLachlan I., "Liposomal formulations for nucleic acid delivery", MacLachlan I., CROOKE STANLEY T, ANTISENSE DRUG TECHNOLOGY: PRINCIPLES, STRATEGIES, AND APPLICATIONS, 2ND ED., US , CRC PRESS , (20070101), pages 237 - 270, ISBN 978-0-8493-8796-8, XP002584305-
OPPOSITION- Meis Judith E, Meis Ronald, "The New mscrip tTM mRNA Production System - Efficient mRNA Transcription, Capping and Tailing for the Highest Yields of Active Protein", EPICENTRE Biotechnolgies Forum, (20170101), vol. 14, no. 1, pages 1 - 3, XP093031513-
OPPOSITION- RICE et al., "Production of Infectious RNA Transcripts from Sinbis Virus cDNA Clones: Mapping of Lethal Mutations, Rescue of a Temperature-Sensitive Marker, and In Vitro Mutagenesis To Generate Defined Mutants", Journal of Virology, (19871200), vol. 61, no. 2, pages 3809 - 3819, XP093031508-
OPPOSITION- SHIN et al., "CleanCAP® Co-transcriptional Capping Streamlines mRNA Manufacturing", TriLink Biotechnologies, URL: https://www.trilinkbiotech.com/media/contentmanager/content/mRNA_WVC2_1.pdf-
OPPOSITION- Soriano Philippe et al, "Targeted and nontargeted liposomes for in vivo transfer to rat liver cells of a plasmid containing the preproinsulin I gene", Proc. Natl. Acad. Sci., (19830101), vol. 80, pages 7128 - 7131, XP093138003-
OPPOSITION- Shayne Cox, Steve Pascolo, "Chapter 7.2. Plasmid DNA and Messenger RNA for Therapy", Handbook of Pharmaceutical Biotechnology, John Wiley & Sons , (20070601), pages 971 - 1011, doi:10.1002/9780470117118.ch07b, ISBN 978-0-471-21386-4, XP055626043
OPPOSITION- MARTINON et al., "Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome- entrapped mRNA", European Journal of Immunology, (19930000), vol. 23, doi:10.1002/eji.1830230749, pages 1719 - 1722, XP002937540
OPPOSITION- MARTINON F, ET AL., "INDUCTION OF VIRUS-SPECIFIC CYTOTOXIC T LYMPHOCYTES IN VIVO BY LIPOSOME-ENTRAPPED MRNA", European Journal of Immunology, Wiley-VCH, Hoboken, USA, Hoboken, USA, (19930101), vol. 23, doi:10.1002/eji.1830230749, ISSN 0014-2980, pages 1719 - 1722, XP002937540
OPPOSITION- LI W, ET AL, "Low-pH-sensitive poly(ethylene glycol)(PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery", The Journal of Gene Medicine, John Wiley & Sons, Inc, US, US , (20050101), vol. 7, no. 1, doi:10.1002/JGM.634, ISSN 1099-498X, pages 67 - 79, XP008126013
OPPOSITION- RAYNER J O, DRYGA S A, KAMRUD K I, "ALPHAVIRUS VECTORS AND VACCINATION", REVIEWS IN MEDICAL VIROLOGY, CHICHESTER, GB, GB , (20020901), vol. 12, no. 05, doi:10.1002/rmv.360, ISSN 1052-9276, pages 279 - 296, XP008035758
OPPOSITION- ZHANG et al., "The Cytoplasmic Tails of the Influenza Virus Spike Glycoproteins Are Required for Normal Genome Packaging", Virology, (20000000), vol. 269, no. 2, doi:10.1006/viro.2000.0228, pages 325 - 334, XP004450270
OPPOSITION- PASCOLO S., "Vaccination with messenger RNA (mRNA", Handb Exp Pharmacol, (20080000), doi:10.1007/978-3-540-72167-3_11, pages 221 - 35, XP001538300
OPPOSITION- Lloyd B. Jeffs et al, "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, Kluwer Academic Publishers-Plenum Publishers, NL, NL , (20050301), vol. 22, no. 3, doi:10.1007/s11095-004-1873-z, ISSN 1573-904X, pages 362 - 372, XP019370801
OPPOSITION- Lloyd B. Jeffs ; Lorne R. Palmer ; Ellen G. Ambegia ; Cory Giesbrecht ; Shannon Ewanick ; Ian MacLachlan, "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, Kluwer Academic Publishers-Plenum Publishers, NL, NL , (20050301), vol. 22, no. 3, doi:10.1007/s11095-004-1873-z, ISSN 1573-904X, pages 362 - 372, XP019370801
