IP Verse

Composition For Cleaving A Target Dna Comprising A Guide Rna Specific For The Target Dna And Cas Protein-Encoding Nucleic Acid Or Cas Protein, And Use Thereof - EP4357457

The patent EP4357457 was granted to Toolgen Incorporated on Oct 16, 2024. The application was originally filed on Oct 23, 2013 under application number EP24158339A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP4357457

TOOLGEN INCORPORATED
Application Number
EP24158339A
Filing Date
Oct 23, 2013
Status
Granted And Under Opposition
Sep 13, 2024
Grant Date
Oct 16, 2024
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (3)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateOpposition Status

Get instant alerts for new oppositions and patent status changes

GRUND GROUP PATENTANWALTE UND SOLICITOR PARTG MBBMar 6, 2025ADMISSIBLE
VERTEX PHARMACEUTICALS INCORPORATEDFeb 28, 2025ADMISSIBLE
VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBOct 16, 2024ADMISSIBLE

Patent Citations (3) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
OPPOSITIONWO2014093595
SEARCHWO2010076939
SEARCHWO2013176772

Non-Patent Literature (NPL) Citations (55) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- C. MUSSOLINO et al., Nucleic Acids Res, (20111100), vol. 39, page 9283-
DESCRIPTION- E. E. PEREZ et al., Nat Biotechnol, (20080700), vol. 26, page 808-
DESCRIPTION- H. J. KIMH. J. LEEH. KIMS. W. CHOJ. S. KIM, Genome Res, (20090700), vol. 19, page 1279-
DESCRIPTION- H. J. LEEE. KIMJ. S. KIM, Genome Res, (20100100), vol. 20, page 81-
DESCRIPTION- H. J. LEEJ. KWEONE. KIMS. KIMJ. S. KIM, Genome Res, (20120300), vol. 22, page 539-
DESCRIPTION- H. KIME. UMS. R. CHOC. JUNGJ. S. KIM, Nat Methods, (20111100), vol. 8, page 941-
DESCRIPTION- J. C. MILLER et al., Nat Biotechnol, (20110200), vol. 29, page 143-
DESCRIPTION- J. COHEN, Science, (20110513), vol. 332, page 784-
DESCRIPTION- M. JINEK et al., Science, (20120817), vol. 337, page 816-
DESCRIPTION- R. GABRIEL et al., Nat Biotechnol, (20110900), vol. 29, page 816-
DESCRIPTION- V. PATTANAYAKC. L. RAMIREZJ. K. JOUNGD. R. LIU, Nat Methods, (20110900), vol. 8, page 765-
OPPOSITION- Alberts Bruce, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, James D.Watson, "Nuclear Localization Signals Direct NuclearProteins to the Nucleus ", MOLECULAR BIOLOGY OF THE CELL, THIRD EDITION, (19940101), pages 563 - 564, XP093266178-
OPPOSITION- Anonymous, "CRISPR-Cas9 protein for genome editing - Getting started guide", ThermoFisher, (20160101), ThermoFisher, URL: https://assets.thermofisher.com/TFS-Assets/LSG/brochures/CRISPR-Cas9-genome-editing-guide.pdf, XP093300427-
OPPOSITION- Anonymous, "PET System Manual, 11th Edition", Novagen, (20060101), Novagen, URL: https://kirschner.med.harvard.edu/files/protocols/Novagen_petsystem.pdf, XP093300430-
OPPOSITION- CONG LE ET AL, "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science - Author Manuscript, American Association for the Advancement of Science, US, US , (20130201), vol. 339, no. 6121, ISSN 0036-8075, pages 819 - 823, XP002779503-
OPPOSITION- D05: Millipore certificate of analysis for ‘Anti-HA Tag’, 2008.-
OPPOSITION- D27 - New England Biolabs, 2016, Protocol (no date found)-
OPPOSITION- D28 - Sequence of NLS-SpCas9-EGFP-NLS-
OPPOSITION- D30 - Sequence of pST1374-NLS-flag-Cas9-
OPPOSITION- D37 - Art.94(3) Communication issued for EP24165188.4-
OPPOSITION- Woo Cho Seung, "Supplementary Material to Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease", Nature Biotechnology, (20130129), pages 1 - 11, XP055285225-
OPPOSITION- Zhang Huiming, "Quantum dot-A10 RNA aptamer-doxorubicin conjugate QD-Apt(Dox)", Molecular Imaging and Contrast Agent Database (MICAD); Bethesda (MD): National Center for Biotechnology Information (US), (20081008), Molecular Imaging and Contrast Agent Database (MICAD); Bethesda (MD): National Center for Biotechnology Information (US), URL: https://www.ncbi.nlm.nih.gov/books/NBK23117/, XP093300422-
