Patent No. EP2222848 (titled "Novel Sirna Structure For Minimizing Off-Target Effects And Relaxing Saturation Of Rnai Machinery And The Use Thereof") was filed by LEE on Dec 18, 2008. The application was issued on Feb 25, 2015.

The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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