OPPOSITION- WILSON et al., "The introduction of poliovirus RNA into cells via lipid vesicles (Liposomes", Cell, (19790000), vol. 17, doi:10.1016/0092-8674(79)90296-4, pages 77 - 84, XP023910555
OPPOSITION- Wilson, T. ; Papahadjopoulos, D. ; Taber, R., "The introduction of poliovirus RNA into cells via lipid vesicles (liposomes)", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (19790501), vol. 17, no. 1, doi:10.1016/0092-8674(79)90296-4, ISSN 0092-8674, pages 77 - 84, XP023910555
OPPOSITION- ZHOU et al., "Self-replicating Semliki forest virus RNA as recombinant vaccine", Vaccine, (19940000), vol. 12, no. 16, doi:10.1016/0264-410X(94)90074-4, pages 1510 - 1514, XP023937577
OPPOSITION- YAMAMOTO et al., "Current prospects for mRNA gene delivery", European Journal of Pharmaceutics and Biopharmaceutics, (20090000), vol. 71, doi:10.1016/j.ejpb.2008.09.016, pages 484 - 489, XP025992169
OPPOSITION- Kim, H.K. ; Davaa, E. ; Myung, C.S. ; Park, J.S., "Enhanced siRNA delivery using cationic liposomes with new polyarginine-conjugated PEG-lipid", International Journal of Pharmaceutics, ELSEVIER, NL, NL , (20100615), vol. 392, no. 1-2, doi:10.1016/j.ijpharm.2010.03.047, ISSN 0378-5173, pages 141 - 147, XP027044515
OPPOSITION- James Heyes et al, "'Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids", Journal of Controlled Release, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL , (20050101), vol. 107, no. 2, doi:10.1016/j.jconrel.2005.06.014, ISSN 0168-3659, pages 276 - 287, XP008157522
OPPOSITION- Obata, Y. ; Tajima, S. ; Takeoka, S., "Evaluation of pH-responsive liposomes containing amino acid-based zwitterionic lipids for improving intracellular drug delivery in vitro and in vivo", Journal of Controlled Release, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL , (20100303), vol. 142, no. 2, doi:10.1016/j.jconrel.2009.10.023, ISSN 0168-3659, pages 267 - 276, XP026905290
OPPOSITION- Wang, D. et al, "Intranasal immunization with liposome-encapsulated plasmid DNA encoding influenza virus hemagglutinin elicits mucosal, cellular and humoral immune responses", Journal of clinical virology, ELSEVIER, AMSTERDAM, NL, NL , (20041201), vol. 31, doi:10.1016/j.jcv.2004.09.013, ISSN 1386-6532, pages 99 - 106, XP004660136
OPPOSITION- SAXENA et al., "Induction of immune responses and protection in mice against rabies using a self-replicating RNA vaccine encoding rabies virus glycoprotein", Veterinary Microbiology, (20090000), doi:10.1016/j.vetmic.2008.10.030, pages 36 - 44, XP026071306
OPPOSITION- FURUICHI et al., "V iral and cellular mRNA capping: past and prospects", Adv Virus Res, (20000000), vol. 55, doi:10.1016/S0065-3527(00)55003-9, pages 135 - 84, XP009124440
OPPOSITION- Furuichi Y; Shatkin A J, "Viral and cellular mRNA capping: past and prospects", Advances in Virus Research, Academic Press, US, US , (20000101), vol. 55, doi:10.1016/S0065-3527(00)55003-9, ISSN 0065-3527, pages 135 - 184, XP009124440
OPPOSITION- Mebatsion Teshome, König Matthias, Conzelmann Karl-Klaus, "Budding of Rabies Virus Particles in the Absence of the Spike Glycoprotein", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (19960301), vol. 84, no. 6, doi:10.1016/S0092-8674(00)81072-7, ISSN 0092-8674, pages 941 - 951, XP093138009
OPPOSITION- Wong, J.P. et al, "DNA vaccination against respiratory influenza virus infection", Vaccine, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20010321), vol. 19, no. 17-19, doi:10.1016/S0264-410X(00)00474-6, ISSN 0264-410X, pages 2461 - 2467, XP004231066
OPPOSITION- YING et al., "Cancer therapy using a self-replicating RNA vaccine", Nature Medicine, (19990000), vol. 5, no. 7, doi:10.1038/10548, pages 823 - 827, XP002224504
