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| DESCRIPTION | - HERMANSON, GREG T., Bioconjugate techniques, Academic press, (20130000), page 289 | - |
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| INTERNATIONAL-SEARCH-REPORT | - CHEENU BHARGAVA ET AL, "Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861", MOLECULAR ONCOLOGY, (20170915), vol. 11, no. 11, doi:10.1002/1878-0261.12115, ISSN 1574-7891, pages 1527 - 1543, XP055677214 [A] 1-57 | |
| INTERNATIONAL-SEARCH-REPORT | - GILABERT-ORIOL ROGER ET AL, "Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma", CANCER IMMUNOLOGY, IMMUNOTHERAPY, SPRINGER, BERLIN/HEIDELBERG, vol. 66, no. 9, doi:10.1007/S00262-017-2013-Z, ISSN 0340-7004, (20170513), pages 1217 - 1228, (20170513), XP036309505 [A] 1-57 | |
| INTERNATIONAL-SEARCH-REPORT | - ROGER GILABERT-ORIOL ET AL, "Combinatorial approach to increase efficacy of Cetuximab, Panitumumab and Trastuzumab by dianthin conjugation and co-application of SO1861", BIOCHEMICAL PHARMACOLOGY, US, (20151001), vol. 97, no. 3, doi:10.1016/j.bcp.2015.07.040, ISSN 0006-2952, pages 247 - 255, XP055677222 [A] 1-57 | |
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| INTERNATIONAL-SEARCH-REPORT | - SABINE SEWING ET AL, "GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells", MOLECULAR THERAPY: NUCLEIC ACIDS., US, (20190301), vol. 14, doi:10.1016/j.omtn.2018.11.005, ISSN 2162-2531, pages 67 - 79, XP055762603 [A] 1-57 | |
| INTERNATIONAL-SEARCH-REPORT | - ROGER GILABERT-ORIOL ET AL, "Modified Trastuzumab and Cetuximab Mediate Efficient Toxin Delivery While Retaining Antibody-Dependent Cell-Mediated Cytotoxicity in Target Cells", MOLECULAR PHARMACEUTICS, US, (20131007), vol. 10, no. 11, doi:10.1021/mp400444q, ISSN 1543-8384, pages 4347 - 4357, XP055677139 [A] 1-57 | |
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| OPPOSITION | - Bachran Christopher, Bachran Silke, Sutherland Mark, Bachran Diana, Fuchs Hendrik, "Saponins in Tumor Therapy", Medicinal Chemistry, (20081231), pages 575 - 584, XP093128536 | - |
| OPPOSITION | - D16a - Supplementary Information from D16 8 January 2020 | - |
| OPPOSITION | - D17a - Online Supplementary Table from D17 | - |
| OPPOSITION | - Cheenu Bhargava et al., "Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861", Mol Oncol, (20170915), vol. 11, no. 11, doi:10.1002/1878-0261.12115, pages 1527 - 1543, XP055677214 | |
| OPPOSITION | - Yangbo Feng et al., "Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy", Cancer Med. , (20181106), vol. 7, doi:10.1002/cam4.1820, pages 6124 - 6136, XP093027357 | |
| OPPOSITION | - Alberto Dal Corso; Luca Pignataro; Laura Belvisi; Cesare Gennari, "Innovative Linker Strategies for Tumor‐Targeted Drug Conjugates", Chemistry - A European Journal, John Wiley & Sons, Inc, DE, DE, (20190920), vol. 25, no. 65, doi:10.1002/chem.201903127, ISSN 0947-6539, pages 14740 - 14757, XP071850847 | |
| OPPOSITION | - Roger Gilabert-Oriol et al., "Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma", Cancer Immunol Immunother., (20170513), vol. 66, no. 9, doi:10.1007/s00262-017-2013-z, pages 1217 - 1228, XP036309505 | |
