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Enhancing Blood-Brain Barrier Drug Transport By Targeting Endogenous Regulators - EP4069368

The patent EP4069368 was granted to The Board OF Trustees OF The Leland Stanford Junior University on May 15, 2024. The application was originally filed on Dec 3, 2020 under application number EP20896434A. The patent is currently recorded with a legal status of "Revoked".

EP4069368

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Application Number
EP20896434A
Filing Date
Dec 3, 2020
Status
Revoked
Sep 5, 2025
Grant Date
May 15, 2024
External Links
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Patent Summary

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Patent Oppositions (4)

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JAMES POOLEFeb 14, 2025CARPMAELS & RANSFORDADMISSIBLE
DORRIESJan 15, 2025DORRIESADMISSIBLE
DORRIESJan 15, 2025DORRIES, HANS ULRICH , DF-MP DORRIES FRANK-MOLNIA & POHLMANADMISSIBLE
CARPMAELS & RANSFORD SPECIALITIESDec 9, 2024CARPMAELS & RANSFORDADMISSIBLE

Patent Citations (20) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS2009238754
DESCRIPTIONUS2013224110
DESCRIPTIONUS4816567
DESCRIPTIONUS5034506
DESCRIPTIONWO0164849
DESCRIPTIONWO2009114533
DESCRIPTIONWO2013126608
DESCRIPTIONWO2015166045
DESCRIPTIONWO8911299
INTERNATIONAL-SEARCH-REPORTGB2563899
INTERNATIONAL-SEARCH-REPORTUS2019083497
INTERNATIONAL-SEARCH-REPORTUS5567724
INTERNATIONAL-SEARCH-REPORTWO2004056386
OPPOSITIONUS10350189
OPPOSITIONUS2011262442
OPPOSITIONWO2008046230
OPPOSITIONWO9427603
SEARCHWO0164849
SEARCHWO2015166045
SEARCHWO8911299