OPPOSITION- FURUICHI et al., "5'-Terminal structure and mRNA stability", Nature, (19770317), vol. 266, doi:10.1038/266235a0, pages 235 - 239, XP037052445
OPPOSITION- Daffis Stephane; Szretter Kristy J.; Schriewer Jill; Li Jianqing; Youn Soonjeon; Errett John; Lin Tsai-Yu; Schneller Stewart; Zust Roland; Dong Hongping; Thiel Volker; Sen Ganes C.; Fensterl Volker; Klimstra William B.; Pierson Theodore C.; Buller R. Mark; Gale Jr Michael; Shi Pei-Yong; Diamond Michael S., "2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members", Nature, (20101101), vol. 468, no. 7322, doi:10.1038/nature09489, ISSN 0028-0836, pages 452 - 456, XP037065800
OPPOSITION- Sean C Semple et al, "Rational design of cationic lipids for siRNA delivery", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20100201), vol. 28, no. 2, doi:10.1038/NBT.1602, ISSN 1087-0156, pages 172 - 176, XP002633693
OPPOSITION- WHEELER et al., "Stabilized plasmid-lipid particles: construction and characterization", Gene Therapy, (19960000), vol. 6, doi:10.1038/sj.gt.3300821, pages 271 - 281, XP037770556
OPPOSITION- SCHIRRMACHER V. ET AL, "Intra-pinna anti-tumor vaccination with self-replicating infectious RNA or with DNA encoding a model tumor antigen and a cytokine", Gene Therapy, Nature Publishing Group, London, GB, GB , (20000701), vol. 7, no. 13, doi:10.1038/sj.gt.3301220, ISSN 0969-7128, pages 1137 - 1147, XP002359468
OPPOSITION- COWLING, "Regulation of mRNA cap methylation", Biochem. J., (20100115), vol. 425, doi:10.1042/BJ20091352, pages 295 - 302, XP055980156
OPPOSITION- Yoffe Aron M., Prinsen Peter, Gopal Ajaykumar, Knobler Charles M., Gelbart William M., Ben-Shaul Avinoam, "Predicting the sizes of large RNA molecules", Proceedings of the National Academy of Sciences (PNAS), National Academy of Sciences, (20081021), vol. 105, no. 42, doi:10.1073/pnas.0808089105, ISSN 0027-8424, pages 16153 - 16158, XP093284207
OPPOSITION- NICOLAU et al., "In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin", Proc. Natl. Acad. Sci. USA, (19830000), vol. 80, doi:10.1073/pnas.80.4.1068, pages 1068 - 1072, XP000602251
OPPOSITION- POLO et al., "Stable alphavirus packaging cell lines for Sindbis virus- and Semliki Forest virus-derived vectors", Proc. Natl. Aca. Sci, (19990400), vol. 96, doi:10.1073/pnas.96.8.4598, pages 4598 - 4603, XP002139370
OPPOSITION- WHITE et al., "Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme", Critical Reviews in Biochemistry and Molecule Biology, (20080000), vol. 43, doi:10.1080/10409230802058320, pages 189 - 219, XP055326250
OPPOSITION- FLEETON M.N. ET AL, "Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus.", Journal of Infectious Diseases, University of Chicago Press, US, US , (20010501), vol. 183, no. 9, doi:10.1086/319857, ISSN 0022-1899, pages 1395 - 1398, XP002224503
OPPOSITION- Gopi S. Mohan et al, "Less is more: ebola virus surface glycoprotein expression levels regulate virus production and infectivity", Journal of Virology, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, US , (20150115), vol. 89, no. 2, doi:10.1128/JVI.01810-14, ISSN 0022-538X, pages 1205 - 1217, XP055544944
OPPOSITION- Anita Bringmann et al, "RNA Vaccines in Cancer Treatment", Journal of Biomedicine and Biotechnology, vol. 2010, doi:10.1155/2010/623687, ISSN 1110-7243, pages 1 - 12, XP002765542
OPPOSITION- Anita Bringmann, Stefanie Andrea Erika Held, Annkristin Heine, Peter Brossart, "RNA Vaccines in Cancer Treatment", Journal of Biomedicine and Biotechnology, vol. 2010, doi:10.1155/2010/623687, ISSN 1110-7243, pages 1 - 12, XP002765542
