| DESCRIPTION | - AB FLUSBERG et al., Nat Methods, (20100000), vol. 7, pages 461 - 465 | - |
| DESCRIPTION | - AB SPARKS et al., Am J Obstet Gynecol, (20120000), vol. 206, page 319 | - |
| DESCRIPTION | - A SRINIVASAN et al., Am J Hum Genet, (20130000), vol. 92, pages 167 - 176 | - |
| DESCRIPTION | - BA FLUSBERG et al., Nat Methods, vol. 7, pages 461 - 465 | - |
| DESCRIPTION | - B NOVAKOVIC et al., Placenta, (20120000), vol. 33, pages 959 - 970 | - |
| DESCRIPTION | - B VOGELSTEIN et al., Proc Natl Acad Sci USA, (19990000), vol. 96, pages 9236 - 9241 | - |
| DESCRIPTION | - BW FUTSCHER et al., Nat Genet, (20020000), vol. 31, pages 1236 - 1242 | - |
| DESCRIPTION | - B ZIMMERMANN et al., Prenat Diagn, (20120000), vol. 32, pages 1233 - 1241 | - |
| DESCRIPTION | - CG LIAN et al., Cell, (20120000), vol. 150, pages 1135 - 1146 | - |
| DESCRIPTION | - DW BIANCHI DW et al., Obstet Gynecol, (20120000), vol. 119, pages 890 - 901 | - |
| DESCRIPTION | - DWY TSUI et al., PLoS One, (20100000), vol. 5, page e15069 | - |
| DESCRIPTION | - EA PAPAGEORGIOU et al., Am J Pathol, (20090000), vol. 174, pages 1609 - 1618 | - |
| DESCRIPTION | - E GEBHART et al., Cytogenet Genome Res, (20040000), vol. 104, pages 352 - 358 | - |
| DESCRIPTION | - EZ CHEN et al., PLoS One, (20110000), vol. 6, page e21791 | - |
| DESCRIPTION | - G HANNUM et al., Mol Cell, (20130000), vol. 49, pages 359 - 367 | - |
| DESCRIPTION | - GJ LIAO et al., PLoS One, (20120000), vol. 7, page e38154 | - |
| DESCRIPTION | - H HIURA et al., Hum Reprod, (20120000), vol. 27, pages 2541 - 2548 | - |
| DESCRIPTION | - JG HERMAN et al., N Engl J Med, (20030000), vol. 349, pages 2042 - 2054 | - |
| DESCRIPTION | - J SHIM et al., Sci Rep, (20130000), vol. 3, page 1389 | - |
| DESCRIPTION | - KCA CHAN et al., Clin Chem, (20040000), vol. 50, pages 88 - 92 | - |
| DESCRIPTION | - KCA CHAN et al., Clin Chem, (20130000), vol. 59, pages 211 - 832 | - |
| DESCRIPTION | - KE HAWORTH et al., Epigenomics, (20130000), vol. 5, pages 37 - 49 | - |
| DESCRIPTION | - LG ACEVEDO et al., Epigenomics, (20110000), vol. 3, pages 93 - 101 | - |
| DESCRIPTION | - L LAURENT et al., Genome Res, (20100000), vol. 20, pages 320 - 331 | - |
| DESCRIPTION | - LLM POON et al., Clin Chem, (20020000), vol. 48, pages 421 - 41 | - |
| DESCRIPTION | - MA GAMA-SOSA et al., Nucleic Acids Res, (19830000), vol. 11, pages 6883 - 6894 | - |
| DESCRIPTION | - M EHRLICH et al., Oncogene, (20020000), vol. 21, pages 5400 - 5413 | - |
| DESCRIPTION | - M ESTELLER et al., Nat Rev Genet, (20070000), vol. 8, pages 286 - 298 | - |
| DESCRIPTION | - M FROMMER et al., Proc Natl Acad Sci USA, (19920000), vol. 89, pages 1827 - 31 | - |
| DESCRIPTION | - M GARDINER-GARDEN et al., J Mol Biol, (19870000), vol. 196, pages 261 - 282 | - |
| DESCRIPTION | - MJ BOOTH et al., Nature Protocols, vol. 8, pages 1841 - 1851 | - |
| DESCRIPTION | - MJ BOOTH et al., Science, (20120000), vol. 336, pages 934 - 937 | - |
| DESCRIPTION | - M KRZYWINSKI et al., Genome Res, (20090000), vol. 19, pages 1639 - 1645 | - |
| DESCRIPTION | - M KULIS et al., Nat Genet, (20120000), vol. 44, pages 1236 - 1242 | - |
| DESCRIPTION | - M YU et al., Nat Protoc, (20120000), vol. 7, pages 2159 - 2170 | - |
| DESCRIPTION | - N HAJJ et al., Diabetes. doi: 10.2337/dbl2-0289 | - |
