A Method For Producing And Purifying Rna, Comprising At Least One Step Of Tangential Flow Filtration - EP4108769

The patent EP4108769 was granted to Curevac Manufacturing on Aug 30, 2023. The application was originally filed on May 30, 2016 under application number EP22190069A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP4108769

CUREVAC MANUFACTURING
Application Number
EP22190069A
Filing Date
May 30, 2016
Status
Granted And Under Opposition
Jul 28, 2023
Grant Date
Aug 30, 2023
External Links
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Patent Family

Patent Oppositions (5)

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CARPMAELS & RANSFORD SPECIALITIESMay 30, 2024ADMISSIBLE
JAMES POOLEMay 30, 2024ADMISSIBLE
HOPFNERMay 29, 2024ADMISSIBLE
PFIZERFeb 29, 2024ADMISSIBLE
COHAUSZ & FLORACK PATENT UND RECHTSANWALTE PARTNERSCHAFTSGESELLSCHAFT MBBFeb 27, 2024ADMISSIBLE

Patent Citations (33) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO2008077592
DESCRIPTIONWO2014140211
DESCRIPTIONWO2014152966
OPPOSITIONCA2277165
OPPOSITIONEP1533020
OPPOSITIONUS2002096474
OPPOSITIONUS2004076980
OPPOSITIONUS2007207493
OPPOSITIONUS6011148
OPPOSITIONUS8075780
OPPOSITIONWO0107599
OPPOSITIONWO03082892
OPPOSITIONWO2004076695
OPPOSITIONWO2008107462
OPPOSITIONWO2010027955
OPPOSITIONWO2012077080
OPPOSITIONWO2013064911
OPPOSITIONWO2014140211
OPPOSITIONWO2014152027
OPPOSITIONWO2014152031
OPPOSITIONWO2014152966
OPPOSITIONWO2015133972
OPPOSITIONWO2015164773
OPPOSITIONWO2015200691
OPPOSITIONWO2016193206
OPPOSITIONWO9204970
SEARCHCA2277165
SEARCHUS2002096474
SEARCHWO0107599
SEARCHWO2014140211
SEARCHWO2014152027
SEARCHWO2014152031
SEARCHWO2014152966

