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Nutritional Product - EP4162934

The patent EP4162934 was granted to UCL Business on Oct 30, 2024. The application was originally filed on Jun 14, 2013 under application number EP22202824A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP4162934

UCL BUSINESS
Application Number
EP22202824A
Filing Date
Jun 14, 2013
Status
Granted And Under Opposition
Sep 27, 2024
Publication Date
Oct 30, 2024
External Links
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Patent Summary

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Patent Oppositions (2)

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MOLNIAJul 29, 2025MOLNIAADMISSIBLE
NUTRICIAJul 24, 2025VOADMISSIBLE

Patent Citations (26) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
EXAMINATIONEP2351491
EXAMINATIONUS3658555
OPPOSITIONEP0059997
OPPOSITIONEP2351491
OPPOSITIONGB1254191
OPPOSITIONJP2012097038
OPPOSITIONUS2004151757
OPPOSITIONUS2010204498
OPPOSITIONUS3658555
OPPOSITIONUS4164594
OPPOSITIONWO2006002927
OPPOSITIONWO2006115412
OPPOSITIONWO2007135376
OPPOSITIONWO2008048094
OPPOSITIONWO2010052847
OPPOSITIONWO2012069790
OPPOSITIONWO2013186570
OTHEREP2351491
OTHERUS3658555
OTHERWO2010052847
OTHERWO2013186570
SEARCHJP2012097038
SEARCHUS2007135376
SEARCHUS2010204498
SEARCHWO2010052847
SEARCHWO2012069790