| DESCRIPTION | - PA FUJITA et al., Nucleic Acids Res, (20110000), vol. 39, pages D876 - 882 | - |
| DESCRIPTION | - PA JONES et al., Cell, (20070000), vol. 128, pages 683 - 692 | - |
| DESCRIPTION | - PA JONES et al., Cell, vol. 128, pages 683 - 692 | - |
| DESCRIPTION | - P JIANG et al., "Methy-Pipe: An integrated bioinformatics data analysis pipeline for whole genome methylome analysis", IEEE International Conference on Bioinformatics and Biomedicine Workshops, Hong Kong, (20101218), page 20101218 | - |
| DESCRIPTION | - P TANGKIJVANICH et al., Clin Chim Acta, (20070000), vol. 379, pages 127 - 133 | - |
| DESCRIPTION | - RJ LEARY et al., Sci Transl Med, (20120000), vol. 4, pages 162 - 154 | - |
| DESCRIPTION | - R LI et al., Bioinformatics, (20090000), vol. 25, pages 1966 - 1967 | - |
| DESCRIPTION | - R LISTER et al., Cell, (20080000), vol. 133, pages 523 - 536 | - |
| DESCRIPTION | - R LISTER et al., Nature, (20090000), vol. 462, pages 315 - 322 | - |
| DESCRIPTION | - RWK CHIU et al., Am J Pathol, (20070000), vol. 170, pages 941 - 950 | - |
| DESCRIPTION | - RWK CHIU et al., BMJ, (20110000), vol. 342, page c7401 | - |
| DESCRIPTION | - RWK CHIU et al., Proc Natl Acad Sci USA, (20070000), vol. 104, pages 13116 - 13121 | - |
| DESCRIPTION | - RWK CHIU et al., Proc Natl Acad Sci USA, (20080000), vol. 105, pages 20458 - 20463 | - |
| DESCRIPTION | - SB BAYLIN et al., Nat Rev Cancer, vol. 11, pages 726 - 734 | - |
| DESCRIPTION | - SCY YU et al., PLoS One, (20130000), vol. 8, page e60968 | - |
| DESCRIPTION | - S.S.C. CHIM et al., Clin Chem, (20080000), vol. 54, pages 500 - 511 | - |
| DESCRIPTION | - SSC CHIM et al., Proc Natl Acad Sci USA, (20050000), vol. 102, pages 14753 - 14758 | - |
| DESCRIPTION | - TM SNYDER et al., Proc Natl Acad Sci USA, (20110000), vol. 108, pages 6229 - 6234 | - |
| DESCRIPTION | - WOODFINE et al., Epigenetics Chromatin, (20110000), vol. 4, page 1 | - |
| DESCRIPTION | - X JIANG et al., FASEB J, (20120000), vol. 26, pages 3563 - 3574 | - |
| DESCRIPTION | - Y LI et al., PLoS Biol, (20100000), vol. 8, page e1000533 | - |
| DESCRIPTION | - YMD LO et al., Am J Hum Genet, (19980000), vol. 62, pages 768 - 775 | - |
| DESCRIPTION | - YMD LO et al., Lancet, (19980000), vol. 351, pages 1329 - 1330 | - |
| DESCRIPTION | - YMD LO et al., Sci Transl Med, (20100000), vol. 2, pages 61 - 91 | - |
| DESCRIPTION | - YW ZHENG et al., Clin Chem, (20120000), vol. 58, pages 549 - 558 | - |
| OPPOSITION | - D21-European Search Opinion issued on EP 22 171 427.2 | - |
| OPPOSITION | - D26 - Declaration Prof. Peiyong Jiang dated 8 January 2025 | - |
| OPPOSITION | - D31-Patentee’s submission of January 9, 2025 in pending opposition proceedings relating to EP 3 536 807 B1 | - |
| OPPOSITION | - D32 - Expert Declaration Rossa Chiu | - |
| OPPOSITION | - James G Herman, Graff Jeremy R, Myohanen Sanna, Nelkin Barry D, Baylin Stephen B, "Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands (DNA methylation/tumor suppressor genes/p16/p15)", Proc. Natl. Acad. Sci, (19960901), vol. 93, pages 9821 - 9826, XP055092786 | - |
| OPPOSITION | - Lizardi Paul M, Qin Yan, And Narendra Wajapeyee, "Analysis of DNA Methylation in Mammalian Cells", Lizardi Paul M, Qin Yan, And Narendra Wajapeyee, Michael R. Green , Joseph Sambrook, Molecular Cloning - A laboratory manual, New York, Cold Spring Harbor Laboratory Press, (20120101), pages 893 - 941, ISBN 978-1-936113-41-5, XP093276891 | - |