Non-Patent Literature (NPL) Citations (53) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- A. AZARANIK.H. HECKER, Nucleic Acids Research, vol. 29, no. 2, page e7-
DESCRIPTION- FERNANDEZ et al., A BIOTECHNOLOGICA, vol. 12, pages 49 - 56-
DESCRIPTION- FLORES et al., Plant Physiol., (19820000), vol. 69, pages 701 - 706-
DESCRIPTION- PASCOLO et al., Methods Mol Med, (20060000), vol. 127, pages 23 - 40-
DESCRIPTION- RATHORE, AS et al., Prep Biochem Biotechnol, (20110000), vol. 41, no. 4, pages 398 - 421-
DESCRIPTION- SAMBROOKRUSSEL, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, (20000000), vol. 3-
OPPOSITION- Alonso Sara V, "Implementation of a New Membrane and the Re-use in a Tangential Flow Filtration System", Manufacturing Engineering, (20140101), XP093191083-
OPPOSITION- Anonymous, "Centricon - Centrifugal filter devices - user guide", (20050301), pages 1 - 23, URL: http://kirschner.med.harvard.edu/files/protocols/Millipore_Centricons.pdf, (20100909), XP002600140-
OPPOSITION- Anonymous, "Filtration Selection Guide - Choosing the Right Filter for Your Application", Lenntech, (20041201), Lenntech, URL: https://www.lenntech.com/Data-sheets/Millipore-Filtration-Selection-Guide-L.pdf, XP093191814-
OPPOSITION- Anonymous, "KrosFlo Research IIi TFF System", SpectrumLabs.com, vol. 67, no. 24, doi:10.1021/acs.jmedchem.4c01725, pages 21717 - 21728, SpectrumLabs.com, URL: https://cdn.thomasnet.com/ccp/01300199/133476.pdf, XP093249026-
OPPOSITION- Anonymous, "Labscale ™ Tangential Flow Filtration System - User Guide", MILLIPORE, (20110401), MILLIPORE, URL: https://labtorg.kz/downloads/Millipore/Labscale-Tangential-Flow-Filtration-System-User-Guide.pdf, XP093191038-
OPPOSITION- Anonymous, "Pall Omega™ Membrane Cassettes - Validation Guide USTR 2143 Rev B", PALL Life Sciences, (20070101), PALL Life Sciences, XP093191076-
OPPOSITION- Anonymous, "Pellicon® 2 vs. Hollow Fiber Filter Cartridge - Application Note AN1020EN00", Millipore Application Note, MILLIPORE, (20010501), pages 1 - 8, XP009558957-
OPPOSITION- Anonymous, "Products and Solutions for the Biopharmaceutical Industry", Sartorius Stedim Biotech document, Sartorius Stedim Biotech GmbH, DE, DE, (20100101), pages 1 - 642, XP009556313-
OPPOSITION- Anonymous, "Protein Concentration and Diafiltration by Tangential Flow Filtration", Millipore, (20030101), pages 1 - 24, XP093191710-
OPPOSITION- Anonymous, "Sartocon® 2Plus Stainless Steel Holder - Crossflow holder for Sartocon® cassettes", Sartorius, (20140924), XP093191802-
OPPOSITION- Anonymous, "Sartocon® Hydrosart® Cassette 3021446830E-BSW", SARTORIUS, (20150511), SARTORIUS, XP093191032-
OPPOSITION- Anonymous, "The Partnership of the Minimate TM TFF Capsule with Liquid Chromatography Systems Facilitates Lab-scale Purifications and Process Development Through In-Line Monitoring", PALL Life Sciences; Scientific & Technical Report PN33339, (20100401), XP093191073-
OPPOSITION- Anonymous, "UltracelTM PLC Membranes - Data Sheet", MILLIPORE, (20020101), XP093191035-
OPPOSITION- Beckwith Michelle, Backer Andrew, Robertson Andrew, Phillips Whitney, Jimenez Malena, Baldwin Brittany, Vagell Michael, "The Role Of Ultrafiltration Membranes In The Recovery Of DNA With Centrifugal Concentrators", International Symposium on Human Identification, (20141001), XP093191078-
OPPOSITION- "Cross Flow Filtration Method Handbook", (20140101), URL: https://www.gelifesciences.com/gehcls_images/GELS/Related Content/Files/1392028292867/litdoc29085076_20140313045908.pdf, (20150625), XP055198384-
OPPOSITION- D63 - Notification of the recording of a change for PCT/EP2015/062002 mailed on 26 October 2015-
OPPOSITION- D64 - PCT request for PCT/EP2016/062152-
OPPOSITION- D65 - Communication of the EPO re 16729807.4 dated 7 February 2020-
OPPOSITION- D66 - Request for grant of a European patent (EP20166485.1)-