OPPOSITION- Haoyi Wang et al., "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", Cell, (2013), vol. 153, doi:10.1016/j.cell.2013.04.025, XP028538358
OPPOSITION- Saldanha Roland, Chen Bing, Wank Herbert, Matsuura Manabu, Edwards Judy, Lambowitz Alan M., "RNA and Protein Catalysis in Group II Intron Splicing and Mobility Reactions Using Purified Components", Biochemistry (Easton), American Chemical Society, United States, United States, (19990701), vol. 38, no. 28, doi:10.1021/bi982799l, ISSN 0006-2960, pages 9069 - 9083, XP093300414
OPPOSITION- Manuela Villion et al., "The double-edged sword of CRISPR-Cas systems", Cell Research, (2013), vol. 23, doi:10.1038/cr.2012.124, XP055086684
OPPOSITION- Nannan Chang et al., "Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos", Cell Research, (2013), vol. 23, doi:10.1038/cr.2013.45, XP055251146
OPPOSITION- Bin Shen et al., "Generation of gene-modified mice via Cas9/RNA-mediated gene targeting", Cell Research, (201305), vol. 23, doi:10.1038/cr.2013.46, XP055141533
OPPOSITION- Rodolphe Barrangou et al., "RNA-mediated programmable DNA cleavage", Nat Biotechnol., (2012), vol. 30, doi:10.1038/nbt.2357, XP055118675
OPPOSITION- Woong Y. Hwang et al., "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nature Biotechnology, (2013), vol. 31, doi:10.1038/nbt.2501, XP055086625
OPPOSITION- Thomas Gaj, Jing Guo, Yoshio Kato, Shannon J Sirk, Carlos F Barbas, "Targeted gene knockout by direct delivery of zinc-finger nuclease proteins", Nature Methods, Nature Publishing Group US, New York, New York, (20120801), vol. 9, no. 8, doi:10.1038/nmeth.2030, ISSN 1548-7091, pages 805 - 807, XP002731080
OPPOSITION- Fyodor D. Urnov et al., "Genome editing with engineered zinc finger nucleases", Nat. Rev. Gene., (2010), vol. 11, doi:10.1038/nrg2842, XP055198280
OPPOSITION- J. Keith Joung, Sander Jeffry D., "TALENs: a widely applicable technology for targeted genome editing", Nature Reviews Molecular Cell Biology, Nature Publishing Group UK, London, London, vol. 14, no. 1, doi:10.1038/nrm3486, ISSN 1471-0072, pages 49 - 55, XP055282847
OPPOSITION- S. Kosugi et al, "Six Classes of Nuclear Localization Signals Specific to Different Binding Grooves of Importin  ", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20090102), vol. 284, no. 1, doi:10.1074/jbc.M807017200, ISSN 0021-9258, pages 478 - 485, XP055267734
OPPOSITION- James E. DiCarlo et al., "Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems", Nucleic Acids Res., (2013), vol. 41, doi:10.1093/nar/gkt135, XP055903957
OPPOSITION- S. Kim, Kim D., Cho S. W., Kim J., Kim J.-S., "Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins", Genome Research, Cold Spring Harbor Laboratory Press, US, US , (20140402), vol. 24, no. 6, doi:10.1101/gr.171322.113, ISSN 1088-9051, pages 1012 - 1019, XP055277723
OPPOSITION- Olaf H. Temmink, Tomohiro Emura, Michiel De Bruin, Masakazu Fukushima, Godefridus J. Peters, "Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies", CANCER SCIENCE, JAPANESE CANCER ASSOCIATION, TOKYO, JP, JP , (20070601), vol. 98, no. 6, doi:10.1111/j.1349-7006.2007.00477.x, ISSN 1347-9032, pages 779 - 789, XP055281121
OPPOSITION- M. Jinek et al, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, American Association for the Advancement of Science, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 00368075, pages 816 - 821, XP055067740
OPPOSITION- S. J. J. Brouns, "A Swiss Army Knife of Immunity", Science, American Association for the Advancement of Science, (20120817), vol. 337, no. 6096, doi:10.1126/science.1227253, ISSN 00368075, pages 808 - 809, XP055113718