OPPOSITION- S. Sonoke, T. Ueda, K. Fujiwara, Y. Sato, K. Takagaki, K. Hirabayashi, T. Ohgi, J. Yano, "Tumor Regression in Mice by Delivery of Bcl-2 Small Interfering RNA with Pegylated Cationic Liposomes", Cancer research, American Association for Cancer Research, (20081101), vol. 68, no. 21, doi:10.1158/0008-5472.CAN-08-0127, ISSN 00085472, pages 8843 - 8851, XP055046252
OPPOSITION- MANNING E J, MILLSON G C, "INFECTIVITY OF LIPOSOMALLY ENCAPSULATED NUCLEIC ACIDS ISOLATED FROMEMC VIRUS AND SCRAPIE-INFECTED MOUSE BRAIN", INTERVIROLOGY., KARGER, CH, CH , (19830101), vol. 20, no. 02/03, doi:10.1159/000149387, ISSN 0300-5526, pages 164 - 168, XP001005390
OPPOSITION- D. B. Fenske, A. Chonn, P. R. Cullis, "Liposomal Nanomedicines: An Emerging Field", Toxicologic Pathology, (20080101), vol. 36, no. 1, doi:10.1177/0192623307310960, ISSN 01926233, pages 21 - 29, XP055179556
OPPOSITION- FENSKE et al., "Liposomal nanomedicines: An emerging field", Toxicologic Pathology, (20080000), vol. 36, doi:10.1177/0192623307310960, pages 21 - 29, XP055179556
OPPOSITION- Joanna Kowalska, Magdalena Lewdorowicz, Joanna Zuberek, Ewa Grudzien-Nogalska, Elzbieta Bojarska, Janusz Stepinski, Robert E. Rhoads, Edward Darzynkiewicz, Richard E. Davis, Jacek Jemielity, "Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS", RNA, COLD SPRING HARBOR LABORATORY PRESS, US, US , (20080601), vol. 14, no. 6, doi:10.1261/rna.990208, ISSN 1355-8382, pages 1119 - 1131, XP002554206
OPPOSITION- PASCOLO S., "Messenger RNA-based vaccines", Expert Opin Biol Ther, (20040800), vol. 4, no. 8, doi:10.1517/14712598.4.8.1285, pages 1285 - 94, XP009095328
SEARCH- BETTINGER T ET AL, "RECENT DEVELOPMENTSIN RNA-BASED STRATEGIES FOR CANCER GENE THERAPY", CURRENT OPINION IN MOLECULAR THERAPEUTICS, CURRENT DRUGS, LONDON, GB, (20010401), vol. 3, no. 2, ISSN 1464-8431, pages 116 - 124, XP009058461 [A] 1-15 * p 117, left-hand column, last paragraph *-
SEARCH- WILSON T ET AL, "The introduction of poliovirus RNA into cells via lipid vesicles (liposomes)", CELL, ELSEVIER, AMSTERDAM NL, vol. 17, no. 1, doi:10.1016/0092-8674(79)90296-4, ISSN 0092-8674, (19790501), pages 77 - 84, (19790501), XP023910555 [I] 1-2,4-15 * abstract; p 78, left-hand column, 1st paragraph; p 83, left-hand column, paragraphs 3-5; Tables 2-4 *
SEARCH- SAXENA S ET AL, "Induction of immune responses and protection in mice against rabies using a self-replicating RNA vaccine encoding rabies virus glycoprotein", VETERINARY MICROBIOLOGY, ELSEVIER BV, NL, vol. 136, no. 1-2, doi:10.1016/J.VETMIC.2008.10.030, ISSN 0378-1135, (20090414), pages 36 - 44, (20081105), XP026071306 [A] 1-15 * section 2.2 *
SEARCH- M MOCKEY ET AL, "mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes", CANCER GENE THERAPY, (20070901), vol. 14, no. 9, doi:10.1038/sj.cgt.7701072, ISSN 0929-1903, pages 802 - 814, XP055007324 [A] 1-15 * p 803, right-hand column, 3rd paragraph *
SEARCH- MANNING E J ET AL, "INFECTIVITY OF LIPOSOMALLY ENCAPSULATED NUCLEIC ACIDS ISOLATED FROMEMC VIRUS AND SCRAPIE-INFECTED MOUSE BRAIN", INTERVIROLOGY, KARGER, CH, (19830101), vol. 20, no. 2/03, doi:10.1159/000149387, ISSN 0300-5526, pages 164 - 168, XP001005390 [A] 1-15 * the whole document *
SEARCH- W Van Der Velden ET AL, "Vector Design for Optimal Protein Expression", doi:10.2144/01313rr02, (20010901), URL: https://www.future-science.com/doi/pdf/10.2144/01313rr02, (20200213), XP055668162 [A] 1-15 * p 576, left-hand column, 2nd paragraph ff. *

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