IP Verse

Substituted Tetrahydrofurans As Modulators Of Sodium Channels - EP4069691

The patent EP4069691 was granted to Vertex Pharmaceuticals Incorporated on Sep 18, 2024. The application was originally filed on Dec 4, 2020 under application number EP20825397A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP4069691

VERTEX PHARMACEUTICALS INCORPORATED
Application Number
EP20825397A
Filing Date
Dec 4, 2020
Status
Granted And Under Opposition
Aug 15, 2024
Grant Date
Sep 18, 2024
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

BARDEHLE PAGENBERGJun 17, 2025BARDEHLE PAGENBERG SLADMISSIBLE

Patent Citations (58) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS2008312235
DESCRIPTIONUS2009048306
DESCRIPTIONUS2011306607
DESCRIPTIONUS2012196869
DESCRIPTIONUS2012220605
DESCRIPTIONUS2012245136
DESCRIPTIONUS2012264749
DESCRIPTIONUS2013274243
DESCRIPTIONUS2013303535
DESCRIPTIONUS2014187533
DESCRIPTIONUS2014213616
DESCRIPTIONUS2014221435
DESCRIPTIONUS2014228371
DESCRIPTIONUS2014296313
DESCRIPTIONUS2015005304
DESCRIPTIONUS2015166589
DESCRIPTIONUS2016152561
DESCRIPTIONUS2019016671
DESCRIPTIONUS2020140411
DESCRIPTIONUS5304121
DESCRIPTIONUS5886026
DESCRIPTIONUS6099562
DESCRIPTIONUS8466188
DESCRIPTIONUS8883840
DESCRIPTIONWO2006011050
DESCRIPTIONWO2008135826
DESCRIPTIONWO2010129864
DESCRIPTIONWO2011026240
DESCRIPTIONWO2011140425
DESCRIPTIONWO2012106499
DESCRIPTIONWO2012112743
DESCRIPTIONWO2012116440
DESCRIPTIONWO2012125613
DESCRIPTIONWO2013061205
DESCRIPTIONWO2013109521
DESCRIPTIONWO2013114250
DESCRIPTIONWO2013131018
DESCRIPTIONWO2014120808
DESCRIPTIONWO2014120815
DESCRIPTIONWO2014120820
DESCRIPTIONWO2015010065
DESCRIPTIONWO2015089361
DESCRIPTIONWO2015157559
DESCRIPTIONWO2017059385
DESCRIPTIONWO2018183781
DESCRIPTIONWO2018183782
DESCRIPTIONWO2018213426
DESCRIPTIONWO2019014352
DESCRIPTIONWO2020014243
DESCRIPTIONWO2020014246
DESCRIPTIONWO2020072835
DESCRIPTIONWO2020092187
DESCRIPTIONWO2020092667
DESCRIPTIONWO2020146612
DESCRIPTIONWO2020146682
INTERNATIONAL-SEARCH-REPORTUS2019016671
OPPOSITIONUS2019016671
OPPOSITIONUS9783527