| OPPOSITION | - Shipp , "A predictive model for aggressive non-Hodgkin's lymphoma - The International Non-Hodgkin's Lymphoma Prognostic Factors Project", The New England Journal of Medicine, (19930101), vol. 329, no. 14, pages 987 - 989, XP093276858 | - |
| OPPOSITION | - Watanabe Yoshihisa, "Methylation of DNA in cancer", Advances in clinical chemistry, (20100101), vol. 52, pages 145 - 167, XP055878833 | - |
| OPPOSITION | - Charlson, M.E. ; Pompei, P. ; Ales, K.L. ; MacKenzie, C.R., "A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation", Journal of Chronic Diseases, (19870101), vol. 40, no. 5, doi:10.1016/0021-9681(87)90171-8, ISSN 0021-9681, pages 373 - 383, XP023088372 | |
| OPPOSITION | - Miljana Tanic et al., "Epigenome-wide association studies for cancer biomarker discovery in circulating cell-free DNA: technical advances and challenges", Current Opinion in Genetics & Development, (2017), vol. 42, doi:10.1016/j.gde.2017.01.017, XP085034155 | |
| OPPOSITION | - Ziegler Annemarie, Zangemeister-Wittke Uwe, Stahel Rolf A, "Circulating DNA: a new diagnostic gold mine?", Cancer Treatment Reviews, AMSTERDAM, NL , (20021001), vol. 28, no. 5, doi:10.1016/S0305-7372(02)00077-4, ISSN 0305-7372, pages 255 - 271, XP055878809 | |
| OPPOSITION | - Qiong Yang, Ying Dong, Wei Wu, Chunlei Zhu, Hui Chong, Jiangyang Lu, Dehai Yu, Libing Liu, Fengting Lv , Shu Wang, "Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation", Nature Communications, (20120101), vol. 3, no. 1, doi:10.1038/ncomms2209, pages 1 - 8, XP055878820 | |
| OPPOSITION | - Guo Shicheng, Diep Dinh, Plongthongkum Nongluk, Fung Ho-Lim, Zhang Kang, Zhang Kun, "Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA", Nature Genetics, New York, (20170401), vol. 49, no. 4, doi:10.1038/ng.3805, ISSN 1061-4036, pages 635 - 642, XP093043427 | |
| OPPOSITION | - K. C. A. Chan, P. Jiang, C. W. M. Chan, K. Sun, J. Wong, E. P. Hui, S. L. Chan, W. C. Chan, D. S. C. Hui, S. S. M. Ng, H. L. Y. Chan, C. S. C. Wong, B. B. Y. Ma, A. T. C. Chan, P. B. S. Lai, H. Sun, R. W. K. Chiu, Y. M. D. Lo, "Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20131119), vol. 110, no. 47, doi:10.1073/pnas.1313995110, ISSN 00278424, pages 18761 - 18768, XP055181312 | |
| OPPOSITION | - Wenyuan Li, Qingjiao Li, Shuli Kang, Mary Same, Yonggang Zhou, Carol Sun, Chun-Chi Liu, Lea Matsuoka, Linda Sher, Wing Hung Wong, Frank Alber, Xianghong jasmine Zhou, "CancerDetector: ultrasensitive and non-invasive cancer detection at the resolution of individual reads using cell-free DNA methylation sequencing data", Nucleic Acids Research, Information Retrieval Ltd., (20180906), vol. 46, no. 15, doi:10.1093/nar/gky423, ISSN 0305-1048, pages e89 - e89, XP055692134 | |
| OPPOSITION | - Louise Laurent , Eleanor Wong, Guoliang Li, Tien Huynh, Aristotelis Tsirigos, Chin Thing Ong, Hwee Meng Low, Ken Wing Kin Sung, Isidore Rigoutsos, Jeanne Loring, Chia-Lin Wei, "Dynamic changes in the human methylome during differentiation", Genome Research, US , (20100301), vol. 20, no. 3, doi:10.1101/gr.101907.109, ISSN 1088-9051, pages 320 - 331, XP055878828 | |
| OPPOSITION | - Yulia Korshunova, "Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer- associated cytosine-methylation patterns obtained from tissue and serum DNA", Genome Research, US , (20080101), vol. 18, doi:10.1101/gr.6883307, ISSN 1088-9051, pages 19 - 29, XP055396258 | |