| OPPOSITION | - Greg T. Hermanson, "2. Functional Targets for Bioconjugation", Greg T. Hermanson, Greg T Hermanson, Bioconjugate Techniques, NL , Elsevier Science & Technology , (20130917), pages 127 - 228, doi:10.1016/B978-0-12-382239-0.00002-9, ISBN 978-0-12-382239-0, XP009562911 | |
| OPPOSITION | - Greg T. Hermanson, "3. The Reactions of Bioconjugation", Greg T. Hermanson, Greg T Hermanson, Bioconjugate Techniques, NL , Elsevier Science & Technology , (20130917), pages 229 - 258, doi:10.1016/B978-0-12-382239-0.00003-0, ISBN 978-0-12-382239-0, XP009562910 | |
| OPPOSITION | - Greg T. Hermanson, "Chapter 17 - Chemoselective Ligation; Bioorthogonal Reagents", Greg T. Hermanson, Greg T Hermanson, Bioconjugate Techniques, NL , Elsevier Science & Technology , (20130917), pages 757 - 786, doi:10.1016/B978-0-12-382239-0.00017-0, ISBN 978-0-12-382239-0, XP009562912 | |
| OPPOSITION | - Xin Ming, Laing Brian, "Bioconjugates for targeted delivery of therapeutic oligonucleotides", Advanced Drug Delivery Reviews, Elsevier, Amsterdam , NL, Amsterdam , NL , (20150629), vol. 87, doi:10.1016/j.addr.2015.02.002, ISSN 0169-409X, pages 81 - 89, XP055346329 | |
| OPPOSITION | - Roger Gilabert-Oriol et al., "Combinatorial approach to increase efficacy of Cetuximab, Panitumumab and Trastuzumab by dianthin conjugation and co-application of SO1861", Biochem Pharmacol, (20151001), vol. 97, no. 3, doi:10.1016/j.bcp.2015.07.040, pages 247 - 255, XP055677222 | |
| OPPOSITION | - Potaczek Daniel P.; Garn Holger; Unger Sebastian D.; Renz Harald, "Antisense molecules: A new class of drugs", Journal of Allergy and Clinical Immunology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20160504), vol. 137, no. 5, doi:10.1016/j.jaci.2015.12.1344, ISSN 0091-6749, pages 1334 - 1346, XP029531137 | |
| OPPOSITION | - Alexander Weng et al., "Saponins modulate the intracellular trafficking of protein toxins", J Controlled Release, (20121010), vol. 164, doi:10.1016/j.jconrel.2012.10.002, pages 74 - 86, XP055428873 | |
| OPPOSITION | - Alexander Weng et al., "The toxin component of targeted anti-tumor toxins determines their efficacy increase by saponins", Mol Oncol, (20120112), vol. 6, doi:10.1016/j.molonc.2012.01.004, page 3, XP028508748 | |
| OPPOSITION | - Yuanyu Huang, "Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics", Molecular Therapy-Nucleic Acids, Cell Press, US, US , (20170301), vol. 6, doi:10.1016/j.omtn.2016.12.003, ISSN 2162-2531, pages 116 - 132, XP055485332 | |
| OPPOSITION | - Sabine Sewing et al., "GalNAc conjugation attenuated the cytotoxicity of antisense oligonucleotide drugs in renal tubular cells", Mol Ther Nucleic Acids, (20190301), vol. 14, doi:10.1016/j.omtn.2018.11.005, XP055762603 | |
| OPPOSITION | - Jan-Philip Meyer et al., "Click chemistry and radiochemistry: the First 10 years", Bioconjug Chem, (20161027), vol. 27, no. 12, doi:10.1021/acs.bioconjchem.6b00561, pages 2791 - 2807, XP055407064 | |
| OPPOSITION | - Cao Xue-Wei, Wang Fu-Jun, Liew Oi-Wah, Lu Ye-Zhou, Zhao Jian, "Analysis of Triterpenoid Saponins Reveals Insights into Structural Features Associated with Potent Protein Drug Enhancement Effects", Molecular Pharmaceutics, American Chemical Society, US, US , doi:10.1021/acs.molpharmaceut.9b01158, ISSN 1543-8384, XP093304078 | |