Non-Patent Literature (NPL) Citations (16) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Deracinois Barbara, Lenfant Anne-Marie, Dehouck Marie-Pierre, Flahaut Christophe, "Tissue Non-specific Alkaline Phosphatase (TNAP) in Vessels of the Brain", Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP), Springer Netherlands, (20150101), vol. 76, pages 125 - 151, doi:10.1007/978-94-017-7197-9_7, ISSN 0306-0225, ISBN 978-94-017-7197-9, XP093262203
OPPOSITION- Catalan, R.E. et al, "Insulin action on brain microvessels; Effect on alkaline phosphatase", Biochemical and Biophysical Research Communications, Elsevier, Amsterdam NL, Amsterdam NL , (19880129), vol. 150, no. 2, doi:10.1016/0006-291X(88)90433-0, ISSN 0006-291X, pages 583 - 590, XP024841907
OPPOSITION- Nwafor Divine C. et al, "Loss of tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis", BRAIN, BEHAVIOR AND IMMUNITY., ACADEMIC PRESS, SAN DIEGO, CA, US, US , (20200201), vol. 84, doi:10.1016/j.bbi.2019.11.016, ISSN 0889-1591, pages 115 - 131, XP093263486
OPPOSITION- Pinkerton Anthony B. et al, "Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor", Bioorganic & Medicinal Chemistry Letters, ELSEVIER, Amsterdam NL, Amsterdam NL , (20180101), vol. 28, no. 1, doi:10.1016/j.bmcl.2017.11.024, ISSN 0960-894X, pages 31 - 34, XP093262209
OPPOSITION- Montagne Axel et al, "Blood-Brain Barrier Breakdown in the Aging Human Hippocampus", Neuron, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (19000101), vol. 85, no. 2, doi:10.1016/j.neuron.2014.12.032, ISSN 0896-6273, pages 296 - 302, XP029134508
OPPOSITION- Russell Dahl et al, "Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).", Journal of Medicinal Chemistry, American Chemical Society, US, US , (20091112), vol. 52, no. 21, doi:10.1021/jm900383s, ISSN 0022-2623, pages 6919 - 6925, XP002669256
OPPOSITION- Ngoc H On et al, "Rapid and Reversible Enhancement of Blood–Brain Barrier Permeability Using Lysophosphatidic Acid", Journal of Cerebral Blood Flow & Metabolism, Nature Publishing Group, US, US , (20131201), vol. 33, no. 12, doi:10.1038/jcbfm.2013.154, ISSN 0271-678X, pages 1944 - 1954, XP055392781
OPPOSITION- Banks William A., "The blood-brain barrier as an endocrine tissue", Nature reviews. Endocrinology, Nature Publ. Group, US, US , (20190524), vol. 15, no. 8, doi:10.1038/s41574-019-0213-7, ISSN 1759-5029, pages 444 - 455, XP036833990
OPPOSITION- Hou Yujun et al, "Ageing as a risk factor for neurodegenerative disease", Nature Reviews Neurology, Nature Publishing Group UK, London, London, (20190909), vol. 15, no. 10, doi:10.1038/s41582-019-0244-7, ISSN 1759-4758, pages 565 - 581, XP036887746
OPPOSITION- Ponzoni M., Issa S., Batchelor T.T., Rubenstein J.L., "Beyond high-dose methotrexate and brain radiotherapy: novel targets and agents for primary CNS lymphoma", Annals of Oncology, Elsevier, (20140201), vol. 25, no. 2, doi:10.1093/annonc/mdt385, ISSN 0923-7534, pages 316 - 322, XP093263482
OPPOSITION- Gruber R. et al, "Dental Pulp Fibroblasts Contain Target Cells for Lysophosphatidic Acid", JOURNAL OF DENTAL RESEARCH, INTERNATIONAL ASSOCIATION FOR DENTAL RESEARCH, US, US , (20040601), vol. 83, no. 6, doi:10.1177/154405910408300611, ISSN 0022-0345, pages 491 - 495, XP093263477
OPPOSITION- Deracinois Barbara et al, "TNAP and EHD1 Are Over-Expressed in Bovine Brain Capillary Endothelial Cells after the Re-Induction of Blood-Brain Barrier Properties", PLOS ONE, Public Library of Science, US, US , vol. 7, no. e48428, doi:10.1371/journal.pone.0048428, ISSN 1932-6203, pages 1 - 12, XP093262199
OPPOSITION- Mills Eric, Dong Xian-Ping, Wang Fudi, Xu Haoxing, "Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders", Future Medicinal Chemistry, Future Science, (20100101), vol. 2, no. 1, doi:10.4155/fmc.09.140, ISSN 1756-8919, pages 51 - 64, XP093262222
OPPOSITION- Banks William A, Greig Nigel H, "Small Molecules As Central Nervous System Therapeutics: Old challenges, New directions, and a Philosophic Divide", Future Medicinal Chemistry, Future Science, (20190301), vol. 11, no. 6, doi:10.4155/fmc-2018-0436, ISSN 1756-8919, pages 489 - 493, XP093263488
SEARCH- BRICHACEK ALLISON L ET AL, "Alkaline phosphatase: a potential biomarker for stroke and implications for treatment", METABOLIC BRAIN DISEASE, KLUWER ACADEMIC - PLENUM PUBLISHERS, NEW YORK, NY, US, vol. 34, no. 1, doi:10.1007/S11011-018-0322-3, ISSN 0885-7490, (20181004), pages 3 - 19, (20181004), XP036687883 [I] 9-15 * page 11 - page 12 * [A] 1-8
SEARCH- BHATT ET AL, "Activities of alkaline phosphatase and Na^+-K^+-adenosine 5'-triphosphatase in the brain of experimentally produced histidinaemic squirrels (Funambulus palmarum)", NEUROSCIENCE, NEW YORK, NY, US, vol. 5, no. 3, doi:10.1016/0306-4522(80)90064-0, ISSN 0306-4522, (19800301), pages 669 - 671, (19800301), XP024382762 [I] 9-15 * results and discussion section * [A] 1-8

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