OPPOSITION- Le Cong et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130215), vol. 339, doi:10.1126/science.1231143, XP055299673
OPPOSITION- Prashant Mali et al., "RNA-Guided Human Genome Engineering via Cas9", Science, (20130215), vol. 339, doi:10.1126/science.1232033, XP002723674
OPPOSITION- Lawrence D. Mayer et al., "Radiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice", Mol Cancer Ther, (2006), vol. 5, doi:10.1158/1535-7163.MCT-06-0118, XP002427287
OPPOSITION- D. Carroll, "Genome Engineering With Zinc-Finger Nucleases", Genetics, Genetics Society of America [etc.], (20110801), vol. 188, no. 4, doi:10.1534/genetics.111.131433, ISSN 00166731, pages 773 - 782, XP055036700
OPPOSITION- Scott J. Gratz et al., "Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease", Genetics, (2013), vol. 194, doi:10.1534/genetics.113.152710, XP055102690
OPPOSITION- S. W. Cho, J. Lee, D. Carroll, J.-S. Kim, "Heritable Gene Knockout in Caenorhabditis elegans by Direct Injection of Cas9-sgRNA Ribonucleoproteins", Genetics, Genetics Society of America [etc.], (20131101), vol. 195, no. 3, doi:10.1534/genetics.113.155853, ISSN 00166731, pages 1177 - 1180, XP055102693
OPPOSITION- Malnoy Mickael, Viola Roberto, Jung Min-Hee, Koo Ok-Jae, Kim Seokjoong, Kim Jin-Soo, Velasco Riccardo, Nagamangala Kanchiswamy Chidananda, "DNA-Free Genetically Edited Grapevine and Apple Protoplast Using CRISPR/Cas9 Ribonucleoproteins", FRONTIERS IN PLANT SCIENCE, Frontiers Research Foundation, CH, CH , (20161220), vol. 7, doi:10.3389/fpls.2016.01904, ISSN 1664-462X, XP055779864
OPPOSITION- Martin Jinek et al, "RNA-programmed genome editing in human cells.", eLife, eLife Sciences Publications Ltd., GB, GB , (20130129), vol. 2, doi:10.7554/eLife.00471, ISSN 2050-084X, pages e00471 - e00471-9, XP002699851
OPPOSITION- Steven Lin, Staahl Brett T, Alla Ravi K, Doudna Jennifer A, "Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery", eLife, England, England , (20141215), vol. 3, doi:10.7554/eLife.04766, page e04766, XP055294945
SEARCH- WANG HAOYI ET AL, "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", CELL, ELSEVIER, AMSTERDAM NL, (20130509), vol. 153, no. 4, doi:10.1016/J.CELL.2013.04.025, ISSN 0092-8674, pages 910 - 918, XP028538358 [AP] 1-13 * the whole document *
SEARCH- F ANN RAN ET AL, "Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity", CELL, (20130829), vol. 154, no. 6, doi:10.1016/j.cell.2013.08.021, ISSN 0092-8674, pages 1380 - 1389, XP055299681 [AP] 1-13 * the whole document *
SEARCH- SEUNG WOO CHO ET AL, "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease (includes Supplementary information)", NATURE BIOTECHNOLOGY, GALE GROUP INC, vol. 31, no. 3, doi:10.1038/NBT.2507, ISSN 1087-0156, (20130129), pages 230 - 232, 1, (20130129), XP002699850 [AP] 1-13 * the whole document *
SEARCH- M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055299674 [A] 1-13 * the whole document *
SEARCH[ ] - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, US, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 1 - 37, XP055067747 [ ] * the whole document *
SEARCH- L. CONG ET AL, "Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055067741 [AP] 1-13 * the whole document *
SEARCH- P. MALI ET AL, "RNA-Guided Human Genome Engineering via Cas9", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055111247 [AP] 1-13 * the whole document *
SEARCH- MARTIN JINEK ET AL, "RNA-programmed genome editing in human cells", ELIFE, ELIFE SCIENCES PUBLICATIONS LTD, GB, vol. 2, doi:10.7554/ELIFE.00471, ISSN 2050-084X, (20130129), pages e00471 - 1, (20130628), XP002699851 [AP] 1-13 * the whole document *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents