System And Method For Protein Corona Sensor Array For Early Detection Of Diseases - EP4056263

The patent EP4056263 was granted to The Brigham And Womens Hospital on Aug 28, 2024. The application was originally filed on Dec 18, 2017 under application number EP21216039A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP4056263

THE BRIGHAM AND WOMENS HOSPITAL
Application Number
EP21216039A
Filing Date
Dec 18, 2017
Status
Granted And Under Opposition
Jul 26, 2024
Grant Date
Aug 28, 2024
External Links
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KLUNKERMay 27, 2025KLUNKER PATENTANWALTE PARTG MBBADMISSIBLE

Patent Citations (2) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS7375234
OPPOSITIONWO2018046542

Non-Patent Literature (NPL) Citations (46) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ANDRIOLE GCRAWFORD EGRUBB R et al., "Mortality results from a randomized prostate-cancer screening trial", New England Journal of Medicine, (20090000), vol. 360, no. 13, pages 1310 - 1319-
DESCRIPTION- BUYS SSPARTRIDGE EBLACK A et al., "Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial", JAMA, (20110000), vol. 305, no. 22, pages 2295 - 2303-
DESCRIPTION- CHINTAMANENIBHASKAR, "Biomarkers in Alzheimer's Disease: A Review", ISRN Pharmacol, (20120628), vol. 2012, page 984786-
DESCRIPTION- CRAMER DWBAST RC JRBERG CD et al., "Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens", Cancer Prevention Research, (20110000), vol. 4, no. 3, pages 365 - 374-
DESCRIPTION- "Label-free quantitative analysis for studying the interactions between nanoparticles and plasma proteins", Analytical and Bioanalytical Chemistry, (20130000), vol. 405, no. 2-3, pages 635 - 645-
DESCRIPTION- MAHMOUDI et al., "Protein-Nanoparticle Interactions: Opportunities and Challenges", Chem. Rev., (20110000), vol. 111, no. 9, pages 5610 - 5637-
DESCRIPTION- MILANI et al., "Reversible versus Irreversible Binding of Transferring to Polystyrene Nanoparticles: Soft and Hard Corona", ACS NANO, (20120000), vol. 6, no. 3, pages 2532 - 2541-
DESCRIPTION- MIRSHAFIEE et al., "Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake", Biomaterials, (20160100), vol. 75, pages 295 - 304-
DESCRIPTION- M. RAHMAN et al., "Protein-Nanoparticle Interactions", Spring Series in Biophysics, (20130000), vol. 15-
DESCRIPTION- SAHA, K.RAHIMI, M.YAZDANI, M.KIM, S. T.MOYANO, D. F.HOU, S.DAS, R.MOUT, R.REZAEE, F.MAHMOUDI, M., ACS nano, (20160000), vol. 10, no. 4, pages 4421 - 4430-
DESCRIPTION- SCHRODER FHHUGOSSON JROOBOL MJ et al., "Screening and prostate-cancer mortality in a randomized European study", New England Journal of Medicine, (20090000), vol. 360, no. 13, pages 1320 - 1328-
DESCRIPTION- "Shotgun proteomic analytical approach for studying proteins adsorbed onto liposome surface", Analytical and Bioanalytical Chemistry, (20130000), vol. 401, no. 4, pages 1195 - 1202-
DESCRIPTION- VAN HOLTEN et al., "Ciculating Biomarkers for Predicting Cardiovascular Disease Risk; a Systemic Review and Comprehensive Overview of Meta-Analyses", PLoS One, (20130000), vol. 8, no. 4, page e62080-
DESCRIPTION- YI FENGMINGWU JIANBING, "Biomarkers of Inflammatory Bowel Disease", Disease Markers, (20140000), vol. 2014, page 11-
DESCRIPTION- MAHMOUDI et al., "Emerging understanding of the protein corona at the nano-bio interfaces", Nanotoday, (20161200), vol. 11, no. 6, doi:10.1016/j.nantod.2016.10.005, pages 817 - 832, XP029840844
OPPOSITION- D10a - Evidence for the publication date of D20 being November 23, 2016-
OPPOSITION- D11 - Yiäitbasl, T. (2012) in “Trends in Immunolabelled and Related Tech- niques”, Abuelzein, E. (ed), InTech (pub), pages 351-360 “Multiplex Immunoassay and Bead Based Multiplex”-
OPPOSITION- D2a - Evidence for the publication date of D9 being August 14, 2017-
OPPOSITION- D8a - Tables S9 and $10 of the supplementary data of D18-
OPPOSITION- Karuna Giri, "Engineered gold nanoparticles for identification of novel ovarian cancer biomarkers ", Thesis, (20160101), pages 1 - 150, XP093166199-
OPPOSITION- Marta Bally, Kelly Bailey, Kaori Sugihara, Dorothee Grieshaber, Janos Vörös, Brigitte Städler, "Liposome and Lipid Bilayer Arrays Towards Biosensing Applications", Small, Wiley, (20101122), vol. 6, no. 22, doi:10.1002/smll.201000644, ISSN 16136810, pages 2481 - 2497, XP055078236
OPPOSITION- Anna Laura Capriotti; Giulio Caracciolo; Chiara Cavaliere; Carlo Crescenzi; Daniela Pozzi; Aldo Laganà, "Shotgun proteomic analytical approach for studying proteins adsorbed onto liposome surface", Analytical and Bioanalytical Chemistry, Springer, Berlin, DE, Berlin, DE , (20110702), vol. 401, no. 4, doi:10.1007/s00216-011-5188-8, ISSN 1618-2650, pages 1195 - 1202, XP019935533
OPPOSITION- Dominic Docter, Ute Distler, Wiebke Storck, Jörg Kuharev, Desirée Wünsch, Angelina Hahlbrock, Shirley K Knauer, Stefan Tenzer, Roland H Stauber, "Quantitative profiling of the protein coronas that form around nanoparticles", Nature Protocols, Nature Publishing Group, GB, GB , (20140901), vol. 9, no. 9, doi:10.1038/nprot.2014.139, ISSN 1754-2189, pages 2030 - 2044, XP055681761
OPPOSITION- Hajipour Mohammad J., Laurent Sophie, Aghaie Afsaneh, Rezaee Farhad, Mahmoudi Morteza, "Personalized protein coronas: a “key” factor at the nanobiointerface", Biomaterials Science, The Royal Society of Chemistry, (20140101), vol. 2, no. 9, doi:10.1039/C4BM00131A, ISSN 2047-4830, page 1210, XP093282477
OPPOSITION- Corbo Claudia, Molinaro Roberto, Tabatabaei Mateen, Farokhzad Omid C., Mahmoudi Morteza, "Personalized protein corona on nanoparticles and its clinical implications", Biomaterials Science, The Royal Society of Chemistry, (20170101), vol. 5, no. 3, doi:10.1039/C6BM00921B, ISSN 2047-4830, pages 378 - 387, XP093282473
OPPOSITION- S. Palchetti, Digiacomo L., Pozzi D., Peruzzi G., Micarelli E., Mahmoudi M., Caracciolo G., "Nanoparticles-cell association predicted by protein corona fingerprints", Nanoscale, Royal Society of Chemistry, United Kingdom, United Kingdom , (20160801), vol. 8, no. 25, doi:10.1039/C6NR03898K, ISSN 2040-3364, pages 12755 - 12763, XP055681674
OPPOSITION- D. Caputo, M. Papi, R. Coppola, S. Palchetti, L. Digiacomo, G. Caracciolo, D. Pozzi, "A protein corona-enabled blood test for early cancer detection", Nanoscale, Royal Society of Chemistry, United Kingdom, United Kingdom , (20170101), vol. 9, no. 1, doi:10.1039/C6NR05609A, ISSN 2040-3364, pages 349 - 354, XP055678638
OPPOSITION- Rahman M.; Mahmoudi M., "Disease specific protein corona", Progress in Biomedical Optics and Imaging, SPIE - International Society for Optical Engineering, BELLINGHAM, WA, US, BELLINGHAM, WA, US , (20150311), vol. 9338, doi:10.1117/12.2079771, ISSN 1605-7422, ISBN 978-1-5106-0027-0, pages 93380V - 93380V-8, XP060049391
OPPOSITION- Rochelle R. Arvizo , Arvizo,Karuna Giri,Daniel Moyano,Oscar R. Miranda,Benjamin Madden,Daniel J. McCormick,Resham Bhattacharya,Vincent M. Rotello,Jean-Pierre Kocher,Priyabrata Mukherjee, "Identifying New Therapeutic Targets via Modulation of Protein Corona Formation by Engineered Nanoparticles", PLOS ONE, Public Library of Science, US, US , (20120319), vol. 7, no. 3, doi:10.1371/journal.pone.0033650, ISSN 1932-6203, pages 1 - 8, XP093166210
OPPOSITION- Affif Zaccaria, Et Al., "Accessing to the minor proteome of red blood cells through the influence of the nanoparticle surface properties on the corona composition", International Journal of Nanomedicine, (20150301), vol. 10, doi:10.2147/IJN.S70503, pages 1869 - 1883, XP055375217
OPPOSITION- Mohammad Javad Hajipour 1 2 3, Forough Ghasemi 4, Haniyeh Aghaverdi 2, Mohammad Raoufi 2 5, Uwe Linne 6, Fatemeh Atyabi 2, Iraj Nabipour 1, Morteza Azhdarzadeh 2, Hossein Derakhshankhah 7, Alireza Lotfabadi 7, Afshar Bargahi 1, Zahra Alekhamis 2, Afsaneh Aghaie 8, Ehsan Hashemi 9, Abbas Tafakhori 10, Vajiheh Aghamollaii 11, Marzie Maserat Mashhadi 10, Sara Sheibani 12, Hojatollah Vali 12, Morteza Mahmoudi 2, "Sensing of Alzheimer’s Disease and Multiple Sclerosis Using Nano- Bio interfaces", Journal of Alzheimer`s Disease, IOS Press, NL, NL , (20170101), vol. 59, no. 4, doi:10.3233/JAD-160206, ISSN 1387-2877, pages 1187 - 1202, XP009561344
OTHER- Türkan Yiğitbaşı, "Multiplex Immunoassay and Bead Based Multiplex", (20120427), URL: https://www.researchgate.net/profile/Ravichandran_Panchanathan/post/What_are_differences_of_different_types_of_multiplex_cytokine_ELISA/attachment/59d61ddf79197b807797b6fb/AS:273775503839238@1442284574432/download/36219.pdf, (20191217), XP055653741-
OTHER- Marta Bally, Kelly Bailey, Kaori Sugihara, Dorothee Grieshaber, Janos Vörös, Brigitte Städler, "Liposome and Lipid Bilayer Arrays Towards Biosensing Applications", Small, (20101122), vol. 6, no. 22, doi:10.1002/smll.201000644, ISSN 16136810, pages 2481 - 2497, XP055078236
OTHER- Stefan Tenzer, Dominic Docter, Susanne Rosfa, Alexandra Wlodarski, Jörg Kuharev, Alexander Rekik, Shirley K. Knauer, Christoph Bantz, Thomas Nawroth, Carolin Bier, Jarinratn Sirirattanapan, Wolf Mann, Lennart Treuel, Reinhard Zellner, Michael Maskos, Hansjörg Schild, Roland H. Stauber, "Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis", ACS Nano, US , (20110927), vol. 5, no. 9, doi:10.1021/nn201950e, ISSN 1936-0851, pages 7155 - 7167, XP055681195
OTHER- Dominic Docter, Ute Distler, Wiebke Storck, Jörg Kuharev, Desirée Wünsch, Angelina Hahlbrock, Shirley K Knauer, Stefan Tenzer, Roland H Stauber, "Quantitative profiling of the protein coronas that form around nanoparticles", Nature Protocols, GB , (20140901), vol. 9, no. 9, doi:10.1038/nprot.2014.139, ISSN 1754-2189, pages 2030 - 2044, XP055681761
OTHER- Giulio Caracciolo, Reihaneh Safavi-Sohi, Reza Malekzadeh, Hossein Poustchi, Mahdi Vasighi, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Aldo Laganà, Mohammad Hajipour, Marina Di Domenico, Angelina Di Carlo, Damiano Caputo, Haniyeh Aghaverdi, Massimiliano Papi, Valentina Palmieri, Angela Santoni, Sara Palchetti, Luca Digiacomo, Daniela Pozzi, Kenneth S. Suslick, Morteza Mahmoudi, "Disease-specific protein corona sensor arrays may have disease detection capacity", Nanoscale Horizons, (20190819), vol. 4, no. 5, doi:10.1039/C9NH00097F, ISSN 2055-6756, pages 1063 - 1076, XP055681766
OTHER- Rahman M.; Mahmoudi M., "Disease specific protein corona", Progress in Biomedical Optics and Imaging, SPIE - International Society for Optical Engineering, BELLINGHAM, WA, US , (20150311), vol. 9338, doi:10.1117/12.2079771, ISSN 1605-7422, ISBN 978-1-5106-0027-0, pages 93380V - 93380V-8, XP060049391
SEARCH- Türkan Yigitbasi, "Multiplex Immunoassay and Bead Based Multiplex", (20120427), URL: https://www.researchgate.net/profile/Ravichandran_Panchanathan/post/What_are_differences_of_different_types_of_multiplex_cytokine_ELISA/attachment/59d61ddf79197b807797b6fb/AS:273775503839238@1442284574432/download/36219.pdf, (20191217), XP055653741 [A] 1-15 * the whole document * * figure 1 *-
SEARCH- MARTA BALLY ET AL, "Liposome and Lipid Bilayer Arrays Towards Biosensing Applications", SMALL, (20101122), vol. 6, no. 22, doi:10.1002/smll.201000644, ISSN 1613-6810, pages 2481 - 2497, XP055078236 [A] 1-15 * the whole document * * Scheme 1 *
SEARCH- STEFAN TENZER ET AL, "Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis", ACS NANO, US, (20110927), vol. 5, no. 9, doi:10.1021/nn201950e, ISSN 1936-0851, pages 7155 - 7167, XP055681195 [A] 1-15 * the whole document * * abstract * * figure 3 *
SEARCH- LIN JIANG ET AL, "Patterning of Plasmonic Nanoparticles into Multiplexed One-Dimensional Arrays Based on Spatially Modulated Electrostatic Potential", ACS NANO, US, (20111025), vol. 5, no. 10, doi:10.1021/nn202967f, ISSN 1936-0851, pages 8288 - 8294, XP055681733 [A] 1-15 * the whole document * * figure 4 *
SEARCH- DOMINIC DOCTER ET AL, "Quantitative profiling of the protein coronas that form around nanoparticles", NATURE PROTOCOLS, GB, (20140731), vol. 9, no. 9, doi:10.1038/nprot.2014.139, ISSN 1754-2189, pages 2030 - 2044, XP055681761 [A] 1-15 * the whole document * * abstract * * figure 2 *
SEARCH- JON R. ASKIM ET AL, "Optical sensor arrays for chemical sensing: the optoelectronic nose", CHEMICAL SOCIETY REVIEWS, (20130101), vol. 42, no. 22, doi:10.1039/c3cs60179j, ISSN 0306-0012, page 8649, XP055128546 [A] 1-15 * the whole document *
SEARCH- S. PALCHETTI ET AL, "Nanoparticles-cell association predicted by protein corona fingerprints", NANOSCALE, United Kingdom, (20160801), vol. 8, no. 25, doi:10.1039/C6NR03898K, ISSN 2040-3364, pages 12755 - 12763, XP055681746 [A] 1-15 * the whole document * * abstract * * figure 2 *
SEARCH- GIULIO CARACCIOLO ET AL, "Disease-specific protein corona sensor arrays may have disease detection capacity", NANOSCALE HORIZONS, (20190101), vol. 4, no. 5, doi:10.1039/C9NH00097F, ISSN 2055-6756, pages 1063 - 1076, XP055681766 [T] * the whole document * * abstract *
SEARCH- RAHMAN M ET AL, "Disease specific protein corona", PROGRESS IN BIOMEDICAL OPTICS AND IMAGING, SPIE - INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, BELLINGHAM, WA, US, (20150311), vol. 9338, doi:10.1117/12.2079771, ISSN 1605-7422, ISBN 978-1-5106-0027-0, pages 93380V - 93380V, XP060049391 [A] 1-15 * the whole document * * abstract * * figure 1 *

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