| OPPOSITION | - BIESSEN E.A.L.,ET AL., "Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes", Bioconjugate Chemistry - Author Manuscript, American Chemical Society, US, US , (20020101), vol. 13, doi:10.1021/bc015550g, ISSN 1043-1802, pages 295 - 302, XP002290397 | |
| OPPOSITION | - Wakefield Darren H., Klein Jason J., Wolff Jon A., Rozema David B., "Membrane Activity and Transfection Ability of Amphipathic Polycations as a Function of Alkyl Group Size", Bioconjugate Chemistry - Author Manuscript, American Chemical Society, US, US , (20050901), vol. 16, no. 5, doi:10.1021/bc050067h, ISSN 1043-1802, pages 1204 - 1208, XP093304077 | |
| OPPOSITION | - Roger Gilabert-Oriol et al., "Modified trastuzumab and cetuximab mediate efficient toxin delivery while retaining antibody-dependent cell-mediated cytotoxicity in target cells", Mol Pharm, (20131007), vol. 10, no. 11, doi:10.1021/mp400444q, pages 4347 - 4357, XP055677139 | |
| OPPOSITION | - Bo Hu, et al., "Therapeutic siRNA: state of the art", Signal Transduct Target Ther, (20200619), vol. 5, doi:10.1038/s41392-020-0207-x, page 1, XP093147548 | |
| OPPOSITION | - David B. Rozema, et al., "Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes", PNAS, (20070807), vol. 104, no. 32, doi:10.1073/pnas.0703778104, pages 12982 - 12987, XP055014142 | |
| OPPOSITION | - Van Rossenberg Sabine, Sliedregt-Bol Karen M., Meeuwenoord Nico J., Van Berkel Theo J.C., Van Boom Jacques H., Van Der Marel Gijs A., Biessen Erik A.L., "Targeted Lysosome Disruptive Elements for Improvement of Parenchymal Liver Cell-specific Gene Delivery", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20021101), vol. 277, no. 48, doi:10.1074/jbc.M203510200, ISSN 0021-9258, pages 45803 - 45810, XP093304075 | |
| OPPOSITION | - So C Wong, Klein Jason J, Hamilton Holly L, Chu Qili, Frey Christina L, Trubetskoy Vladimir S, Hegge Julia, Wakefield Darren, Rozema David B, Lewis David L, "Co-Injection of a Targeted, Reversibly Masked Endosomolytic Polymer Dramatically Improves the Efficacy of Cholesterol-Conjugated Small Interfering RNAs In Vivo", Nucleic acid therapeutics, Mary Ann Liebert, Inc, United States, United States , doi:10.1089/nat.2012.0389, (20121201), pages 380 - 390, Nucleic acid therapeutics, URL: http://online.liebertpub.com/doi/pdf/10.1089/nat.2012.0389, (20160330), XP055261447 | |
| OPPOSITION | - Aaron D. Springer, Steven F. Dowdy, "GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics", Nucleic Acid Therapeutics, Mary Ann Liebert, Inc. Publishers, US, US , (20180601), vol. 28, no. 3, doi:10.1089/nat.2018.0736, ISSN 2159-3337, pages 109 - 118, XP055555952 | |
| OPPOSITION | - Rudolph L. Juliano, "The delivery of therapeutic oligonucleotides", Nucleic Acid Res, (20160415), vol. 44, no. 14, doi:10.1093/nar/gkw236, pages 6518 - 6548, XP055491290 | |
| OPPOSITION | - Jorine M. Eeftens, Jaco Van Der Torre, Daniel R. Burnham, Cees Dekker, "Copper-free click chemistry for attachment of biomolecules in magnetic tweezers", BMC Biophysics, PhysMed Central, (20151225), vol. 8, no. 1, doi:10.1186/s13628-015-0023-9, XP055432659 | |
| OPPOSITION | - Hendrik Fuchs, et al., "Glycosylated triterpenoids as endosomal escape enhancers in targeted tumor therapies", Biomedicines, (20170329), vol. 5, no. 2, doi:10.3390/biomedicines5020014, page 14, XP055429235 | |