| OPPOSITION | - Peiyong Jiang ; Xiaoxi Sun ; Eric Z Chen ; Kun Sun ; Rossa W.K. Chiu ; Y.M. Dennis Lo ; Hao Sun, "Methy-Pipe: An integrated bioinformatics data analysis pipeline for whole genome methylome analysis", 2010 IEEE International Conference on Bioinformatics and Biomedicine workshops (BIBMW 2010) : Hong Kong, China, 18 - 21 December 2010, Piscataway, NJ , (20101218), doi:10.1109/BIBMW.2010.5703866, ISBN 978-1-4244-8303-7, pages 585 - 590, XP031885588 | |
| OPPOSITION | - IVY H. N. WONG; Y. M. DENNIS LO; PHILIP J. JOHNSON, "Epigenetic Tumor Markers in Plasma and Serum", Annals of the New York Academy of Sciences, US , (20060125), vol. 945, no. 1, doi:10.1111/j.1749-6632.2001.tb03862.x, ISSN 0077-8923, pages 36 - 50, XP071394462 | |
| OPPOSITION | - J. M. Rizzo, M. J. Buck, "Key Principles and Clinical Applications of "Next-Generation" DNA Sequencing", Cancer prevention research, United States , (20120701), vol. 5, no. 7, doi:10.1158/1940-6207.CAPR-11-0432, ISSN 1940-6207, pages 887 - 900, XP055486092 | |
| OPPOSITION | - Altuna Akalin;Matthias Kormaksson;Sheng Li;Francine E Garrett-Bakelman;Maria E Figueroa;Ari Melnick;Christopher E Mason, "methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles", Genome Biology, (20121003), vol. 13, no. 10, doi:10.1186/gb-2012-13-10-r87, ISSN 1465-6906, page R87, XP021108527 | |
| OPPOSITION | - Christophe Legendre, Gooden Gerald C., Johnson Kyle, Martinez Rae Anne, Liang Winnie S., Salhia Bodour, "Whole-genome bisulfite sequencing of cell-free DNA identifies signature associated with metastatic breast cancer", Clinical Epigenetics, BioMed Central Ltd, London, UK, London, UK, (20151201), vol. 7, no. 1, doi:10.1186/s13148-015-0135-8, ISSN 1868-7075, pages 1 - 10, XP055441164 | |
| OPPOSITION | - David S Shames , Luc Girard, Boning Gao, Mitsuo Sato, Cheryl M Lewis, Narayan Shivapurkar, Aixiang Jiang, Charles M Perou, Young H Kim, Jonathan R Pollack, Kwun M Fong, Chi-Leung Lam, Maria Wong, Yu Shyr, Rita Nanda, Olufunmilayo I Olopade, William Gerald, David M Euhus, Jerry W Shay, Adi F Gazdar, John D Minna, "A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies.", Plos medicine, US , (20061201), vol. 3, no. 12, doi:10.1371/journal.pmed.0030486, ISSN 1549-1676, pages 2244 - 2263, XP002527542 | |
| OPPOSITION | - Mikeska Thomas, Bock Christoph, Do Hongdo, Dobrovic Alexander, "DNA methylation biomarkers in cancer: progress towards clinical implementation", Expert Reviews in Molecular Diagnostics, GB , (20120601), vol. 12, no. 5, doi:10.1586/erm.12.45, ISSN 1473-7159, pages 473 - 487, XP055878813 | |
| OPPOSITION | - Rihong Zhai, Zhao Yang, Su Li, Cassidy Lauren, Liu Geoffrey, Christiani David C., "Genome-wide DNA Methylation Profiling of Cell-Free Serum DNA in Esophageal Adenocarcinoma and Barrett Esophagus", Neoplasma, US , (20120101), vol. 14, no. 1, doi:10.1593/neo.111626, ISSN 1476-5586, pages 29 - 33, XP055318524 | |
| OPPOSITION | - Vlassov V., Laktionov P., Rykova E., "Circulating Nucleic Acids as a Potential Source for Cancer Biomarkers", Current molecular medicine, NL , (20100301), vol. 10, no. 2, doi:10.2174/156652410790963295, ISSN 1566-5240, pages 142 - 165, XP055878810 | |