Non-Patent Literature (NPL) Citations (30) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BLAIR, N.T.B.P. BEAN, "Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons", J. Neurosci., (20020000), vol. 22, no. 23, pages 10277 - 90-
DESCRIPTION- CHAHINE, M.CHATELIER, A.BABICH, O.KRUPP, J. J., "Voltage-gated sodium channels in neurological disorders", CNS Neurol. Disord. Drug Targets, (20080000), vol. 7, no. 2, pages 144 - 58-
DESCRIPTION- CHOI, J.S.S.G. WAXMAN, "Physiological interactions between Na l.7 and Na l.8 sodium channels: a computer simulation study", J. Neurophysiol., vol. 106, no. 6, pages 3173 - 84-
DESCRIPTION- COWARD, K. et al., "Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states", Pain, (20000000), vol. 85, no. 1-2, pages 41 - 50-
DESCRIPTION- ENGLAND, S., "Voltage-gated sodium channels: the search for subtypeselective analgesics", Expert Opin. Investig. Drugs, (20080000), vol. 17, no. 12, pages 1849 - 64-
DESCRIPTION- JOSHI, S.K. et al., "Involvement of the TTX-resistant sodium channel Navl.8 in inflammatory and neuropathic, but not post-operative, pain states", Pain, (20060000), vol. 123, no. 1-2, pages 75 - 82-
DESCRIPTION- "Periodic Table of the Elements, CAS version", Handbook of Chemistry and Physics-
DESCRIPTION- RENGANATHAN, M.T.R. CUMMINSS.G. WAXMAN, "Contribution of Na( )1.8 sodium channels to action potential electrogenesis in DRG neurons", J. Neurophysiol., (20010000), vol. 86, no. 2, pages 629 - 40-
DESCRIPTION- ROZA, C. et al., "The tetrodotoxin-resistant Na+ channel Na l.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice", J. Physiol., (20030000), vol. 550, pages 921 - 6-
DESCRIPTION- RUSH, A.M. et al., "A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons", Proc. Natl. Acad. Sci. USA, (20060000), vol. 103, no. 21, pages 8245 - 50-
DESCRIPTION- S. L. HARBESONR. D. TUNG, "Deuterium In Drug Discovery and Development", Ann. Rep. Med. Chem., (20110000), vol. 46, pages 403 - 417-
DESCRIPTION- S. M. BERGE et al., J. Pharmaceutical Sciences, (19770000), vol. 66, pages 1 - 19-
DESCRIPTION- SUN, W. et al., "Reduced conduction failure of the main axon of polymodal nociceptive C-fibers contributes to painful diabetic neuropathy in rats", Brain, vol. 135, pages 359 - 75-
DESCRIPTION- WANG, G. K.MITCHELL, J.WANG, S. Y., "Block of persistent late Na+ currents by antidepressant sertraline and paroxetine", J. Membr. Biol., (20080000), vol. 222, no. 2, pages 79 - 90, XP019622596-
DESCRIPTION- BLACK, J.A. et al., "Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas", Ann. Neurol., (20080000), vol. 64, no. 6, doi:10.1002/ana.21527, pages 644 - 53, XP009143330
DESCRIPTION- KRAFTE, D. S.BANNON, A. W., "Sodium channels and nociception: recent concepts and therapeutic opportunities", Curr. Opin. Pharmacol., (20080000), vol. 8, no. 1, doi:10.1016/j.coph.2007.09.007, pages 50 - 56, XP002540499
DESCRIPTION- STRICKLAND, I.T. et al., "Changes in the expression of Na l.7, Na l.8 and Na l.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain", Eur. J. Pain, (20080000), vol. 12, no. 5, doi:10.1016/j.ejpain.2007.09.001, pages 564 - 72, XP022632366
DESCRIPTION- QIU, F. et al., "Increased expression of tetrodotoxin-resistant sodium channels Na l.8 and Na l.9 within dorsal root ganglia in a rat model of bone cancer pain", Neurosci. Lett., vol. 512, no. 2, doi:10.1016/j.neulet.2012.01.069, pages 61 - 6, XP028903612
DESCRIPTION- DONG, X.W. et al., "Small interfering RNA-mediated selective knockdown of Na l.8 tetrodotoxin-resistant sodium channel reverses mechanical allodynia in neuropathic rats", Neuroscience, (20070000), vol. 146, no. 2, doi:10.1016/j.neuroscience.2007.01.054, pages 812 - 21, XP022061734
DESCRIPTION- DIELEMAN, J.P. et al., "Incidence rates and treatment of neuropathic pain conditions in the general population", Pain, (20080000), vol. 137, no. 3, doi:10.1016/j.pain.2008.03.002, pages 681 - 8, XP022853979
DESCRIPTION- YIANGOU, Y. et al., "SNS/PN3 and SNS2/NaN sodium channel-like immunoreactivity in human adult and neonate injured sensory nerves", FEBS Lett., (20000000), vol. 467, no. 2-3, doi:10.1016/S0014-5793(00)01166-2, pages 249 - 52, XP004260962
DESCRIPTION- LAI, J. et al., "Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, Na l.8", Pain, (20020000), vol. 95, no. 1-2, doi:10.1016/S0304-3959(01)00391-8, pages 143 - 52, XP002374879
DESCRIPTION- AKOPIAN, A.N.L. SIVILOTTIJ.N. WOOD, "A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons", Nature, (19960000), vol. 379, no. 6562, doi:10.1038/379257a0, pages 257 - 62, XP000605462
DESCRIPTION- SODERPALM, B., "Anticonvulsants: aspects of their mechanisms of action", Eur. J. Pain, (20020000), doi:10.1053/eujp.2001.0315, pages 3 - 9, XP003009563
DESCRIPTION- JARVIS, M.F. et al., "A-803467, a potent and selective Na l.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat", Proc. Natl. Acad. Sci. USA, (20070000), vol. 104, no. 20, doi:10.1073/pnas.0611364104, pages 8520 - 5, XP055030736
DESCRIPTION- RUANGSRI, S. et al., "Relationship of axonal voltage-gated sodium channel 1.8 (Na l.8) mRNA accumulation to sciatic nerve injury-induced painful neuropathy in rats", J. Biol. Chem., vol. 286, no. 46, doi:10.1074/jbc.M111.261701, pages 39836 - 47, XP055624203
DESCRIPTION- RUSH, A.M.T.R. CUMMINS, "Painful Research: Identification of a Small-Molecule Inhibitor that Selectively Targets Navl.8 Sodium Channels", Mol. Interv., (20070000), vol. 7, no. 4, doi:10.1124/mi.7.4.4, pages 192 - 5, XP009165204
DESCRIPTION- CATTERALL, W. A.GOLDIN, A. L.WAXMAN, S. G., "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels", Pharmacol. Rev., (20050000), vol. 57, no. 4, doi:10.1124/pr.57.4.4, page 397, XP055213863
DESCRIPTION- HUANG, H.L. et al., "Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves", Mol. Pain, (20080000), vol. 4, doi:10.1186/1744-8069-4-33, page 33, XP021045080
INTERNATIONAL-SEARCH-REPORT- M. F. JARVIS ET AL, "From the Cover: A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20070515), vol. 104, no. 20, doi:10.1073/pnas.0611364104, ISSN 0027-8424, pages 8520 - 8525, XP055030736 [AD] 1-116 * A-803467 *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents