Dosing Regimen Associated With Long Acting Injectable Paliperidone Esters

A long-acting injectable formulation of paliperidone palmitate for treating schizophrenia and other psychiatric disorders. The formulation is administered via intramuscular injection, with a loading dose of 150-200 mg paliperidone palmitate given in the deltoid muscle on the first day, followed by a second loading dose of 100 mg paliperidone palmitate in the deltoid muscle 7-10 days later. Subsequent maintenance doses of 25-150 mg paliperidone palmitate are administered every 4 weeks, either in the deltoid or gluteal muscle. The formulation is an aqueous nanoparticle suspension that provides sustained release of paliperidone over a 4-week period.