Non-Patent Literature (NPL) Citations (35) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- BOUGH, K.J, Ann. Neurol., (20060000), vol. 60, pages 223 - 235
OPPOSITION- Alonso, L. ; Fontecha, J. ; Lozada, L. ; Fraga, M.J. ; Juarez, M., "Fatty Acid Composition of Caprine Milk: Major, Branched-Chain, and Trans Fatty Acids", Journal of Dairy Science, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL, (19990501), vol. 82, no. 5, ISSN 0022-0302, pages 878 - 884, XP026993413
OPPOSITION- D21a - Product data sheet Compact Protein 300/18 Vanilla, N.V. Nutricia, 15 March 2012
OPPOSITION- D2a - Decision dated 10 June 2025 of the Opposition Division regarding European patent EP 2 861 226
OPPOSITION- D43 - European search opinion of 13.03.2023
OPPOSITION- D44 - Patentee’s response letter of 06.10.2023
OPPOSITION- D45 - Patentee’s response letter of 08.05.2024
OPPOSITION- Fortimel, "Nutricia Fortimel Compact Protein with Vanilla Flavor", Innova Market Insights, (20120301), Database accession no. 1225595, XP093303887
OPPOSITION- Fresubin (innova), "1.5 kcal Fresubin -Protein Energy Drink with Vanilla Flavor", Innova Market Insights, (20070801), Database accession no. 640857, XP093303893
OPPOSITION- Khabbush Aziza, "Metabolic consequences of cellular exposure to decanoic acid", Khabbush Aziza, Khabbush, Metabolic consequences of cellular exposure to decanoic acid, PhD thesis, University College London, 2018 , Doctoral thesis (Ph.D), UK, UCL (University College London), (20180101), pages 1 - 286, XP093303824
OPPOSITION- Tonin, A.M. ; Grings, M. ; Busanello, E.N.B. ; Moura, A.P. ; Ferreira, G.C. ; Viegas, C.M. ; Fernandes, C.G. ; Schuck, P.F. ; Wajner, M., "Long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies induce oxidative stress in rat brain", Neurochemistry International, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20100701), vol. 56, no. 8, ISSN 0197-0186, pages 930 - 936, XP027050357
OPPOSITION- Kristopher J. Bough; Jonathon Wetherington; Bjørnar Hassel; Jean Francois Pare; Jeremy W. Gawryluk; James G. Greene; Renee Shaw; Yoland Smith; Jonathan D. Geiger; Raymond J. Dingledine, "Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet", Annals of Neurology, John Wiley and Sons, Boston , US, Boston , US , (20060628), vol. 60, no. 2, doi:10.1002/ana.20899, ISSN 0364-5134, pages 223 - 235, XP071638742
OPPOSITION- Miglio, G. ; Rosa, A.C. ; Rattazzi, L. ; Collino, M. ; Lombardi, G. ; Fantozzi, R., "PPAR@c stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss", Neurochemistry International, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20091201), vol. 55, no. 7, doi:10.1016/j.neuint.2009.05.001, ISSN 0197-0186, pages 496 - 504, XP026562414
OPPOSITION- Piotr Wlaź, Katarzyna Socała, Dorota Nieoczym, Jarogniew J Łuszczki, Iwona Zarnowska, Tomasz Zarnowski, Stanisław J Czuczwar, Maciej Gasior, "Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice", Neuropharmacology, Pergamon, (20120301), vol. 62, no. 4, doi:10.1016/j.neuropharm.2011.12.015, ISSN 00283908, pages 1882 - 1889, XP055075889
OPPOSITION- Pishan Chang, Nicole Terbach, Nick Plant, Philip E. Chen, Matthew C. Walker, Robin S.B. Williams, "Seizure control by ketogenic diet-associated medium chain fatty acids", Neuropharmacology, Pergamon, (20130601), vol. 69, doi:10.1016/j.neuropharm.2012.11.004, ISSN 00283908, pages 105 - 114, XP055075887
OPPOSITION- Pieczenik, S.R. Neustadt, J., "Mitochondrial dysfunction and molecular pathways of disease", EXPERIMENTAL AND MOLECULAR PATHOLOGY., ACADEMIC PRESS., US, US , (20070602), vol. 83, no. 1, doi:10.1016/j.yexmp.2006.09.008, ISSN 0014-4800, pages 84 - 92, XP022103261
OPPOSITION- R. R. V. Malapaka, Et Al, "Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20120102), vol. 287, no. 1, doi:10.1074/jbc.M111.294785, ISSN 0021-9258, pages 183 - 195, XP055380112
OPPOSITION- Haidukewych, Dan; Forsythe, W. Ian; Sills, Michael, "Monitoring octanoic and decanoic acids in plasma from children with intractable epilepsy treated with medium-chain triglyceride diet", Clinical Chemistry, Oxford University Press, US, US , (19820401), vol. 28, no. 4, doi:10.1093/clinchem/28.4.642, ISSN 0009-9147, pages 642 - 645, XP009171987
OPPOSITION- Dean H G, Bonser J C, Gent J P, "HPLC analysis of brain and plasma for octanoic and decanoic acids.", Clinical Chemistry, Oxford University Press, US, US , (19890901), vol. 35, no. 9, doi:10.1093/clinchem/35.9.1945, ISSN 0009-9147, pages 1945 - 1948, XP009562409
OPPOSITION- Jancovski Nikola, Baldwin Tomas, Orford Michael, Li Melody, Jones Gabriel Davis, Burbano Lisseth Estefania, Rutherford Tricia, Reid Christopher, Heales Simon, Eaton Simon, Petrou Steven, "Protective effects of medium chain triglyceride diet in a mouse model of Dravet syndrome", Epilepsia, Raven press LTD, New York , US, New York , US , (20211201), vol. 62, no. 12, doi:10.1111/epi.17101, ISSN 0013-9580, pages 3131 - 3142, XP093150463