OPPOSITION- D67 - Request for grant of a European patent (EP22190069.9)-
OPPOSITION- Jagan Nathan S, Shivanandappa K C, Sundran B K N, Venkataramana K R, Mani, "Filtration Technique in Vaccine Manufacturing", Tools & Techniques, (20080801), page 37, XP093191090-
OPPOSITION- Joachim K. Walter, Zuwei Jin, Maik W. Jornitz, Uwe Gottschalk, "Chapter 12: Membrane Separations", Joachim K. Walter, Zuwei Jin, Maik W. Jornitz, Uwe Gottschalk, JANSON, JAN-CHRISTER, Protein Purification, Hoboken, NJ, USA , John Wiley & Sons, Inc. , (20110322), pages 281 - 317, ISBN 978-0-471-74661-4, XP009556204-
OPPOSITION- Julie L. Brunelle et al., "In Vitro Transcription from Plasmid or PCR-amplified DNA", Methods in Enzymology, (2013), vol. 530, XP009190475-
OPPOSITION- Koolman, Jan; Röhm, Klaus-Heinrich, "Basics and Biomolecules", Koolman, Jan; Röhm, Klaus-Heinrich, J. Koolman, K.H. Roehm, Color Atlas of Biochemistry, 2nd Edition, Thieme, (20050101), pages 1 - 87, ISBN 1-58890-247-1, XP009559384-
OPPOSITION- Krieg Paul A, "MATERIALS AND METHODS Materials for Production of Synthetic mRNA", A LABORATORY GUIDE TO RNA, Isolation, Analysis, and Synthesis, WILEY-LISS, (19960101), pages 143 - 145, XP093191508-
OPPOSITION- Michaelis, Stephen L. et al, "Tangential Flow Filtration", Michaelis, Stephen L. et al, Olson Wayne P., Separations TECHNOLOGY, Pharmaceutical and Biotechnology Applications, CRC Press, (20150101), pages 1 - 20, XP093191574-
OPPOSITION- NESTOLA PIERGIUSEPPE ET AL, "Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5) concentration.", PLOS ONE, Public Library of Science, US, US , (20140101), vol. 9, no. 12, ISSN 1932-6203, page e115802, XP002760961-
OPPOSITION- Raymond H Colton, Ina Pahl, Liana E Ottaviano, Travis Bodeutsch, Frank Meyeroltmanns, "Study of Protein Adsorption Effects on Crossflow Filtration Using BSA and Milk Protein", PDA Journal of Pharmaceutical Science and Technology, Parenteral Drug Association, US, US , (20020101), vol. 56, no. 1, ISSN 1079-7440, pages 20 - 30, XP009556243-
OPPOSITION- Rivera Esteban, Dominguez Carlos A, Escobar Carlos, Weidner James, "Improving Tangential Flow Filtration Yield", BIOPHARM INTERNATIONAL, ADVANSTAR COMMUNICATIONS, DULUTH, MN, US, US , (20080701), vol. 21, no. 7, ISSN 1542-166X, page 42, XP093191069-
OPPOSITION- Schwartz, Larry; Seeley, Kevin, "Introduction to Tangential Flow Filtration for Laboratory and Process Development Applications", Scientific & Technical Report, PALL Life Sciences, Ann Arbor, US, Ann Arbor, US, pages 1 - 12, Scientific & Technical Report , URL: https://www.pall.com/content/dam/pall/laboratory/literature-library/non-gated/Molecular_Tech_Report_Minimate_Intro_to_TFF.pdf, (20200527), XP055698772-
OPPOSITION- Stephen L. Michaels, Chris Antoniou, Vinay Goel, Paula Keating, Ralf Kuriyel, Alan S. Michaels, Steven R. Pearl, Gaston de los Reyes, Eric Rudolph, Marty Siwak, "3 Tangential Flow Filtration", Separations Technology, Pharmaceutical and Biotechnology Applications, Taylor & Francis Ltd, (19950101), pages 57 - 194, ISBN 9780935184723, XP009556274-
OPPOSITION- Thomas Paul, "Tangential Flow Filtration Explores New Niches", Pharma Manufacturing, (20080819), Pharma Manufacturing, URL: https://www.pharmamanufacturing.com/home/article/11362204/pharmaceutical-flow-filtration-tangential-flow-filtration-explores-new-niches-pharmaceutical-manufacturing, XP093191084-
OPPOSITION- Williams N T, "Continuous Production of RNA using a Stir-cell Bioreactor", Thesis, (19950322), pages 1 - 132, XP093136738-
OPPOSITION- Young Clare, "Pall Corporation introduces T-series cassettes for TFF applications News", Filtration + Separation, (20100429), Filtration + Separation, URL: https://www.filtsep.com/content/news/pall-corporation-introduces-t-series-cassettes-for-tff-applications/, XP093191087-
OPPOSITION- Stefanie Hoffmann, Johannes Hoos, Sven Klussmann, Stefan Vonhoff, "RNA Aptamers and Spiegelmers: Synthesis, Purification, and Post-Synthetic PEG Conjugation", Current Protocols in Nucleic Acid Chemistry, Hoboken, NJ, USA , John Wiley & Sons, Inc. , (20110101), doi:10.1002/0471142700.nc0446s46, ISBN 9780471142706, XP055058007
OPPOSITION- Allegrezza Anthony, Ireland Todd, Kools Willem, Phillips Michael, Raghunath Bala, Wilkins Randy, Xenopoulos Alex, "Membranes in the Biopharmaceutical Industry", Membranes for the Life Sciences, Wiley, (20071017), pages 91 - 153, doi:10.1002/9783527631360.ch4, XP093191013
OPPOSITION- Beckert Bertrand, Masquida Benoît, "Synthesis of RNA by In Vitro Transcription : Methods and Protocols", RNA : Methods and Protocols : Methods and Protocols, Totowa, NJ, Humana Press, (20110101), vol. 703, pages 29 - 41, doi:10.1007/978-1-59745-248-9_3, ISSN 1064-3745, ISBN 978-1-59745-248-9, XP093153524
OPPOSITION- Boedtker Helga, "[129] Molecular weight and conformation of RNA", Nucleic acids / Series title: Methods in Enzymology, Elsevier Science & Technology, (19680101), vol. 12, pages 429 - 458, doi:10.1016/0076-6879(67)12154-X, ISSN 0076-6879, ISBN 9780121818562, XP009556211
OPPOSITION- Alex Eon-Duval, Robert H. MacDuff, Carol A. Fisher, Mark J. Harris, Chris Brook, "Removal of RNA impurities by tangential flow filtration in an RNase-free plasmid DNA purification process", Analytical Biochemistry, Academic Press, Amsterdam, NL, Amsterdam, NL , (20030501), vol. 316, no. 1, doi:10.1016/S0003-2697(03)00050-2, ISSN 0003-2697, pages 66 - 73, XP002622156
OPPOSITION- Kim L. Hossner et al., "Improved recovery of insulin-like growth factors (IGFs) from bovine colostrum using alkaline diafiltration", Biotechnol. Appl. Biochem. , (2000), vol. 32, doi:10.1042/BA20000056, XP008085428
OPPOSITION- A. S. Rathore, A. Shirke, "RECENT DEVELOPMENTS IN MEMBRANE-BASED SEPARATIONS IN BIOTECHNOLOGY PROCESSES: REVIEW", Preparative Biochemistry and Biotechnology, (20111001), vol. 41, no. 4, doi:10.1080/10826068.2011.613976, ISSN 10826068, pages 398 - 421, XP055153231
OPPOSITION- Sophia T. Mundle, Hector Hernandez, John Hamberger, John Catalan, Changhong Zhou, Svetlana Stegalkina, Andrea Tiffany, Harry Kleanthous, Simon Delagrave, Stephen F. Anderson, "High-Purity Preparation of HSV-2 Vaccine Candidate ACAM529 Is Immunogenic and Efficacious In Vivo", PLoS ONE, vol. 8, no. 2, doi:10.1371/journal.pone.0057224, page e57224, XP055180742
OPPOSITION- Murphy Jason C., Winters Michael A., Sagar Sangeetha L., "Chapter 24: Large-Scale, Nonchromatographic Purification of Plasmid DNA", DNA Vaccines, Totowa, NJ, Humana Press, (20060101), vol. 127, pages 351 - 362, doi:10.1385/1-59745-168-1:351, ISSN 1543-1894, ISBN 9781588294845, XP009556210
OPPOSITION- Hui F. Liu, Ma Junfen, Winter Charles, Bayer Robert, "Recovery and purification process development for monoclonal antibody production", mAbs, (20100901), vol. 2, no. 5, doi:10.4161/mabs.2.5.12645, ISSN 19420862, pages 480 - 499, XP055027612
SEARCH- Anonymous, "Cross Flow Filtration Method Handbook", (20140101), pages 1 - 82, GE life sciences, URL: https://www.gelifesciences.com/gehcls_images/GELS/Related Content/Files/1392028292867/litdoc29085076_20140313045908.pdf, (20150625), XP055198384 [A] 1-15 * the whole document *-
SEARCH- NESTOLA PIERGIUSEPPE ET AL, "Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5) concentration.", PLOS ONE, (20141229), vol. 9, no. 12, doi:10.1371/journal.pone.0115802, ISSN 1932-6203, pages 1 - 22, XP002760961 [A] 1-15 * the whole document *-
SEARCH- ALEX EON-DUVAL ET AL, "Removal of RNA impurities by tangential flow filtration in an RNase-free plasmid DNA purification process", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 316, no. 1, doi:10.1016/S0003-2697(03)00050-2, ISSN 0003-2697, (20030501), pages 66 - 73, (20030402), XP002622156 [A] 1-15 * abstract *

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