OPPOSITION- Robert S. Fisher; Walter van Emde Boas; Warren Blume; Christian Elger; Pierre Genton; Phillip Lee; Jerome Engel, "Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)", Epilepsia, Raven press LTD, New York , US, New York , US , (20050329), vol. 46, no. 4, doi:10.1111/j.0013-9580.2005.66104.x, ISSN 0013-9580, pages 470 - 472, XP071208199
OPPOSITION- Hughes Sean David, Kanabus Marta, Anderson Glenn, Hargreaves Iain P., Rutherford Tricia, Donnell Maura O’, Cross J. Helen, Rahman Shamima, Eaton Simon, Heales Simon J. R., "The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells", Journal of Neurochemistry, Wiley-Blackwell Publishing Ltd., GB, GB , (20140501), vol. 129, no. 3, doi:10.1111/jnc.12646, ISSN 0022-3042, pages 426 - 433, XP093037136
OPPOSITION- M A Sills, W I Forsythe, D Haidukewych, "Role of octanoic and decanoic acids in the control of seizures.", Archives of Disease in Childhood, BMJ Group, (19861201), vol. 61, no. 12, doi:10.1136/adc.61.12.1173, ISSN 0003-9888, pages 1173 - 1177, XP055075892
OPPOSITION- J. E. Milam, V. G. Keshamouni, S. H. Phan, B. Hu, S. R. Gangireddy, C. M. Hogaboam, T. J. Standiford, V. J. Thannickal, R. C. Reddy, "PPAR-  agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis", American journal of physiology. Lung cellular and molecular physiology, American Physiological Society, vol. 294, no. 5, doi:10.1152/ajplung.00333.2007, ISSN 10400605, pages 891 - 901, XP055160001
OPPOSITION- Yu Joe Yuezhou, Pearl Phillip L., "Metabolic Causes of Epileptic Encephalopathy", Epilepsy Research and Treatment, (20130522), vol. 2013, doi:10.1155/2013/124934, ISSN 2090-1348, pages 1 - 20, XP093093467
OPPOSITION- Jones Patricia M, Butt Yasmeen, Bennett Michael J, "Accumulation of 3-Hydroxy-Fatty Acids in the Culture Medium of Long-Chain l-3-Hydroxyacyl CoA Dehydrogenase (LCHAD) and Mitochondrial Trifunctional Protein-Deficient Skin Fibroblasts: Implications for Medium Chain Triglyceride Dietary Treatment of LCHAD Deficiency", Pediatric Research, Lippincott Williams & Wilkins, New York, US, US , (20030501), vol. 53, no. 5, doi:10.1203/01.PDR.0000059748.67987.1F, ISSN 0031-3998, pages 783 - 787, XP093093455
OPPOSITION- Huttenlocher PR, Wilbourn AJ, Signore JM., "Medium-chain triglycerides as a therapy for intractable childhood epilepsy", Neurology, Lippincott Williams & Wilkins, (19711101), vol. 21, no. 11, doi:10.1212/WNL.21.11.1097, ISSN 0028-3878, pages 1097 - 1103, XP009172447
OPPOSITION- Chang P, Orabi B, Deranieh R, Dham M, Hoeller O, Shimshoni J, Yagen B, Bialer M, Greenberg M L, Walker M C, Williams R S, "The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium.", Disease Models & Mechanisms, The Company of Biologists Ltd., GB, GB , (20120118), vol. 5, no. 1, doi:10.1242/DMM.008029, ISSN 1754-8403, pages 115 - 124, XP002667391
OPPOSITION- NAKAMURA J, ET AL, "Effect of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole in mice.", JOURNAL OF PHARMACOBIO-DYNAMICS, TOKYO, JP, JP , (19900101), vol. 13, no. 1, doi:10.1248/bpb1978.13.76, ISSN 0386-846X, pages 76 - 81, XP002723393
OTHER- Yu Joe Yuezhou, Pearl Phillip L., "Metabolic Causes of Epileptic Encephalopathy", Epilepsy Research and Treatment, (20130522), vol. 2013, doi:10.1155/2013/124934, ISSN 2090-1348, pages 1 - 20, XP093093467
OTHER- Jones Patricia M, Butt Yasmeen, Bennett Michael J, "Accumulation of 3-Hydroxy-Fatty Acids in the Culture Medium of Long-Chain l-3-Hydroxyacyl CoA Dehydrogenase (LCHAD) and Mitochondrial Trifunctional Protein-Deficient Skin Fibroblasts: Implications for Medium Chain Triglyceride Dietary Treatment of LCHAD Deficiency", Pediatric Research, US , (20030501), vol. 53, no. 5, doi:10.1203/01.PDR.0000059748.67987.1F, ISSN 0031-3998, pages 783 - 787, XP093093455
SEARCH- ALONSO L ET AL, "Fatty Acid Composition of Caprine Milk: Major, Branched-Chain, and Trans Fatty Acids", JOURNAL OF DAIRY SCIENCE, AMERICAN DAIRY SCIENCE ASSOCIATION, US, vol. 82, no. 5, ISSN 0022-0302, (19990501), pages 878 - 884, (19990501), XP026993413 [X] 1-5,8,10,11 * table 1 * [A] 13-15 [I] 6,7,9,12
SEARCH- PIOTR WLAZ ET AL, "Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice", NEUROPHARMACOLOGY, (20120301), vol. 62, no. 4, doi:10.1016/j.neuropharm.2011.12.015, ISSN 0028-3908, pages 1882 - 1889, XP055075889 [A] 1-15 * abstract * * page 1888, column l, lines 9-12, paragraph 2 *
SEARCH- PISHAN CHANG ET AL, "Seizure control by ketogenic diet-associated medium chain fatty acids", NEUROPHARMACOLOGY, (20130601), vol. 69, doi:10.1016/j.neuropharm.2012.11.004, ISSN 0028-3908, pages 105 - 114, XP055075887 [IP] 1-15 * 3.1 Results; figures 1, 2 *
SEARCH- CHANG P ET AL, "The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium", DISEASE MODELS & MECHANISMS, THE COMPANY OF BIOLOGISTS LTD, GB, vol. 5, no. 1, doi:10.1242/DMM.008029, ISSN 1754-8403, (20120118), pages 115 - 124, (20110829), XP002667391 [I] 1-12 * abstract * * page 118, column l, paragraph 1 * * figures 6, 7 * * page 121, column l, paragraph 2 - page 122, column l, paragraph 3 * * page 123, column l, paragraphs 2-3 * [A] 13-15

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